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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Role of Microorganisms and Their Metabolites in Agriculture, Food and the Environment: 3rd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 153 | Submission Open
Keywords: fermentation; biopreservation; biocontrol; biodegradation; bioremediation; bioaugmentation; omic-technologies
(This special issue belongs to the Section Molecular Microbiology)
Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses and Therapies
edited by Magdalena Wawrzyńska
submission deadline 20 Jun 2026 | Viewed by 146 | Submission Open
Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound
edited by Alicia Paz
submission deadline 20 Jun 2026 | Viewed by 144 | Submission Open
Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives
(This special issue belongs to the Section Molecular Microbiology)
Nanobiotechnology: Breaking Barriers in Phytomedicine submission deadline 20 Jun 2026 | Viewed by 140 | Submission Open
Keywords: nanotechnology; nanobiotechnology; phytocompounds; phytochemistry; natural products
(This special issue belongs to the Section Molecular Nanoscience)
Genetic Susceptibility in Human Diseases
edited by Xiaowu Gai
submission deadline 20 Jun 2026 | Viewed by 140 | Submission Open
Keywords: bioinformatics; genomics; genetic susceptibility to disease; genetic variation; gene– environment interactions; biomarkers; epigenetic mechanisms; pharmacogenomics; population genetics; bioinformatics tools and databases; novel diagnostics; targeted therapies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Metabolism of Alzheimer’s Disease
edited by and Maria Letizia Trincavelli
submission deadline 20 Jun 2026 | Viewed by 140 | Submission Open
Keywords: Alzheimer’ s disease; brain metabolism; insulin resistance; lipid metabolism; APOE ε 4; metabolic targets; insulin-sensitizing drugs; lifestyle and metabolic interventions
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications
edited by
submission deadline 20 Jun 2026 | Viewed by 138 | Submission Open
Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling
(This special issue belongs to the Section Molecular Biology)
From Discovery to Clinic: Overcoming Barriers in Antimicrobial Peptide Development
edited by José M. Pérez De la Lastra
submission deadline 20 Jun 2026 | Viewed by 136 | Submission Open
Keywords: antimicrobial peptides (AMPs); translational challenges; in vivo efficacy; drug delivery and formulation; computational approaches; pharmacokinetics; toxicity prediction; antibiotic resistance; animal models; nanotechnology
(This special issue belongs to the Section Molecular Microbiology)
Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration
edited by Seema Singh
submission deadline 20 Jun 2026 | Viewed by 135 | Submission Open
Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections
(This special issue belongs to the Section Molecular Immunology)
Wired for Change: Neurotransmitter Plasticity and Circuit Dynamics in Health and Disease
edited by Alessandra Porcu
submission deadline 20 Jun 2026 | Viewed by 135 | Submission Open
Keywords: neurotransmitter; behavioral neuroscience; neuropsychiatric disorders; neurological disorders; neuroplasticity; neuronal circuit
(This special issue belongs to the Section Molecular Neurobiology)
Epigenetic Alterations in Hepatocellular Carcinoma
edited by
submission deadline 20 Jun 2026 | Viewed by 135 | Submission Open
Keywords: hepatocellular carcinoma (HCC); epigenetics; DNA methylation; histone modification; chromatin remodeling; non-coding RNAs epigenetic biomarkers; cancer progression
(This special issue belongs to the Section Molecular Oncology)
Molecular Studies of DNA Strand Exchange
edited by
submission deadline 20 Jun 2026 | Viewed by 134 | Submission Open
Keywords: DNA strand exchange; homologous recombination: RecA-family recombinases; drug resistance: drug development against recombinases; evolution
(This special issue belongs to the Section Molecular Biophysics)
Unravelling Molecular Pathways in Ocular Disease and Degeneration submission deadline 20 Jun 2026 | Viewed by 130 | Submission Open
Keywords: molecular mechanisms; ocular disease; biomarkers; therapeutic targets; regenerative; gene therapies; corneal degeneration; retinal degeneration; optic nerve pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms Underlying the Pathogenesis and Treatment of Gastrointestinal Disorders
edited by
submission deadline 20 Jun 2026 | Viewed by 128 | Submission Open
Keywords: gastrointestinal disorders; molecular mechanisms; diagnosis; treatment; precision medicine; biomarkers; gastrointestinal cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Targeted Therapies and Immunometabolic Pathways in Cancer
edited by Medhi Wangpaichitr
submission deadline 20 Jun 2026 | Viewed by 120 | Submission Open
Keywords: immunotherapy; targeted therapy; tumor metabolism pathway; tumor microenvironment; immune checkpoint blockade; immune evasion; glucose/amino acids/lipid metabolism
(This special issue belongs to the Section Molecular Immunology)
Artificial Intelligence and Data Science for the Discovery of Anticancer Targets and Decision Support
edited by
submission deadline 20 Jun 2026 | Viewed by 120 | Submission Open
Keywords: artificial intelligence in oncology; data science and decision support in cancer therapy; target discovery and biomarker identification; machine learning and multi-omics integration; predictive modeling in precision medicine
(This special issue belongs to the Section Molecular Informatics)
Structure and Function of Subcellular Organelle and Protein-Membrane Systems
edited by
submission deadline 20 Jun 2026 | Viewed by 119 | Submission Open
Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton
(This special issue belongs to the Section Molecular Biophysics)
Anticancer Drugs: Current Status and Future Directions submission deadline 20 Jun 2026 | Viewed by 116 | Submission Open
Keywords: anticancer drugs; hybrids; combinations; nanoparticles
(This special issue belongs to the Section Molecular Pharmacology)
Genome Editing and Biotechnology in Fruit Improvement
edited by Hongxia Miao
submission deadline 20 Jun 2026 | Viewed by 109 | Submission Open
Keywords: fruit improvement; horticultural crops; genome editing; biotechnology; molecular biology; plant genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular and Adaptive Mechanisms in Plant Genetics
edited by
submission deadline 20 Jun 2026 | Viewed by 109 | Submission Open
Keywords: forest genetics; breeding techniques; molecular breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Deciphering the Molecular Mechanisms That Regulate Plant Disease and Immunity
edited by Bourlaye Fofana and
submission deadline 20 Jun 2026 | Viewed by 106 | Submission Open
Keywords: plants; biotic stressors; molecular mechanisms; omics technologies; plant immunity
(This special issue belongs to the Section Molecular Plant Sciences)
Medicinal Plants, Animal-Derived Products, and Natural Compounds: Roles in Health and Disease submission deadline 20 Jun 2026 | Viewed by 56 | Submission Open
Keywords: natural bioactive compounds; medicinal plants; animal-derived products; marine natural products; chronic diseases; inflammation; oxidative stress; molecular mechanisms; therapeutic peptides; natural toxins; antioxidant activity; anti-inflammatory agents; nanoformulations; nanodelivery systems; drug delivery; pharmacological properties; translational research; integrative medicine; natural therapeutics; disease prevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Evolution, Genetics and Pathogenesis of Viruses, 2nd Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 47 | Submission Open
Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents
(This special issue belongs to the Section Molecular Microbiology)
New Molecular Mechanisms and Markers in Inflammatory Disorders, 4th Edition
edited by
submission deadline 20 Jun 2026 | Viewed by 36 | Submission Open
Keywords: inflammation; inflammatory disorders; biomarkers; molecular mechanism of inflammation; molecular signaling
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms and Therapies of Pancreatic Cancer: 3rd Edition submission deadline 20 Jun 2026 | Viewed by 21 | Submission Open
Keywords: pancreatic cancer; metabolism; cellular plasticity; tumor microenvironment; target therapy
(This special issue belongs to the Section Molecular Oncology)
Natural Products: Pharmacological Insights and Advances
edited by
submission deadline 20 Jun 2026 | Viewed by 17 | Submission Open
Keywords: natural products; biological activity; pharmacology; mechanism of action; molecular targets
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Genetic Mechanism of Stress Resistance in Plants
edited by Mohammad Nurul Matin
submission deadline 21 Jun 2026 | Viewed by 12 | Submission Open
Keywords: stress response and resistance; environmental adaptation; abiotic and biotic stress; gene regulation network; functional genomics; molecular signalling pathways; CRISPR/cas systems; epigenetic regulation; transcriptome profiling; metabolic reprogramming; stress-responsive genes
(This special issue belongs to the Section Molecular Genetics and Genomics)
Functions and Applications of Natural Products: 2nd Edition
edited by
submission deadline 25 Jun 2026 | 1 articles | Viewed by 731 | Submission Open
Keywords: natural products; biomedicine/phytomedicine; biologically active extracts and compounds; pharmacological and toxicological mechanisms of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research in Pregnancy-Related Complications
edited by Kallirhoe Kalinderi
submission deadline 25 Jun 2026 | Viewed by 252 | Submission Open
Keywords: preeclampsia; gestetional diabetes mellitus; pregnancy; complications; gene; molecular; pathways; biomarkers; diagnosis; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Colorectal Cancer: A Molecular Genetics Perspective (2nd Edition)
edited by
submission deadline 25 Jun 2026 | Viewed by 106 | Submission Open
Keywords: colorectal cancer; chromosomal and microsatellite instability; CpG island methylator phenotype; molecular characteristics; early diagnosis; targeted therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Function in Human Health and Disease: 3rd Edition
edited by
submission deadline 25 Jun 2026 | Viewed by 86 | Submission Open
Keywords: mitochondial genesis and disease; mitochondrial function and aging; mitochondrial dysfunction and cancer; mitochondrial function and apoptosis; mitophage; autophage; mitochondrial AKT
(This special issue belongs to the Section Biochemistry)
Molecular Progression of Gut Microbiota—2nd Edition
edited by
submission deadline 25 Jun 2026 | Viewed by 84 | Submission Open
Keywords: gut microbiota; microbiome; differences in gut microflora; molecular techniques; gut microbiota’ s role and composition; healthy state; dysbiosis
(This special issue belongs to the Section Molecular Microbiology)
Glycosylation in Tumor Microenvironment: Roles, Mechanisms and Interventions
edited by
submission deadline 25 Jun 2026 | Viewed by 21 | Submission Open
Keywords: glycoproteins; glycolipids; signaling; cell– cell interaction; cell membrane
(This special issue belongs to the Section Molecular Oncology)
Advances in Materials for Water Treatment and Metal/Nutrient Recovery
edited by
submission deadline 25 Jun 2026 | Viewed by 9 | Submission Open
Keywords: water treatment; wastewater treatment; recalcitrant pollutants; metal recovery; nutrient recovery; molecularly engineered materials; functional materials; adsorption and remediation
(This special issue belongs to the Section Materials Science)
Cancer Stem Cells: Molecular Mechanisms and Therapeutic Targeting
edited by Pablo Pérez-Moreno
submission deadline 25 Jun 2026 | Viewed by 8 | Submission Open
Keywords: cancer stem cells; CSCs clinical biomarkers; CSCs as therapeutic targets; cancer cell biology of CSCs; prognosis and CSCs; molecular biology and CSCs
(This special issue belongs to the Section Molecular Oncology)
Current Research on Cancer Biology and Therapeutics: Fourth Edition submission deadline 29 Jun 2026 | 4 articles | Viewed by 2413 | Submission Open
Keywords: cancer and anticancer peptides; substance P/neurokinin-1 receptor system; neurokinin-1 receptor antagonists
(This special issue belongs to the Section Molecular Oncology)
Plant Growth: Molecular Mechanisms submission deadline 29 Jun 2026 | Viewed by 118 | Submission Open
Keywords: plant growth; hormonal crosstalk; epigenetics; CRISPR/Cas9 genome editing technologies; metabolomics; transcriptomics
(This special issue belongs to the Section Molecular Plant Sciences)
State-of-the-Art Molecular Immunology in Chile, 2nd Edition submission deadline 30 Jun 2026 | 7 articles | Viewed by 15775 | Submission Open
Keywords: innate immunity; adaptive immunity; host– pathogen interactions; immunopathology; osteoimmunology; immunosenescence; immunotherapy; antibody; vaccines; Chile
(This special issue belongs to the Section Molecular Immunology)
Latest Reviews in Molecular Plant Science 2025
edited by and
submission deadline 30 Jun 2026 | 4 articles | Viewed by 10376 | Submission Open
Keywords: gene cloning and gene functional analysis; gene editing; QTL mapping; multi-omics integration analysis; agronomically characteristics; plant development; metabolic pathway; biotic and abiotic stresses
(This special issue belongs to the Section Molecular Plant Sciences)
Wnt/β-Catenin Signaling in Cancer submission deadline 30 Jun 2026 | 1 articles | Viewed by 6890 | Submission Open
Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches
(This special issue belongs to the Section Molecular Oncology)
Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 30 Jun 2026 | 4 articles | Viewed by 6738 | Submission Open
Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Preclinical and Translational Research in Thyroid Cancer submission deadline 30 Jun 2026 | 2 articles | Viewed by 5964 | Submission Open
Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Natural Products for Cancer Therapy
edited by María Jesus Rodríguez-Yoldi
submission deadline 30 Jun 2026 | 1 articles | Viewed by 4278 | Submission Open
Keywords: apoptosis; antioxidant; anti-inflammatory; cancer; cell viability; food-by-products; natural products; polyphenols
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Pathogenesis and Antiviral Treatment of Emerging and Reemerging Viral Infections submission deadline 30 Jun 2026 | 1 articles | Viewed by 3080 | Submission Open
Keywords: viral replication; antiviral; inflammation; vaccine; arbovirus; respiratory virus; hemorrhagic virus; neurotropic virus
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Hormone Receptor in Breast Cancer: 2nd Edition submission deadline 30 Jun 2026 | 2 articles | Viewed by 2845 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Oncology)
Molecular Endocrine Regulation in Health and Diseases
edited by Fady Hannah-Shmouni
submission deadline 30 Jun 2026 | 1 articles | Viewed by 2751 | Submission Open
Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Functional Genomics and Molecular Mechanisms of Plant Stress Responses
edited by
submission deadline 30 Jun 2026 | 1 articles | Viewed by 729 | Submission Open
Keywords: plant stress responses; abiotic stress; biotic stress; molecular mechanisms; functional genomics
(This special issue belongs to the Section Molecular Plant Sciences)
Oxidative Stress Unveiled: Mechanisms and Implications in Cardiac Pathologies
edited by Sukkum Ngullie Chang and Vernat Exil
submission deadline 30 Jun 2026 | Viewed by 576 | Submission Open
Keywords: reactive oxygen species (ROS); electron transport chain (ETC); mitochondrial permeability transition pore (mPTP); endothelial– cardiomyocyte– fibroblast crosstalk; metabolic adaptation; inflammation; cardiovascular disease (CVD)
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
RNA Modifications in Response to Physical Activity: Implications for Rehabilitation and Disease Management
edited by Roberto Tedeschi and Francesca Gorini
submission deadline 30 Jun 2026 | Viewed by 357 | Submission Open
Keywords: RNA modifications; non-coding RNAs (ncRNAs); physical activity; gene expression; rehabilitation and disease management; epigenetic regulation; exercise-induced RNA expression; miRNA in inflammation control
(This special issue belongs to the Section Molecular Biology)
Genetic Regulation of Plant Growth and Protection (2nd Edition)
edited by and
submission deadline 30 Jun 2026 | Viewed by 205 | Submission Open
Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions
(This special issue belongs to the Section Molecular Plant Sciences)
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