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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Advances in Cardiovascular Diseases: The Cutting Edge
edited by
submission deadline 20 Jan 2026 | 4 articles | Viewed by 5209 | Submission Open
Keywords: cardiovascular disease (CVD); preventive cardiology; cardiac pharmacology; coronary artery disease (CAD); heart failure (HF); atrial fibrillation (AF); supraventricular and ventricular arrhythmias
(This special issue belongs to the Section Cardiovascular Medicine)
Eating Disorders: Current Epidemiology and Advances in Diagnosis and Treatment—Second Edition submission deadline 20 Jan 2026 | 4 articles | Viewed by 4559 | Submission Open
Keywords: eating disorder; bulimia nervosa; anorexia nervosa; binge eating disorder; sociocultural context; epidemiology; di-agnosis; treatment; prevention
(This special issue belongs to the Section Mental Health)
Microsurgery: Current and Future Challenges submission deadline 20 Jan 2026 | 5 articles | Viewed by 4435 | Submission Open
Keywords: microsurgery; reconstruction; reconstructive surgery; breast reconstruction; extremity reconstruction
(This special issue belongs to the Section Plastic, Reconstructive and Aesthetic Surgery/Aesthetic Medicine)
Endodontic Disease: Prevalence, Risk Factors, and Treatment Outcome submission deadline 20 Jan 2026 | 3 articles | Viewed by 4078 | Submission Open
Keywords: endodontics; apical periodontitis; pulpitis; root canal treatment; risk factors; treatment outcomes; regenerative endodontics
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Clinical Insights into Pediatric Critical Care
edited by Katherine Biagas and Daniel E Sloniewsky
submission deadline 20 Jan 2026 | 3 articles | Viewed by 4056 | Submission Open
Keywords: PICU; anemia; blood transfusion; critically ill children; traumatic hemorrhage
(This special issue belongs to the Section Intensive Care)
Artificial Intelligence (AI) and Deep Learning (DL) in Medical Imaging submission deadline 20 Jan 2026 | 2 articles | Viewed by 4007 | Submission Open
Keywords: artificial intelligence; deep learning; imaging; diagnosis; precision medicine; oncologic
(This special issue belongs to the Section Nuclear Medicine & Radiology)
Sustaining Success Through Innovation in Kidney Transplantation
edited by Junji Uchida
submission deadline 20 Jan 2026 | 4 articles | Viewed by 3955 | Submission Open
Keywords: kidney transplantation; long-term graft survival; immunosuppression; organ shortage; post-transplant complication
(This special issue belongs to the Section Nephrology & Urology)
Long COVID and Cardiovascular Health: Clinical Perspectives on Risk and Management
edited by Mariana Tudoran and
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3719 | Submission Open
Keywords: long COVID; cardiovascular disease; long COVID therapy; management of long COVID; mechanisms of long COVID
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Management of Cardiogenic Shock and Cardiac Arrest: 2nd Edition
edited by Jaime A. Hernández-Montfort
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3691 | Submission Open
Keywords: cardiogenic shock; cardiac arrest; temporary mechanical circulatory support; ECMO; transitions; heart recovery; heart replacement
(This special issue belongs to the Section Cardiology)
Clinical Advances in Autoimmune Disorders submission deadline 20 Jan 2026 | 3 articles | Viewed by 3569 | Submission Open
Keywords: systemic sclerosis; Raynaud’ s phenomenon; digital ulcers; scleroderma renal crisis; pulmonary arterial hypertension; interstitial lung disease; fibrosis
(This special issue belongs to the Section Immunology & Rheumatology)
Allergen-Specific Immunotherapy (AIT) for Allergic Diseases of the Respiratory Tract and Food Allergies
edited by
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3354 | Submission Open
Keywords: allergy; allergic rhinitis; allergic conjunctivitis; allergic asthma; food allergy; peptide immunotherapy; allergoids; SLIT; SCIT; OIT
(This special issue belongs to the Section Immunology & Rheumatology)
Sports Injuries: Recent Advances in Prevention and Rehabilitation, 2nd Edition submission deadline 20 Jan 2026 | 2 articles | Viewed by 3345 | Submission Open
Keywords: sports injuries; treatment; musculoskeletal disorders; rehabilitation; physical rehabilitation; exercise science; sports science; injury prevention
(This special issue belongs to the Section Sports Medicine)
Clinical Application of Radiotherapy in Modern Oncology submission deadline 20 Jan 2026 | 2 articles | Viewed by 3305 | Submission Open
Keywords: brain metastasis; bone metastasis; brain tumors; head and neck cancers; thoracic oncology; breast cancer; prostate cancer; sarcoma
(This special issue belongs to the Section Oncology)
Recent Clinical Research on Nonalcoholic Fatty Liver Disease: 2nd Edition
edited by Gerond V. Lake-Bakaar
submission deadline 20 Jan 2026 | 2 articles | Viewed by 3188 | Submission Open
Keywords: NAFLD; NASH; cirrhosis; hepatocellular carcinoma; hepatitis
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Current and Emerging Therapies for Rheumatoid Arthritis
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 3151 | Submission Open
Keywords: DMARDs (disease-modifying anti-rheumatic drugs); boDMARDs (biological DMARDs); bsDMARDs (biosimilar DMARDs); csDMARDs (conventional synthetic DMARDs); rheumatoid arthritis; tsDMARDs (targeted synthetic DMARDs)
(This special issue belongs to the Section Immunology & Rheumatology)
Current Situation and Challenges of Endovascular Treatment Strategies for Acute Ischemic Stroke
edited by
submission deadline 20 Jan 2026 | 3 articles | Viewed by 3150 | Submission Open
Keywords: acute ischemic stroke; endovascular treatment; imaging; management of ischemic stroke; system and strategy for acute ischemic stroke; multidisciplinary approach for acute ischemic stroke
(This special issue belongs to the Section Clinical Neurology)
Advances and Trends in Pediatric Surgery submission deadline 20 Jan 2026 | 3 articles | Viewed by 2937 | Submission Open
Keywords: pediatric surgery; minimally invasive surgery; robotics; trends; advances
(This special issue belongs to the Section Clinical Pediatrics)
Emerging Treatment Options in Inflammatory Bowel Disease
edited by and Roberta Maselli
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2595 | Submission Open
Keywords: inflammatory bowel disease; Crohn’ s disease; ulcerative colitis; biologics; small molecule therapies; personalized medicine; therapeutic drug monitoring; immunology; gut microbiome; clinical practice; endoscopic mucosal resection (EMR); endoscopic submucosal dissection (ESD); endoscopic balloon dilation and endoscopic stent placement; chromoendoscopy; confocal laser endomicroscopy; artificial intelligence
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Sarcopenia Across the Lifespan: Risk Factors, Mechanisms, and Management in Aging and Disease submission deadline 20 Jan 2026 | 2 articles | Viewed by 2532 | Submission Open
Keywords: sarcopenia; aging; chronic disease; risk factors; muscle physiology; prevention; nutrition; exercise; treatment strategies
(This special issue belongs to the Section Orthopedics)
Advances in the Treatment of Glaucoma and Ocular Hypertension
edited by Ahnul Ha
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2464 | Submission Open
Keywords: glaucoma; ocular hypertension; intraocular pressure (IOP); minimally invasive glaucoma surgery (MIGS); artificial intelligence (AI); neuroprotection; meta-analysis
(This special issue belongs to the Section Ophthalmology)
Advances in Tuberculosis: Comprehensive Insights and Management Strategies
edited by Aliaksandr Skrahin
submission deadline 20 Jan 2026 | 2 articles | Viewed by 2395 | Submission Open
Keywords: pulmonary and extra-pulmonary tuberculosis (TB); TB epidemiology; TB screening; TB prevention; TB diagnostics; TB treatment; TB co-infections (e.g.; HIV; Hepatitis B and C); TB co-morbidities (e.g.; diabetes); host and Mycobacteria genetic; molecular mechanisms and genotype/phenotype correlations
(This special issue belongs to the Section Infectious Diseases)
Advanced Diagnostic and Therapeutic Strategies for Sarcoidosis submission deadline 20 Jan 2026 | 2 articles | Viewed by 2354 | Submission Open
Keywords: sarcoidosis; cardiac sarcoidosis; pulmonary fibrosis; magnetic resonance imaging; FDG-PET/CT; echocardiography; neurosarcoidosis; differential diagnosis; hypercalcaemia; IGRA; sarcoidosis-associated pulmonary hypertension; fatigue; corticosteroids; metotrexat; infliximab; antifibrotic treatment; lung transplantation; artificial intelligence; broncho-alveolar lavage; cytokines
(This special issue belongs to the Section Respiratory Medicine)
Endometriosis: Diagnosis and Treatment submission deadline 20 Jan 2026 | 2 articles | Viewed by 1681 | Submission Open
Keywords: endometriosis; diagnosis; video laparoscopy with and without robotic assistance; chronic pelvic pain; fertility preservation; minimally invasive surgery; biomarkers; artificial intelligence in endometriosis; adenomyosis; and adenomyoma care; multidisciplinary care; personalized medicine
(This special issue belongs to the Section Obstetrics & Gynecology)
Glaucoma Surgery: Current Challenges and Future Perspectives submission deadline 20 Jan 2026 | 2 articles | Viewed by 1522 | Submission Open
Keywords: glaucoma; filtration surgery; trabeculectomy; MIGS; scarring; anti-metabolites; wound healing; anti-fibrotics
(This special issue belongs to the Section Ophthalmology)
Acute Myocardial Infarction: Diagnosis, Treatment, and Rehabilitation
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1165 | Submission Open
Keywords: acute myocardial infarction; coronary angioplasty; acute heart failure; cardiogenic shock; rehabilitation programs
(This special issue belongs to the Section Cardiovascular Medicine)
Neuro-Cardiology: An Obligation for Combined Care of Stress and Heart Diseases
edited by Mario J. Garcia and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1161 | Submission Open
Keywords: neuro-cardiology; cardiovascular; segmental remodeling; stressors; hypertension; triple S
(This special issue belongs to the Section Cardiology)
Insights and Innovations in Sports Cardiology submission deadline 20 Jan 2026 | 2 articles | Viewed by 1048 | Submission Open
Keywords: sports cardiology; athlete heart; cardiovascular screening; arrhythmias; sudden cardiac death; cardiac rehabilitation; exercise prescription; mobile health; preventive cardiology; personalized medicine; pediatric fitness
(This special issue belongs to the Section Sports Medicine)
Cardiac Arrest Research: Neuroprognostication and Improving Outcomes
edited by and Jin-hong Min
submission deadline 20 Jan 2026 | 1 articles | Viewed by 1002 | Submission Open
Keywords: cardiac arrest; prognosis; hypothermia; induced; resuscitation; magnetic resonance imaging; electroencephalography; blood pressure; hypoxia-ischemia; brain; extracorporeal membrane oxygenation
(This special issue belongs to the Section Cardiovascular Medicine)
Advancements in the Treatment of Myeloproliferative Neoplasms and Myelodysplastic Syndromes
edited by Ivan Krečak, Marko Skelin and Zinaida Perić
submission deadline 20 Jan 2026 | 1 articles | Viewed by 913 | Submission Open
Keywords: myeloproliferative neoplasms; myelodysplastic syndromes; treatment; risk stratification; prognosis
(This special issue belongs to the Section Hematology)
Idiopathic Pulmonary Fibrosis (IPF): Current Perspectives and Future Directions
edited by Vito D’Agnano
submission deadline 20 Jan 2026 | 1 articles | Viewed by 903 | Submission Open
Keywords: pulmonary fibrosis; IPF; ILD; antifibrotics; EMT; respiratory physiology; metabolism
(This special issue belongs to the Section Respiratory Medicine)
New Perspectives in Chronic Kidney Disease, Transplantation and Immune System
edited by and Dimitrios A. Tsakiris
submission deadline 20 Jan 2026 | 1 articles | Viewed by 886 | Submission Open
Keywords: kidney transplantation; HLA; matching at the epitope level; DSAs; complement; kidney disease epigenetics; diabetic nephropathy; hemostasis; graft rejection; B and T cell immunophenotyping; end stage renal disease
(This special issue belongs to the Section Nephrology & Urology)
Current Practice and Future Perspectives on Laryngeal Surgery submission deadline 20 Jan 2026 | 1 articles | Viewed by 800 | Submission Open
Keywords: laryngeal disorders; laryngeal surgery; microsurgery; endoscopic surgery; open surgery; laser surgery
(This special issue belongs to the Section Otolaryngology)
Artificial Intelligence (AI) in Dental Clinical Practice
edited by and Keiichiro Watanabe
submission deadline 20 Jan 2026 | 1 articles | Viewed by 799 | Submission Open
Keywords: artificial intelligence; dental diagnostics; machine learning; deep learning; digital dentistry; clinical decision support; diagnostic automation; data transparency; evidence-based dentistry
(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)
Rehabilitation and Treatment of Post-COVID-19 Condition submission deadline 20 Jan 2026 | 1 articles | Viewed by 747 | Submission Open
Keywords: post-COVID-19 condition; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); comorbidities; interdisciplinary; multimodal; digital medicine; rehabilitation; treatment; health-related quality of life; disability; return to work
(This special issue belongs to the Section Clinical Rehabilitation)
Multiple Myeloma: Therapeutic and Management Strategies
edited by Terri Parker
submission deadline 20 Jan 2026 | 1 articles | Viewed by 727 | Submission Open
Keywords: multiple myeloma; frontline treatment; monoclonal antibodies; sequencing of treatment; immunotherapy; CAR T; Bi-specific T cell engagers; toxicity management
(This special issue belongs to the Section Hematology)
Aortic Valve Disease: Current Evolution and Future Opportunities
edited by Gianluigi Perri
submission deadline 20 Jan 2026 | 1 articles | Viewed by 695 | Submission Open
Keywords: aortic valve disease; aortic valve repair; Ross procedure; aortic valve replacement; diagnosis of aortic valve disease
(This special issue belongs to the Section Cardiology)
Obesity-Related Metabolic and Cardiovascular Disorders
edited by and Federica Vinciguerra
submission deadline 20 Jan 2026 | 1 articles | Viewed by 652 | Submission Open
Keywords: obesity; type 2 diabetes mellitus; insulin resistance; metabolic syndrome; cardiovascular disease; lipid disorder; adipose tissue dysfunction; visceral adiposity; cardiometabolic risk; endothelial dysfunction; health disparities; gut microbiota; bariatric surgery; precision medicine
(This special issue belongs to the Section Cardiovascular Medicine)
Clinical Advances in Prenatal Diagnosis and Fetal Therapy
edited by
submission deadline 20 Jan 2026 | 1 articles | Viewed by 567 | Submission Open
Keywords: prenatal diagnosis; fetal therapy; genetic screening; non-invasive testing; fetal surgery; imaging technologies; high-risk pregnancies; in utero treatments; stem cell therapies; clinical innovations
(This special issue belongs to the Section Obstetrics & Gynecology)
Cardiopulmonary Resuscitation in the Emergency Care Unit
edited by , Felipe Fernández-Méndez, and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 467 | Submission Open
Keywords: cardiopulmonary resuscitation; advanced life support; new technologies; special circumstances; emergency care unit
(This special issue belongs to the Section Emergency Medicine)
Current Status and Future of Urological Surgery
edited by , Davide De Marchi and
submission deadline 20 Jan 2026 | 1 articles | Viewed by 428 | Submission Open
Keywords: urological surgery; robotic-assisted surgery; minimally invasive surgery; artificial intelligence; augmented reality; surgical navigation; endourology; laparoscopic urology; reconstructive urology; functional urology; bph treatment; urinary incontinence; prostate cancer surgery; bladder cancer surgery; surgical innovation; digital surgery
(This special issue belongs to the Section Nephrology & Urology)
Clinical Comparisons of Nonpharmaceutical and Pharmaceutical Analgesia
edited by and
submission deadline 20 Jan 2026 | Viewed by 374 | Submission Open
Keywords: acute pain; chronic pain; postoperative pain; non-pharmaceutical; pharmaceutical; analgesia; clinical
(This special issue belongs to the Section Anesthesiology)
Shaping Modern Gastroenterology: Bridging Advancements in Digestive Endoscopy and Clinical Research
edited by Manuele Furnari and Stefano Kayali
submission deadline 20 Jan 2026 | Viewed by 359 | Submission Open
Keywords: digestive endoscopy; gastrointestinal disorders; endoscopic ultrasound (EUS); endoscopic retrograde cholangiopancreatography (ERCP); therapeutic endoscopy; artificial intelligence; pancreatic and biliary diseases; small bowel pathology; early neoplastic lesions; inflammatory bowel diseases (IBDs); translational gastroenterology; endoscopic submucosal dissection (ESD); per-oral endoscopic myotomy (POEM); endoscopic imaging; gastrointestinal pathophysiology
(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)
Beyond the Kidney: Managing Chronic Kidney Disease in the Era of Cardio-Metabolic-Kidney Syndrome submission deadline 20 Jan 2026 | Viewed by 334 | Submission Open
Keywords: chronic kidney disease; disease-modifying therapy; physical exercise; cardio-metabolic-kidney syndrome; SGLT2 in-hibitors; MRA; renal nutrition; innovative therapies; low protein diet
(This special issue belongs to the Section Nephrology & Urology)
Metabolic Dysregulation Across the Spectrum from Anorexia Nervosa to Obesity
edited by Andriana C. Kaliora
submission deadline 20 Jan 2026 | Viewed by 271 | Submission Open
Keywords: metabolic dysregulation; anorexia nervosa; obesity; environmental factors in metabolic health; gut microbiota and metabolism; hormonal regulation of appetite; inflammation and metabolic disorders; dietary influence on metabolism
(This special issue belongs to the Section Endocrinology & Metabolism)
Clinical Updates and Current Challenges in Obstetrical Anesthesia
edited by Michael Froelich
submission deadline 20 Jan 2026 | Viewed by 261 | Submission Open
Keywords: obstetrical anesthesia; clinical innovation; practice guidelines; neuraxial techniques; enhanced recovery; risk stratification; maternal safety; multimodal analgesia; health systems innovation; global and low-resource care
(This special issue belongs to the Section Obstetrics & Gynecology)
Innovations and Evolution of Extracorporeal Organ Support in Critical Care
edited by , and Antonella Tosi
submission deadline 20 Jan 2026 | Viewed by 247 | Submission Open
Keywords: critical care; extracorporeal organ support; critical care nephrology; cardiology; ARDS; sepsis; blood purification; liver support
(This special issue belongs to the Section Intensive Care)
Innovations in Infertility Treatment and Assisted Reproductive Technologies (ARTs)
edited by Diana Alecsandru
submission deadline 20 Jan 2026 | Viewed by 218 | Submission Open
Keywords: infertility; assisted reproductive technology (ARTs); fertility preservation; in vitro fertilization (IVF); reproductive endocrinology
(This special issue belongs to the Section Obstetrics & Gynecology)
Haemophilia: Current Treatment and Clinical Outcomes, Challenges and Opportunities: 2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 218 | Submission Open
Keywords: haemophilia A and B; FVIII EHL; FIX EHL; prophylaxis; emicizumab; health-related quality of life; population pharmacokinetics
(This special issue belongs to the Section Hematology)
Bronchoscopy and Interventional Pulmonology
edited by Bryan S. Benn and
submission deadline 20 Jan 2026 | Viewed by 212 | Submission Open
Keywords: navigation-guided bronchoscopy; Robotic-guided bronchoscopy; 3D imaging integration; lung nodule/peripheral pulmonary lesion marking; transbronchial lung cryobiopsy and interstitial lung disease; malignant and benign central airway obstruction and stenosis; airway stents; pleuroscopic procedures; bronchoscopic lung volume reduction
(This special issue belongs to the Section Respiratory Medicine)
Cardiac and Pulmonary Involvements in High-Risk Neonatal Cohorts: Short- and Long-Term Issues
edited by Arvind Sehgal
submission deadline 20 Jan 2026 | 1 articles | Viewed by 210 | Submission Open
Keywords: fetal growth restriction; lung disease; cardiac maladaptation; placenta; public health; neurodevelopment; long term; adulthood; Barker’ s hypothesis; newborn; vascular
(This special issue belongs to the Section Clinical Pediatrics)
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