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Pelvic Organ Prolapse: Current Challenges and Future Perspectives
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Pelvic Organ Prolapse: Current Challenges and Future Perspectives

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Obstetrics & Gynecology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 2105

Special Issue Editor

Dr. Marco Soligo

E-Mail Website
Guest Editor
Obstetrics and Gynecology Department, Hospital of Lodi, Via Largo Donatori del Sangue, 26900 Lodi, Italy
Interests: urogynecology; genital prolapse; urinary incontinence; urodynamics; anal incontinece; obstetric anal sphincter injuries; pelvico floor disorders

Special Issue Information

Dear Colleagues,

Pelvic organ prolapse (POP) is a quite common condition in the female population, which has a detrimental impact on quality of life (QoL), due to subjective discomfort along with a potential interference with visceral function (lower urinary tract disorders (LUTDs) and bowel disorders) and reproductive aspects of women’s life, including sexuality.

Gynecologists have always been confronted with this disorder, but traditional approaches deserve to be reassessed in the light of new scientific evidence concerning POP management.

Amongst innovative aspects are the following concepts:

  • Multidisciplinarity and multiprofessionality;
  • Improvements in classification and clinical assessment with a more patient-centered vision;
  • Risk factors and potential preventive strategies of POP;
  • Making conservative management available to a wider population;
  • Discussing a modern approach to surgical treatment based on a critical interpretation of the available literature;
  • Looking for innovation in the crucial aspects of tissue engineering and technological support to surgery;
  • Debating the actual role of hysterectomy in the treatment of POP.

In drafting this Special Issue, we aim at highlighting what is controversial in the current standards of care, and to focus on possible solutions that may be around the corner. I hope that you will join us in this effort to advance the field.

Dr. Marco Soligo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pelvic organ prolapse
  • urinary incontinence
  • lower urinary disorders
  • quality of life
  • patient-reported outcomes

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Published Papers (2 papers)

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Review

12 pages, 254 KiB  
Review
Is There a Role for Urodynamic Investigation in the Management of Pelvic Organ Prolapse?
by Eleonora Rosato, Lorenzo Vacca, Andrea Lombisani, Giuseppe Campagna, Luca Orecchia, Daniele Bianchi, Yuri Cavaleri, Maurizio Serati and Enrico Finazzi Agrò
J. Clin. Med. 2025, 14(4), 1163; https://doi.org/10.3390/jcm14041163 - 11 Feb 2025
Viewed by 563
Abstract
Background/Objectives: The role of urodynamic study (UDS) in women with pelvic organ prolapse (POP) and concurrent lower urinary tract symptoms (LUTS) remains controversial. Although LUTS alone often fail to yield an accurate diagnosis, routine UDS is debated due to its invasiveness, cost, [...] Read more.
Background/Objectives: The role of urodynamic study (UDS) in women with pelvic organ prolapse (POP) and concurrent lower urinary tract symptoms (LUTS) remains controversial. Although LUTS alone often fail to yield an accurate diagnosis, routine UDS is debated due to its invasiveness, cost, patient discomfort, and risk of urinary tract infections. The aim of this narrative review is to summarise the utility of UDS in the pre- and postoperative management of POP, focusing on its role in diagnosing and predicting outcomes for detrusor overactivity (DO), bladder outlet obstruction (BOO), detrusor underactivity (DU), and SUI. Methods: An extensive search of the available medical literature was conducted using PubMed, Scopus, and Embase to identify relevant studies published up to December 2024. The search combined keywords and MeSH terms related to pelvic organ prolapse (POP), urodynamic studies (UDS), overactive bladder, detrusor overactivity, stress urinary incontinence (SUI), female bladder outlet obstruction (BOO), detrusor underactivity (DU), preoperative assessment, and postoperative outcomes. Results: Occult stress urinary incontinence (SUI) detection with UDS can aid in planning concurrent anti-incontinence procedures, while preoperative assessment of DO or DU helps predict postoperative complications like urinary retention or overactive bladder symptoms. Conclusions: Despite its diagnostic advantages, evidence on UDS parameters and surgical outcomes remains inconsistent. The most important societies’ guidelines promote the use of UDS in selected cases, highlighting the need for individualised assessments to optimise patient counselling and management strategies. Full article
(This article belongs to the Special Issue Pelvic Organ Prolapse: Current Challenges and Future Perspectives)
11 pages, 928 KiB  
Review
Laparoscopic Hysteropexy: How, When and for Whom Is It an Alternative Option? A Narrative Review of the Literature
by Anna Pitsillidi and Günter Karl Noé
J. Clin. Med. 2025, 14(4), 1080; https://doi.org/10.3390/jcm14041080 - 8 Feb 2025
Cited by 1 | Viewed by 1062
Abstract
Background/Objectives: Surgical repair of apical prolapse most commonly includes hysterectomy. However, nowadays, the number of women who seek uterine preserving surgical treatment is increasing. Our objective is to review the current evidence on laparoscopic hysteropexy techniques, outcomes and appropriate patient selection. Methods [...] Read more.
Background/Objectives: Surgical repair of apical prolapse most commonly includes hysterectomy. However, nowadays, the number of women who seek uterine preserving surgical treatment is increasing. Our objective is to review the current evidence on laparoscopic hysteropexy techniques, outcomes and appropriate patient selection. Methods: A literature search was carried out in MEDLINE/PubMed and ClinicalTrials.gov databases. The search was restricted to humans, female patients and currently used surgical procedures. Results: Laparoscopic hysteropexy was found to be associated with good anatomic outcomes, symptom improvement and low complication or reoperation rates. Conclusions: Laparoscopic hysteropexy appears to be a good alternative option for women who undergo surgical treatment for apical prolapse and desire preservation of the uterus. However, further prospective comparative studies, as well as longer follow-up periods, are necessary for evaluating long-term safety and efficacy outcomes of the method. Full article
(This article belongs to the Special Issue Pelvic Organ Prolapse: Current Challenges and Future Perspectives)
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