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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Secondary Metabolites of Pathogenic Fungi: From Mechanism to Medicine

edited by

Kritsada Pruksaphon

and

Nopawit Khamto

submission deadline 30 Nov 2026 | Viewed by 76 | Submission Open

Keywords: fungal secondary metabolites; mycotoxins; fungal virulence and fungal pathogenesis; biosynthetic gene clusters (BGCs); one strain– many compounds (OSMAC); metabolomics; host– pathogen interaction; ribotoxic stress; one health and climate change; diagnostic biomarkers; antifungal therapeutics; medicinal chemistry; structural biology

(This special issue belongs to the Section Molecular Microbiology)

The Molecular Mechanisms of Lead-Induced Neurotoxicity

edited by

Irena Baranowska-Bosiacka

and

Magdalena Gąssowska-Dobrowolska

submission deadline 30 Nov 2026 | Viewed by 75 | Submission Open

Keywords: lead; neurogenesis and neuronal development; intracellular signaling pathways; synaptic protein function; synaptic transmission and plasticity; neuroinflammation and inflammatory signaling; astrocyte– neuron metabolic cooperation; disturbances in vitamin and micronutrient metabolism; lead-induced alterations of the gut microbiota and gut– brain axis; molecular mechanisms underlying cognitive impairment; pathways contributing to the progression of neurodegenerative disorders following lead exposure

(This special issue belongs to the Section Molecular Toxicology)

The Effects of Natural Products on Neurological Disorders

edited by Erika Monserrat Estrada-Camarena,

María Eva González Trujano

and Carolina López-Rubalcava

submission deadline 30 Nov 2026 | Viewed by 74 | Submission Open

Keywords: natural products; plants; fungi; vegetables; neurodegeneration; neuroinflammation; mechanism of action; neurodegenerative disorders; mental disorders; animal models; bioactive compounds; behavior

(This special issue belongs to the Section Molecular Neurobiology)

Reproductive Toxicity of Chemicals: 2nd Edition

edited by

Maria Laura Zenclussen

submission deadline 30 Nov 2026 | Viewed by 74 | Submission Open

Keywords: reproductive health; fertility; anthropogenic chemicals; impaired fertility; reproductive toxicity; embryo; toxicants; hormone disruption; chemical exposure

(This special issue belongs to the Section Molecular Toxicology)

Microbial Enzymes: Molecular Structure and Mechanism

edited by Rui Ma

submission deadline 30 Nov 2026 | Viewed by 74 | Submission Open

Keywords: microbial enzymes; biocatalytic application; molecular enzymology

(This special issue belongs to the Section Molecular Biology)

Carbohydrate-Based Materials: Self-Assemblies and Applications

edited by

Redouane Borsali

and

Hong Li

submission deadline 30 Nov 2026 | Viewed by 74 | Submission Open

Keywords: carbohydrate-based materials; sustainable polymers; self-assembly; structure– property– function relationships; functional materials

(This special issue belongs to the Section Materials Science)

ABA Mediated Plant Growth and Development, and Response to Drought and Salt Stress

edited by

Kun Li

and Fengbo Yang

submission deadline 30 Nov 2026 | Viewed by 66 | Submission Open

Keywords: ABA; drought; salt stress; osmotic stress; signal transduction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Plant Sciences)

Recent Progress of Biopolymers in Drug Delivery Systems

edited by

Narendra Kale

submission deadline 30 Nov 2026 | Viewed by 65 | Submission Open

Keywords: biopolymers; biomaterials; drug delivery systems; nanomedicine; targeted delivery; polymer therapeutics; bioengineering; quantitative imaging; stimuli-responsive drug delivery; biomedical polymers

(This special issue belongs to the Section Macromolecules)

Molecular Mechanisms Regulating Plant Growth, Development, and Stress Adaptation

edited by

Asma Ayaz

submission deadline 30 Nov 2026 | Viewed by 61 | Submission Open

Keywords: plant growth; plant development; molecular mechanisms; phytohormone signaling; abiotic stress; biotic stress; molecular cloning; plant– microbe interactions; omics approaches; crop improvement

(This special issue belongs to the Section Molecular Plant Sciences)

Advancements in Antimicrobial Agents: Focus on Biofilm Eradication

edited by

Marcus Vinícius Dias-Souza

submission deadline 30 Nov 2026 | Viewed by 60 | Submission Open

Keywords: antibiofilm plant extracts; antibiofilm phytomolecules; antibiofilm nanoparticles; antibiofilm liposomes; biofilm physiology; biofilm biochemistry; molecular biology of biofilms; biofilm eradication; biofilm growth control; structure of biofilms

(This special issue belongs to the Section Molecular Microbiology)

Probiotics in Metabolism, Inflammation and Nervous System Disorders

edited by Subramanian Thangaleela

submission deadline 30 Nov 2026 | Viewed by 59 | Submission Open

Keywords: probiotics; gut– brain axis; metabolic diseases; neurological disorders; inflammation; secondary metabolites

(This special issue belongs to the Section Molecular Microbiology)

A New Perspective on Fruit Quality: From Molecular Regulatory Mechanisms to Nutritional Value

edited by Xuelian Zhang

submission deadline 30 Nov 2026 | Viewed by 53 | Submission Open

Keywords: fruit quality; color regulation; texture; flavor; bioactive compounds; anthocyanins; carotenoids; human nutrition; CRISPR/Cas9; multi omics; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Leveraging Multiomics for Resilient Crop Development and Food Security

edited by Niharika Sharma

submission deadline 30 Nov 2026 | Viewed by 52 | Submission Open

Keywords: multiomics; crop resilience; climate smart crops; stress tolerance; sustainable crop improvement; genotype‑by‑environment interactions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Research on Choroid Plexus

edited by

Telma Quintela

submission deadline 30 Nov 2026 | Viewed by 52 | Submission Open

Keywords: choroid plexus; blood– cerebrospinal fluid barrier; cerebrospinal fluid; neurological diseases; brain homeostasis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Biology and Therapeutic Applications of Medicinal Plants

edited by Gothai Sivapragasam and Nanthiney Ragavan

submission deadline 30 Nov 2026 | Viewed by 47 | Submission Open

Keywords: medicinal plants; molecular biology; phytochemicals; wound healing; oxidative stress; inflammation; molecular pharmacology; regenerative medicine; bioactive compounds

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Engineering of Photo(electro)catalysts: Rational Design and Electron Transfer

edited by Bingqing Zhang

submission deadline 30 Nov 2026 | Viewed by 44 | Submission Open

Keywords: photocatalysis; photoelectrocatalysis; molecular engineering; semiconductor materials; artificial photosynthesis; (photo)electrochemical sensors; energy materials; electron transfer

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Mechanisms Underlying Plant Responses to Biotic and Abiotic Stress

edited by

Mohamed Ait-El-Mokhtar

and

Raja Ben-Laouane

submission deadline 30 Nov 2026 | Viewed by 41 | Submission Open

Keywords: plant stress responses; abiotic stress; biotic stress; signal transduction; multi-omics; epigenetic regulation; plant– microbe interactions; biostimulants; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Skin Inflammation (2nd Edition)

edited by

Nabiha Yusuf

submission deadline 30 Nov 2026 | Viewed by 38 | Submission Open

Keywords: skin inflammation; molecular diagnosis; dermatitis; molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Therapeutic Targets in Cancers: 5th Edition

edited by

Elena Levantini

submission deadline 30 Nov 2026 | Viewed by 38 | Submission Open

Keywords: targeted therapy; precision oncology; immune modulation; cancer stem cell targeting; RNA-based therapy

(This special issue belongs to the Section Molecular Oncology)

Artificial Intelligence, Multi-Omics, and Molecular Modelling in Modern Drug Discovery

edited by

Shaban Ahmad

submission deadline 30 Nov 2026 | Viewed by 37 | Submission Open

Keywords: artificial intelligence (AI); machine learning; multi-omics integration; molecular modelling; computational drug discovery; virtual screening; generative AI; explainable AI (XAI); ADMET prediction; pharmacogenomics; systems biology

(This special issue belongs to the Section Molecular Pharmacology)

Multi-Omics and Computational Simulation Approaches: Unraveling Novel Antibacterial Mechanisms of Natural Products

edited by Lili Li

submission deadline 30 Nov 2026 | Viewed by 36 | Submission Open

Keywords: natural products; antibacterial mechanism; anti-biofilm; multi-omics; computational simulation; drug-resistant pathogens

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Diabetes: Molecular Perspectives—From Genetic Risk to Precision Therapy

edited by Suma Elumalai

submission deadline 30 Nov 2026 | Viewed by 34 | Submission Open

Keywords: diabetes mellitus; insulin signaling; β -cell dysfunction; insulin resistance; genomics; epigenetics; multi-omics; inter-organ communication; molecular therapeutics; precision medicine

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Role of Angiotensin II in Cardiac Fibrosis and Heart Failure

edited by

Nancy Martínez-Rodríguez

submission deadline 30 Nov 2026 | Viewed by 31 | Submission Open

Keywords: angiotensin II; cardiac fibrosis; heart failure; renin– angiotensin– aldosterone system (RAAS); extracellular matrix remodeling; myofibroblast activation; cardiovascular genomics; molecular biomarkers

(This special issue belongs to the Section Molecular Biology)

Antiviral Drug Target Discovery and Design

edited by

Dongwei Kang

and Huajun Zhao

submission deadline 30 Nov 2026 | Viewed by 28 | Submission Open

Keywords: antiviral; drug discovery; drug resistance; immune and pharmacological mechanisms; immunotherapy; immunopathology; vaccines and adjuvants

(This special issue belongs to the Section Molecular Pharmacology)

Mitochondrial DNA and Its Multiple Functions in Health and Disease

edited by

Izinara Cruz

and Vanessa F. Gonçalves

submission deadline 30 Nov 2026 | Viewed by 28 | Submission Open

Keywords: mitochondrial DNA; mtDNA; mitochondrial genome sequencing; mitochondrial dysfunction; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Kidney Disease: From Biomarkers, Molecular Mechanisms to Targeted Therapy

edited by

Rusu Crina Claudia

submission deadline 30 Nov 2026 | Viewed by 18 | Submission Open

Keywords: kidney disease; biomarkers; molecular mechanisms; precision nephrology; chronic kidney disease; acute kidney injury; renal fibrosis; omics technologies; targeted therapy; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advance in Periodontitis

edited by Maja Miletić and

Natasa Nikolic-Jakoba

submission deadline 30 Nov 2026 | Viewed by 17 | Submission Open

Keywords: periodontitis; molecular mechanisms; inflammation; oral microbiome; multi-omics; biomarkers; cytokines; oxidative stress; immune regulation; tissue regeneration

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Endocrine Disruptors and the Nervous System: From Neurodevelopment to Neurotoxicity

edited by

Eui-Bae Jeung

submission deadline 30 Nov 2026 | Viewed by 16 | Submission Open

Keywords: endocrine disruptors; neurodevelopment; neurotoxicity; neuroendocrine; behavior; cognitive function; molecular mechanisms; alternative testing methods; developmental toxicity; nervous system

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Research Advances in HIV Infection

edited by

Sıla Akhan

submission deadline 30 Nov 2026 | Viewed by 16 | Submission Open

Keywords: HIV-1; CAR-T therapy; late HIV diagnosis; viral transmission; immune exhaustion; antiretroviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Studies of Neurocognitive Disorders

edited by

Cristián Sandoval

and Edgar Vásquez Carrasco

submission deadline 30 Nov 2026 | Viewed by 14 | Submission Open

Keywords: neurocognitive disorders; mild cognitive impairment; Alzheimer’ s disease; neuroinflammation; biomarkers; oxidative stress; neurodegeneration; multi-omics; precision medicine; cognitive decline

(This special issue belongs to the Section Molecular Neurobiology)

Unraveling the Mechanistic Pathways of Immune Cell Engagers in Lymphoproliferative Diseases

edited by

Stella Bouziana

submission deadline 30 Nov 2026 | Viewed by 14 | Submission Open

Keywords: lymphoproliferative diseases; immune cell engagers; BiTEs; molecular pathways; next-generation T cell engagers

(This special issue belongs to the Section Molecular Immunology)

Research of Aldo-Keto Reductases in Human Disease

edited by

Ping Zhu

and

Hao Luo

submission deadline 30 Nov 2026 | Viewed by 13 | Submission Open

Keywords: aldo-keto reductase (AKR); protein engineering; AKR1B10; cancer biomarker; chemoresistance

(This special issue belongs to the Section Biochemistry)

Spectroscopic Techniques in Molecular Sciences, 2nd Edition

edited by

Angela Staicu

submission deadline 30 Nov 2026 | Viewed by 13 | Submission Open

Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems

(This special issue belongs to the Section Biochemistry)

Molecular Advances in Parkinson’s Disease: Current Insights and Future Directions

edited by Laura Adalid-Peralta

submission deadline 30 Nov 2026 | Viewed by 11 | Submission Open

Keywords: Parkinson’ s disease; neurodegenerative mechanisms; genetic susceptibility; alpha-synuclein aggregation; neuroinflammation; mitochondrial dysfunction; oxidative stress; autophagy– lysosomal pathway; gut– brain axis; microbiome dysbiosis

(This special issue belongs to the Section Molecular Neurobiology)

RNA Structure, Folding and Cellular Function: Mechanisms and Biological Significance

edited by

Ilias Skeparnias

submission deadline 30 Nov 2026 | Viewed by 10 | Submission Open

Keywords: RNA structure; RNA folding; RNA– protein interactions; R-loops; RNA:DNA hybrids; non-coding RNA; RNA biogenesis; gene regulation; ribozymes; RNA therapeutics

(This special issue belongs to the Section Molecular Biology)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment—2nd Edition

edited by Manuel Morales-Ruiz and

Jordi Ribera

submission deadline 30 Nov 2026 | Viewed by 9 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Bacterial Multidrug Resistance

edited by

Andrea Marino

and

Stefano Stracquadanio

submission deadline 30 Nov 2026 | Viewed by 9 | Submission Open

Keywords: antimicrobial resistance; multidrug resistance; horizontal gene transfer; biofilms; molecular epidemiology; efflux pumps

(This special issue belongs to the Section Molecular Microbiology)

Extraction, Characterization and Application of Bioactive Compounds

edited by

Dorota Gumul

and Marek Kruczek

submission deadline 30 Nov 2026 | Viewed by 8 | Submission Open

Keywords: bioactive compounds; extraction methods; molecular mechanisms; antioxidants; encapsulation; functional foods; bioavailability; food by-products

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Design, Stabilization, and Controlled Delivery of Probiotics and Bioactive Compounds

edited by Chuang Zhang

submission deadline 30 Nov 2026 | Viewed by 8 | Submission Open

Keywords: probiotics; bioactive compounds; functional foods; microencapsulation; controlled delivery; food biopolymers; molecular interactions; bioavailability; gut microbiota; powder-based delivery systems

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Pediatric Diseases: From Molecular Mechanisms to Novel Therapeutic Strategies—2nd Edition

edited by

Elena Tarca

submission deadline 30 Nov 2026 | Viewed by 7 | Submission Open

Keywords: congenital abnormalities; genetic disease; molecular mechanism; therapeutic agents; maternal and fetal medicine; pediatric diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Biomarkers: From Early Detection to Prognosis

edited by

Luís Lima

submission deadline 30 Nov 2026 | Viewed by 6 | Submission Open

Keywords: cancer biomarkers; early detection; prognosis; liquid biopsy; personalized oncology; multi-omics; translational research; predictive modeling

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathogenesis and Targeted Therapies of Hematological Malignancies

edited by

Can Küçük

submission deadline 30 Nov 2026 | Viewed by 4 | Submission Open

Keywords: hematological malignancies; precision oncology; molecular mechanisms; therapeutic resistance; targeted therapy; cellular immunotherapies; multi-omics; artificial intelligence; translational medicine

(This special issue belongs to the Section Molecular Oncology)

Advances in the Integrin System: Relevance of Receptors, Ligands, and Counter-Receptors in Signaling and Pathophysiology

edited by

Carlos Cabañas

and

Carmelo Bernabeu

submission deadline 30 Nov 2026 | Viewed by 3 | Submission Open

Keywords: integrin function; integrin signalling pathways; integrin conformational changes; integrin disease and therapeutic strategies; integrin-ligand interactions; integrin counter-receptors (ICRs); extracellular matrix (ECM) integrin ligands

(This special issue belongs to the Section Molecular Biology)

Oxidative Stress, Biomarkers and Dysregulated Lipid Metabolism in Cardiovascular Diseases

edited by

Amilia Aminuddin

and Adila Abdul A. Hamid

submission deadline 30 Nov 2026 | Viewed by 3 | Submission Open

Keywords: cardiovascular diseases; oxidative stress; lipid metabolism; atherosclerosis; endothelial dysfunction; inflammation; biomarkers; reactive oxygen species (ROS); dyslipidemia; vascular function

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Viper Envenomation: From Molecular Mechanisms to Treatment

edited by Svjetlana Karabuva

submission deadline 30 Nov 2026 | Viewed by 2 | Submission Open

Keywords: snake envenomation; viper envenomation; antiviper serum; Europe; guidelines

(This special issue belongs to the Section Molecular Toxicology)

Diabetes and Metabolic Dysfunction (Second Edition)

edited by

Vasilis K. Tsimihodimos

submission deadline 30 Nov 2026 | Viewed by 1 | Submission Open

Keywords: diabetes; metabolic dysfunction; glucose metabolism; metabolic disturbances; complications

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Research on Neurotransmitters (Second Edition)

edited by

Mario Manto

Hiroshi Mitoma

and Jing-Ning Zhu

submission deadline 30 Nov 2026 | Submission Open

Keywords: neurotransmitters; GABA; glutamate; monoamines; dopamine; serotonin; norepinephrine; neuropeptides; nitric oxide; neurosteroids; stress; neurotrophins; epigenetics; gut– brain axis

(This special issue belongs to the Section Molecular Neurobiology)

Tumor Immunology: Molecular Research and Advances

edited by Elizabeth Cristina Perez Hurtado

submission deadline 30 Nov 2026 | Submission Open

Keywords: tumor microenvironment; tumor evasion; immune checkpoint inhibitors; macrophages; biomarkers in cancer; CAR cell therapy; cancer vaccines; lipid metabolism in cancer; metabolic reprogramming of immune response

(This special issue belongs to the Section Molecular Immunology)

Molecular Research on Inflammation in Neurodegenerative Diseases

edited by

Selçuk Özdemir

submission deadline 1 Dec 2026 | Viewed by 91 | Submission Open

Keywords: neuroinflammation; neurodegenerative diseases; molecular pathways; neuronal cell death; mitochondrial dysfunction; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms of Bladder Cancer

edited by

Hironobu Yamashita

submission deadline 1 Dec 2026 | Viewed by 69 | Submission Open

Keywords: urothelial carcinoma; molecular subtypes; tumor microenvironment (TME); epigenetics; precision medicine; chemoresistance

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 2851-2900 on page 58 of 65.

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