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Gut Microbiota-Derived Metabolites in Human Health and Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 2

Special Issue Editor


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Guest Editor
Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA
Interests: microbiome; cardiovascular research; analytical biochemistry; mass spectrometry; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The gut microbiota, composed of trillions of microorganisms residing in the human gut, are often regarded as a “virtual organ” with extensive digestive, metabolic, and endocrine functions. They play a pivotal role in maintaining health but can also contribute to the onset and progression of disease. Many of these effects are mediated through metabolites produced by gut microbes, which influence diverse aspects of human physiology and pathology. Continued investigation of these metabolites will provide a strong theoretical foundation for strategies to promote human health.

The Special Issue, “Gut Microbiota-Derived Metabolites in Human Health and Disease”, aims to stimulate comprehensive research that adopts a holistic perspective. We welcome articles on topics including the biosynthesis of gut microbiota-derived metabolites (such as specific bacterial strains, relevant substrates, and regulatory strategies) as well as the roles of these metabolites in chronic diseases, ranging from inflammatory bowel disease and cardiovascular disorders to neurodegenerative conditions.

Dr. Zeneng Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microbiome
  • microbiota
  • gut
  • metabolomics
  • health
  • disease
  • inflammation

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Published Papers

This special issue is now open for submission.
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