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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Transcatheter Aortic Valve Replacement: Second Edition

edited by

Anna Olasińska-Wiśniewska

and Maciej Dąbrowski

submission deadline 18 Dec 2025 | 2 articles | Viewed by 1331 | Submission Open

Keywords: aortic stenosis; transcatheter; bioprosthesis; TAVI; transcatheter aortic valve replacement

(This special issue belongs to the Section Cardiovascular Medicine)

Clinical and Surgical Insights on Lung Cancer Treatment

edited by

Eleonora Faccioli

and Marco Schiavon

submission deadline 18 Dec 2025 | 1 articles | Viewed by 1139 | Submission Open

Keywords: lung cancer; surgery; minimally invasive surgery; immunotherapy; clinical trials; robotic surgery; diagnosis; multimodal treatment; outcomes; targeted therapy

(This special issue belongs to the Section Respiratory Medicine)

Innovations in the Clinical Management of Retinal Diseases: Emerging Therapies and Visual Rehabilitation

edited by

Francisco J. Povedano-Montero

submission deadline 19 Dec 2025 | 3 articles | Viewed by 2368 | Submission Open

Keywords: retinal diseases; macular degeneration; maculopathies; diabetic retinopathy; retinal vascular occlusions; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

An Update on Retinal Diseases: From Diagnosis to Treatment

edited by

Shigeru Honda

, Masahiko Sugimoto and Kenji Yamashiro

submission deadline 20 Dec 2025 | 15 articles | Viewed by 27616 | Submission Open

Keywords: retinal diseases; diagnosis; treatment; etiology; original article; review paper

(This special issue belongs to the Section Ophthalmology)

Recent Advances in Therapy of Trauma and Surgical Critical Care

edited by Rita Galeiras

submission deadline 20 Dec 2025 | 7 articles | Viewed by 24927 | Submission Open

Keywords: trauma management; trauma care; burn; critical care; damage control surgery; traumatic spinal cord injury

(This special issue belongs to the Section Emergency Medicine)

Sepsis and Organ Dysfunction: New Insights into Diagnosis and Treatment

edited by

Barbara Adamik

submission deadline 20 Dec 2025 | 10 articles | Viewed by 21428 | Submission Open

Keywords: intensive care; sepsis; septic shock; biomarkers; multiorgan dysfunction syndrome; ex-tracorporeal methods; mortality

(This special issue belongs to the Section Intensive Care)

Clinical Diagnosis and Management of Neonatal Diseases

edited by Ayala Gover and

Arieh Riskin

submission deadline 20 Dec 2025 | 10 articles | Viewed by 16839 | Submission Open

Keywords: newborn; preterm; neonatal intensive care; low birth weight; point-of-care ultrasound; neonatal monitoring

(This special issue belongs to the Section Clinical Pediatrics)

Substance and Behavioral Addictions: Prevention and Diagnosis

edited by

Icro Maremmani

submission deadline 20 Dec 2025 | 7 articles | Viewed by 16334 | Submission Open

Keywords: substance addiction; behavioural addiction; clinical perspectives; prevention strategies; diagnostic protocols; differential diagnosis; psychopathology of addiction; psychopathology as a diagnostic tool; craving behavioural covariates

(This special issue belongs to the Section Mental Health)

Gynecologic and Obstetric Pathologies: From Birth to Menopause (Third Edition)

edited by

Panagiotis Christopoulos

submission deadline 20 Dec 2025 | 5 articles | Viewed by 13899 | Submission Open

Keywords: obstetrics; gynecology; pathology; pediatric and adolescent gynecology; menopause; urinary disorders; infertility; gynecologic oncology; maternal– fetal medicine; incontinence; menstruation; reproduction; polycystic ovarian syndrome; endometriosis; dysmenorrhea; assisted reproduction; IVF; laparoscopy; hysteroscopy; gynecologic robotic surgery; high-risk pregnancy

(This special issue belongs to the Section Obstetrics & Gynecology)

Thoracic Surgery: Current Challenges and Future Perspectives

edited by

Jon Zabaleta

and José Luis Campo-Cañaveral de la Cruz

submission deadline 20 Dec 2025 | 6 articles | Viewed by 12097 | Submission Open

Keywords: minimally invasive surgery; robotic-assisted thoracic surgery; lung cancer management; esophageal surgery; pleural diseases and interventions; thoracic trauma surgery; tracheal and bronchial surgery; thoracic endoscopy; lung transplantation; lung segmentectomy; 3D printing; pneumothorax; surgical planification; education; simulation; artificial intelligence

(This special issue belongs to the Section Respiratory Medicine)

Trauma and Acute Care Surgery Research: Innovations, Challenges, and Future Directions

edited by Frederick Rogers

submission deadline 20 Dec 2025 | 7 articles | Viewed by 11965 | Submission Open

Keywords: trauma care; best practices; clinical care; trauma system development; optimal trauma care

(This special issue belongs to the Section Intensive Care)

State-of-the-Art Innovations in Oral and Maxillofacial Surgery

edited by Marcin Kozakiewicz and Katarzyna Bogusiak

submission deadline 20 Dec 2025 | 8 articles | Viewed by 11502 | Submission Open

Keywords: oral surgery; maxillofacial surgery; traumatology; orthognatic surgery; infections; oncology; diagnostics; treatment; implantology; augmentation; imaging; computer-assisted techniques

(This special issue belongs to the Section Otolaryngology)

Advances in Trauma Care and Emergency Medicine

edited by

Lothar Andreas Schwarte

Patrick Schober

and

Georgios F. Giannakopoulos

submission deadline 20 Dec 2025 | 2 articles | Viewed by 10858 | Submission Open

Keywords: trauma; trauma care; emergency medicine; pre-hospital; emergency room; intensive care unit

(This special issue belongs to the Section Emergency Medicine)

Advances in Leveraging Big Data for Improving Patient Outcomes in Gastrointestinal and Hepatopancreatobiliary Diseases

edited by Saurabh Chawla

submission deadline 20 Dec 2025 | 4 articles | Viewed by 10152 | Submission Open

Keywords: big data; machine learning; artificial intelligence; gastroenterology; research; hepatopancreatobiliary

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Surgical Treatment and Postoperative Recovery of Heart and Lung Disease

edited by

Yasushige Shingu

submission deadline 20 Dec 2025 | 6 articles | Viewed by 9159 | Submission Open

Keywords: heart and lung disease; complications; frailty; rehabilitation; atrial fibrillation; infections

(This special issue belongs to the Section Cardiovascular Medicine)

New Advances in Extracorporeal Membrane Oxygenation (ECMO)

edited by Camilla L'Acqua

submission deadline 20 Dec 2025 | 5 articles | Viewed by 8511 | Submission Open

Keywords: ECMO; anticoagulation; circuit; global collaboration

(This special issue belongs to the Section Emergency Medicine)

Diagnosis and Treatment of Rheumatic Diseases

edited by Răzvan Gabriel Drăgoi and

Codrina Ancuta

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8347 | Submission Open

Keywords: rheumatic diseases; patient-reported outcomes; assessment; arthritis; impairment; connective tissue diseases; biological and targeted synthetic therapies; impairment

(This special issue belongs to the Section Immunology & Rheumatology)

New Insights in Ophthalmic Surgery

edited by Irina S. Barequet

submission deadline 20 Dec 2025 | 8 articles | Viewed by 8284 | Submission Open

Keywords: cataract surgery; corneal surgery; refractive surgery; ocular surface reconstruction; anterior segment surgery

(This special issue belongs to the Section Ophthalmology)

Pelvic Organ Prolapse: Current Challenges and Future Perspectives

edited by Marco Soligo

submission deadline 20 Dec 2025 | 5 articles | Viewed by 8080 | Submission Open

Keywords: pelvic organ prolapse; urinary incontinence; lower urinary disorders; quality of life; patient-reported outcomes

(This special issue belongs to the Section Obstetrics & Gynecology)

Patient Reported Outcomes (PROs) in Inflammatory Bowel Disease (IBD) Around the World

edited by Irina Blumenstein

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7448 | Submission Open

Keywords: inflammatory bowel disease; patient reported outcomes; symptom burden; quality of life; treatment satisfaction

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Hirsh D. Trivedi

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7197 | Submission Open

Keywords: metabolic dysfunction-associated steatotic liver disease; MASLD; non-alcoholic fatty liver disease; NAFLD; liver disease; liver fibrosis; metabolic syndrome

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Perspectives on Congenital Heart Disease from Children to Adults

edited by

Raffaele Giordano

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7060 | Submission Open

Keywords: congenital heart disease; pediatric cardiac surgery; pediatric cardiology; children; adult congenital heart disease

(This special issue belongs to the Section Cardiology)

Clinical Treatment and Management of Rheumatic Diseases, Autoinflammatory Diseases, and Autoimmune Disorders

edited by Merav Lidar and

Abdulla Watad

submission deadline 20 Dec 2025 | 6 articles | Viewed by 7021 | Submission Open

Keywords: rheumatic diseases; autoinflammatory diseases; autoimmune disorders; rheumatoid arthritis; diagnosis

(This special issue belongs to the Section Immunology & Rheumatology)

Robotic Bariatric Surgery

edited by

Antonio Vitiello

and Vincenzo Pilone

submission deadline 20 Dec 2025 | 2 articles | Viewed by 6139 | Submission Open

Keywords: bariatric surgery; metabolic surgery; sleeve gastrectomy; bariatrics; general surgery; gastric bypass; robotic surgery; robotics

(This special issue belongs to the Section General Surgery)

State of the Art in Hand Surgery

edited by Leszek Romanowski and

Piotr Czarnecki

submission deadline 20 Dec 2025 | 5 articles | Viewed by 5756 | Submission Open

Keywords: hand surgery; nerve surgery; state-of-the-art; hand therapy; tendons; thumb arthritis; hand fractures

(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)

Emergency Ultrasound: State of the Art and Perspectives

edited by

Yale Tung-Chen

and

Gonzalo Garcia Casasola

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5302 | Submission Open

Keywords: point-of-care ultrasound; emergency ultrasound; focus cardiac ultrasound; lung ultrasound; shock; venous thromboembolic disease; systemic venous congestion; resuscitation; polytrauma

(This special issue belongs to the Section Emergency Medicine)

Latest Advances in Orthodontics

edited by

Giuseppina Laganà

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5295 | Submission Open

Keywords: digital treatment planning; clear aligners; skeletal anchorage; OSAS; artificial intelligence

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements in Gait Rehabilitation: Innovative Approaches and Clinical Insights

edited by

Shinichi Watanabe

Nobuto Nakanishi

and

Yuki Iida

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4594 | Submission Open

Keywords: sarcopenia; swallowing therapy; physical therapy; early mobilization; early rehabilitation; robot-assisted gait training; neurorehabilitation; wearable sensors

(This special issue belongs to the Section Clinical Rehabilitation)

Clinical Perspectives on Acute Coronary Syndrome

edited by

Marius Rus

and

Massimo Mancone

submission deadline 20 Dec 2025 | 3 articles | Viewed by 4442 | Submission Open

Keywords: acute coronary syndrome; ischemic heart disease; multidisciplinary approach; interventional cardiology; new research lines; diagnosis and risk stratification; biomarkers; reperfusion strategies

(This special issue belongs to the Section Cardiovascular Medicine)

Accelerating Fracture Healing: Clinical Diagnosis and Treatment

edited by Seong-Eun Byun

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4366 | Submission Open

Keywords: fracture; fracture surgery; fracture healing; diagnosis; treatment

(This special issue belongs to the Section Orthopedics)

Clinical Advances in Trauma and Orthopaedic Surgery

edited by Valerio Pace and Pierluigi Antinolfi

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3932 | Submission Open

Keywords: orthopaedic surgery; hand/wrist surgery; tendon injury; ligament injury; artificial intelligence (AI); robotic surgery; orthopaedic injections; nerve injury

(This special issue belongs to the Section Orthopedics)

Anesthesia and Intensive Care in Orthopedic and Trauma Surgery

edited by Liliana Mirea, Răzvan Ene and Cristian Cobilinschi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3740 | Submission Open

Keywords: opioid sparing analgetic technique; pain management; perioperative medicine; perioperative cognitive disfunction; delirium

(This special issue belongs to the Section Intensive Care)

Targeted Treatment of Oral Cancer

edited by

Yasmine Ghantous

and

Claudia Malheiros Coutinho-Camillo

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3737 | Submission Open

Keywords: precision medicine; immunotherapy; targeted drugs; combination therapy; tumor immune evasion; clinical trials

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advancements in Femtosecond Laser Applications

edited by Luca Schwarzenbacher, Eva Stifter and Philipp Roberts

submission deadline 20 Dec 2025 | 4 articles | Viewed by 3619 | Submission Open

Keywords: femtosecond laser; cataract surgery; DSAEK; DALK; femto-CAIRS; congenital cataract

(This special issue belongs to the Section Ophthalmology)

Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 2nd Edition

edited by Juan Luis Rodriguez Hermosa, José Luis Álvarez-Sala Walther and Myriam Calle Rubio

submission deadline 20 Dec 2025 | 4 articles | Viewed by 3330 | Submission Open

Keywords: COPD; diagnosis; comorbidities; respiratory rehabilitation; inhaled therapy; biological therapies

(This special issue belongs to the Section Respiratory Medicine)

Maternal–Fetal Medicine: Current Status, Challenges, and Future Directions

edited by Jessian Munoz

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3323 | Submission Open

Keywords: maternal– fetal medicine; preterm delivery; preterm birth management; newborn; obstetrics; high-risk pregnancy; perinatal outcome; placenta accreta; fetal surgery

(This special issue belongs to the Section Obstetrics & Gynecology)

Colorectal Surgery: Current Practice and Future Perspectives

edited by

Karel Kostev

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3287 | Submission Open

Keywords: colorectal surgery; minimal invasive surgery; open surgery; robot assisted surgery; colorectal cancer; stomach cancer; pancreatic cancer; diverticular disease

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Investigations into Diagnosing and Managing Strabismus

edited by Mario Cantó Cerdán and Pilar Cacho-Martínez

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3265 | Submission Open

Keywords: oculomotricity; binocular vision; strabismus; ocular motility disorders; exotropia; esotropia; video oculography; eye tracker; ocular deviation

(This special issue belongs to the Section Ophthalmology)

Clinical Management of Burns: Past, Present and Future

edited by Lior Rosenberg

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3262 | Submission Open

Keywords: history of burn care; burn care infection; inflammation; burn wound care and closure; debridement; traditional Chinese burn care; traditional Indian (Ayurveda) burn care; burn mass casualty incidents (BMCIs); surge capacity; burn pain control; pruritus; burn scar treatment

(This special issue belongs to the Section General Surgery)

Updates on the Clinical Applications of Dental Restorative Materials

edited by

Vittorio Checchi

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2771 | Submission Open

Keywords: restorative dentistry; restorations; adhesive dentistry; resin composites; ceramics; aesthetics; dental materials; direct restorations; indirect restorations; conservative dentistry; prosthetic dentistry; partial restorations; total restorations

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Periodontitis and Other Periodontal Diseases

edited by

Giovanna Murmura

submission deadline 20 Dec 2025 | 4 articles | Viewed by 2761 | Submission Open

Keywords: periodontal diseases; gingivitis; periodontitis; systemic disease; classification

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Multiple Sclerosis: Clinical Advances in Diagnosis and Treatment

edited by

Marta Simone

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2681 | Submission Open

Keywords: relapse-remitting multiple sclerosis; progressive multiple sclerosis; immunomodulatory treatments; cognitive impairment; personalized medicine in multiple sclerosis

(This special issue belongs to the Section Clinical Neurology)

Genitourinary Cancers: Clinical Advances and Practice Updates

edited by David Benjamin and Arash Rezazadeh Kalebasty

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2266 | Submission Open

Keywords: rare tumors; genitourinary cancers; urachal cancer; penile cancer; testicular cancer; variant histology

(This special issue belongs to the Section Nephrology & Urology)

Clinical Innovations in Dental Implant: Expanding Possibilities for Oral Rehabilitation

edited by Marco Severino

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2220 | Submission Open

Keywords: dental implants; oral rehabilitation; computer-guided surgery; biocompatibility; regenerative treatments; mini-implants; minimally invasive surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Management of Bladder Cancer

edited by

Antonio Franco

, Antonio Cicione and

Francesco Ditonno

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2216 | Submission Open

Keywords: bladder cancer; minimally invasive surgery; immunotherapy; targeted therapy; biomarkers; imaging techniques; muscle invasive bladder cancer; non-muscle-invasive bladder cancer

(This special issue belongs to the Section Nephrology & Urology)

Antithrombotic Therapies for Acute Coronary Syndrome and Atrial Fibrillation

edited by

Mojca Božič Mijovski

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1845 | Submission Open

Keywords: atrial fibrillation; acute coronary syndrome; antiplatelet agents; anticoagulants; thrombolysis; direct coagulation factor inhibitors; medical laboratory technology

(This special issue belongs to the Section Cardiology)

New Insights in Maxillofacial Surgery

edited by

Izumi Asahina

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1627 | Submission Open

Keywords: maxillofacial surgery; surgical techniques; imaging technologies; biomaterials; regenerative medicine

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Advances in Diagnosis and Treatment of Urological Cancers

edited by Davide Campobasso,

Stefano Puliatti

and

Daniele Amparore

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1579 | Submission Open

Keywords: prostate cancer; kidney cancer; urothelial carcinoma; testis cancer; mini-invasive surgery; precision surgery; target therapy; immunotherapy; nuclear medicine; artificial intelligence; augmented reality; biomarkers; prognostic factors and models; focal therapy; radiotherapy; imaging; genetics

(This special issue belongs to the Section Nephrology & Urology)

Clinical Perspectives of Vascular and Endovascular Surgeries

edited by

Adrian Vasile Muresan

Emil Marian Arbănași

and

Eliza Russu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1458 | Submission Open

Keywords: vascular surgery; varicose veins; abdominal aortic aneurysms; carotid disease; peripheral arterial disease

(This special issue belongs to the Section Vascular Medicine)

Key Challenges in Heart Transplantation and Their Solutions

edited by Elizabeth J. Maynes

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1245 | Submission Open

Keywords: heart transplantation; heart failure; cardiac surgery; minimally invasive techniques; general surgery; heart diseases

(This special issue belongs to the Section Cardiology)

Displaying special issue 201-250 on page 5 of 32.

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