The Role of Complement Regulation in Kidney Disease
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 April 2026
Special Issue Editor
Interests: renal pathology; complement system; immune-mediated kidney injury; molecular mechanisms of kidney diseases; nephropathology; translational nephropathology; uropathology
Special Issue Information
Dear Colleagues,
The complement system represents a fundamental component of innate immunity and plays a pivotal role in kidney homeostasis and disease. Dysregulation of complement activation is increasingly recognized as a key pathogenic mechanism in a broad spectrum of renal disorders, including glomerulonephritides, thrombotic microangiopathies, and tubulointerstitial injuries. The identification of genetic and acquired defects in complement-regulatory proteins has not only improved our understanding of disease mechanisms but has also led to the development of novel targeted therapies that reshape modern nephrology and pathology.
This Special Issue, “The Role of Complement Regulation in Kidney Disease”, aims to bring together original research articles and comprehensive reviews that explore molecular mechanisms, biomarkers, and therapeutic strategies related to complement activation and regulation in kidney diseases. Topics of interest include the structural and functional characterization of complement components, their crosstalk with immune and inflammatory pathways, and the clinical relevance of complement inhibition in renal pathology.
We warmly invite investigators to contribute their latest findings to this Special Issue, which will advance our understanding of complement-mediated renal injury and foster translational insights into precision medicine approaches in nephrology.
This Special Issue is supervised by Professor Dr. Jasmina Marković-Lipkovski and assisted by Guest Editor Assistant Professor Dr. Maja Životić (maja.zivotic@med.bg.ac.rs, Institute of Pathology, Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia).
Prof. Dr. Jasmina Marković Lipkovski
Guest Editor
Manuscript Submission Information
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Keywords
- complement system
- kidney disease
- glomerulonephritis
- C3 glomerulopathy
- membranous nephropathy
- complement regulation
- innate immunity
- molecular pathology
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