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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Cancer Stem Cells and Tumor Microenvironment
edited by Shaoguang Li
submission deadline 20 Oct 2025 | Viewed by 157 | Submission Open
Keywords: cancer stem cells; tumor microenvironment; tumor initiation; tumor progression; chemoresistance
(This special issue belongs to the Section Molecular Oncology)
Triosephosphate Isomerase: Potential Target in Cancer Treatment and Other Diseases submission deadline 20 Oct 2025 | Viewed by 152 | Submission Open
Keywords: cancer; glycolytic; triosephosphate isomerase; TPI; post-translational modification; cancer treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Application of Hyaluronan in Tissue Healing submission deadline 20 Oct 2025 | Viewed by 144 | Submission Open
Keywords: wound healing; inflammation; remodeling; chronic wound; wound dressing; scar tissue; sound tissue; biomarkers; chemical modification; crosslinked; biopolymer; biological activity
(This special issue belongs to the Section Macromolecules)
Musculoskeletal Physiology: Mechanical Stimulation, Mechanical Disuse and Hormone Signaling
edited by Whitney A. Bullock
submission deadline 20 Oct 2025 | Viewed by 118 | Submission Open
Keywords: mechanotransduction; musculoskeletal; hormonal signaling; muscle– bone crosstalk; mechanical stimuli; mechanical disuse
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Progress in Astrocyte Research
edited by Carla Caruso
submission deadline 20 Oct 2025 | Viewed by 106 | Submission Open
Keywords: astrocyte biology; astrocyte heterogeneity; astrocyte metabolism; astrocyte-derived extracellular vesicles; neuroinflammation; neurodegeneration; neuroprotection
(This special issue belongs to the Section Molecular Neurobiology)
Hyaluronan and Proteoglycans in Cancer and Inflammatory Diseases: Molecular Mechanisms and Therapeutic Implications
edited by Angela D’Ascola and
submission deadline 20 Oct 2025 | Viewed by 91 | Submission Open
Keywords: hyaluronan; proteoglycans; inflammation; cancer; tumor microenvironment; therapy
(This special issue belongs to the Section Molecular Oncology)
Advances in Plant Genomics and Genetics: 3rd Edition
edited by
submission deadline 20 Oct 2025 | Viewed by 75 | Submission Open
Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genomic and Molecular Insights into Emerging and Reemerging Pathogens
edited by
submission deadline 20 Oct 2025 | Viewed by 53 | Submission Open
Keywords: pathogens genomic analysis; evolution transmission dynamics; pathogenic mechanisms; viruses; bacteria; fungi; parasites; next-generation sequencing; metagenomics; bioinformatics; genetic variations; adaptive mutations; host– pathogen interactions; emerging pathogens; molecular epidemiology; host immune responses; pathogen genetics
(This special issue belongs to the Section Molecular Immunology)
Melanin Pigmentation: Physiology and Pathology submission deadline 20 Oct 2025 | Viewed by 40 | Submission Open
Keywords: eumelanin; pheomelanin; melanogenesis; photoprotection; pigmentary disorders; depigmenting agents; extracutaneous melanins
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurological Diseases: From Physiology to Therapy submission deadline 20 Oct 2025 | Viewed by 37 | Submission Open
Keywords: neurophysiology; genetics; Alzheimer’ s disease; neurological diseases; neurodegenerative diseases
(This special issue belongs to the Section Molecular Neurobiology)
Plant Physiology and Molecular Nutrition: 2nd Edition
edited by and
submission deadline 20 Oct 2025 | Viewed by 37 | Submission Open
Keywords: plant nutritional physiology; nutrient signaling; phytohormones; gene regulation network; environment and nutrition crosstalk
(This special issue belongs to the Section Molecular Plant Sciences)
The Impact of Circulating Biomarkers and Metabolites on Cardiometabolic Disease and Cancer: New Insights and Therapeutic Opportunities
edited by Melania Gaggini and
submission deadline 20 Oct 2025 | Viewed by 36 | Submission Open
Keywords: lipidomic; metabolomic; lipotoxicity; oxidative stress; amino acids; metabolic disease; cardiovascular risk; tumorigenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Next-Generation Cancer Immunotherapies: Tracking, Targeting and Reprogramming the Immune Response submission deadline 20 Oct 2025 | Viewed by 36 | Submission Open
Keywords: immunotherapy; cancer treatment; immune evasion; therapy resistance; immune monitoring; CAR-T; CAR-NK; immune cell engineering; synthetic immunology; programmable immune circuits; tumor– immune system interactions; biomarker-guided therapy; translational applications; hematological malignancies; solid malignancies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Liver Disease: Pathogenesis, Progression, and Therapeutic Strategies
edited by
submission deadline 20 Oct 2025 | Viewed by 34 | Submission Open
Keywords: liver disease; molecular pathogenesis; therapeutic strategies; liver fibrosis; hepatocellular carcinoma; MASLD and MetALD; molecular biomarkers; tailored medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Roles of Diet and Nutrition in Metabolic Diseases: Advancements in Molecular Insights
edited by Ramos-López Omar
submission deadline 20 Oct 2025 | Viewed by 31 | Submission Open
Keywords: diet; nutrition; metabolic diseases; obesity; genetics; microbiota; epigenetics; metabolomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research in Acute Lung Injury
edited by
submission deadline 20 Oct 2025 | Viewed by 29 | Submission Open
Keywords: acute lung injury; ARDS; primary graft dysfunction; immune cells; neutrophils; pulmonary edema; alveolar epithelium; lung endothelium
(This special issue belongs to the Section Molecular Immunology)
Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies
edited by
submission deadline 20 Oct 2025 | Viewed by 28 | Submission Open
Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Sight of Biomarkers in Cardiovascular Disease
edited by
submission deadline 20 Oct 2025 | Viewed by 28 | Submission Open
Keywords: precision medicine; precision nursing; biomarkers; molecular biology; biochemistry; genetics; molecular sciences; molecular research; vascular disease; vascular surgery; wounds; diabetic foot ulcers; peripheral artery disease; chronic venous disease; abdominal aortic aneurysm; thoracic aortic aneurysm; peripheral aneurysm; social and molecular determinants of health; molecular sociology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Antimicrobial Agents: Natural Products or Synthetic Compounds 2nd Edition
edited by
submission deadline 20 Oct 2025 | Viewed by 26 | Submission Open
Keywords: multidrug resistance; natural antimicrobial agents; synthetic antimicrobial compounds; combination therapy; severe infectious diseases
(This special issue belongs to the Section Molecular Microbiology)
Evolutionary Genomics in Plants: From Single Gene to Genome
edited by
submission deadline 20 Oct 2025 | Viewed by 25 | Submission Open
Keywords: evolutionary genomics; plant adaptation; genome evolution; crop improvement; bioinformatics; polyploidy
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms and Pathophysiology of Myocardial Disease, 2nd Edition
edited by , and Hongyu Qiu
submission deadline 20 Oct 2025 | Viewed by 23 | Submission Open
Keywords: myocardial disease; cardiomyopathy; fibrosis and remodeling; inflammation; hypertension; heart failure; cardiometabolic; cardio-renal; heart-liver axis; comorbidity; molecular mechanisms; pathophysiology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Osteoarthritis: From Molecular Mechanism to Novel Therapy (2nd Edition)
edited by
submission deadline 20 Oct 2025 | Viewed by 19 | Submission Open
Keywords: osteoarthritis; joint inflammation; cartilage and chondrocyte function; cartilage regeneration and repair; post-traumatic osteoarthritis; synovium
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanodrug Bioavailability and Biocompatibility in Cancer and CNS Disorders submission deadline 20 Oct 2025 | Viewed by 17 | Submission Open
Keywords: nanomedicine; bioavailability; biocompatibility; tumor microenvironment; Blood– Brain Barrier; targeted drug delivery; neurodegenerative diseases
(This special issue belongs to the Section Molecular Nanoscience)
Graphene Based Nanocomposite
edited by
submission deadline 20 Oct 2025 | Viewed by 17 | Submission Open
Keywords: graphite intercalates; graphene; reduced graphene oxide; grafting; vertical heterostructures; nanocomposites; covalent organic frameworks (COFs); 2D nanomaterials; biomimetic interfaces; interfacial engineering
(This special issue belongs to the Section Molecular Nanoscience)
Regulation and Targeting of Ferroptosis in Tumor and Beyond (Second Edition)
edited by
submission deadline 20 Oct 2025 | Viewed by 11 | Submission Open
Keywords: ferroptosis; iron; tumor survival and cell death; oxidation; drug development; anti-cancer strategies
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Neuroimaging
edited by
submission deadline 22 Oct 2025 | Viewed by 22 | Submission Open
Keywords: positron emission tomography pulmonary immunology; single photon emission computed tomography; artificial intelligence; neuro-oncology imaging; neurodegenerative disorders imaging; molecular neuroimaging
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Pathogenesis of Mycobacteria
edited by Ivana Palucci
submission deadline 24 Oct 2025 | Viewed by 96 | Submission Open
Keywords: mycobacteria; mycobacterial pathogenesis; host– pathogen interactions
(This special issue belongs to the Section Molecular Microbiology)
Recent Molecular Basis of Neurocognitive Mechanism
edited by
submission deadline 25 Oct 2025 | 1 articles | Viewed by 852 | Submission Open
Keywords: cognitive functioning; epigenomics; high-throughput omics; metabolomics; molecular pathways; multi-modal datasets; neurocognition; neurodegeneration; neurorehabilitation; proteomics; transcriptomics
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Understanding Respiratory Virus–Host Interactions
edited by Kun Li
submission deadline 25 Oct 2025 | Viewed by 247 | Submission Open
Keywords: respiratory viruses; virus– host interactions; molecular mechanisms; viral replication; host– immune response; molecular pathogenesis; molecular signaling; antiviral strategies
(This special issue belongs to the Section Molecular Microbiology)
Latest Review Papers on Bioactives and Nutraceuticals 2025
edited by
submission deadline 25 Oct 2025 | Viewed by 133 | Submission Open
Keywords: bioactives; nutrients; nutraceuticals; molecular biology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Multiple Sclerosis: Molecular Basis and New Therapy
edited by Vito A. G. Ricigliano
submission deadline 25 Oct 2025 | Viewed by 91 | Submission Open
Keywords: multiple sclerosis; inflammation; microglia; Epstein– Barr virus; neurodegeneration; remyelination; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Medical Applications of Polymer Materials
edited by Zhen Zhang
submission deadline 25 Oct 2025 | Viewed by 61 | Submission Open
Keywords: medical polymers; drug delivery; tissue engineering; medical devices; diagnostics
(This special issue belongs to the Section Macromolecules)
New Molecular Research of Foodborne Pathogens
edited by
submission deadline 25 Oct 2025 | Viewed by 58 | Submission Open
Keywords: foodborne pathogens; molecular mechanisms; antimicrobial resistance; pathogen detection; host–microbe interactions
(This special issue belongs to the Section Molecular Microbiology)
Molecular Insights in Medical Microbiology and Infectious Diseases: The Role of Artificial Intelligence and Machine Learning
edited by
submission deadline 25 Oct 2025 | Viewed by 42 | Submission Open
Keywords: molecular diagnostics; pathogen genomics; antimicrobial resistance; host– pathogen interaction; infectious diseases surveillance; artificial intelligence; machine learning
(This special issue belongs to the Section Molecular Informatics)
Molecular Pathways, Microbiome, and Chronic Inflammatory Skin Diseases: Bridging the Gap
edited by
submission deadline 25 Oct 2025 | Viewed by 24 | Submission Open
Keywords: psoriasis; skin microbiome; chronic inflammatory skin diseases; molecular pathogenesis; biomarkers
(This special issue belongs to the Section Molecular Biology)
Zebrafish as a Novel Model for Toxicological Research
edited by Leobardo Manuel Gómez-Oliván
submission deadline 25 Oct 2025 | Viewed by 22 | Submission Open
Keywords: zebrafish; toxicological assessment; organic and inorganic contaminants; oxidative stress; developmental toxicity; neurotoxicity; reproductive toxicity; genotoxicity; alternative testing models; One Health
(This special issue belongs to the Section Molecular Toxicology)
Gut–Brain Axis: Pathophysiological Mechanisms in Neurological Disorders and Metabolic Diseases
edited by
submission deadline 25 Oct 2025 | Viewed by 17 | Submission Open
Keywords: gut– brain axis; intestinal microbiota; mood diseases; immune system; microbial molecules; behavior; metabolic diseases; signaling pathways; inflammation; neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Exploring Cannabinoids: Molecular Mechanisms and Potential Therapeutic Applications
edited by
submission deadline 27 Oct 2025 | Viewed by 95 | Submission Open
Keywords: cannabinoids; endocannabinoid system; δ 9-tetrahydrocannabinol (THC); cannabidiol (CBD); inflammation; chronic pain; neurodegenerative disorders; epilepsy; psychosis; cancer-related symptoms
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Current Insights into the Role of Exosomes in Intercellular Communication
edited by
submission deadline 30 Oct 2025 | 10 articles | Viewed by 19595 | Submission Open
Keywords: exosomes; extravesicles; intracellular communication
(This special issue belongs to the Section Molecular Biology)
The Evolution, Genetics and Pathogenesis of Viruses
edited by
submission deadline 30 Oct 2025 | 6 articles | Viewed by 8762 | Submission Open
Keywords: viruses; genome structure; viral RNA/DNA; replication viral cycle; recombination; viral infection; antiviral agents
(This special issue belongs to the Section Molecular Microbiology)
Molecular Mechanisms of Obesity and Metabolic Diseases
edited by
submission deadline 30 Oct 2025 | 7 articles | Viewed by 7954 | Submission Open
Keywords: molecular pharmacology; molecular mechanisms; obesity; metabolic diseases; metabolic syndrome; type 2 diabetes; atherosclerosis; cardio-metabolic disorders; non-alcoholic fatty liver disease (NAFLD)
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Emerging Topics in Metal Complexes: Pharmacological Activity, 2nd Edition submission deadline 30 Oct 2025 | 4 articles | Viewed by 6538 | Submission Open
Keywords: metal complexes; polyoxometalates; biological activity; pharmacokinetic parameters; mechanistic analysis; cancer/neurodegenerative diseases; innovative strategies; laboratory diagnostics; clinical studies
(This special issue belongs to the Section Molecular Pharmacology)
Cytochrome P450: Metabolism, Structure-Function, Evolution and Applications submission deadline 30 Oct 2025 | 4 articles | Viewed by 5641 | Submission Open
Keywords: cytochrome P450 monooxygenase; metabolism; structure-function; evolution; applications
(This special issue belongs to the Section Biochemistry)
Radiation-Induced DNA Damage and Toxicity submission deadline 30 Oct 2025 | 2 articles | Viewed by 1744 | Submission Open
Keywords: radiation; DNA damage; toxicity; immune response
(This special issue belongs to the Section Molecular Biology)
New Advances in Molecular Research in Leukemia submission deadline 30 Oct 2025 | 1 articles | Viewed by 1481 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); chronic lymphocytic leukemia (CLL); acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML); hairy cell leukemia (HCL); T-cell prolymphocytic leukemia (T-PLL); large granular lymphocytic leukemia; measurable residual disease (MRD)
(This special issue belongs to the Section Molecular Oncology)
Molecular Advances in Blood Disorders
edited by
submission deadline 30 Oct 2025 | 1 articles | Viewed by 1465 | Submission Open
Keywords: acquired and inherited blood disorders; diagnostic; prognostic and predictive biomarkers; molecular profiling; molecular monitoring; targeted therapy; leukaemia; lymphoma; disorders of haemostasis and thrombosis; genetic predisposition; germline pathogenic variants; molecular mechanisms; (epi)genomics
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Complications of Type 1 Diabetes in Pediatric Age: Early Biomarkers and New Insights into Diagnosis and Prevention Strategies
edited by and Francesca Di Candia
submission deadline 30 Oct 2025 | 1 articles | Viewed by 999 | Submission Open
Keywords: pediatrics; endocrinology; diabetology; complications; type 1 diabetes; prevention; early biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancement of Understanding Alzheimer’s Disease Susceptibility and Novel Drug Targets
edited by Kunie Ando and Jean-Pierre Brion
submission deadline 30 Oct 2025 | Viewed by 831 | Submission Open
Keywords: Alzheimer’ s disease; neurodegenerative diseases; tau; amyloid; inflammation; disease modifying treatments; biomarkers; genetic variants; risk factors; mechanisms; protein– protein interactions; post-translational modifications
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms of Vascular Protection by Means of Nutraceuticals
edited by
submission deadline 30 Oct 2025 | 1 articles | Viewed by 688 | Submission Open
Keywords: cardiovascular disease; drugs; nutrients
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Abiotic Stress Signaling in Plants: Focus on Atmospheric Stressors, 2nd Edition
edited by
submission deadline 30 Oct 2025 | 2 articles | Viewed by 663 | Submission Open
Keywords: abiotic stress; interactomics; gene expression regulation; kinases; oxidative stress; phytohormones; signaling; sugar sensing and signaling; transcription factors
(This special issue belongs to the Section Molecular Plant Sciences)
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