Drug and Non-Drug Treatment of Cerebral Ischemia
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 23
Special Issue Editor
Interests: brain ischemic injury; neurodegeneration; neuroprotection; neurogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Cerebral ischemia remains a major cause of stroke and long-term neurological disability, demanding comprehensive treatment strategies that are carefully adapted to both adults and neonates. In this Special Issue, we explore a range of current and emerging pharmacological and non-pharmacological interventions designed to minimize brain injury and enhance recovery across the lifespan.
Pharmacological approaches include thrombolytics, neuroprotective agents (e.g., erythropoietin, melatonin), and anti-inflammatory therapies designed to reduce oxidative stress and apoptosis. In neonates, where ischemia is often linked to birth asphyxia or perinatal stroke, innovative therapies such as stem cell treatment and therapeutic hypothermia are showing increasing promise.
Non-pharmacological strategies are equally essential. Hypothermia remains the standard of care for neonatal hypoxic-ischemic encephalopathy (HIE), while early neurorehabilitation - through sensory stimulation and motor training - supports plasticity and functional recovery in both age groups. Emerging tools like near-infrared spectroscopy (NIRS), along with the identification of biomarkers of brain damage, are also gaining attention for their potential in patient stratification and individualized neurocritical care. Special consideration is given to the unique challenges in neonates, including narrow therapeutic windows and the heightened vulnerability of the developing brain.
By integrating pharmacological and supportive therapies, this Special issue aims to showcase the most recent and innovative research that may inform optimized treatment protocols and contribute to improved long-term outcomes for patients affected by cerebral ischemia, whether at birth or later in life.
Dr. Silvia Carloni
Guest Editor
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Keywords
- cerebral ischemia
- neonatal hypoxic-ischemic encephalopathy (HIE)
- neuroprotection
- therapeutic hypothermia
- neurorehabilitation
- oxidative stress
- stem cell therapy
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