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Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities
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Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 10 July 2025 | Viewed by 655

Special Issue Editors

Dr. Dhrubajyoti Bandyopadhyay

E-Mail Website
Guest Editor
Division of Cardiovascular Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Interests: clinical cardiology; heart failure; myocardial infarction; atrial fibrillation; echocardiography; hypertension
Dr. Vikash Jaiswal

E-Mail Website
Guest Editor
Department of Cardiovascular Research, Larkin Community Hospital, South Miami, FL 33143, USA
Interests: heart failure; cardio-oncology; preventive cardiology
Special Issues, Collections and Topics in MDPI journals
Dr. Adrija Hajra

E-Mail Website
Guest Editor
Department of Internal Medicine, Brigham and Women’s Hospital, Boston, MA 02115, USA
Interests: heart failure; cardiovascular medicine; echocardiography.
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We would like to invite you submit a manuscript for a Special Issue on heart failure and coronary artery disease, specifically dealing with cardiovascular comorbidities and complications. This area of research is trending because of newer advancements in diagnosis as well as management, thus significantly improving patient outcomes.

Heart failure and coronary artery disease occur frequently together and are still a significant cause of mortality and morbidity. Hence, understanding the underlying pathology is essential.

Certain newer improvements in this field include the following:

  1. Integrated care AI models focused on comprehensive patient care.
  2. Advanced diagnostics, including imaging and biomarker discovery, for early detection and monitoring of cardiovascular complications.
  3. Lifestyle modification to reduce the risk.
  4. Personalised treatment plan as per individual patient risk profile.

We encourage you to submit your [article types] to enrich your knowledge of heart failure and coronary artery disease.

Dr. Dhrubajyoti Bandyopadhyay
Dr. Vikash Jaiswal
Dr. Adrija Hajra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • heart failure
  • acute myocardial infarction
  • coronary artery diseases
  • cardiac imaging
  • biomarkers
  • artificial intelligence

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

14 pages, 3829 KiB  
Article
Effectiveness of a Simplified Checklist to Overcome the Inertia of Treatment Implementation in ACS Patients with High Comorbidity Burden
by Jonathan X. Fang, Yap-Hang Chan, Zaid I. Almarzooq, Cheung-Chi Simon Lam, Yiu-Tung Anthony Wong, Han Naung Tun, Kai-Hang Yiu, Hung-Fat Tse, Hon-Wah Chan and Chor-Cheung Frankie Tam
J. Clin. Med. 2025, 14(7), 2469; https://doi.org/10.3390/jcm14072469 - 4 Apr 2025
Viewed by 399
Abstract
Background/Objective: High-risk subsets of patients with acute coronary syndrome (ACS) experience decreased access to optimal care and have poor clinical outcomes, reflecting an inertia to the delivery of guideline-directed and evidence-based therapy and implementation of critical care pathways. We aim to investigate [...] Read more.
Background/Objective: High-risk subsets of patients with acute coronary syndrome (ACS) experience decreased access to optimal care and have poor clinical outcomes, reflecting an inertia to the delivery of guideline-directed and evidence-based therapy and implementation of critical care pathways. We aim to investigate the clinical effectiveness of a simplified implementation checklist to counter treatment inertia in patients with high comorbidity burden. Methods: An ACS critical care pathway was simplified and reduced to a minimalistic checklist including only items on GDMT and invasive strategy. A total of 2005 consecutive patients with ACS were evaluated including 1499 patients receiving standard care and 506 patients managed with the checklist. Patients with STEMI undergoing primary percutaneous coronary interventions and patients receiving upfront cardiovascular intensive care were excluded. Multivariate regression spline models were used to study the relationship between comorbidity, expressed as the Charlson Comorbidity Index (CCI) and a management strategy including guideline-directed medical therapy (GDMT) and an early invasive approach. Inverse probability of treatment weighting (IPTW) was used to address confounding factors. The use of GDMT and early invasive therapy were compared in patients receiving standard care and checklists. The 90-day composite outcome of all-cause mortality, recurrent ACS and stroke were compared between patients receiving standard care and those receiving checklists. Results: High CCI was associated with decreased GDMT, invasive strategy and the utilization of critical care pathway. Checklist utilization was unaffected by high CCI and led to sustained and higher use of GDMT and invasive approach in patients despite high CCI. Checklist managed patients have >10% higher rates of prescription of each class of GDMT (p < 0.0001) and more than twice the rate of early invasive approach (51.0% vs. 20.7%, (p < 0.0001) compared to patients receiving standard care. The 90-day composite outcome was lower in checklist management patients compared to patients receiving standard care, adjusted hazard ratio 0.61 (95% CI 0.46–0.81), log-rank p = 0.0006, especially in patients with high CCI, adjusted hazard ratio 0.60 (95% CI 0.38–0.97), log-rank p = 0.035 for CCI 5–6; adjusted hazard ratio 0.53 (95% CI 0.35–0.84), log-rank p = 0.0057 for CCI 7 or more. Conclusions: The use of a simplified checklist is associated with better implementation of GDMT and invasive strategy as well as better 90-day clinical outcomes in ACS patients with high comorbidity burden Full article
(This article belongs to the Special Issue Heart Failure and Coronary Artery Diseases: Cardiovascular Complications and Comorbidities)
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