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Clinical and Surgical Insights on Lung Cancer Treatment
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Clinical and Surgical Insights on Lung Cancer Treatment

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 10 June 2025 | Viewed by 505

Special Issue Editors

Dr. Eleonora Faccioli

E-Mail Website
Guest Editor
Thoracic Surgery Unit, Department of Cardiothoracic Surgery and Vascular Sciences, Padua University Hospital, University of Padua, 35122 Padua, Italy
Interests: lung cancer; mesothelioma; robotic surgery; minimally invasive surgery; immunotherapy; clinical trials
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Schiavon

E-Mail Website
Guest Editor
Thoracic Surgery Unit, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, 35122 Padua, Italy
Interests: lung cancer; thoracic surgery; minimally invasive surgery; mesothelioma

Special Issue Information

Dear Colleagues,

As one of the leading causes of cancer-related mortality worldwide, lung cancer continues to present a critical need for innovative approaches in both clinical and surgical fields. 

The aim of this Special Issue, entitled “Clinical and Surgical Insights on Lung Cancer Treatment”, aims to provide a comprehensive exploration of the latest advancements, challenges, and future directions in the management of lung cancer. By bringing together a collection of original research, expert reviews, and meta-analyses, this Special Issue delves into the multimodal strategies employed in the diagnosis, treatment, and post-operative care of patients with lung cancer. The focus on advanced surgical interventions in the context of recent personalized treatment protocols (target molecular therapies and immune response modulators) highlights the evolving landscape of lung cancer care. The insights shared within this Special Issue aim to enhance our understanding and applications of best practices, fostering improvements in patients’ outcomes and quality of life. Ultimately, this Special Issue aspires to contribute meaningfully to the ongoing fight against lung cancer by showcasing the latest developments that have the potential to reshape the future of lung cancer treatment.

Dr. Eleonora Faccioli
Dr. Marco Schiavon
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lung cancer
  • surgery
  • minimally invasive surgery
  • immunotherapy
  • clinical trials
  • robotic surgery
  • diagnosis
  • multimodal treatment
  • outcomes
  • targeted therapy

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Published Papers (1 paper)

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Research

13 pages, 2454 KiB  
Article
Prognostic Value of Single Nodal Zone Metastasis in Non-Small-Cell Lung Cancer—A Multi-Institutional Study
by Samanta Nicosia, Paraskevas Lyberis, Stefano Rudella, Paolo Olivo Lausi, Simona Sobrero, Riccardo Carlo Cristofori, Matteo Roffinella, Elisa Carla Fontana, Francesco Leo, Enrico Ruffini and Francesco Guerrera
J. Clin. Med. 2025, 14(9), 2938; https://doi.org/10.3390/jcm14092938 - 24 Apr 2025
Viewed by 258
Abstract
Objectives: Lung cancer is the leading cause of cancer-related deaths worldwide and mediastinal lymph node involvement is an important negative prognostic factor. Nevertheless, the involvement of a single mediastinal nodal zone has been reported to have favorable outcomes. This study aims to [...] Read more.
Objectives: Lung cancer is the leading cause of cancer-related deaths worldwide and mediastinal lymph node involvement is an important negative prognostic factor. Nevertheless, the involvement of a single mediastinal nodal zone has been reported to have favorable outcomes. This study aims to assess whether the prognosis of non-small-cell lung cancer (NSCLC) with single-zone lymph node involvement varies by the affected lymph node zone. Methods: We retrospectively analyzed patients affected by NSCLC with a single lymph node zone involvement who underwent anatomical resection. The prognosis of patients was statistically compared based on the different affected lymph node zones. Results: A total of 135 patients were enrolled. All patients underwent anatomical lung resection and systematic lymph node dissection. Lymph node involvement was observed in 50 cases (37%) for the upper zone, 36 cases (27%) for the aorto-pulmonary (AP) zone, 41 cases (30%) for the subcarinal zone and 8 cases (6%) for the lower zone. The median follow-up was 37 months [ranging from 1 to 115 months]. Cancer recurrence was reported in 64 cases (52%) during this period. The 2-year and 4-year overall survival (OS) were 69% and 49%, respectively. The 2-year and 4-year relapse-free survival (RFS) were 55% and 41%. The OS and RFS change relating to the different involved lymph node zones (p < 0.01). Lower zone involvement predicts worse prognosis, upper zone and subcarinal zone better outcomes, and the AP zone involvement intermediate survival. Conclusions: The location of the affected lymph nodes appears to be an important prognostic factor in patients with NSCLC, with significant impacts on both OS and RFS. It may play a key role in the disease progression and patient survival by providing more personalized therapy. Full article
(This article belongs to the Special Issue Clinical and Surgical Insights on Lung Cancer Treatment)
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