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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Translationally Controlled Tumor Protein (TCTP) in Human Health and Disease: From Bench to Bedside

edited by

Decha Pinkaew

submission deadline 31 Oct 2025 | Viewed by 224 | Submission Open

Keywords: TCTP; fortilin; histamine releasing factor; human disease; cancer; inflammation and allergy; cardiovascular; therapeutic target; biomarker discovery

(This special issue belongs to the Section Molecular Biology)

Innovative Nanomaterials from Functional Molecules

edited by Xiaoming Zhang and

Yi Jia

submission deadline 31 Oct 2025 | Viewed by 120 | Submission Open

Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing

(This special issue belongs to the Section Molecular Nanoscience)

Toxicity of Metals, Metal-Based Drugs, and Microplastics

edited by

Agnieszka Scibior

Manuel Aureliano

and

Juan Llopis

submission deadline 31 Oct 2025 | Viewed by 99 | Submission Open

Keywords: metal toxicity and pollution; microplastic toxicity and pollution; metal and microplastic bioaccumulation; metal-based drugs; protein metalation; human health problems; diseases; in vitro/in vivo studies; human studies

(This special issue belongs to the Section Molecular Toxicology)

Ferroptosis and Cuproptosis: Mechanism and Crosstalk in Cancer, Neurodegeneration, and Metabolic Syndrome

edited by

Rosanna Squitti

submission deadline 31 Oct 2025 | Viewed by 88 | Submission Open

Keywords: ferroptosis; cuproptosis; Alzheimer's disease; colorectal cancer; neurodegeneration; metabolic syndrome; regulated cell death; iron metabolism; copper metabolism; psychiatric disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Insights and Discoveries in the Pathogenesis, Diagnosis and Therapy of Neuromuscular Diseases

edited by

Dimitrios Kanakis

submission deadline 31 Oct 2025 | Viewed by 87 | Submission Open

Keywords: neuromuscular diseases; autophagy; mitochondrial dysfunction; molecular genetics; blood-based biomarkers; antisense oligonucleotides; monoclonal antibodies

(This special issue belongs to the Section Molecular Neurobiology)

Immune Cell Therapy and Genome Engineering

edited by

Kieu C. D. Nguyễn

submission deadline 31 Oct 2025 | Viewed by 84 | Submission Open

Keywords: immune cell therapies; regenerative therapy; gene editing technologies; epigenetic modulation; precision medicine; personalized therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Comparative Reproductive Physiology

edited by

Heriberto Rodriguez-Martinez

and

Manuel Álvarez-Rodríguez

submission deadline 31 Oct 2025 | Viewed by 79 | Submission Open

Keywords: andrology; sperm; oocyte; gamete interactions; reproductive morphology; reproductive endocrinology; omics; epigenetics; pregnancy; all animal species

(This special issue belongs to the Section Molecular Biology)

Autophagy, Apoptosis and Cell Cycle Checkpoints in Deregulated Cellular Plasticity

edited by

Elena Matei

submission deadline 31 Oct 2025 | Viewed by 73 | Submission Open

Keywords: autophagy; apoptosis; cell cycle; cell plasticity; regulation pathways; checkpoints

(This special issue belongs to the Section Molecular Biology)

Proteolysis-Targeting Chimeras (PROTACs) in Drug Design

edited by

Asim Debnath

submission deadline 31 Oct 2025 | Viewed by 72 | Submission Open

Keywords: PROTAC; drug design; medicinal chemistry

(This special issue belongs to the Section Molecular Pharmacology)

Musculoskeletal Diseases: Advances in Molecular Mechanisms and Therapeutic Approaches

edited by

Jung Eun Kim

submission deadline 31 Oct 2025 | Viewed by 62 | Submission Open

Keywords: bone; muscle; tendon; cartilage; osteoporosis; sarcopenia; tendinopathy; osteoarthritis; musculoskeletal pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Vector–Pathogen–Host Interaction, Vaccines and Immunobiologicals

edited by Carlo José Freire Oliveira and

Marcos Vinícius Da Silva

submission deadline 31 Oct 2025 | Viewed by 61 | Submission Open

Keywords: host– pathogen– vector interactions; active biomolecules; immunomodulation; vaccines; binding molecules; immunobiologicals

(This special issue belongs to the Section Molecular Immunology)

Bone Metabolism and Bone Diseases

edited by

Giacomina Brunetti

submission deadline 31 Oct 2025 | Viewed by 59 | Submission Open

Keywords: bone metabolism; bone diseases; osteoclast; osteoblasts and osteocytes; bone remodelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mesenchymal Stem/Stromal Cells: Mechanisms and Applications in Tissue Regeneration

edited by

Daiva Bironaite

submission deadline 31 Oct 2025 | Viewed by 57 | Submission Open

Keywords: MSC isolation; identification; and viability; MSC differentiation mechanisms; extracellular environment modifications; intracellular signalling systems; cytotoxicity investigations; tissue regeneration mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

G Protein-Coupled Receptors: Signaling, Regulation and Therapeutic Opportunities, 2nd Edition

edited by

Joanna Filipowska

submission deadline 31 Oct 2025 | Viewed by 56 | Submission Open

Keywords: GPCR; cell signaling; small-molecule drugs; biased signaling; endosomal signaling; post-translational modification; GPCR internalization; phosphorylation barcode

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanisms of Genetic and Acquired Acid-Base Disorders

edited by

Manoocher Soleimani

submission deadline 31 Oct 2025 | Viewed by 56 | Submission Open

Keywords: acid– base balance; bicarbonate transport; metabolic acidosis; metabolic alkalosis; renal tubular acidosis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Targeting Cancer Metabolism: From Mechanism to Therapies

edited by

Zisis Kozlakidis

submission deadline 31 Oct 2025 | Viewed by 50 | Submission Open

Keywords: cancer metabolism; metabolic alterations; Warburg effect; metabolic reprogramming; metabolic disorder; mitochondrial dysfunction; mitochondrial dynamics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Pathogen Interactions: 3nd Edition

edited by

Sixue Chen

submission deadline 31 Oct 2025 | Viewed by 50 | Submission Open

Keywords: pathogenicity; plant immunity; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); effectors; avirulent; virulent; biotroph; necrotrophy; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Innovative Therapeutic Approaches to Endocrine Disorders

edited by

Gilberta Giacchetti

and

Emanuele-Salvatore Scarpa

submission deadline 31 Oct 2025 | Viewed by 49 | Submission Open

Keywords: endocrine disorders; osteoporosis; diabetes; obesity; synthetic drugs; nutraceuticals; biomarkers

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advanced Molecular Diagnostic Approaches for Neurodevelopmental Disorders: Applications and Future Perspectives

edited by

Barbara Lombardo

and Michele Pinelli

submission deadline 31 Oct 2025 | Viewed by 47 | Submission Open

Keywords: neurodevelopmental disorders; array CGH; NGS

(This special issue belongs to the Section Molecular Neurobiology)

Advanced Research on the Major Histocompatibility Complex (MHC): From Bench to Bedside

edited by Antonio Arnaiz-Villena

submission deadline 31 Oct 2025 | Viewed by 45 | Submission Open

Keywords: HLA; immunology; HLA genetics and pharmacogenetics; immune and other functions of the MHC; classical and nonclassical MHC class I HLA genes; HLA-G; HLA-E; HLA-F; MHC evolution; complement; autoimmunity; immunodeficiency; cancer; HIV

(This special issue belongs to the Section Molecular Immunology)

Heterocyclic Compounds: Molecular Modelling Studies and Pharmacological Investigation

edited by

Gabriella Guerrini

and

Maria P. Giovannoni

submission deadline 31 Oct 2025 | Viewed by 40 | Submission Open

Keywords: heterocycles; fused heteocycles; synthesis; small-molecules; natural product; drug design; biological studies; molecular modeling

(This special issue belongs to the Section Biochemistry)

Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton

edited by

Nikolas Nikolaidis

submission deadline 31 Oct 2025 | Viewed by 40 | Submission Open

Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane– protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling

(This special issue belongs to the Section Molecular Biology)

Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases

edited by

Cinzia Signorini

submission deadline 31 Oct 2025 | Viewed by 38 | Submission Open

Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Human Drug Transporters: From Molecular Mechanisms to Drug Development

edited by Ágnes Telbisz

submission deadline 31 Oct 2025 | Viewed by 37 | Submission Open

Keywords: human drug transporters; multidrug resistance; drug– drug interaction; ABC transporters; SLC transporters

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Antimicrobial Agents: Mechanisms and Applications

edited by

Aleksandra Maria Kocot

submission deadline 31 Oct 2025 | Viewed by 35 | Submission Open

Keywords: antimicrobial compounds; antibacterial activity; antibiotic resistance; pathogen-tailored therapeutic targeting; novel antimicrobials; molecular aspects of the mechanisms of action of antibacterial substances; effectiveness of antibacterial substances

(This special issue belongs to the Section Biochemistry)

Emerging Treatments in Aging-Related Cerebrovascular Diseases

edited by

Aurel Popa-Wagner

submission deadline 31 Oct 2025 | Viewed by 33 | Submission Open

Keywords: aging; cerebrovascular diseases; therapeutic tools; senolytic drugs; gene editing technologies; RNA-based therapies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Genomic Aspects of Viral Pathogens

edited by

Joanna Dąbrowska

submission deadline 31 Oct 2025 | Viewed by 33 | Submission Open

Keywords: viral pathogens; genetic and molecular mechanisms; viral infection; viral replication; host interaction

(This special issue belongs to the Section Molecular Microbiology)

Antiviral Drug Targets: Structure, Function, and Drug Design—3rd Edition

edited by

Mattia Mori

and

Ilaria Vicenti

submission deadline 31 Oct 2025 | Viewed by 33 | Submission Open

Keywords: viral infections; drug design; protein structures; functional studies; viruses; antiviral drugs

(This special issue belongs to the Section Molecular Pharmacology)

Sex and Gender Medicine–Physiology: A New Horizon in Human Physiology

edited by

Rosanna Mallamaci

submission deadline 31 Oct 2025 | Viewed by 33 | Submission Open

Keywords: sex and gender; personalized medicine; sex-specific evidence; sex-specific differences

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Interplay Between Aging, Dementia and Renal Function: Mechanisms, Biomarkers and Therapeutic Targets

edited by

Luca Soraci

submission deadline 31 Oct 2025 | Viewed by 32 | Submission Open

Keywords: aging; dementia; neuroinflammation; kidney– brain axis; translational research; biomarkers; oxidative stress

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nano-Biomaterials and Biotechnology for Biomedicine and Tissue Regeneration

edited by

Laura Giannotti

submission deadline 31 Oct 2025 | Viewed by 32 | Submission Open

Keywords: nano-biomaterials; regenerative medicine; tissue engineering; drug delivery systems; bioactive interfaces

(This special issue belongs to the Section Materials Science)

Genetic Regulation of Plant Growth and Protection (2nd Edition)

edited by

Yuxuan Hou

and

Zhiyong Li

submission deadline 31 Oct 2025 | Viewed by 30 | Submission Open

Keywords: molecular regulation; genetic resources; functional genomics; plant growth and development; abiotic and biotic stresses; plant– microbe interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Progress in Molecular Breeding and Genetic Engineering for Fruit Crop Improvement

edited by

Amelia Salimonti

submission deadline 31 Oct 2025 | Viewed by 29 | Submission Open

Keywords: genetics; GWAS; genome; abiotic and biotic stress; transcriptomic analysis; fruit crop germplasm; breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Perineuronal Nets and Fear Memories Erasure: State of the Art and Future Directions

edited by

Andrea Poli

submission deadline 31 Oct 2025 | Viewed by 28 | Submission Open

Keywords: perineuronal nets (PNNs); extracellular matrix (ECM); fear erasure; traumatic memories; PTSD; translation research; clinical treatment; therapeutical strategies

(This special issue belongs to the Section Molecular Neurobiology)

Functional Adsorption Materials: From Design to Application

edited by Qi Liu

submission deadline 31 Oct 2025 | Viewed by 28 | Submission Open

Keywords: functional adsorption materials; molecular design; selective adsorption

(This special issue belongs to the Section Materials Science)

Micro-Nano Materials for Drug Delivery and Disease Treatment

edited by

Maoquan Chu

submission deadline 31 Oct 2025 | Viewed by 27 | Submission Open

Keywords: biomaterials; nanoparticle-loaded bacterial cells; nanoparticle-loaded cells; bioimaging and diagnosis; therapy

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Molecular Mechanisms of Neurodegeneration and Neuroinflammation

edited by Marika Lanza and

Giovanna Casili

submission deadline 31 Oct 2025 | Viewed by 26 | Submission Open

Keywords: neuroinflammation; neurodegeneration; mitochondrial dysfunction; oxidative stress; metabolomics; therapeutic strategies

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Skin Health and Disease

edited by

Mihaela Pertea

submission deadline 31 Oct 2025 | Viewed by 26 | Submission Open

Keywords: wound healing; molecular research in skin lesions; dermatologic surgery; cosmetic surgery; exosomes: new molecular targets of diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Molecular Advances in Apoptosis

edited by Mariarosaria Boccellino and

Davide Viggiano

submission deadline 31 Oct 2025 | Viewed by 26 | Submission Open

Keywords: apoptosis; glomerulonephritis; aging; caspase; endonuclease; DNA; cytokeratin

(This special issue belongs to the Section Biochemistry)

Molecular and Physiological Strategies for Plant Drought Resilience

edited by

Mariapina Rocco

submission deadline 31 Oct 2025 | Viewed by 25 | Submission Open

Keywords: abiotic stress; reactive oxygen species; oxidative stress; adaptive response; signaling pathways; phytohormones; physiological adaptation; molecular adaptation

(This special issue belongs to the Section Molecular Plant Sciences)

Transforming in Cancer Therapy: Advances in Immunotherapy and Tyrosine Kinase Inhibitors

edited by

Walid Shalata

submission deadline 31 Oct 2025 | Viewed by 24 | Submission Open

Keywords: tyrosine kinase inhibitors; immunotherapy; monoclonal antibodies; CAR-T cells

(This special issue belongs to the Section Molecular Oncology)

Molecular Biology of Host and Pathogen Interactions: 3rd Edition

edited by

Ana Paula Arez

submission deadline 31 Oct 2025 | Viewed by 24 | Submission Open

Keywords: microbe; pathogen; virus; bacteria; parasite; fungi; infection; disease; interaction; host response

(This special issue belongs to the Section Molecular Microbiology)

Mitochondria-Associated Non-Coding RNAs

edited by

Verónica A. Burzio

, Jaime E. Villegas and

Samirjit Das

submission deadline 31 Oct 2025 | Viewed by 23 | Submission Open

Keywords: mitochondrial-encoded ncRNAs; mitochondrial miRNAs; mitochondrial lncRNAs; mitochondrial circRNAs; nuclear-encoded mitochondrial ncRNAs

(This special issue belongs to the Section Molecular Biology)

Molecular Genetics in the Pathogenesis of Neurological Disorders

edited by Jeannette Hübener-Schmid

submission deadline 31 Oct 2025 | Viewed by 23 | Submission Open

Keywords: ataxia; genetic modifier; genetic landscape; genomics; long-read sequencing; neurodegeneration; personalized medicine; personalized treatmen; polymorphisms; single cell sequencing

(This special issue belongs to the Section Molecular Neurobiology)

TRP Channels: Mechanisms, Functions, and Therapeutic Implications

edited by

Stefan Mergler

submission deadline 31 Oct 2025 | Viewed by 23 | Submission Open

Keywords: transient receptor potential (TRP) channels; calcium signaling; ion channels; tissue homeostasis; receptor activation

(This special issue belongs to the Section Biochemistry)

Trace Elements, Metals and Bioactive Compounds: Homeostasis and Metabolic Impairment

edited by

Graziantonio Lauria

and

Rosita Curcio

submission deadline 31 Oct 2025 | Viewed by 22 | Submission Open

Keywords: trace elements; bioactive compounds; metals; human health; human diseases

(This special issue belongs to the Section Biochemistry)

Molecular Mechanisms in Rare and Hereditary Vascular Diseases

edited by

Antonino Tuttolomondo

submission deadline 31 Oct 2025 | Viewed by 22 | Submission Open

Keywords: Klippel– Trenaunay syndrome; Parkes– Weber syndrome; CLOVES syndrome; Proteus syndrome; hereditary hemorrhagic telangiectasia; blue rubber bleb nevus syndrome; COL4A1/A2-related disorders; CADASIL; Fabry disease; cerebral amyloid angiopathy

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Lipopolysaccharide as a Drug Target

edited by

Martina Schmidt

submission deadline 31 Oct 2025 | Viewed by 22 | Submission Open

Keywords: tissue barriers; neuroinflammation; macrophages; microglia; organoids; scaffolds; infections; cry-EM

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Computational Research in Pharmacological Structure–Efficacy

edited by

José Rogério A. Silva

and Jerônimo Lameira

submission deadline 31 Oct 2025 | Viewed by 20 | Submission Open

Keywords: molecular modeling; structure– activity relationship (SAR); pharmacological efficacy; quantum chemistry; molecular dynamics; free energy calculations; drug design; enzyme inhibition; ligand– receptor interactions; computational pharmacology

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research on Proglucagon-Derived Peptides

edited by

Camilla Krizhanovskii

submission deadline 31 Oct 2025 | Viewed by 20 | Submission Open

Keywords: proglucagon; peptide hormones; post-translational processing; prohormone convertase; G-protein-coupled receptors; tissue specificity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Displaying special issue 3001-3050 on page 61 of 70.

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