Pulmonary Embolism—Current and Novel Approaches

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 372

Special Issue Editors


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Guest Editor
The Cardiovascular Division, Leviev Heart Center, Sheba Medical Center, Tel-Hashomer, The Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
Interests: acute coronary syndrome; myocardial infarction; heart failure; echocardiography; intensive cardiac care; valvular heart disease; clinical cardiology; pulmonary embolism
Special Issues, Collections and Topics in MDPI journals

E-Mail
Guest Editor
The Cardiovascular Division, Leviev Heart Center, Sheba Medical Center, Tel-Hashomer, The Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel
Interests: acute coronary syndrome; myocardial infarction; heart failure; clinical cardiology; pulmonary embolism; intensive cardiac care

Special Issue Information

Dear Colleagues,

In recent years, there have been significant advances in our understanding and management of patients with pulmonary embolism, a condition that continues to be a major challenge worldwide. Pulmonary embolism is the third most frequent cause for cardiovascular death and one of the leading causes of in-hospital mortality. In the past decade, there has been tremendous advancement in the field of invasive percutaneous therapeutic options for the treatment of complex cases, providing more specific options for the complex pulmonary embolism patient. Nonetheless, there are still many gaps in our knowledge regarding the optimal use of these novel techniques and their associated outcomes, as well as there still being a need to discuss future perspectives on the topic and unmet needs.

This Special Issue aims to bring focus to the topic of pulmonary embolism from leading scientists and clinicians around the world in order to share their latest insights on the developments, methods for diagnosis, and novel treatments in the field. This issue will include original research and reviews relating to the epidemiology, diagnosis, risk stratification, and treatment of venous thromboembolic disease and specifically pulmonary embolism.

We are pleased to invite you take part in this Special Issue focusing on pulmonary embolism and look forward to receiving your contributions.

Prof. Dr. Roy Beigel
Prof. Dr. Shlomi Matetzky
Guest Editors

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Keywords

  • pulmonary embolism
  • treatment
  • coagulation
  • venous thrombosis
  • thrombolysis
  • anticoagulation
  • risk stratification

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Published Papers (1 paper)

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Research

12 pages, 2783 KiB  
Article
Echocardiography-Based Pulmonary Artery Pulsatility Index Correlates with Outcomes in Patients with Acute Pulmonary Embolism
by Gassan Moady, Loai Mobarki, Tsafrir Or, Alexander Shturman and Shaul Atar
J. Clin. Med. 2025, 14(8), 2685; https://doi.org/10.3390/jcm14082685 - 14 Apr 2025
Viewed by 200
Abstract
Objectives: The pulmonary artery pulsatility index (PAPI) is a novel hemodynamic parameter that reflects right ventricular (RV) function. PAPI was shown to be useful in predicting outcomes following left ventricular assist device (LVAD) implantation, acute RV infarction, and in patients with chronic [...] Read more.
Objectives: The pulmonary artery pulsatility index (PAPI) is a novel hemodynamic parameter that reflects right ventricular (RV) function. PAPI was shown to be useful in predicting outcomes following left ventricular assist device (LVAD) implantation, acute RV infarction, and in patients with chronic RV failure. The standard method to estimate PAPI is during right heart catheterization (RHC); however, echocardiography-based PAPI was also shown to be accurate. In the current study, we evaluated the ability of echocardiography-based PAPI to predict outcomes of patients with acute pulmonary embolism (PE). Methods: A total of 177 patients (mean age 67 ± 15, 54.1% male) with acute PE were included in the study. PAPI was calculated based on measurements from standard transthoracic echocardiography. Results: 27% of patients needed oxygen support, 5.6% were on mechanical ventilation, and 7.3% were on inotropic support. The 30-day mortality rate in the whole cohort was 8.3%. Lower PAPI measurements were associated with increased 30-day mortality (p < 0.05), a higher rate of RV failure (p < 0.001), and the need for inotropic support (p < 0.05). There was no association between PAPI and the need for oxygen support (p = 0.59), mechanical ventilation (0.06), or length of stay (LOS) (p = 0.414). PAPI was superior to tricuspid annular plane systolic excursion (TAPSE) in predicting mortality and RV failure. Conclusions: Echocardiography-derived PAPI is feasible and superior over TAPSE in predicting RV failure and mortality among patients with acute PE. Full article
(This article belongs to the Special Issue Pulmonary Embolism—Current and Novel Approaches)
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