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Journal of Clinical Medicine publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Degenerative Cervical Myelopathy and Traumatic Spinal Cord Injury: Recent Advances and Future Directions

edited by Nader Hejrati,

Michael G. Fehlings

and Maryam Seif

submission deadline 28 Mar 2026 | 1 articles | Viewed by 1688 | Submission Open

Keywords: degenerative cervical myelopathy; traumatic spinal cord injury; clinical assessment; surgical management; non-operative management; neuroprotective therapies; neuroregenerative therapies; outcome prediction

(This special issue belongs to the Section Clinical Neurology)

Clinical Management of Cholecystitis and Complications

edited by Dimitrios Balalis,

Dimitrios K. Manatakis

and Nikolaos Vassos

submission deadline 28 Mar 2026 | 1 articles | Viewed by 779 | Submission Open

Keywords: gallbladder; cholecystitis; right upper quadrant pain; ultrasound; laparoscopic approach

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Clinical Novel Research in the Management of Cardiac Arrest

edited by Giovanni Babini and

Alberto Cucino

submission deadline 28 Mar 2026 | Viewed by 745 | Submission Open

Keywords: cardiac arrest; post-cardiac arrest syndrome; resuscitation; temperature control; target temperature management; neuroprotection; neuroprognostication; defibrillation; extracorporeal life support

(This special issue belongs to the Section Cardiology)

Advances in the Diagnosis, Treatment of Intestinal Cancer: 2nd Edition

edited by

Eyal Klang

and

Adi Lahat

submission deadline 28 Mar 2026 | Viewed by 225 | Submission Open

Keywords: colorectal cancer; early detection; treatment; immune therapy; radiation therapy; chemotherapy; risk factors; improved prognosis

(This special issue belongs to the Section Oncology)

Mitral Valve Stenosis or Aortic Valve Stenosis: Progress from Diagnosis to Treatment

edited by Francesco Melillo

submission deadline 28 Mar 2026 | Viewed by 111 | Submission Open

Keywords: aortic stenosis; mitral stenosis; TAVI

(This special issue belongs to the Section Cardiology)

Management of Female Pelvic Floor Disorders and Incontinence

edited by Luis López Fando

submission deadline 28 Mar 2026 | Viewed by 105 | Submission Open

Keywords: pelvic floor disorders; urinary incontinence; pelvic organ prolapse; reconstructive urology; voiding dysfunction; multidisciplinary care; surgical techniques; urodynamics; patient-centered outcomes; digital learning in urology

(This special issue belongs to the Section Nephrology & Urology)

Challenges in Minimally Invasive Colorectal and Abdominal Wall Surgery

edited by Francesco Ferrara and

Roberto Peltrini

submission deadline 31 Mar 2026 | 2 articles | Viewed by 3789 | Submission Open

Keywords: colorectal surgery; laparoscopy; abdominal wall surgery; hernia; diastasis recti; surgical oncology; rectal tumor; colon tumor; colorectal neoplasia

(This special issue belongs to the Section General Surgery)

Advances in Perioperative Care: Challenges and Perspectives in Enhanced Recovery After Surgery, Perioperative Optimization and Prehabilitation: 2nd Edition

edited by

Carlos Cerdán Santacruz

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1343 | Submission Open

Keywords: perioperative care; enhanced recovery after surgery; prehabilitation; minimally invasive surgery; patient-related outcome measures; colorectal surgery; general surgery; thoracic surgery; vascular surgery; optimal functional recovery

(This special issue belongs to the Section General Surgery)

Recent Clinical Perspective in Kidney Transplantation

edited by Nikolina Bašić-Jukić

submission deadline 31 Mar 2026 | 2 articles | Viewed by 1196 | Submission Open

Keywords: kidney transplantation; outcomes; desensitization; xenotransplantation; transplant nephropathology; multiorgan transplantations; post-transplant complications; inequities in transplantation

(This special issue belongs to the Section Nephrology & Urology)

Acute Trauma and Trauma Care in Orthopedics: 2nd Edition

edited by

Pietro Maniscalco

and

Gianfilippo Caggiari

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1039 | Submission Open

Keywords: orthopedics; trauma; injury; musculoskeletal; surgery; knee; osteoarthritis; spinal deformity; fracture; joint replacement; hip fractur; fragility fracture; minimally invasive surgery; post-traumatic care and rehabilitation; pain management; emergency assessment

(This special issue belongs to the Section Orthopedics)

Artificial Intelligence in Women’s Health and Medicine: Improving Clinical Practice, Diagnosis, Treatment Management and Patient Experiences

edited by

Shivaram Poigai Arunachalam

and Nasibeh Zanjirani Farahani

submission deadline 31 Mar 2026 | 1 articles | Viewed by 1033 | Submission Open

Keywords: women’ s health; artificial intelligence; machine learning; personalized medicine; reproductive health; health equity; social determinants of health; mental health; cancer; cardiovascular disease

(This special issue belongs to the Section Epidemiology & Public Health)

Paradigm Changes in Cardiac Surgery and Interventional Cardiology

edited by

Miklos Bitay

submission deadline 31 Mar 2026 | 1 articles | Viewed by 817 | Submission Open

Keywords: cardiac surgery; trans-catheter interventions; ischaemic heart disease; structural heart disease; electrophysiological interventions; state-of-the-art techniques; golden standards; therapeutic guidelines

(This special issue belongs to the Section Cardiology)

JSOPB 2025–2026 Congress Special Issue–Update on Organ Preservation and Transplantation

edited by

Issei Saitoh

and

Takashi Kenmochi

submission deadline 31 Mar 2026 | 1 articles | Viewed by 810 | Submission Open

Keywords: organ preservation; transplantation; pharmacology; engineering; stem cell therapy

(This special issue belongs to the Section General Surgery)

Cardiovascular Autonomic Function: From Bench to Bedside—2nd Edition

edited by

Vera Geraldes

and

Isabel Rocha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 631 | Submission Open

Keywords: dysautonomia; heart rate variability; autonomic function testing; cardiovascular autonomic function; autonomic neuroscience; syncope; orthostatic hypotension; baroreflex; autonomic molecular mechanisms

(This special issue belongs to the Section Cardiology)

New Insights into Clinical Application of Embolization Techniques

edited by

Bedros Taslakian

and Yan Epelboym

submission deadline 31 Mar 2026 | 1 articles | Viewed by 628 | Submission Open

Keywords: embolization; interventional radiology; musculoskeletal embolization; uterine artery embolization; prostate artery embolization; vascular malformations; catheter-directed therapy

(This special issue belongs to the Section Vascular Medicine)

Advancements in Lumbar Spine Surgery: Modern Strategies and Techniques

edited by Christian von der Brelie and Frank Beyer

submission deadline 31 Mar 2026 | 1 articles | Viewed by 350 | Submission Open

Keywords: lumbar spine; spine surgery; new techniques; robotics; minimally-invasive; artificial intelligence (AI); navigation

(This special issue belongs to the Section Orthopedics)

Pregnancy and Delivery Complications: Bridging Research and Clinical Practice

edited by

Maria Patricia Roman

, Andrei Mihai Malutan and Răzvan Ciortea

submission deadline 31 Mar 2026 | Viewed by 113 | Submission Open

Keywords: maternal– fetal medicine; obstetric complications; perinatal health; pelvic floor disorders; childbirth perineal trauma; risk stratification; patient-reported outcomes; patient-reported outcome measures

(This special issue belongs to the Section Obstetrics & Gynecology)

Latest Advances in Glaucoma, Cataracts, and Refractive Surgery

edited by

Adrian Gericke

, Felix Wagner and

Julia Verena Stingl

submission deadline 31 Mar 2026 | Viewed by 106 | Submission Open

Keywords: glaucoma; cataract surgery; refractive surgery; minimally invasive glaucoma surgery (MIGS); laser vision correc-tion (LVC); keratorefractive lenticule extraction (KLEx); lenticule implantation; multifocal IOLs; extended depth-of-focus (EDOF) lenses; ocular imaging; optical coherence tomography (OCT); artificial intelligence in ophthalmology; corneal biomechanics; surgical innovation

(This special issue belongs to the Section Ophthalmology)

Thoracic Radiochemoimmunotherapy for Non-Small Cell Lung Cancer (NSCLC): Evolving Techniques and Clinical Applications

edited by

Franz Zehentmayr

submission deadline 31 Mar 2026 | Viewed by 105 | Submission Open

Keywords: radiotherapy; radiology; oncology; non-small cell lung cancer; real-world data; immunotherapy; radiation dose escalation

(This special issue belongs to the Section Oncology)

Endodontic Diseases: Prevalence, Risk Factors, and Treatment Outcomes

edited by Iris Slutzky-Goldberg, Shlomo Matalon and

Hagay Slutzky

submission deadline 31 Mar 2026 | Viewed by 95 | Submission Open

Keywords: cone beam computed tomography (cbct); diagnostic tools; endodontic therapy; peri-radicular pathologies; regenerative endodontics; risk factors; systemic disease; treatment outcome; vital pulp therapy

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Clinical Advances in Laser Dentistry: Emerging Therapeutic Concepts

edited by

Satoshi Watanabe

and Risako Mikami

submission deadline 31 Mar 2026 | Viewed by 88 | Submission Open

Keywords: laser dentistry; dental treatment guidelines; refractory endodontic infection; root canal therapy; minimally invasive endodontics; anatomy; cone-beam computed tomography

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Oral Biology: Advances of Translating Experimental Findings into Clinical Dentistry and Oral Medicine

edited by

Andrea Palermo

submission deadline 31 Mar 2026 | Viewed by 85 | Submission Open

Keywords: oral surgery; biomaterials; tissue engineering; regenerative medicine; dentistry dentin graft; growth factors; ad-vances orthodontics; skeletal anchorage with miniscrews; TADS; MADS; MARPE; aligner

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Current Emerging Treatment Options in Atrial Fibrillation

edited by Hoang Nhat Pham and Amitoj Singh

submission deadline 31 Mar 2026 | Viewed by 77 | Submission Open

Keywords: atrial fibrillation; AF ablation; lifestyle intervention; rhythm control; pulsed field ablation; antiarrhythmic drugs; direct oral anticoagulants

(This special issue belongs to the Section Cardiology)

Acute Myocardial Infarction: Diagnosis and Novel Treatment Opportunities

edited by

Danilo Menichelli

and Flavio Giuseppe Biccirè

submission deadline 31 Mar 2026 | Viewed by 72 | Submission Open

Keywords: acute myocardial infarction; atherosclerosis; percutaneous coronary intervention; atherothrombosis; inflammation; dyslipidemia; lipid-lowering therapy

(This special issue belongs to the Section Cardiology)

Current Challenges and Updates in Therapeutic Advancements of Prostatectomy

edited by

Luca Lambertini

and

Francesco Lasorsa

submission deadline 31 Mar 2026 | Viewed by 68 | Submission Open

Keywords: radical prostatectomy; robot-assisted surgery; single port; artificial intelligence; complications; same day discharge; learning curve; training models; outcomes

(This special issue belongs to the Section Nephrology & Urology)

New Insights into Cardiovascular Radiology

edited by Amalia Lupi and Riccardo Cau

submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open

Keywords: CMR; tissue characterization; 4Dflow; CCTA; photon counting CT; plaque characterization

(This special issue belongs to the Section Nuclear Medicine & Radiology)

Glaucoma: Diagnosis and Management Insights

edited by

Stamatios Lampsas

and Eythimios Karmiris

submission deadline 31 Mar 2026 | Viewed by 64 | Submission Open

Keywords: glaucoma; risk factors; progression; novel biomarkers; diagnosis; management

(This special issue belongs to the Section Ophthalmology)

Acute Care Surgery: The Evolution of a Modern Specialty

edited by Mayur Narayan

submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open

Keywords: acute care surgery; emergency surgery; health equity; global surgery; trauma care; surgical workforce; surgical in-novation; decision-making

(This special issue belongs to the Section Emergency Medicine)

Geriatric Diseases: Management and Epidemiology

edited by

Luís Midão

submission deadline 5 Apr 2026 | 9 articles | Viewed by 18462 | Submission Open

Keywords: ageing and health; older care; chronic diseases; preventive health strategies; multidisciplinary approaches; health inequalities; innovation in care; global ageing challenges; epidemiology of ageing; quality of life in older adults

(This special issue belongs to the Section Geriatric Medicine)

Clinical Advances in Inflammatory Bowel Disease: 2nd Edition

edited by

Lorenzo Bertani

submission deadline 5 Apr 2026 | 1 articles | Viewed by 688 | Submission Open

Keywords: inflammatory bowel diseases; IBD; Crohn’ s disease; ulcerative colitis; biomarkers; biologics; anti-JAKs; personalized medicine

(This special issue belongs to the Section Gastroenterology & Hepatopancreatobiliary Medicine)

Breaking Barriers in Respiratory Conditions: From Clinical Pathophysiology to Treatment Across the Spectrum of Severity

edited by

Antenor Rodrigues

submission deadline 5 Apr 2026 | Viewed by 108 | Submission Open

Keywords: pulmonary rehabilitation; skeletal muscle; exercise physiology; exercise intolerance; physical activity; respiratory conditions

(This special issue belongs to the Section Respiratory Medicine)

Neurosurgery and Spine Surgery: From Up-to-Date Practitioners, 2nd Edition

edited by

Massimiliano Visocchi

submission deadline 10 Apr 2026 | 7 articles | Viewed by 9216 | Submission Open

Keywords: neurosurgery; spine surgery; surgical techniques; research; advances; patient outcomes; interdisciplinary collaboration; healthcare; medical innovation; clinical practices

(This special issue belongs to the Section Clinical Neurology)

Oral and Maxillofacial Surgery: Recent Clinical Advances and Future Directions

edited by Funda Göker,

Gianluca M. Tartaglia

and

Massimo Del Fabbro

submission deadline 10 Apr 2026 | 2 articles | Viewed by 3789 | Submission Open

Keywords: oral and maxillofacial reconstructive surgery; MRONJ management; temporomandibular joint disorders; sental implants; zygomatic implants; guided surgery; alveolar bone regeneration; maxillofacial deformities; bone regeneration; head and neck cancer

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

COVID-19 and Endocrine Complications

edited by

Kamyar Asadipooya

submission deadline 10 Apr 2026 | 2 articles | Viewed by 1605 | Submission Open

Keywords: adrenal; ACE2; diabetes; gonads; pituitary; SARS-CoV-2; thyroid

(This special issue belongs to the Section Endocrinology & Metabolism)

Clinical Management of Patients with Heart Failure: 3rd Edition

edited by

Cristina Tudoran

submission deadline 10 Apr 2026 | 1 articles | Viewed by 574 | Submission Open

Keywords: acute heart failure; chronic heart failure; treatment options; management of heart failure; lifestyle changes; diagnosis of heart failure

(This special issue belongs to the Section Cardiovascular Medicine)

Current Updates on Functional Endoscopic Sinus Surgery for Chronic Rhinosinusitis

edited by

Nikolaos Tsetsos

, Georgios Fyrmpas and

Konstantinos Garefis

submission deadline 10 Apr 2026 | Viewed by 115 | Submission Open

Keywords: endoscopic sinus surgery; rhinology; chronic rhinosinusitis management; functional endoscopic sinus surgery (FESS); sinonasal inflammation; transnasal approach; postoperative outcomes

(This special issue belongs to the Section Otolaryngology)

Cesarean Section Versus Vaginal Delivery

edited by

Demetra Gabriela Socolov

Angela Vinturache

and

Liana Ples

submission deadline 10 Apr 2026 | Viewed by 105 | Submission Open

Keywords: cesarean section; vaginal delivery; birth outcomes; birth complications; delivery mode; labor process; obstetric care; trial of labor after cesarean (TOLAC); intrapartum care; obstetric decision-making

(This special issue belongs to the Section Obstetrics & Gynecology)

Advances in Diagnosis and Treatment for Thymic Pathology

edited by Charalambos Zisis

submission deadline 10 Apr 2026 | Viewed by 53 | Submission Open

Keywords: immunobiology; myasthenia gravis; thymoma; thymic carcinoma; thymic hyperplasia; paraneoplastic disorders; histology; classification; staging; Masaoka; autoimmune disorders

(This special issue belongs to the Section Oncology)

Clinical Therapeutic Innovations in Maternal Fetal Medicine

edited by

Martina Derme

and

Giuseppe Rizzo

submission deadline 10 Apr 2026 | Viewed by 44 | Submission Open

Keywords: maternal-fetal medicine; prenatal screening; artificial intelligence; prenatal imaging; gene therapy

(This special issue belongs to the Section Obstetrics & Gynecology)

Clinical Management of Skin Cancer: From Pathology Advances to Techniques Applications

edited by Guy Orchard

submission deadline 15 Apr 2026 | 6 articles | Viewed by 18201 | Submission Open

Keywords: skin cancer; surgery; chemotherapy; radiotherapy; photothermal therapy; combination therapy; molecular target strategies

(This special issue belongs to the Section Dermatology)

Clinical Research in Radiation Oncology: Current Status and Future Directions

edited by Paolo Borghetti

submission deadline 15 Apr 2026 | 2 articles | Viewed by 5558 | Submission Open

Keywords: radiation oncology; radiobiology; stereotactic body radiotherapy; multidisciplinary team; integrated treatment; predictive and prognostic biomarkers; cancer treatment

(This special issue belongs to the Section Oncology)

Novel Insights into Neonatal Intensive Care

edited by

Vasilios Giapros

and Maria Baltogianni

submission deadline 15 Apr 2026 | 2 articles | Viewed by 3765 | Submission Open

Keywords: neonatology; neonatal intensive care; neonate; sepsis; nutrition; ventilation; hemodynamic; neurodevelopment

(This special issue belongs to the Section Clinical Pediatrics)

Modern Approaches to the Management of Orthopedic Injuries

edited by

Moshe Salai

submission deadline 15 Apr 2026 | 2 articles | Viewed by 3388 | Submission Open

Keywords: orthopedic trauma; surgical integration; trauma management; modern approaches; rehabilitation advances

(This special issue belongs to the Section Orthopedics)

Diagnosis and Treatment of Sjogren’s Syndrome: 2nd Edition

edited by

Yoshiro Horai

submission deadline 15 Apr 2026 | 1 articles | Viewed by 2865 | Submission Open

Keywords: biological agents; JAK inhibitors; magnetic resonance imaging; noncoding RNA; Sjö gren's syndrome; ultrasound

(This special issue belongs to the Section Immunology & Rheumatology)

Clinical Diagnostics and Therapeutic Advances in Pregnancy Complications

edited by

Theresa Reischer

and

Gülen Yerlikaya-Schatten

submission deadline 15 Apr 2026 | 2 articles | Viewed by 1554 | Submission Open

Keywords: prenatal diagnosis; pre-eclampsia; gestational diabetes; pregnancy complications; preterm labor; congenital mal-formations; prenatal genetic testing

(This special issue belongs to the Section Obstetrics & Gynecology)

Oral and Maxillofacial Surgery: Current Trends, Innovations and Techniques

edited by Gabriel Armencea and

Florin Onisor

submission deadline 15 Apr 2026 | Viewed by 1345 | Submission Open

Keywords: maxillofacial; trauma; deformities; cleft lip and palate; OMF surgery; head and neck; head and neck oncology; orthognathic surgery

(This special issue belongs to the Section Dentistry, Oral Surgery and Oral Medicine)

Retinal Dystrophies—Structure and Function Relationship

edited by

Katarzyna Nowomiejska

submission deadline 15 Apr 2026 | 1 articles | Viewed by 800 | Submission Open

Keywords: retinal dystrophies; structural changes; functional impairment; in retinal degenerative diseases; retinitis pigmentosa

(This special issue belongs to the Section Ophthalmology)

Retinal Diseases: Emerging Therapies and Vision Rehabilitation

edited by

Hisanori Imai

submission deadline 15 Apr 2026 | 1 articles | Viewed by 779 | Submission Open

Keywords: vitreoretinal disorder; vitrectomy; digital assisted vitrectomy; intraoperative optical coherence tomography; diabetic retinopathy; epiretinal membrane

(This special issue belongs to the Section Ophthalmology)

Nasopharyngeal Carcinoma: Recent Advances in Clinical Diagnosis and Treatment

edited by

Federico Sireci

submission deadline 15 Apr 2026 | 1 articles | Viewed by 610 | Submission Open

Keywords: nasopharyngeal carcinoma; early diagnosis; radiotherapy advances; immunotherapy; targeted therapy; biomarkers; precision medicine; recurrence and metastasis management

(This special issue belongs to the Section Otolaryngology)

Clinical Advances in the Management of Melanoma

edited by

Kelly M. Mahuron

and

Yan Xing

submission deadline 15 Apr 2026 | 1 articles | Viewed by 462 | Submission Open

Keywords: melanoma immunotherapy; targeted therapy; immune checkpoint inhibitors; melanoma subtypes; adjuvant treatment; neoadjuvant treatment; tumor-infiltrating lymphocytes (TILs) therapy; combination therapy; molecular profiling; bi-omarker-driven therapy; clinical decision-making; liquid biopsy

(This special issue belongs to the Section Dermatology)

Displaying special issue 1001-1050 on page 21 of 31.

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