Pediatric Nephrology: Advances in the Diagnosis and Management of Pediatric Kidney Disorders

Dear Colleagues,

Pediatric kidney disorders refer to various conditions, sudden or chronic, including congenital abnormalities of the kidney and urinary tract, glomerulopathies, or tubulo-interstitial diseases. They may have different background, but nevertheless, most are at risk of chronic kidney disease. That is why achieving the right diagnosis, enabling early interventions, is crucial.

Advances in diagnosing and the further management of kidney diseases in the pediatric population have significantly improved outcomes. One of the major developments is the search for biomarkers, which are useful in the early diagnosis and treatment of kidney problems. What is more, these potential biomarkers seem to have moved from research to clinical use, aiding in the early detection and monitoring of several kidney diseases, especially acute kidney injury. Additionally, but also extremely important in inherited kidney disease diagnosis, is genetic testing. This may allow for the early and precise identification of specific genetic abnormalities and, in some cases, more personalized management plans.

As for the management of kidney diseases, we have observed the development of new biologics and immunosuppressants introduced for the therapy of conditions related to nephrotic and nephritic syndromes. RNA interference therapies help to effectively treat rare diseases. In renal replacement therapy there are improved dialysis machines for newborns and preterm infants. We have all witnessed emerging technologies, like bioengineering and artificial intelligence, that have begun to impact clinical practice.

This advancements collectively highlight the importance of integrating genetic tools, new kidney biomarkers, and innovative therapies to optimize treatment for children with kidney diseases. This Special Issue seeks contributions elucidating mechanistic insights, diagnostic innovations, and therapeutic advances in pediatric nephrology. Submissions of reviews and original research articles are invited, with particular emphasis on the interdisciplinary integration of molecular diagnostics, biomarker science, and precision therapeutics.

Dr. Agnieszka Rybi-Szumińska
Prof. Dr. Anna Maria Wasilewska
Guest Editors

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• diagnosis
• management
• treatment
• kidney disorders
• chronic kidney disease
• biomarkers
• genetic testing
• kidney
• children
• newborn