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JCM
Special Issues
Paradigms, Advances and Future Directions in Oral Medicine
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Paradigms, Advances and Future Directions in Oral Medicine

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 466

Special Issue Editor

Prof. Dr. Pia Lopez-Jornet

E-Mail Website
Guest Editor
Oral Medicine in the Department of Stomatology, Faculty of Dentistry, University of Murcia, 30008 Murcia, Spain
Interests: oral mucosa; oral lichen planus; leukoplakia; aphta; oral potentially malignant disorders (OPMDs); xerostomia; oral pain
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

There have been remarkable advances in the field of oral medicine. However, research is still needed in many areas of oral medicine, such as potentially malignant disorders, dermatologic diseases of the oral cavity, and orofacial pain.

The development and advancement of diagnostic techniques and treatments, many of them minimally invasive, have led to improvements in diagnoses and quality of life.

In this Special Issue, we invite authors to present papers on clinical advances in oral medicine diagnostics and treatment.

Prof. Dr. Pia Lopez-Jornet
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oral medicine
  • oral potentially malignant disorders
  • leukoplakia
  • oral lichen planus
  • orofacial pain
  • biopsy and liquid biopsy
  • biomarkers

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Published Papers (1 paper)

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12 pages, 3928 KB  
Case Report
Kaposiform Hemangioendothelioma of the Oral Cavity in an Adult Woman: A Case Report
by Martina Caputo, Gaspare Palaia, Daniele Pergolini, Alessandra Putrino, Amelia Bellisario, Gianluca Tenore, Federica Rocchetti, Angela Galeotti, Cira Rosaria Tiziana Di Gioia and Umberto Romeo
J. Clin. Med. 2025, 14(22), 8228; https://doi.org/10.3390/jcm14228228 - 20 Nov 2025
Viewed by 253
Abstract
Background: Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that shares histological features with Kaposi’s sarcoma. It usually occurs in infancy or early childhood and is seldom reported in adults. The most common sites are the skin and retroperitoneum, whereas the [...] Read more.
Background: Kaposiform hemangioendothelioma (KHE) is a rare, locally aggressive vascular tumor that shares histological features with Kaposi’s sarcoma. It usually occurs in infancy or early childhood and is seldom reported in adults. The most common sites are the skin and retroperitoneum, whereas the head, neck, and mediastinum are less frequently involved. KHE rarely regresses spontaneously, and metastasis is uncommon, but up to 70% of cases may develop Kasabach–Merritt Syndrome (KMS), a life-threatening coagulopathy. Here, we present an unusual case of KHE in an adult patient, emphasizing the importance of early recognition and management. Methods: A 39-year-old woman with systemic lupus erythematosus presented with an exophytic lesion in the left retromolar region. Clinical and radiological evaluations were followed by both incisional and excisional biopsies. Histopathological and immunohistochemical analyses were performed, and surgical resection with wide margins was undertaken according to recommendations from a multidisciplinary tumor board. Results: Histology revealed spindle cell clusters, slit-like vascular spaces, endothelial cells with eosinophilic cytoplasm, and immunopositivity for CD31, CD34, and smooth muscle actin, confirming the diagnosis of KHE. Given the tumor’s locally aggressive behavior and potential risk of KMS, extended surgical excision was performed. Conclusions: This case underscores the diagnostic challenges of KHE in adults and highlights the essential role of histopathology, immunohistochemistry, and multidisciplinary evaluation. Prompt diagnosis and radical surgical management are critical to preventing complications and improving patient outcomes. Full article
(This article belongs to the Special Issue Paradigms, Advances and Future Directions in Oral Medicine)
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