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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell–Cell Communication Through Extracellular Vesicles
edited by Federica Fratini
submission deadline 20 Dec 2025 | Viewed by 190 | Submission Open
Keywords: EV biomarkers; EV biogenesis; EV drug delivery; EV trafficking; EV immuno escape
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Chronic Liver Disease and Liver Failure
edited by Paolo Gallo
submission deadline 20 Dec 2025 | Viewed by 187 | Submission Open
Keywords: cirrhosis; portal hypertension; liver failure; advanced chronic liver disease; sarcopenia and malnutrition; ascites; medical treatment
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Roles of AI in Disease Diagnosis and Treatment submission deadline 20 Dec 2025 | Viewed by 187 | Submission Open
Keywords: artificial intelligence; radiomics; machine learning; deep learning; diagnosis; treatment; cancer
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Abscisic Acid, a New Old Friend to Regulate Abiotic Stress Tolerance in Plants
edited by Marta Marina Pérez-Alonso and
submission deadline 20 Dec 2025 | Viewed by 181 | Submission Open
Keywords: abscisic acid (ABA); ABA perception; ABA signaling network; abiotic stress; hormonal crosstalk; crop species; stress tolerance; plant productivity; agriculture
(This special issue belongs to the Section Molecular Plant Sciences)
Neural Stem Cells: Latest Applications and Future Perspectives submission deadline 20 Dec 2025 | Viewed by 178 | Submission Open
Keywords: neural differentiation; embryonic stem cells; neural stem cells; neural progenitor cells; neuropathology; neurological disease
(This special issue belongs to the Section Molecular Biology)
Molecular Immunology of Infectious Diseases submission deadline 20 Dec 2025 | Viewed by 175 | Submission Open
Keywords: molecular immunology; infectious diseases; innate immunity; adaptive immunity; immunomodulation-based therapies
(This special issue belongs to the Section Molecular Immunology)
Advances in Targeted Cancer Therapy and Side-Effect Management
edited by Wei-Min Chang
submission deadline 20 Dec 2025 | Viewed by 172 | Submission Open
Keywords: targeted cancer therapy; novel therapy approaches; personalized treatment; small molecule inhibitors; combination strategies; multi-omics integration; proton therapy; reduced cancer treatment side effects; therapeutic resistance; biomarkers
(This special issue belongs to the Section Molecular Oncology)
Stem Cell or Exosome-Based Therapy for Kidney Diseases: Mechanisms, Applications, and Future Perspectives
edited by
submission deadline 20 Dec 2025 | Viewed by 168 | Submission Open
Keywords: stem cell therapy; exosome therapy; kidney disease; regenerative medicine; cell differentiation; tissue engineering; drug discovery; in vitro 3D models; anti-inflammation; antioxidant stress; antifibrosis; extracellular vesicles; precision medicine; bioengineering; artificial intelligence; bioinformatics
(This special issue belongs to the Section Molecular Biology)
Molecular Pharmacology of Cation-Permeable Ion Channels
edited by
submission deadline 20 Dec 2025 | Viewed by 167 | Submission Open
Keywords: cation-permeable ion channel structure; cation-permeable ion channel functions; cation-permeable ion channel pharmacology; cation-permeable ion channel and diseases; innovative techniques for cation-permeable ion channel research
(This special issue belongs to the Section Molecular Pharmacology)
Chronic Kidney Disease: Novel Advances in Pathophysiology and Therapeutics
edited by
submission deadline 20 Dec 2025 | Viewed by 161 | Submission Open
Keywords: anti-fibrosis; anti-inflammation; biomarker; chronic kidney disease; complement; glucagon-like peptide-1 receptor agonist; immuno modulaton; sodium– glucose cotransporter-2 inhibitor
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Action and Cytotoxicity of Platinum-Based Therapeutics
edited by
submission deadline 20 Dec 2025 | Viewed by 160 | Submission Open
Keywords: platinum-based drugs; cancer therapy; cisplatin; drug resistance; nanodrugs; targeted delivery systems; molecular mechanisms; systemic toxicity
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Epigenetic and RNA-Based Regulation in Cancer: Mechanism, Therapeutic Targets, and Translational Perspectives
edited by
submission deadline 20 Dec 2025 | Viewed by 159 | Submission Open
Keywords: molecular underpinnings of DNA; histone; RNA-based epigenetic regulation; small molecules and epigenetic inhibitors; epigenetic signatures; oncology
(This special issue belongs to the Section Molecular Genetics and Genomics)
Immunology and Immunotherapy for Head and Neck Cancer
edited by
submission deadline 20 Dec 2025 | Viewed by 151 | Submission Open
Keywords: immunotherapy; head and neck cancer; toxicity management; immune system; nutrition; immune therapy and organ failure; mechanisms of immunotherapy resistance
(This special issue belongs to the Section Molecular Immunology)
Coenzyme Q Redox State and Cellular Homeostasis: Implications for Clinical Practice
edited by
submission deadline 20 Dec 2025 | Viewed by 150 | Submission Open
Keywords: coenzyme Q; cellular homeostasis; cellular energy production; antioxidant defense
(This special issue belongs to the Section Molecular Biology)
Benchmarking of Modeling and Informatic Methods in Molecular Sciences
edited by Abby Parrill
submission deadline 20 Dec 2025 | Viewed by 145 | Submission Open
Keywords: modeling; informatics; simulation; benchmarking; performance comparison; modeling method evaluation; informatic method evaluation
(This special issue belongs to the Section Molecular Informatics)
Biological Study of Plant Bioactive Compounds submission deadline 20 Dec 2025 | Viewed by 145 | Submission Open
Keywords: plants’ biological activity; analysis of plant and plant preparations; interactions between plants and drugs; drugs inspired by plant actives; misuse of plant preparations
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Advanced Cell Based Biomaterials for Musculoskeletal Tissue Engineering
edited by Isabel Calejo
submission deadline 20 Dec 2025 | Viewed by 140 | Submission Open
Keywords: cell-based materials; bioprinting; microfluidics; hydrogels; vascularization; innervation; hierarchical; fiber technologies; microtissues
(This special issue belongs to the Section Materials Science)
Emerging Trends in Adductomics: From Adduct Detection to Environmental Implications submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open
Keywords: adductomics; covalent adducts; crosslinks; biomarkers; electrophilic species; exposome; environmental toxicants; high-resolution tandem mass spectrometry; post-data analysis
(This special issue belongs to the Section Molecular Toxicology)
Acute Leukemia: From Basic Research to Clinical Application, Second Edition
edited by
submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open
Keywords: acute lymphoblastic leukemia (ALL); acute myeloid leukemia (AML); genomic findings; post-genomic findings; targeted therapies; immunotherapies; novel markers
(This special issue belongs to the Section Molecular Oncology)
Molecular Applications of Nanoparticles in Cancer Therapy
edited by Carlos Caro and Iñigo Martínez-Zubiaurre
submission deadline 20 Dec 2025 | Viewed by 139 | Submission Open
Keywords: nanomedicine; molecular biology of cancer; advanced therapies; tumor microenvironment; cellular crosstalk
(This special issue belongs to the Section Materials Science)
Biomolecular Condensates and Their Role in Cellular Organization and Disease
edited by Anna Bratek-Skicki
submission deadline 20 Dec 2025 | Viewed by 131 | Submission Open
Keywords: biocondensates; membrane-less organelles; liquid-liquid phase separation; protein aggregation; neurogenerative diseases
(This special issue belongs to the Section Molecular Biology)
Proteases and Their Inhibitors: From Biochemistry to Applications
edited by
submission deadline 20 Dec 2025 | Viewed by 126 | Submission Open
Keywords: proteases; peptidases; proteinases; proteolysis; hydrolysis; enzymes; inhibitors; biotechnology; drug discovery; therapeutics
(This special issue belongs to the Section Molecular Biology)
Myosin: Structure, Function and Evolution
edited by Barbara Baryłko and
submission deadline 20 Dec 2025 | Viewed by 123 | Submission Open
Keywords: myosins; actin; molecular motors; organelle trafficking; endocytosis; secretion; membrane tension; RNA transport; force generation; ATPase activity
(This special issue belongs to the Section Macromolecules)
Autophagic Related Proteins in Cancer
edited by Pietri Puustinen
submission deadline 20 Dec 2025 | Viewed by 122 | Submission Open
Keywords: cancer; autophagy; tumor suppressor; tumorigenesis; pro-survival mechanism; therapeutic strategies; cancer metabolism; signaling pathways; mTORC1; AMPK; CIP2A; PP2A; DNA damage response (DDR); DNA-PK; ATM/ATR; cellular growth
(This special issue belongs to the Section Molecular Oncology)
Cracking the Molecular Code of Breast Cancer
edited by Bartlomiej Taciak
submission deadline 20 Dec 2025 | Viewed by 121 | Submission Open
Keywords: breast cancer; TNBC; immunotherapy; microRNAs; NGS; therapeutics; biomarkers; epigenetics
(This special issue belongs to the Section Molecular Oncology)
Molecular Basis of Inorganic Phosphate Transport Regulation in Protozoan Parasites submission deadline 20 Dec 2025 | Viewed by 117 | Submission Open
Keywords: inorganic phosphate transport; protozoan parasites; cell proliferation
(This special issue belongs to the Section Molecular Biology)
Bioactives in Processed Foods: Profiling and Bioavailability Assessment
edited by Cong Wang
submission deadline 20 Dec 2025 | Viewed by 109 | Submission Open
Keywords: food processing; food bioactives; composition; bioavailability; functionality; novel food processing techniques; structure/constituents– bioactivity relationship
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Properties and Applications of Nanoparticles and Nanomaterials: 3rd Edition
edited by Xiaogang Li
submission deadline 20 Dec 2025 | Viewed by 82 | Submission Open
Keywords: nanostructures; nanoparticles; microstructure characterization; material design; evaluation of mechanical properties; applications of nanomaterials
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Research Advances in Metabolic Syndrome submission deadline 20 Dec 2025 | Viewed by 80 | Submission Open
Keywords: metabolic syndrome; sepsis; molecular mechanisms; inflammation; insulin resistance; cardiovascular parameters; immune– metabolic crosstalk; experimental models; biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Stress Adaptation and Immune Surveillance: Extracellular Vesicles, Autophagy, and Inflammasomes in Cancer and Neurodegeneration
edited by Seema Singh
submission deadline 20 Dec 2025 | Viewed by 71 | Submission Open
Keywords: autophagy; ferroptosis; inflammasome activation; extracellular vesicle (EV); cancer; neurodegeneration; chronic infections
(This special issue belongs to the Section Molecular Immunology)
Molecular Research of Neonicotinoid Toxicity
edited by
submission deadline 20 Dec 2025 | Viewed by 69 | Submission Open
Keywords: neonicotinoids; sex-specific effects; brain– gut– microbiome; endocrine organs; genotoxic effects; epigenetic effects
(This special issue belongs to the Section Molecular Toxicology)
MicroRNAs and mRNA in Human Health and Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 60 | Submission Open
Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA
(This special issue belongs to the Section Molecular Biology)
Recent Advances in Molecular Mechanisms of Human Papillomavirus Family (HPV) Induced Oncogenesis, 2nd Edition
edited by
submission deadline 20 Dec 2025 | Viewed by 39 | Submission Open
Keywords: human papillomavirus (HPV); oncogenesis; mechanism; diagnosis; classification; etiology; pathophysiology; biochemistry; genetics; molecular biology; epidemiology; cervical cancer; oropharyngeal cancer; oncology
(This special issue belongs to the Section Molecular Oncology)
The Role of Ion Channels in Health and Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 30 | Submission Open
Keywords: ion channel; molecular mechanisms; channelopathies; drug discovery; electrophysiology
(This special issue belongs to the Section Molecular Biology)
Male Reproduction: Unveiling the Molecular Revolution
edited by
submission deadline 20 Dec 2025 | Viewed by 29 | Submission Open
Keywords: testosterone; spermatogenesis; capacitation; acrosome reaction; endocrine disruptors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Intestinal Diseases and Gut Microbiota
edited by
submission deadline 20 Dec 2025 | Viewed by 28 | Submission Open
Keywords: gut microbiota; dysbiosis; natural compounds; colorectal cancer; neurological diseases; autoimmune diseases; probiotics; gut-brain axis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
25th Anniversary of IJMS: Updates and Advances in Molecular Biophysics submission deadline 20 Dec 2025 | Viewed by 27 | Submission Open
Keywords: biomolecular interactions; biomolecular NMR; biophysics; chaperones; computational modeling; computer simulations; crystal thermodynamics; DNA structure and dynamics; drug– receptor interactions; enzymology; fluorescence imaging; genome structure; inter-molecular interactions; intrinsically disordered proteins; ion channels; macromolecular crystallography; macromolecular structure and dynamics; membrane dynamics; microcalorimetry; molecular dynamics; molecular imprinting; molecular mechanics; molecular modeling; molecular simulations; molecular modeling; molecular structure; molecular recognition; nucleic acid– protein interactions; post-translational modifications; protein design; protein– DNA interactions; protein engineering; protein– ligand binding; protein– membrane interactions; protein structure and folding; RNA structure; single-molecule techniques; spectroscopic techniques; statistical mechanics; structure– function relationships; structure prediction; thermodynamics; transient kinetic techniques; transmembrane proteins; x-ray crystallography
(This special issue belongs to the Section Molecular Biophysics)
Metabolomics of Medicinal Plants submission deadline 20 Dec 2025 | Viewed by 25 | Submission Open
Keywords: metabolomics; medicinal plants; nuclear magnetic resonance; mass spectrometry; bioinformatic; phenotyping; metabolic pathways; bioactive metabolites
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Stem Cell-Mediated Tendon Regeneration: From Signaling Pathways to Therapeutic Applications
edited by
submission deadline 20 Dec 2025 | Viewed by 23 | Submission Open
Keywords: regenerative medicine; tissue engineering; stem cells; scaffolds; 3D in vitro models; tenogenic differentiation; tendon regeneration; molecular mechanisms; intercellular crosstalk; paracrine signaling; extracellular matrix remodeling
(This special issue belongs to the Section Molecular Biology)
Advancing Mental Disorder Therapies: Drug Repositioning and Translational Insights from Animal Models
edited by Claudia Bregonzio and Mariela Fernanda Pérez
submission deadline 20 Dec 2025 | Viewed by 21 | Submission Open
Keywords: anxiety; depression; Parkinson's disease; Alzheimer; schizophrenia; neurotransmitter imbalance; novel treatments; new pharmacological targets; preclinical studies
(This special issue belongs to the Section Molecular Neurobiology)
Sperm Physiology and Male Infertility: From Basic Biology to Molecular Genetics submission deadline 20 Dec 2025 | Viewed by 19 | Submission Open
Keywords: human sperm; fertilization; infertility; biomarkers; genetics
(This special issue belongs to the Section Molecular Biology)
Ongoing Anticancer Agents
edited by
submission deadline 20 Dec 2025 | Viewed by 17 | Submission Open
Keywords: tumorigenesis; anticancer drugs; therapeutic innovation; platinum-based drugs; anticancer therapies
(This special issue belongs to the Section Molecular Oncology)
Developmental Origins of Kidney Disease: Renal Programming
edited by Hyung-Eun Yim
submission deadline 20 Dec 2025 | Viewed by 16 | Submission Open
Keywords: air pollution; chronic kidney disease; congenital anomalies of the kidneys and urinary tract; high-risk pregnancy; nephrogenesis; renal programming; renin angiotensin system
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insight into Natural Nutraceuticals for Cancer Chemoprevention submission deadline 20 Dec 2025 | Viewed by 5 | Submission Open
Keywords: natural nutraceuticals; cancer; cancer chemoprevention; natural compounds
(This special issue belongs to the Section Molecular Oncology)
Molecular Aspects of Tumor Radiotherapy
edited by
submission deadline 20 Dec 2025 | Submission Open
Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Gastrointestinal Cancer, 3rd Edition
edited by
submission deadline 20 Dec 2025 | Submission Open
Keywords: gastrointestinal cancer; chemotherapeutic agents; innovative therapies; human nutrition; nutrigenomics; nutrition and immunity epigenetics; cytotoxicity; apoptosis
(This special issue belongs to the Section Molecular Oncology)
Redox Physiology
edited by Mateusz Mołoń
submission deadline 21 Dec 2025 | Viewed by 274 | Submission Open
Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling
(This special issue belongs to the Section Molecular Biology)
Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases submission deadline 25 Dec 2025 | 1 articles | Viewed by 821 | Submission Open
Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular and Genetic Advances in Plant Breeding
edited by Francesca Taranto
submission deadline 25 Dec 2025 | Viewed by 165 | Submission Open
Keywords: genetic diversity; next-generation sequencing; marker-assisted selection; GWAS/QTL mapping; KASP genotyping; molecular biology   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Plant Sciences)
Skin Cancer: From Molecular Pathophysiology to Novel Treatment
edited by Soon-Hyo Kwon
submission deadline 25 Dec 2025 | Viewed by 123 | Submission Open
Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma
(This special issue belongs to the Section Molecular Oncology)
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