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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Research on Metabolomics and Cancer Pathogenesis

edited by

Danuta Dudzik

submission deadline 25 Dec 2026 | Viewed by 218 | Submission Open

Keywords: cancer metabolomics; metabolic reprogramming; biomarkers; tumor microenvironment; systems biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insight in Reproductive Immunology

edited by Ruben Motrich

submission deadline 25 Dec 2026 | Viewed by 214 | Submission Open

Keywords: reproductive immunology; immune tolerance; male reproductive tract; female reproductive tract; fertility disorders; inflammation; pregnancy complications; immunoregulation

(This special issue belongs to the Section Molecular Immunology)

Curcumin Derivatives and Curcuminoids with Potential Biomedical Applications

edited by

Paola Bonaccorsi

and

Chiara Maria Antonietta Gangemi

submission deadline 25 Dec 2026 | Viewed by 211 | Submission Open

Keywords: curcumin; curcuminoids; synthesis; biomedicine; bioimaging; supramolecular; sensors; photodynamic therapy; antitumor properties; antiviral properties; antibacterial properties; antioxidant properties

(This special issue belongs to the Section Molecular Pharmacology)

Nanoscale Materials for Advanced Electrocatalysts

edited by

Safia Khan

submission deadline 25 Dec 2026 | Viewed by 148 | Submission Open

Keywords: nanomaterials; electrocatalysis; electrocatalysts; energy conversion; fuel cells

(This special issue belongs to the Section Molecular Nanoscience)

Advances in T Cell-Based Cancer Immunotherapy

edited by

Ying Luo

submission deadline 30 Dec 2026 | 2 articles | Viewed by 1282 | Submission Open

Keywords: T cell immunotherapy; CAR-T cell; immune checkpoint blockade; T cell exhaustion; tumor microenvironment

(This special issue belongs to the Section Molecular Immunology)

Mitochondrial Function and Therapies

edited by

Iain P. Hargreaves

submission deadline 30 Dec 2026 | 1 articles | Viewed by 1060 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; antioxidants; biogenesis; transcription factors

(This special issue belongs to the Section Biochemistry)

Stem Cell Innovations and Reproductive Biotechnologies

edited by

Marcin Samiec

submission deadline 30 Dec 2026 | Viewed by 797 | Submission Open

Keywords: mammals; birds; stem cell research; pluri-/multipotency; differentiation/dedifferentiation; assisted reproductive technologies (ARTs); transgenic research; biomedicine

(This special issue belongs to the Section Molecular Biology)

Research Progress on Disease Models Based on Induced Pluripotent Stem Cells

edited by

Delger Bayarsaikhan

submission deadline 30 Dec 2026 | Viewed by 339 | Submission Open

Keywords: induced pluripotent stem cells; iPSC-derived cells; disease modeling; precision and regenerative medicine; genome editing; CRISP/Cas; organoid; cell sheet; personalized therapeutics; drug discovery

(This special issue belongs to the Section Molecular Biology)

Advances in Malnutrition and Infectious Diseases: Molecular Perspectives and Host-Pathogen Interactions

edited by

Sajid Ur Rahman

submission deadline 30 Dec 2026 | Viewed by 319 | Submission Open

Keywords: malnutrition; host-pathogen interactions; immunometabolism; micronutrient deficiency; innate and adaptive immunity; microbiome dysbiosis; infection-induced inflammation

(This special issue belongs to the Section Molecular Microbiology)

Hybrid Materials: Antimicrobial Performance and Molecular Mechanisms

edited by

Albena Bachvarova-Nedelcheva

and Kalina Ivanova

submission deadline 30 Dec 2026 | Viewed by 201 | Submission Open

Keywords: hybrid materials; molecular mechanisms; antimicrobial activity; nanomaterials; chemistry of ma-terials

(This special issue belongs to the Section Materials Science)

Molecular Interactions for Advanced Food Safety Biosensing

edited by

Long Wu

and Yang Zhou

submission deadline 30 Dec 2026 | Viewed by 189 | Submission Open

Keywords: food safety; molecular interaction; biosensors; signal transduction; precise recognition

(This special issue belongs to the Section Biochemistry)

Molecular Synthesis, Properties, and Biomedical Applications of Bioceramics

edited by

Amine Bendahhou

and

Mohamed Azzouzi

submission deadline 30 Dec 2026 | Viewed by 176 | Submission Open

Keywords: bioceramics; ceramic materials; dielectric materials; photocatalysis; perovskite ceramics; materials chemistry; solid-state materials; functional materials; environmental materials; energy materials

(This special issue belongs to the Section Materials Science)

AI-Driven Molecular Modeling and Simulation in Biomedical Research and Biophysics

edited by

Whelton Miller

submission deadline 30 Dec 2026 | Viewed by 91 | Submission Open

Keywords: artificial intelligence (AI); machine learning (ML); biophysics; computational biology; molecular docking; molecular dynamics (MD); quantum mechanics; structure– activity relationships; computer-aided drug design (CADD); homology modeling

(This special issue belongs to the Section Molecular Informatics)

Molecular Animal Nutrition

edited by

Umair Ahsan

submission deadline 30 Dec 2026 | Viewed by 75 | Submission Open

Keywords: animal nutrition; feed additives; molecular mechanisms; nutrition and health; sustainability

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Pathology and Pathogenetic Mechanisms of Diabetic Neuropathy

edited by

Aditya K. Singh

submission deadline 30 Dec 2026 | Viewed by 74 | Submission Open

Keywords: diabetic; neuroinflammation; neurovascular pathology; neuropathy; nerve injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Concepts on the Mechanisms of Inflammation, Autoimmunity and Tumorigenesis

edited by

Marina Arleevskaya

and Yves Renaudineau

submission deadline 30 Dec 2026 | Viewed by 61 | Submission Open

Keywords: autoimmunity; immunology; inflammation; tumorigenesis; lipid metabolism; rheumatology

(This special issue belongs to the Section Molecular Immunology)

Plant Responses to Biotic and Abiotic Stresses—Second Edition

edited by

Shu Yuan

submission deadline 30 Dec 2026 | Viewed by 10 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; acclimation and tolerance; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen resistance

(This special issue belongs to the Section Molecular Plant Sciences)

The Biology of Human Melanocytes and Pigmentation

edited by Tai Kyung Noh

submission deadline 30 Dec 2026 | Viewed by 5 | Submission Open

Keywords: melanogenesis; pigmentary disorders; hyperpigmentation; molecular signaling pathways; dermatological therapeutics; skin microenvironment; laser– tissue interaction; skin-brightening agents; melasma; photobiology

(This special issue belongs to the Section Molecular Biology)

Natural Bioactive Compounds as Modulators of Oxidative Stress and Inflammation

edited by

Ignazio Barbagallo

submission deadline 30 Dec 2026 | Viewed by 1 | Submission Open

Keywords: natural compounds; redox homeostasis; inflammatory signaling; nutraceuticals; antioxidant response; sports nutrition

(This special issue belongs to the Section Biochemistry)

Galectins (Gals), 2nd Edition

edited by

Luciano Pirone

submission deadline 31 Dec 2026 | 10 articles | Viewed by 22350 | Submission Open

Keywords: galectin; inhibitors; cancer; inflammation; glycans; drug design; modeling; biomarkers

(This special issue belongs to the Section Molecular Biology)

Natural Products for Neuroprotection and Neurodegeneration

edited by

Patrycja Kupnicka

submission deadline 31 Dec 2026 | 7 articles | Viewed by 10264 | Submission Open

Keywords: natural products; bioactive compounds; neuroprotection; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Environmental Sensitivity Illnesses: Advances in Mechanisms and Molecular Signatures

edited by

Daniela Caccamo

submission deadline 31 Dec 2026 | 3 articles | Viewed by 9176 | Submission Open

Keywords: electromagnetic hypersensitivity; multiple chemical sensitivity; fibromyalgia; chronic fatigue syndrome; chronic pain disorder; toxicant-induced loss of tolerance; total allergy syndrome; circulating biomarkers; genetic susceptibility factors; immune system alterations

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Trends in Redox Physiology Research

edited by Fotios Tekos

submission deadline 31 Dec 2026 | 3 articles | Viewed by 6315 | Submission Open

Keywords: redox biology; oxidative stress; antioxidant mechanisms; redox signaling; cellular homeostasis; inflammation and redox; nutritional redox modulation; environmental toxicology and redox; mitochondrial dysfunction; oxidative stress biomarkers

(This special issue belongs to the Section Biochemistry)

Viral Biology: Infection and Pathology, Diagnosis and Treatment

edited by

Gergana Zahmanova

submission deadline 31 Dec 2026 | 7 articles | Viewed by 5779 | Submission Open

Keywords: viral infection; viral pathogenesis; diagnostics; antiviral therapy; host– virus interactions; emerging viruses; zoonotic viruses; one health; vaccine development; CRISPR antivirals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liquid Biopsies in Oncology—3rd Edition

edited by

Sandra V. Fernandez

and

Carmela Paolillo

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4949 | Submission Open

Keywords: precision oncology; personalized therapy; cancer biomarkers; liquid biopsy; biological fluids; circulating molecules; circulating tumor cells; CTCs; ctDNA; ctRNA; cell-free DNA; cfDNA; NGS; circulating miRNAs; exosomes; extracellular vesicles

(This special issue belongs to the Section Molecular Oncology)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4333 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells: Dynamic Regulators, Disease Indicators and Therapeutic Targets

edited by Leonid Livshits

submission deadline 31 Dec 2026 | 1 articles | Viewed by 4201 | Submission Open

Keywords: red blood cell (RBC); RBC biochemical; hemodynamic; biophysical properties

(This special issue belongs to the Section Molecular Biology)

Advances in HIV Research: Molecular Basis and Potential Therapies

edited by

Sharilyn Almodovar

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3556 | Submission Open

Keywords: human immunodeficiency virus; HIV prevention; HIV therapeutics; HIV vaccines; antiretroviral therapies; long-acting ART; HIV genetic therapy; HIV animal models; HIV in vitro models; viral reservoirs; HIV latency; HIV persistence; HIV evolution; HIV quasispecies; HIV proteins; HIV cure; HIV immunopathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cardiovascular and Metabolic Pharmacology

edited by

Alma Martelli

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3535 | Submission Open

Keywords: cardiovascular pharmacology; metabolic pharmacology; hypertension; diabetes; obesity; atherosclerosis; hyperlipidemias; heart failure

(This special issue belongs to the Section Molecular Pharmacology)

Osteoporosis: From Molecular Research to Novel Therapies

edited by

Agostino Gaudio

and Anastasia Xourafa

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3421 | Submission Open

Keywords: osteoporosis; bone metabolism; OPG/RANK/RANKL system; Wnt/beta catenin signalling; secondary osteoporosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3285 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

Functional Proteomics: Insights from Biomedical Applications and Beyond

edited by

Elva Morretta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 3170 | Submission Open

Keywords: functional proteomics; drug discovery; biomedicine; biomarker identification; protein molecular functions; pathway investigation

(This special issue belongs to the Section Molecular Immunology)

Current Insights into the Role of Exosomes in Intercellular Communication, 2nd Edition

edited by

Orit Uziel

submission deadline 31 Dec 2026 | 5 articles | Viewed by 3159 | Submission Open

Keywords: exosomes; extracellular vesicles; intracellular communication; intercellular communication

(This special issue belongs to the Section Molecular Biology)

Advances in Animal Molecular Genetics

edited by

Jarosław Króliczewski

submission deadline 31 Dec 2026 | 3 articles | Viewed by 3101 | Submission Open

Keywords: epigenetics; functional genomics; gene expression; gene polymorphism; genetic diseases; genetic techniques and assays; genome-wide association; genetic markers; quantitative genetics

(This special issue belongs to the Section Molecular Genetics and Genomics)

The Interactions Between Nutrients and Adipose Tissue

edited by

Junseok Son

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2764 | Submission Open

Keywords: adipose tissue; nutrients; metabolic health; insulin resistance; inflammation; energy homeostasis; adipokines; obesity; lipolysis; thermogenesis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Roles of Non-Coding RNAs in Cancer

edited by Amit K. Mitra

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2680 | Submission Open

Keywords: lncRNA; miRNA; cancer; genomics; targeted therapy; biomarkers; drug resistance

(This special issue belongs to the Section Molecular Genetics and Genomics)

Biotransformation and Engineering of Fungals and Microalgae

edited by

Alejandro Chamizo-Ampudia

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2337 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Biological Effects of Radiation on Human Cells and Tissues

edited by

Maria Paola Bertuccio

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2308 | Submission Open

Keywords: radiation exposure; molecular pathways; inflammation; immune response; biochemical markers; electromagnetic hypersensitivity

(This special issue belongs to the Section Molecular Biology)

Human Virome and Emerging Viruses: Characterization, Interactions, and Molecular Insights

edited by

Luigi Rosa

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2308 | Submission Open

Keywords: human virome; molecular virology; functional virology; metagenomics; virus– host interactions; immune modulation; pseudovirus assays; antiviral screening; omics integration; molecular immunology

(This special issue belongs to the Section Molecular Microbiology)

Stress-Activated Molecular Remodeling: Lipids, Chaperones, and the Cytoskeleton

edited by

Nikolas Nikolaidis

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2242 | Submission Open

Keywords: cellular stress response; molecular remodeling; lipid signaling; membrane dynamics; cytoskeletal reorganization; chaperones; heat shock proteins; proteostasis; membrane– protein interactions; stress-induced trafficking; mechano-transduction; cell survival signaling

(This special issue belongs to the Section Molecular Biology)

Flowers: Molecular and Genetic Regulation of Growth and Development

edited by Yaqin Wang

submission deadline 31 Dec 2026 | 3 articles | Viewed by 2237 | Submission Open

Keywords: flower; growth and development; molecular regulation; genetic breeding

(This special issue belongs to the Section Molecular Plant Sciences)

ROS and Abiotic Stress in Plants, 3rd Edition

edited by

Tsanko S. Gechev

and

Veselin Petrov

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2223 | Submission Open

Keywords: chilling and freezing; drought stress; heat stress; heavy metals stress; nutrient and mineral stress; oxidative stress; resurrection plants and desiccation tolerance; salinity

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Breeding: Improvements and Applications of High-Yield, High-Quality and Stress-Resistant Genetic Traits

edited by Juwu Gong

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2201 | Submission Open

Keywords: plant breeding; crop genetic improvement; gene editing; stress resistance; crop quality; crop yield; gene resource utilization

(This special issue belongs to the Section Molecular Plant Sciences)

PPAR Update: Molecular Mechanisms and Therapeutic Perspectives

edited by

Naoki Tanaka

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2188 | Submission Open

Keywords: PPAR; PPARα ; SPPARMα ; pemafibrate; lipid metabolism; inflammation; fibrosis; nuclear receptor; translational research; precision medicine

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Research in Nanotechnology for Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 31 Dec 2026 | 1 articles | Viewed by 2090 | Submission Open

Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances on Viral Immunology and Pathogenesis of Viral Infections

edited by Yeong-Bin Baek

submission deadline 31 Dec 2026 | 2 articles | Viewed by 2022 | Submission Open

Keywords: viral immunology; viral pathogenesis; innate sensing and interferon; cytokine networks and inflammasomes; adaptive immunity (T- and B-cell quality); immunometabolism and lipid signaling; host-directed antiviral strategies; transcriptomics and spatial omics; mechanism of action and target engagement; complex bioactive modulators

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Translational Insights in Neurological Disorders

edited by Tiago Santos

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1901 | Submission Open

Keywords: neurological disorders; molecular mechanisms; translational neuroscience; drug targets; biomarkers; neurodegenerative disorders; neuroinflammatory conditions; demyelinating conditions; cerebrovascular conditions; neurodevelopmental disorders; mood disorders; anxiety disorders; spinal cord injury; traumatic brain injury; precision neurology; therapeutic development

(This special issue belongs to the Section Molecular Neurobiology)

Genomic-Defined Non-Small Lung Cancer (NSCLC) in the Real World: From Biology to Clinical Approaches

edited by

Eric Santoni-Rugiu

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1753 | Submission Open

Keywords: genomic-defined NSCLC; molecular diagnostics; actionable targets; intrinsic resistance; acquired resistance

(This special issue belongs to the Section Molecular Oncology)

Membrane Channels in Intercellular Communication

edited by

Camillo Peracchia

and

Jean Jiang

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1726 | Submission Open

Keywords: gap junctions; connexins; innexins; channels; hemichannels; connexin mutations; channel gating; chemical gating; voltage gating; cell– cell coupling; cell-cell uncoupling; cell communication; intercellular communication; calcium; pH

(This special issue belongs to the Section Biochemistry)

Advances in Antimicrobial Agents and Resistance Mechanisms

edited by

Julieta Luna-Herrera

submission deadline 31 Dec 2026 | 2 articles | Viewed by 1687 | Submission Open

Keywords: acquired resistance; antibiotic inactivation; antibiotic modifications; antibiotic uptake; antibiotics; antimicrobial agents; bacterial dormancy; efflux pumps; extrachromosomal elements; genomic mutations; novel antimicrobial molecules; resistant mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Displaying special issue 3001-3050 on page 61 of 65.

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