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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Omics Technologies in Molecular Biology
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 2538 | Submission Open
Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology
(This special issue belongs to the Section Molecular Biology)
Advances in Primary Nephropathies: Pathogenesis, Inflammatory Response and Advanced Treatments
edited by and Juliana Bordignon-Draibe
submission deadline 30 Dec 2025 | 1 articles | Viewed by 2330 | Submission Open
Keywords: primary glomerular diseases; membranous nephropathy; IgA nephropathy; glomerular inflammatory mechanisms; aberrantly glycosylated IgA1; galactose-deficient IgA1 (Gd-IgA1); alternative complement pathway; C5; factor B; factor D; APRIL; BAFF; phospholipase A2 receptor (PLA2R); thrombospondin type I domain-containing 7A (THSD7A); exostosins 1 and 2 (EXT1/2); neural epidermal growth factor-like 1 protein (NELL-1); semaphorin 3B (Sema3B); neural cell adhesion molecule 1 (NCAM1)
(This special issue belongs to the Section Molecular Immunology)
Artificial Intelligence: Applications in the Field of Immune-Mediated Inflammatory Diseases and Onco-Hematology submission deadline 30 Dec 2025 | 1 articles | Viewed by 1420 | Submission Open
Keywords: artificial intelligence; machine learning; immune-mediated diseases; cancers; hematological ma-lignancies
(This special issue belongs to the Section Molecular Immunology)
Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 1362 | Submission Open
Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Advances in Hypertension and Cardiovascular Disease: 2nd Edition
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 1342 | Submission Open
Keywords: hypertension; hypertension pathophysiology; hypertension molecular mechanisms; cardiovascular disease; cardiovascular pathophysiology; cardiovascular molecular mechanisms; cardiovascular biomarkers; heart failure; coronary artery disease; chronic kidney disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Emerging Role of Quantum Sciences and Radiation Biology in Biomedical Applications, 2nd Edition submission deadline 30 Dec 2025 | 1 articles | Viewed by 1148 | Submission Open
Keywords: quantum sciences; radiation biology; biomedical applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances in the Pathogenesis and Treatment of Heart Failure submission deadline 30 Dec 2025 | 1 articles | Viewed by 1148 | Submission Open
Keywords: heart failure; biomarkers; pathways of heart failure; treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Dietary Antioxidants in Human Health submission deadline 30 Dec 2025 | 1 articles | Viewed by 990 | Submission Open
Keywords: diet; functional food; oxidative stress; mitochondrial disfunction; human health; animal models; nutrition; molecular pathways; human pathology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Stroke: Novel Molecular Mechanisms and Therapeutic Approaches
edited by Kang-Ho Choi
submission deadline 30 Dec 2025 | 1 articles | Viewed by 913 | Submission Open
Keywords: stroke; cerebrovascular disease; mechanisms; treatment; diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Multifunctional Materials with Electrical, Catalytic, and Biological Properties
edited by and
submission deadline 30 Dec 2025 | Viewed by 710 | Submission Open
Keywords: novel multifunctional materials; innovative design and synthesis; electrical properties; catalytic properties; biological properties
(This special issue belongs to the Section Materials Science)
Advances in Leptin Biology submission deadline 30 Dec 2025 | 1 articles | Viewed by 660 | Submission Open
Keywords: leptin; leptin expression; leptin receptor; leptin action
(This special issue belongs to the Section Molecular Biology)
Molecular and Cellular Mechanisms in Learning and Memory
edited by
submission deadline 30 Dec 2025 | Viewed by 486 | Submission Open
Keywords: learning; memory; animal models; conditioning; molecular mechanisms; genetic mechanisms; epigenetic mechanisms
(This special issue belongs to the Section Molecular Neurobiology)
Metal-Based Compounds: Molecular Mechanisms of Pharmacological Action and Toxicity submission deadline 30 Dec 2025 | Viewed by 419 | Submission Open
Keywords: metal elements and ions; metal complexes; metal nanoclusters; pharmacology andpharmacokinetics; in vitro toxicity; in vivo toxicity; toxicity biomarkers; enzymes as pharmacological and toxicity targets; toxicity mechanisms; metallodrugs
(This special issue belongs to the Section Molecular Toxicology)
Cellular Mechanisms and Signaling Pathways in Normal Tissue Repair and Fibrosis
edited by and Jeffrey R. Koenitzer
submission deadline 30 Dec 2025 | 1 articles | Viewed by 388 | Submission Open
Keywords: fibrosis; inflammation; senescence; myofibroblasts; Wnt/hedgehog; extracellular matrix; hedgehog; angiotensin II/transforming growth factor-beta; ephrins
(This special issue belongs to the Section Molecular Biology)
Advances in the Pathophysiology and Treatment of Eye Diseases
edited by
submission deadline 30 Dec 2025 | Viewed by 291 | Submission Open
Keywords: ocular pathophysiology; eye diseases; molecular mechanisms; biomolecular pathways; therapeutic targets; translational ophthalmology; retinal degeneration; oxidative stress in ocular disorders; angiogenesis in eye diseases; neuroprotection in ophthalmology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Brain Ischemia: From Molecular Mechanisms to Innovative Therapies
edited by
submission deadline 30 Dec 2025 | Viewed by 211 | Submission Open
Keywords: ischemic neurodegeneration; focal brain ischemia; global brain ischemia; perinatal asphyxia; ischemic stroke; traumatic brain injury; apnea; neuroinflammation; proteins; genes; genes involved in neurodegeneration; glia-to-neurons genetic conversion; dementia; Alzheimer’s disease; genetic conversion of ischemia to Alzheimer's disease; new therapeutic approaches; biomarkers
(This special issue belongs to the Section Molecular Biology)
Molecular Insight into Antimicrobial Resistance submission deadline 30 Dec 2025 | Viewed by 209 | Submission Open
Keywords: antimicrobial resistance; MRSA; ESBL-producing bacteria; carbapenem-resistant enterobacterales (CRE); vancomycin-resistant enterococci (VRE); linezolid resistance; novel antibiotic combinations; resistance mechanisms; horizontal gene transfer; molecular epidemiology
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Basis for Sustainable Management of Migratory Insects
edited by
submission deadline 30 Dec 2025 | Viewed by 148 | Submission Open
Keywords: migrant insects; molecular basis of population growth; migration and reproduction; migration and immunity; migration and diapause; migration and orientation; molecular regulation of migration
(This special issue belongs to the Section Molecular Biology)
Role of Mitochondria in Neurodegenerative Diseases
edited by Małgorzata Wojtkowska
submission deadline 30 Dec 2025 | Viewed by 130 | Submission Open
Keywords: mitochondria; ccfDNA; Parkinson’ s disease’ Alzheimer’ s disease
(This special issue belongs to the Section Molecular Neurobiology)
25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology
edited by
submission deadline 30 Dec 2025 | Viewed by 121 | Submission Open
Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome– brain– gut axis; virus– host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)
(This special issue belongs to the Section Molecular Microbiology)
Innovative Strategies in Cancer Therapy submission deadline 30 Dec 2025 | Viewed by 101 | Submission Open
Keywords: tumor microenvironment; small molecules; IDO1 inhibition; checkpoint inhibitor therapy; adoptive T cell therapy; metabolic reprogram; resistance mechanisms; immune modulation; immune reconstitution; combination therapy; immunosuppression
(This special issue belongs to the Section Molecular Oncology)
Role of Immune and Inflammatory Cells in Pulmonary Fibrosis
edited by Remo C. Russo
submission deadline 30 Dec 2025 | Viewed by 94 | Submission Open
Keywords: idiopathic pulmonary fibrosis (IPF); pulmonary immunology; precision medicine; single-cell RNA sequencing (scRNA-seq); spatial transcriptomics sequencing; animal model of pulmonary fibrosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Skin Cancer: A Focus from Pathophysiology to Novel Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | Viewed by 93 | Submission Open
Keywords: skin cancer; melanoma; keratinocyte carcinoma; pathophysiology; biomarkers; immunotherapy; targeted therapy; nanomedicine; resistance; precision oncology
(This special issue belongs to the Section Molecular Oncology)
Plant Stress Biology
edited by Rui Li
submission deadline 30 Dec 2025 | Viewed by 83 | Submission Open
Keywords: abiotic stress; biotic stress; stress response mechanisms; oxidative stress; phytohormones signaling; stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Innovative Immune-Modulating Therapies and Cutting-Edge Technologies for Immune-Related Diseases
edited by
submission deadline 30 Dec 2025 | Viewed by 78 | Submission Open
Keywords: immune heomostasis; immune related diseases; small molecules; cell therapy; bacteria and virus; antibodies
(This special issue belongs to the Section Molecular Immunology)
Evolutionary Drivers and Adaptive Mechanisms in Algal Organellar Genomes
edited by
submission deadline 30 Dec 2025 | Viewed by 42 | Submission Open
Keywords: organellar genome of algae; molecular evolution; secondary structure of intron; evolutionary driving force; horizontal gene transfer
(This special issue belongs to the Section Molecular Plant Sciences)
IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals
edited by
submission deadline 30 Dec 2025 | Viewed by 39 | Submission Open
Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Myocardial Injury and Ventricular Dysfunction: Pathways and Therapeutic Targets
edited by
submission deadline 30 Dec 2025 | Viewed by 35 | Submission Open
Keywords: myocardial injury; ventricular dysfunction; drug development; gene therapy; molecular modulators
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Circulating Cell-Free Nucleic Acids and Cancers: 3rd Edition
edited by
submission deadline 30 Dec 2025 | Viewed by 30 | Submission Open
Keywords: biological fluids; cancer; cancer biomarkers; cfDI; cfDNA; cfNA; copy number variation; ctDNA; ddPCR; disease-free survival; epigenetic; epigenetic sequencing; exosome; extracellular vesicle; genotyping; liquid biopsy; miRNA; mRNA; mutation; ncRNA; next-generation sequencing; overall survival; progression-free survival; recurrence-free survival; whole-exome sequencing
(This special issue belongs to the Section Molecular Oncology)
Molecular and Cellular Biology of Pregnancy Complications
edited by Elżbieta Poniedziałek-Czajkowska and Radzisław Mierzyñski
submission deadline 30 Dec 2025 | Viewed by 27 | Submission Open
Keywords: molecular biology of pregnancy complications; maternal pregnancy complications; neonatal pregnancy complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Challenges of Parkinson’s Disease, 2nd Edition submission deadline 30 Dec 2025 | Viewed by 26 | Submission Open
Keywords: Parkinson’ s disease; neurodegeneration; synuclein; diagnosis; genetics; epigenetics; extracellular vesicles; biomarkers; treatments; rehabilitation
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Forensic Science: Integrating Innovation and Investigation
edited by
submission deadline 30 Dec 2025 | Viewed by 25 | Submission Open
Keywords: DNA profiling; artificial intelligence; trace evidence analysis; immunohistochemical markers; molecular biology techniques; super-resolution microscopy; integrated forensic approach; new bioinformatics techniques; digital pathology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Recent Research in RNA-Protein Networks
edited by Hidenori Tani
submission deadline 30 Dec 2025 | Viewed by 22 | Submission Open
Keywords: machine learning; bioinformatics; ribonucleoprotein; RNA-protein complex; alternative splicing; RNA stability; RNA localization
(This special issue belongs to the Section Molecular Biology)
25th Anniversary of IJMS: Updates and Advances in Molecular Plant Sciences
edited by
submission deadline 30 Dec 2025 | Viewed by 20 | Submission Open
Keywords: plant science; plant biochemistry; mechanisms; plant development; stress responses; plant physiology; genetics
(This special issue belongs to the Section Molecular Plant Sciences)
Epigenetic Regulation in Cell Development, Differentiation and Cell Fate
edited by Gang Ren
submission deadline 30 Dec 2025 | Viewed by 16 | Submission Open
Keywords: 3D genome; myogenesis; transgenerational inheritance; enhancer– promoter interaction; histone modification; epigenetic variation; complex traits
(This special issue belongs to the Section Molecular Genetics and Genomics)
Machine Learning in Disease Diagnosis and Treatment: 2nd Edition
edited by
submission deadline 30 Dec 2025 | Viewed by 15 | Submission Open
Keywords: machine learning; diagnosis; treatment; algorithm; predictive; artificial intelligence
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neutrophil Extracellular Traps (NETs) in Human Disease: Mechanisms, Pathophysiology and Therapeutic Potential
edited by
submission deadline 30 Dec 2025 | Viewed by 14 | Submission Open
Keywords: neutrophil extracellular traps (NETs)  ; NETosis  ; inflammation  ; cancer microenvironment  ; autoimmune disease  ; thrombosis  ; molecular signaling  ; innate immunity  ; biomarkers  ; targeted therapy
(This special issue belongs to the Section Molecular Immunology)
Plasma-Based Technologies for Food Safety and Health Enhancement
edited by
submission deadline 30 Dec 2025 | Viewed by 14 | Submission Open
Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation
(This special issue belongs to the Section Biochemistry)
Research on the Key Role of Ubiquitination in Signaling and Cancer
edited by
submission deadline 30 Dec 2025 | Viewed by 11 | Submission Open
Keywords: ubiquitin; ubiquitination; E3 ligase; deubiquitinating enzymes; protein degradation; mutations; cancer progression; signal transduction; drug development
(This special issue belongs to the Section Molecular Oncology)
Synthesis, Characterization and Applications of Advanced Polymer Materials
edited by Namil Kim
submission deadline 30 Dec 2025 | Viewed by 10 | Submission Open
Keywords: synthesis methodologies; molecular architecture; functional polymers; characterization techniques; cutting-edge applications
(This special issue belongs to the Section Macromolecules)
Role of Microorganisms and Their Metabolites in Agriculture, Food and the Environment: 3rd Edition
edited by
submission deadline 30 Dec 2025 | Viewed by 8 | Submission Open
Keywords: fermentation; biopreservation; biocontrol; biodegradation; bioremediation; bioaugmentation; omic-technologies
(This special issue belongs to the Section Molecular Microbiology)
Cellular Physiology and Aging: Membrane Dynamics, Intracellular Environment and Signaling Pathways
edited by , and Sara Spinelli
submission deadline 30 Dec 2025 | Viewed by 2 | Submission Open
Keywords: aging; oxidative stress; ion channels; antioxidant molecules; membrane transport systems; redox signaling; cellular senescence; inflammation; intracellular signaling pathways; mitochondrial dysfunction; bioactive compounds; cell physiology; homeostasis; longevity; age-related diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products in Immune Regulation
edited by
submission deadline 30 Dec 2025 | Viewed by 1 | Submission Open
Keywords: natural products; immune responses; immunomodulatory therapies
(This special issue belongs to the Section Molecular Immunology)
The Unresolved Molecular Bases of Major Histocompatibility Complex (MHC) Function with Transplantation and Diseases Linkage
edited by Antonio Arnaiz-Villena
submission deadline 30 Dec 2025 | Submission Open
Keywords: HLA; disease; autoimmunity; immune deficiency; MHC phylogeny; HLA pharmacogenomics; immune modulatory MHC and HLA genes (G; E; F); transplantation; hemochromatosis; MHC/HLA epithelial interaction; MHC evolu-tion; MHC phylogenetics
(This special issue belongs to the Section Molecular Immunology)
Schizophrenia: From Molecular Mechanism to Therapy submission deadline 31 Dec 2025 | 5 articles | Viewed by 11789 | Submission Open
Keywords: schizophrenia; neurodevelopmental disorders; therapeutic approaches; drug of abuse; mental disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Cancer Metastasis submission deadline 31 Dec 2025 | 4 articles | Viewed by 9331 | Submission Open
Keywords: biomarkers; liquid biopsy; premetastatic niche; angiogenesis; immune evasion and suppression; genetic and epigenetic determinants; chemoresistance; extracellular vesicles
(This special issue belongs to the Section Molecular Oncology)
Research Progress of Metabolomics in Health and Disease submission deadline 31 Dec 2025 | 7 articles | Viewed by 6776 | Submission Open
Keywords: metabolomics; health; diseases; target metabolites; mass spectrometry; hyphenated techniques
(This special issue belongs to the Section Molecular Biology)
The Impact of Natural Bioactive Compounds on Human Health and Disease
edited by
submission deadline 31 Dec 2025 | 5 articles | Viewed by 6172 | Submission Open
Keywords: natural product chemistry; nuclear magnetic resonance; structural elucidation; herbal drug
(This special issue belongs to the Section Molecular Pharmacology)
Natural Products in Drug Discovery and Development
edited by Tian-Le Gao
submission deadline 31 Dec 2025 | 7 articles | Viewed by 5735 | Submission Open
Keywords: natural product components; traditional medicine; biological entropy reduction; aromatic drugs; essential oils; gut microbiota modulation; probiotics; drug discovery
(This special issue belongs to the Section Molecular Pharmacology)
Coordination Complexes: From Molecular Design to Functional Applications
edited by
submission deadline 31 Dec 2025 | 2 articles | Viewed by 5400 | Submission Open
Keywords: coordination complexes; organometallic complexes; functional materials; metal– ligand interactions; homogenous catalysis; sensing; magnetic materials; ligand tunability
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
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