Clinical Advances in the Management of Melanoma
A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".
Deadline for manuscript submissions: 15 April 2026 | Viewed by 29
Special Issue Editors
Interests: melanoma; surgical oncology; immuno-oncology
Special Issue Information
Dear Colleagues,
Melanoma management has undergone transformative clinical advances in recent years, driven by breakthroughs in targeted therapies and immunomodulation. This review highlights key innovations shaping contemporary treatment paradigms, including BRAF/MEK inhibitors for mutation-specific targeting, immune checkpoint inhibitors such as anti-PD-1/CTLA-4, and TIL adoptive cell therapy that have improved survival in advanced disease. As our understanding of the underlying genomic alterations that drive melanoma improves, there is increased interest in tailoring therapy regimens based on histologic and molecular subtypes. Emerging approaches such as oncolytic viruses, cancer vaccines, bispecific T-cell Engagers (BiTEs), bispecific antibodies, and combination regimens are discussed, with attention to their real-world efficacy and safety profiles. Additionally, we address challenges in treatment sequencing, the clinical utility of adjuvant and neoadjuvant strategies for stage III/IV resectable melanoma, resistance mechanisms, and biomarker and liquid-biopsy development to guide personalized decision-making. The integration of these innovations into multidisciplinary care models underscores the importance of tailored therapies in optimizing patient outcomes. By synthesizing recent trial data and expert consensus, this work provides a practical framework for clinicians navigating the rapidly evolving landscape of melanoma therapeutics.
Dr. Kelly M. Mahuron
Dr. Yan Xing
Guest Editors
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Keywords
- melanoma immunotherapy
- targeted therapy
- immune checkpoint inhibitors
- melanoma subtypes
- adjuvant treatment
- neoadjuvant treatment
- tumor-infiltrating lymphocytes (TILs) therapy
- combination therapy
- molecular profiling
- bi-omarker-driven therapy
- clinical decision-making
- liquid biopsy
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