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Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD):...
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Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 2nd Edition

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Respiratory Medicine".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 707

Special Issue Editors

Dr. Juan Luis Rodriguez Hermosa

E-Mail Website
Guest Editor
1. Pulmonary Department, Research Institute of Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain
2. Respiratory Department, Hospital Clinico San Carlos, 28015 Madrid, Spain
3. Department of Medicine, Universidad Complutense de Madrid, 28015 Madrid, Spain
Interests: COPD; bronchiectasis; alpha 1 antitrypsin deficiency; lung
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. José Luis Álvarez-Sala Walther

E-Mail Website
Guest Editor
1. Pulmonology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain
2. Department of Medicine, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: COPD; obstructive sleep apnea; interstitial lung disease
Dr. Myriam Calle Rubio

E-Mail Website
Guest Editor
1. Departamento de Medicina, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain
2. Servicio de Neumología, Instituto de Investigación Sanitaria San Carlos (IdISSC), 28040 Madrid, Spain
Interests: COPD; respiratory rehabilitation; inhaled therapy; telemedicine; biological therapies

Special Issue Information

Dear Colleagues,

We are pleased to announce the Special Issue “Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 2nd Edition”. Building upon the success of the first edition, where we received numerous outstanding papers, we are delighted to announce this new edition.

Chronic obstructive pulmonary disease (COPD) is characterised by airflow limitations and persistent respiratory symptoms. Various respiratory function tests, radiological tests, and clinical questionnaires are available to assess the severity and follow-up of COPD.

COPD is often associated with a number of comorbidities that have a significant impact on the overall health of patients. Cardiovascular disease, metabolic disorders, psychiatric disturbances, chronic inflammation, and the systemic effects of COPD often complicate the management of the disease.

There have been advances in the treatment of COPD, with bronchodilator drugs, LAMA and LABA, as well as inhaled corticosteroids, and different combinations of these in a single device. In the near future, biologics with new therapeutic targets will be incorporated. Non-pharmacological measures such as respiratory rehabilitation, smoking cessation, oxygen therapy and mechanical ventilation, vaccination, and lifestyle changes have been shown to improve disease prognosis.

The aim of this Special Issue is to bring together articles focusing on improving the diagnosis of COPD, the influence of comorbidities, as well as advances in the treatment of COPD, considering both the pharmacological and non-pharmacological interventions.

Dr. Juan Luis Rodriguez Hermosa
Prof. Dr. José Luis Álvarez-Sala Walther
Dr. Myriam Calle Rubio
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • COPD
  • diagnosis
  • comorbidities
  • respiratory rehabilitation
  • inhaled therapy
  • biological therapies

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Published Papers (1 paper)

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24 pages, 3765 KiB  
Systematic Review
Effect of Chronic Obstructive Pulmonary Disease (COPD) on Biventricular Mechanics in Patients Without Severe Airflow Obstruction
by Andrea Sonaglioni, Massimo Baravelli, Antonella Caminati, Federico Tagariello, Federico De Cesco, Gian Luigi Nicolosi, Michele Lombardo and Sergio Harari
J. Clin. Med. 2025, 14(11), 3660; https://doi.org/10.3390/jcm14113660 - 23 May 2025
Viewed by 388
Abstract
Background: Over the last 15 years, few echocardiographic studies have examined the biventricular mechanics by speckle tracking echocardiography (STE) in patients affected by chronic obstructive pulmonary disease (COPD) without advanced lung disease. We aimed to summarize the main findings of these studies and [...] Read more.
Background: Over the last 15 years, few echocardiographic studies have examined the biventricular mechanics by speckle tracking echocardiography (STE) in patients affected by chronic obstructive pulmonary disease (COPD) without advanced lung disease. We aimed to summarize the main findings of these studies and quantify the overall effect of COPD on biventricular mechanics in patients without severe airflow obstruction. Methods: Eligible studies assessing cardiac function by conventional transthoracic echocardiography (TTE), implemented with a STE analysis of left ventricular (LV)-global longitudinal strain (GLS) and/or right ventricular (RV)-GLS in COPD patients without severe airflow obstruction vs. healthy controls, were selected from the PubMed, Embase and Scopus databases. The primary endpoint was to quantify the effect of COPD on LV-GLS and RV-GLS in individuals without advanced lung disease. Continuous data [LV-GLS, RV-GLS, left ventricular ejection fraction (LVEF) and tricuspid annular plane systolic excursion (TAPSE)] were pooled as the standardized mean difference (SMD) comparing COPD cohorts with healthy controls. Results: Ten studies were included, totaling 682 COPD patients and 316 healthy controls. Overall, COPD showed a large effect on LV-GLS (SMD −1.296; 95%CI −2.010, −0.582, p < 0.001) and RV-GLS (SMD −1.474; 95% CI −2.142, −0.805, p < 0.001), a medium-to-large effect on TAPSE (SMD −0.783, 95% CI −0.949, −0.618, p < 0.001) and a small effect on LVEF (SMD −0.366, 95% CI −0.659, −0.074, p = 0.014). The I2 statistic value for the LV-GLS (91.1%), RV-GLS (88.2%) and LVEF (76.7%) studies suggested a high between-study heterogeneity, while that for the TAPSE (38.1%) studies was compatible with a low-to-moderate between-study heterogeneity. Egger’s test yielded a p-value of 0.16, 0.48, 0.58 and 0.50 for LV-GLS, RV-GLS, LVEF and TAPSE studies, respectively, indicating an absence of publication bias. Meta-regression analyses excluded that the effect of COPD on biventricular mechanics might be influenced by potential confounders (all p > 0.05). Sensitivity analysis confirmed the robustness of the LV-GLS, RV-GLS and TAPSE studies’ results. Conclusions: COPD appears to be independently associated with a mild attenuation of biventricular mechanics in patients with moderate airflow limitations, despite a preserved LVEF and TAPSE on conventional TTE. STE analysis may allow clinicians to identify COPD patients with subclinical myocardial dysfunction and an increased risk of heart failure and cardiovascular complications early. Full article
(This article belongs to the Special Issue Diagnosis, Treatment and Comorbidities in Chronic Obstructive Pulmonary Disease (COPD): 2nd Edition)
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