Targeted Treatment of Oral Cancer

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dentistry, Oral Surgery and Oral Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1017

Special Issue Editors


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Guest Editor
Department of Oral and Maxillofacial Surgery, Baruch Padeh Medical Center Poriya, Tiberias 158001, Israel
Interests: oral and maxillofacial surgery; facial aesthetic surgery; basic science; head and neck cancer
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Guest Editor
International Research Center, A. C. Camargo Cancer Center, Rua Taguá 440, São Paulo 01508-010, Brazil
Interests: genetics; molecular biology

Special Issue Information

Dear Colleagues,

Oral cancer is a significant global health concern, with increasing incidence rates and diverse treatment approaches. The Special Issue focuses on targeted treatment strategies that aim to improve therapeutic outcomes while minimizing adverse effects. By exploring personalized medicine approaches and innovative therapeutic modalities, this Special Issue aims to contribute to the advancement of clinical practice in oral cancer treatment.

The Special Issue invites original research articles and reviews that cover a wide range of topics related to the targeted treatment of oral cancer. We encourage submissions that address the following areas:

  1. Novel therapeutic agents and drug delivery systems;
  2. Immunotherapy and its role in oral cancer treatment;
  3. Combination therapies and their synergistic effects.

We hope that this collection of articles will facilitate the development of more effective and personalized treatment strategies, ultimately improving patient outcomes in the field of oral oncology.

Dr. Yasmine Ghantous
Dr. Claudia Malheiros Coutinho-Camillo
Guest Editors

Manuscript Submission Information

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Keywords

  • precision medicine
  • immunotherapy
  • targeted drugs
  • combination therapy
  • tumor immune evasion
  • clinical trials

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Published Papers (1 paper)

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Research

10 pages, 2716 KiB  
Article
Gold-Nanoparticles Reflectance Discriminates Benign from Malignant Salivary Gland Neoplasms
by Shiran Sudri, Irit Allon, Ilana Kaplan, Abraham Hirshberg, Dror Fixler and Imad Abu El-Naaj
J. Clin. Med. 2025, 14(5), 1672; https://doi.org/10.3390/jcm14051672 - 1 Mar 2025
Viewed by 798
Abstract
Objectives: This study aimed to assess the effectiveness of gold nanoparticles conjugated with anti-EGFR monoclonal antibodies (GNPs-EGFR) in distinguishing between benign and malignant salivary gland tumors. Methods: A total of 49 oral salivary gland tissue samples were analyzed, including 22 malignant salivary gland [...] Read more.
Objectives: This study aimed to assess the effectiveness of gold nanoparticles conjugated with anti-EGFR monoclonal antibodies (GNPs-EGFR) in distinguishing between benign and malignant salivary gland tumors. Methods: A total of 49 oral salivary gland tissue samples were analyzed, including 22 malignant salivary gland tumors (MSGTs), 15 benign salivary gland tumors (BSGTs), and 12 control samples. For each sample, three 5 μm consecutive tissue sections were prepared. The first section was stained with hematoxylin and eosin (H&E) to confirm the diagnosis, the second was immunohistochemically stained for anti-EGFR, and the third was treated with GNPs-EGFR followed by hyperspectral microscopy to analyze the reflectance spectrum. Results: Reflectance intensity was significantly higher (p < 0.001) in MSGTs compared to BSGTs and controls, with intensity levels increasing alongside tumor grade. The average hyperspectral reflectance values were strongly correlated with the GNPs-EGFR immunohistochemical score and varied significantly between subgroups (p < 0.001). Conclusions: GNPs-EGFR reflection measurements effectively differentiate MSGTs from BSGTs with high sensitivity. This diffusion–reflection technique holds potential as a valuable tool for tumor detection, surgical margin assessment, and intraoperative identification of residual disease in salivary gland tumors. Full article
(This article belongs to the Special Issue Targeted Treatment of Oral Cancer)
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