Bioactive Molecules in Infection and Toxicity: Antimicrobial Peptides and Drug-Induced Damage in Disease Models
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 31 May 2026 | Viewed by 1906
Special Issue Editor
Interests: cytochromes P450; CYP; malaria; lipid peroxidation; HETE; 4-hydroxynonenal; 4-HNE; hemozoin; monocytes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infectious diseases remain major global health challenges. Drug-induced toxicity also poses significant risks, demanding ongoing research and innovative solutions. These issues drive the urgent need for new therapeutic strategies and deeper mechanistic insights. This Special Issue brings together cutting-edge research focused on two key areas: the role of antimicrobial peptides (AMPs) in fighting infections, and the molecular mechanisms of drug-induced damage—including AMP-related toxicity—in experimental disease models.
AMPs, naturally occurring defense molecules, offer promising alternatives to conventional antibiotics, especially in the context of rising antimicrobial resistance. Their multifunctional properties—ranging from direct microbial killing to immunomodulatory and antitumor effects—make them strong candidates for next-generation anti-infective therapies. At the same time, understanding how drugs, particularly AMPs, interact with biological systems to cause toxicity is essential for improving safety and efficacy. Novel formulations or delivery systems may help reduce unwanted side effects.
By exploring cellular responses, signaling pathways, and biomarkers of damage, this Special Issue aims to clarify which bioactive molecules—and through which mechanisms—affect both infection outcomes and toxicological profiles. Together, the contributions will offer a comprehensive view of how molecular interventions can be leveraged to mitigate disease and enhance therapeutic precision.
Prof. Dr. Oleksii Skorokhod
Guest Editor
Manuscript Submission Information
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Keywords
- antimicrobial peptides (AMPs)
- infectious diseases
- drug-induced toxicity
- disease models
- therapeutic strategies
- drug delivery systems
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