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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Biomolecular Recognition: 3rd Edition
edited by
submission deadline 20 Dec 2025 | Viewed by 507 | Submission Open
Keywords: proteins; nucleic acids; membrane; ligand; binding
(This special issue belongs to the Section Molecular Biophysics)
Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics
edited by Clinton B. Mathias and Michiko K. Oyoshi
submission deadline 20 Dec 2025 | 1 articles | Viewed by 507 | Submission Open
Keywords: food allergy; allergic mechanisms; asthma; allergic disease; mast cells; ILC2s; Th2 cells; eosinophils; IL-4; IL-33; IL-13
(This special issue belongs to the Section Molecular Immunology)
Preclinical and Translational Research in Thyroid Cancer submission deadline 20 Dec 2025 | 1 articles | Viewed by 487 | Submission Open
Keywords: thyroid cancers; pathogenesis; molecular bases of thyroid cancer; precision medicine; gender medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Exploring Natural Products for Antimicrobial Innovation: New Paths and Promising Leads
edited by
submission deadline 20 Dec 2025 | Viewed by 469 | Submission Open
Keywords: antimicrobial agents; drug resistance; plant-derived compounds; bioactive molecules; phytochemicals; marine natural products; fungal metabolites; novel drug discovery; microbial pathogens; natural product isolation; drug development; biotechnology in antimicrobial research
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Role of Fibrinolytic Factors in Disease
edited by
submission deadline 20 Dec 2025 | Viewed by 437 | Submission Open
Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1
(This special issue belongs to the Section Molecular Biology)
Future Perspectives and Challenges in Molecular Research of Glioma
edited by Shanchun Guo
submission deadline 20 Dec 2025 | Viewed by 435 | Submission Open
Keywords: gliomas; genetic and epigenetic changes; molecular mechanisms; immunotherapy; innovative therapeutic strategies
(This special issue belongs to the Section Molecular Neurobiology)
Structural Characterization and Pharmacological Activity of Natural Compounds
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 422 | Submission Open
Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Red Blood Cells in Health and Disease
edited by Annamaria Russo and Ester Tellone
submission deadline 20 Dec 2025 | Viewed by 384 | Submission Open
Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes
(This special issue belongs to the Section Biochemistry)
The Role of Non-Coding RNAs in Female Reproduction
edited by
submission deadline 20 Dec 2025 | Viewed by 373 | Submission Open
Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network
(This special issue belongs to the Section Molecular Genetics and Genomics)
Innovative Research on Nutrition and Epigenetics in Cancer
edited by Marisabel Mecca
submission deadline 20 Dec 2025 | Viewed by 351 | Submission Open
Keywords: diet; nutrition; epigenetics; cancer; cancer therapy; lifestyle
(This special issue belongs to the Section Molecular Oncology)
Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine
edited by Martin Braun, and
submission deadline 20 Dec 2025 | Viewed by 348 | Submission Open
Keywords: collagen; tissue engineering; advanced biomaterials; biodegradable composites; scaffolds; protein structure; biochemical analysis; material characterization; medical application; gelatine
(This special issue belongs to the Section Macromolecules)
New Advances in Cancer Genomics
edited by
submission deadline 20 Dec 2025 | 1 articles | Viewed by 346 | Submission Open
Keywords: cancer genomics; biomarker discovery; precision oncology; KRAS and undruggable targets; artificial intelligence in oncology; multi-omics data integration; drug discovery
(This special issue belongs to the Section Molecular Biology)
Molecular and Immunological Biomarkers in Cervical Cancer
edited by Janaina Cristiana de Oliveira Crispim and
submission deadline 20 Dec 2025 | Viewed by 339 | Submission Open
Keywords: cervical cancer; molecular biomarkers; immunological biomarkers; human papillomavirus (HPV); tumor microenvironment; immune responses; immunotherapy; diagnostic biomarkers; prognostic biomarkers; therapeutic targets
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Physiopathology and Therapeutics of HIV Infection
edited by
submission deadline 20 Dec 2025 | Viewed by 334 | Submission Open
Keywords: HIV; physiopathology; ART; HAART; NRTIs; NNRTIs; PIs; INSTIs; fusion inhibitors; CCR5 antagonists; post-attachment inhibitors; capsid inhibitors
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Quantum Chemistry, Vibrational Spectroscopy and Biophysics on Biomolecules submission deadline 20 Dec 2025 | Viewed by 332 | Submission Open
Keywords: molecular simulations; computer calculations; structure predictions; molecular structure; DNA structure; nucleobases pairs; inter-molecular interactions; spectroscopic predictions; scaling; Raman simulations; macromolecular crystallography; molecular modeling; electronic properties
(This special issue belongs to the Section Molecular Biophysics)
New Insights into the Molecular Mechanisms of the UPR and Cell Stress
edited by
submission deadline 20 Dec 2025 | Viewed by 327 | Submission Open
Keywords: unfolded protein response; ER stress; oxidative stress; mitochondrial dysfunction; cell stress; stress response; UPR signaling pathway; immunity; inflammation; infection
(This special issue belongs to the Section Molecular Biology)
Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research
edited by Oliver Felthaus
submission deadline 20 Dec 2025 | Viewed by 322 | Submission Open
Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering
(This special issue belongs to the Section Molecular Biology)
Effects of Xenobiotic Exposure on Human Health: A Molecular Perspective submission deadline 20 Dec 2025 | Viewed by 318 | Submission Open
Keywords: xenobiotic exposure; human health; toxic effects; environmental chemicals; molecular research
(This special issue belongs to the Section Molecular Toxicology)
Sleep and Breathing: From Molecular Perspectives
edited by Alberto Alonso-Fernández
submission deadline 20 Dec 2025 | Viewed by 316 | Submission Open
Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics
(This special issue belongs to the Section Molecular Biology)
Circumventing Resistance to Channel-Targeting Insecticides: A Challenge for Global Health and Food Security
edited by and David Barry Sattelle
submission deadline 20 Dec 2025 | Viewed by 303 | Submission Open
Keywords: pest insects and resistance; resistance in insect vectors of human and livestock diseases; mechanisms of resistance; circumventing resistance; ion channels and resistance; integrated approaches to resistance management; alternating insecticide classes; minimizing risk to beneficial insects; novel control strategies
(This special issue belongs to the Section Molecular Biology)
Antifungal Drug Discovery: Progresses, Challenges, Opportunities, 2nd Edition
edited by
submission deadline 20 Dec 2025 | Viewed by 300 | Submission Open
Keywords: antifungal drugs; fungal infections; drug design; drug discovery; targeted therapy; drug resistance; fungal drug targets; neglected tropical diseases
(This special issue belongs to the Section Molecular Pharmacology)
Pediatric Autoimmune Diseases: Molecular Basis, Diagnostic and Therapy
edited by
submission deadline 20 Dec 2025 | Viewed by 299 | Submission Open
Keywords: autoimmunity; immune regulation; biomarker analysis; molecular pathways; precision medicine; genetics
(This special issue belongs to the Section Molecular Immunology)
Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases
edited by
submission deadline 20 Dec 2025 | Viewed by 297 | Submission Open
Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Roles and Mechanisms of Non-Coding RNAs in Breast Cancer
edited by
submission deadline 20 Dec 2025 | Viewed by 293 | Submission Open
Keywords: breast cancer; NcRNA; MmiRNA; LncRNA; CircRNA; PiRNA; exosome-packed ncRNA; role and mechanisms of ncRNA in breast cancer tissue or cell lines; modulation of ncRNA levels by knock-out or knock-down approaches; effects on breast cancer cell proliferation; invasion; or apoptosis; identification of BC-relevant ncRNA– mRNA networks; targeting ncRNAs with potential clinical implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Role of EGFR in Colorectal Cancer submission deadline 20 Dec 2025 | Viewed by 290 | Submission Open
Keywords: EGFR; RAS; biomarkers/prognosis; resistance mechanisms; tumor microenvironment; EGFR signaling pathways; EGFR inhibitors; onco-immunology
(This special issue belongs to the Section Biochemistry)
Anticancer Antibiotics: Progresses, Opportunities and Challenges
edited by Jose Kaneti
submission deadline 20 Dec 2025 | Viewed by 286 | Submission Open
Keywords: tetracycline antibiotics; antitumor activity; molecular mechanism; G-quadruplex complexes; computational modeling; pharmacological evaluation
(This special issue belongs to the Section Molecular Pharmacology)
Thrombo-Inflammatory Signaling and Complications in Autoimmune Disorders submission deadline 20 Dec 2025 | Viewed by 270 | Submission Open
Keywords: inflammation; thrombosis; platelets; coagulation; autoimmune disorders; rheumatoid arthritis; systematic erythematosus lupus; antiphospholipid syndrome; thrombo-inflammation; antithrombotic; antiplatelet
(This special issue belongs to the Section Molecular Immunology)
Mechanotransduction and Tissue Regeneration in Skeletal Muscle
edited by
submission deadline 20 Dec 2025 | Viewed by 267 | Submission Open
Keywords: skeletal muscle tissue regeneration; mechanotransduction; skeletal muscle spindles; tissue-resident macrophages
(This special issue belongs to the Section Molecular Biology)
Design, Synthesis and Biological Activity of Heterocyclic Compounds submission deadline 20 Dec 2025 | Viewed by 266 | Submission Open
Keywords: synthesis of new bioactive compounds; biological activity of heterocyclic compounds; structural analysis; pharmacokinetic analysis of potential drugs; molecular docking study of new heterocyclic compounds
(This special issue belongs to the Section Biochemistry)
Tumor Angiogenesis and Metastasis: From Molecular Signalling to Therapeutic Approaches submission deadline 20 Dec 2025 | Viewed by 265 | Submission Open
Keywords: tumour angiogenesis; tumour invasion; tumour metastasis; molecular mechanisms; metabolic patterns; signalling pathways
(This special issue belongs to the Section Molecular Oncology)
Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases
edited by
submission deadline 20 Dec 2025 | Viewed by 264 | Submission Open
Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging
(This special issue belongs to the Section Molecular Neurobiology)
Host-Virus Interaction
edited by and
submission deadline 20 Dec 2025 | Viewed by 264 | Submission Open
Keywords: viral entry; viral replication; virus assembly and release; pro-viral factors; restriction factors; interferon pathway; viral immune evasion; antiviral strategies
(This special issue belongs to the Section Molecular Immunology)
Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing
edited by
submission deadline 20 Dec 2025 | Viewed by 249 | Submission Open
Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Advances in Chronic Pain: Mechanisms and Therapeutic Innovations
edited by
submission deadline 20 Dec 2025 | Viewed by 248 | Submission Open
Keywords: chronic pain; pain mechanisms; pain management; therapeutic innovation; translational research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Natural Products for Cancer Therapy: Mechanisms, Synergies, and Clinical Applications
edited by and Hiu Yee Kwan
submission deadline 20 Dec 2025 | Viewed by 246 | Submission Open
Keywords: natural products; cancer therapy; traditional Chinese medicine (TCM); integrative medicine; cancer drug resistance; antitumor mechanisms; molecular targeting; drug synergy; clinical application
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in 3D Tumor Models for Cancer Research
edited by , and Alessandra Lo Cicero
submission deadline 20 Dec 2025 | Viewed by 243 | Submission Open
Keywords: 3D systems; cancer research; spheroids; organoids; organ-on-chip; scaffolds; tissue engineering; biomedical technologies; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Growth Factor Signaling in Cancer Progression
edited by and Abdo J. Najy
submission deadline 20 Dec 2025 | Viewed by 239 | Submission Open
Keywords: growth factor signaling; proteolysis; cancer progression; tumor dormancy; metastasis; tumor microenvironment; therapeutic strategies
(This special issue belongs to the Section Molecular Biology)
New Insights of Autophagy and Apoptosis in Cells submission deadline 20 Dec 2025 | Viewed by 232 | Submission Open
Keywords: autophagy; apoptosis; signal transduction; cell survival
(This special issue belongs to the Section Molecular Biology)
Regulatory Mechanisms Underlying Tumorigenesis
edited by
submission deadline 20 Dec 2025 | Viewed by 232 | Submission Open
Keywords: tumor suppressor genes; tumor microenviroment; cell-cycle checkpoint; novel fusion genes; novel molecular targets; small-molecule drugs; animal models
(This special issue belongs to the Section Molecular Oncology)
DNA Methylation in Cancer: Progress and Challenges
edited by
submission deadline 20 Dec 2025 | Viewed by 223 | Submission Open
Keywords: DNA methylation; cancer; hypomethylation; hypermethylation; epigenetics; tumor onset; tumor progression; technologies
(This special issue belongs to the Section Molecular Genetics and Genomics)
Mechanistic and Data-Driven Modelling Approaches for Regulatory Networks and Diseases
edited by
submission deadline 20 Dec 2025 | Viewed by 220 | Submission Open
Keywords: mathematical modelling; data-driven approach; mechanistic and data dual-driven approach; hybrid modelling; machine learning; modelling of regulatory network; inference of molecular regulation; cancer; infection disease; disease intervention
(This special issue belongs to the Section Molecular Informatics)
Molecular Research on Aging: How Can We Live Beyond 100 Years?
edited by
submission deadline 20 Dec 2025 | Viewed by 217 | Submission Open
Keywords: aging; biomarkers; centenarians; longevity interventions; stress resistance and metabolism; age-related diseases
(This special issue belongs to the Section Molecular Biology)
Protein Modification: New Insights
edited by
submission deadline 20 Dec 2025 | Viewed by 217 | Submission Open
Keywords: post-translational modifications (PTMs); side chain modifications; backbone modifications; analytical protein chemistry; mass spectrometry
(This special issue belongs to the Section Biochemistry)
Bacteria-Mediated Cancer Therapy: New Molecular Insights
edited by
submission deadline 20 Dec 2025 | Viewed by 215 | Submission Open
Keywords: bacteria-mediated cancer therapy; tumor microenvironment (TME); tumour immunotherapy; anticancer bacteria
(This special issue belongs to the Section Molecular Oncology)
Apoptosis and Autophagy in Cancer Research submission deadline 20 Dec 2025 | Viewed by 212 | Submission Open
Keywords: apoptosis; autophagy; cancer biology; coding and noncoding genomes; cell homeostasis; therapeutic strategies; cell death and survival
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Metabolism-Related Pathways in Animal Growth, Development, Disease and Behavior
edited by
submission deadline 20 Dec 2025 | Viewed by 212 | Submission Open
Keywords: metabolism pathway; signal pathway; animal development; animal behavior; animal disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Hormone Receptor in Breast Cancer: 2nd Edition submission deadline 20 Dec 2025 | Viewed by 209 | Submission Open
Keywords: estradiol; progesterone; calcitriol; androgen; resveratrol; phytoestrogens; therapeutic targets; fulvestrant; treatment response; SERM; estrogen receptor isoforms; selective ligands; hormonal carcinogenesis; breast cancer prevention; hormone signaling; endocrine disruptor compounds; ER-negative breast cancer; ER-positive breast cancer; aromatase inhibitors
(This special issue belongs to the Section Molecular Oncology)
Physiology and Pathophysiology of Neurodegeneration: New Insights and Advances from Molecular to Cellular Level submission deadline 20 Dec 2025 | Viewed by 203 | Submission Open
Keywords: central and peripheral nervous systems; neuron homeostasis; neurodegeneration; neurodegenerative disease; neurophysiology; -omic technologies; induced pluripotent stem cell (iPSC); three-dimensional cell culture; organ-on-a-chip (OoC)
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research on Depression—2nd Edition submission deadline 20 Dec 2025 | Viewed by 199 | Submission Open
Keywords: depression; epigenetics; animal models of depression; serotonin; glutamate; dopamine; neurotrophic factors
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Studies of Skin Diseases: From Mechanisms to Therapy
edited by
submission deadline 20 Dec 2025 | Viewed by 197 | Submission Open
Keywords: multiomics; genomics; transcriptomics; proteomics; metabolomics; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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