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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Emerging Trends in Adductomics: From Adduct Detection to Environmental Implications

edited by

Mu-Rong Chao

Marcus S. Cooke

and

Chiung Wen Hu

submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open

Keywords: adductomics; covalent adducts; crosslinks; biomarkers; electrophilic species; exposome; environmental toxicants; high-resolution tandem mass spectrometry; post-data analysis

(This special issue belongs to the Section Molecular Toxicology)

Acute Leukemia: From Basic Research to Clinical Application, Second Edition

edited by

Luca Lo Nigro

submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open

Keywords: acute lymphoblastic leukemia (ALL); acute myeloid leukemia (AML); genomic findings; post-genomic findings; targeted therapies; immunotherapies; novel markers

(This special issue belongs to the Section Molecular Oncology)

Molecular Applications of Nanoparticles in Cancer Therapy

edited by Carlos Caro and Iñigo Martínez-Zubiaurre

submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open

Keywords: nanomedicine; molecular biology of cancer; advanced therapies; tumor microenvironment; cellular crosstalk

(This special issue belongs to the Section Materials Science)

Biomolecular Condensates and Their Role in Cellular Organization and Disease

edited by Anna Bratek-Skicki

submission deadline 20 Dec 2025 | Viewed by 131 | Submission Open

Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases

(This special issue belongs to the Section Molecular Biology)

Proteases and Their Inhibitors: From Biochemistry to Applications

edited by

Gonzalo Izaguirre

submission deadline 20 Dec 2025 | Viewed by 126 | Submission Open

Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics

(This special issue belongs to the Section Molecular Biology)

Myosin: Structure, Function and Evolution

edited by Barbara Baryłko and

Joseph P. Albanesi

submission deadline 20 Dec 2025 | Viewed by 123 | Submission Open

Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity

(This special issue belongs to the Section Macromolecules)

Autophagic Related Proteins in Cancer

edited by Pietri Puustinen

submission deadline 20 Dec 2025 | Viewed by 122 | Submission Open

Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth

(This special issue belongs to the Section Molecular Oncology)

Cracking the Molecular Code of Breast Cancer

edited by Bartlomiej Taciak

submission deadline 20 Dec 2025 | Viewed by 121 | Submission Open

Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics

(This special issue belongs to the Section Molecular Oncology)

Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites

edited by

Jose Roberto Meyer-Fernandes

submission deadline 20 Dec 2025 | Viewed by 117 | Submission Open

Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation

(This special issue belongs to the Section Molecular Biology)

Bioactives in Processed Foods: Profiling and Bioavailability Assessment

edited by Cong Wang

submission deadline 20 Dec 2025 | Viewed by 109 | Submission Open

Keywords: food processing; food bioactives; composition; bioavailability; functionality; novel food processing techniques; structure/constituents– bioactivity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition

edited by Xiaogang Li

submission deadline 20 Dec 2025 | Viewed by 82 | Submission Open

Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Research Advances in Metabolic Syndrome

edited by

Phileno Pinge-Filho

submission deadline 20 Dec 2025 | Viewed by 80 | Submission Open

Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration

edited by Seema Singh

submission deadline 20 Dec 2025 | Viewed by 71 | Submission Open

Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections

(This special issue belongs to the Section Molecular Immunology)

Molecular Research of Neonicotinoid Toxicity

edited by

Fatima Smagulova

submission deadline 20 Dec 2025 | Viewed by 69 | Submission Open

Keywords: neonicotinoids; sex-specific effects; brain– gut– microbiome; endocrine organs; genotoxic effects; epigenetic effects

(This special issue belongs to the Section Molecular Toxicology)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Dec 2025 | Viewed by 60 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition

edited by

Subhasis B. Biswas

submission deadline 20 Dec 2025 | Viewed by 39 | Submission Open

Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology

(This special issue belongs to the Section Molecular Oncology)

The Role of Ion Channels in Health and Disease

edited by

Joohyun Nam

submission deadline 20 Dec 2025 | Viewed by 30 | Submission Open

Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology

(This special issue belongs to the Section Molecular Biology)

Male Reproduction: Unveiling the Molecular Revolution

edited by

Anthony Archibong

submission deadline 20 Dec 2025 | Viewed by 29 | Submission Open

Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Intestinal Diseases and Gut Microbiota

edited by

Anna Duda-Madej

submission deadline 20 Dec 2025 | Viewed by 28 | Submission Open

Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics

edited by

Vladimir N. Uversky

submission deadline 20 Dec 2025 | Viewed by 27 | Submission Open

Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography

(This special issue belongs to the Section Molecular Biophysics)

Metabolomics of Medicinal Plants

edited by

L. Gerardo Zepeda Vallejo

and

Elvia Becerra-Martínez

submission deadline 20 Dec 2025 | Viewed by 25 | Submission Open

Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications

edited by

Mohammad El Khatib

submission deadline 20 Dec 2025 | Viewed by 23 | Submission Open

Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling

(This special issue belongs to the Section Molecular Biology)

Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models

edited by Claudia Bregonzio and Mariela Fernanda Pérez

submission deadline 20 Dec 2025 | Viewed by 21 | Submission Open

Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies

(This special issue belongs to the Section Molecular Neurobiology)

Sperm Physiology and Male Infertility: From Basic Biology to Molecular Genetics

edited by

Mónica Vazquez-Levin

and

Robert John Aitken

submission deadline 20 Dec 2025 | Viewed by 19 | Submission Open

Keywords: human sperm; fertilization; infertility; biomarkers; genetics

(This special issue belongs to the Section Molecular Biology)

Ongoing Anticancer Agents

edited by

Mauro Coluccia

submission deadline 20 Dec 2025 | Viewed by 17 | Submission Open

Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies

(This special issue belongs to the Section Molecular Oncology)

Developmental Origins of Kidney Disease: Renal Programming

edited by Hyung-Eun Yim

submission deadline 20 Dec 2025 | Viewed by 16 | Submission Open

Keywords: air pollution; chronic kidney disease; congenital anomalies of the kidneys and urinary tract; high-risk pregnancy; nephrogenesis; renal programming; renin angiotensin system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention

edited by

Jia-Feng Chang

and

Chih-Hsin Tang

submission deadline 20 Dec 2025 | Viewed by 5 | Submission Open

Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds

(This special issue belongs to the Section Molecular Oncology)

Redox Physiology

edited by Mateusz Mołoń

submission deadline 21 Dec 2025 | Viewed by 274 | Submission Open

Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling

(This special issue belongs to the Section Molecular Biology)

Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases

edited by

Paschalis Karakasis

submission deadline 25 Dec 2025 | 1 articles | Viewed by 808 | Submission Open

Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Genetic Advances in Plant Breeding

edited by Francesca Taranto

submission deadline 25 Dec 2025 | Viewed by 165 | Submission Open

Keywords: genetic diversity; next-generation sequencing; marker-assisted selection; GWAS/QTL mapping; KASP genotyping; molecular biology TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Plant Sciences)

Skin Cancer: From Molecular Pathophysiology to Novel Treatment

edited by Soon-Hyo Kwon

submission deadline 25 Dec 2025 | Viewed by 123 | Submission Open

Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma

(This special issue belongs to the Section Molecular Oncology)

Molecular Endocrine Regulation in Health and Diseases

edited by Fady Hannah-Shmouni

submission deadline 25 Dec 2025 | Viewed by 82 | Submission Open

Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Spectroscopic Techniques in Molecular Sciences

edited by

Angela Staicu

submission deadline 25 Dec 2025 | Viewed by 62 | Submission Open

Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems

(This special issue belongs to the Section Molecular Biology)

Roots, Transporters, and Signals: Molecular Insights into Plant Mineral Nutrition and Heavy Metals Stress

edited by

Alessio Aprile

submission deadline 25 Dec 2025 | Viewed by 55 | Submission Open

Keywords: plant mineral nutrition; heavy metals; toxic element; transporter; signaling pathway

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Tryptophan Metabolism

edited by

Katsunori Nonogaki

submission deadline 25 Dec 2025 | Viewed by 30 | Submission Open

Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”

edited by

Julia Kzhyshkowska

submission deadline 25 Dec 2025 | Viewed by 12 | Submission Open

Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights in Diabetes

edited by

Mariann Harangi

and

Ferenc Sztanek

submission deadline 25 Dec 2025 | Viewed by 9 | Submission Open

Keywords: insulin signalling pathway; pancreatic beta-cell dysfunction; oxidative stress; epigenetic modifications; metabolic memory; small regulatory RNAs (miRNAs); inflammation and insulin resistance; glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); molecular therapeutic targets; glucose homeostasis regulation

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound

edited by Alicia Paz

submission deadline 25 Dec 2025 | Submission Open

Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives

(This special issue belongs to the Section Molecular Microbiology)

Emerging Strategy in Bacterial Antibiotic Resistance

edited by Lili Li

submission deadline 28 Dec 2025 | Viewed by 14 | Submission Open

Keywords: fast detection; antimicrobial resistance; virulence; antibacterial action of natural compounds

(This special issue belongs to the Section Molecular Microbiology)

Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?

edited by

Dimitrios Kanakis

submission deadline 30 Dec 2025 | 5 articles | Viewed by 13412 | Submission Open

Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD）; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition

edited by

Ralf Kircheis

and

Oliver Planz

submission deadline 30 Dec 2025 | 6 articles | Viewed by 7927 | Submission Open

Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies

(This special issue belongs to the Section Molecular Immunology)

Potential Prevention and Treatment of Neurodegenerative Disorders

edited by

Maria Paola Bertuccio

submission deadline 30 Dec 2025 | 5 articles | Viewed by 7563 | Submission Open

Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention

(This special issue belongs to the Section Molecular Neurobiology)

Animal Research Model for Neurological Diseases, 2nd Edition

edited by

Giuseppe Montalbano

and

Sepand Rastegar

submission deadline 30 Dec 2025 | 3 articles | Viewed by 7482 | Submission Open

Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration

(This special issue belongs to the Section Molecular Neurobiology)

Host-Pathogen Interaction, 6th Edition

edited by

Andreas Burkovski

submission deadline 30 Dec 2025 | 4 articles | Viewed by 7083 | Submission Open

Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms

(This special issue belongs to the Section Molecular Microbiology)

Advances in Molecular Research on Autoimmune Diseases, 2nd Edition

edited by

Davide Cossu

submission deadline 30 Dec 2025 | 4 articles | Viewed by 6428 | Submission Open

Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

The Characterization and Application of Enzymes in Bioprocesses

edited by Loredana Marcolongo

submission deadline 30 Dec 2025 | 5 articles | Viewed by 6083 | Submission Open

Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing

(This special issue belongs to the Section Biochemistry)

Mitochondrial Biology and Human Diseases

edited by

Francesco Bruni

and

Paola Loguercio Polosa

submission deadline 30 Dec 2025 | 4 articles | Viewed by 4238 | Submission Open

Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases

(This special issue belongs to the Section Molecular Biology)

The Effect of Food-Derived Compounds on Brown Fat Cell Function

edited by

Nobuyuki Takahashi

submission deadline 30 Dec 2025 | 2 articles | Viewed by 4164 | Submission Open

Keywords: brown adipocyte; beige adipocyte; nutrients; food-derived components; thermogenesis; energy homeostasis; inflammation; obesity; diabetes; insulin resistance; metabolic syndrome; adipokines; lipid and carbohydrate metabolism

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Pathogenesis and Therapies for Retinal and Optic Nerve Diseases

edited by

Toshiyuki Oshitari

submission deadline 30 Dec 2025 | 1 articles | Viewed by 3854 | Submission Open

Keywords: neurovascular unit; neurovascular cell death; neuroprotection; vasoprotection; regeneration; molecular and cellular pathologies; current and future therapies; drug delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Cancer and Cell Metabolism—2nd Edition

edited by

Maria Concetta Faniello

Maria Mesuraca

and

Barbara Quaresima

submission deadline 30 Dec 2025 | 4 articles | Viewed by 2796 | Submission Open

Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Displaying special issue 2951-3000 on page 60 of 70.

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