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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Insights into Porous Polymers

edited by Bolin Ji

submission deadline 31 Oct 2025 | Viewed by 18 | Submission Open

Keywords: porous organic polymer; covalent organic framework; adsorption and separation of gases; energy storage materials; water treatment; antimicrobial; fluorescence imaging; tumor treatment

(This special issue belongs to the Section Materials Science)

miRNA in Human Diseases

edited by

Anna Valentino

submission deadline 31 Oct 2025 | Viewed by 18 | Submission Open

Keywords: microRNA; gene regulation; disease biomarkers; miRNAs expression profiling; miRNA-based therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Novel Agents and Molecular Research in Multiple Myeloma

edited by

Claudio Cerchione

submission deadline 31 Oct 2025 | Viewed by 17 | Submission Open

Keywords: multiple myeloma; novel agents; target therapy; immunotherapy; bispecific antibodies; CAR-T

(This special issue belongs to the Section Molecular Oncology)

Molecular Insights into Sex Determination and Differentiation

edited by

Martin A. Estermann

submission deadline 31 Oct 2025 | Viewed by 17 | Submission Open

Keywords: sex determination; sex differentiation; ovary; testis; epigenetics; gene regulatory networks; DSDs; transcriptomics; evolution

(This special issue belongs to the Section Molecular Biology)

Genomics, Genetics, and the Future of Fruit Improvement

edited by Zoe Hilioti

submission deadline 31 Oct 2025 | Viewed by 16 | Submission Open

Keywords: fruit traits; genetics; genetic diversity; omics; new breeding techniques; fruit quality; shelf life

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research in Brain Cancer

edited by

Gerardo Caruso

submission deadline 31 Oct 2025 | Viewed by 16 | Submission Open

Keywords: brain tumor biomarkers; genomic and epigenomic alterations; microenvironment; targeted therapies; angiogenesis

(This special issue belongs to the Section Molecular Neurobiology)

Dynamic Nanoarchitectonics in Supramolecular Assemblies and Nanosystems: From Synthesis to Applications

edited by Vicente Martí-Centelles

submission deadline 31 Oct 2025 | Viewed by 15 | Submission Open

Keywords: supramolecular chemistry; synthetic chemistry; nanoscale materials; nanostructured materials; molecular self-assembly; nanoparticles; nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Recent Research on Biomimetic Chromatography, QSAR and Chemoinformatics in Molecular Modeling and Drug Design

edited by

Małgorzata Janicka

submission deadline 31 Oct 2025 | Viewed by 14 | Submission Open

Keywords: biomimetic chromatography; QSARs; QRARs; molecular modelling; chemoinformatics; pharmacokinetics

(This special issue belongs to the Section Molecular Informatics)

Advanced Molecular Research in Cardiology and Treatment Approaches

edited by Ludger Hauck

submission deadline 31 Oct 2025 | Viewed by 13 | Submission Open

Keywords: TAp63; EzH2; histone methyltransferase; cardiomyocyte proliferation; myocardial infarction; heart regeneration; heart repair; epigenetic regulation; cardiac regeneration; Skp2-p27KIP1 pathway

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Risk Stratification in Sarcomas: Epigenomics in Osteosarcomas

edited by Empar Mayordomo-Aranda

submission deadline 31 Oct 2025 | Viewed by 13 | Submission Open

Keywords: sarcomas; malignant neoplasms; oncogenic pathways; optical genome mapping; epigenomics

(This special issue belongs to the Section Molecular Oncology)

Molecular Targets of Disease—Changing Treatment Strategies for Parkinson's Disease

edited by

Chung-Yin Lin

submission deadline 31 Oct 2025 | Viewed by 12 | Submission Open

Keywords: Parkinson’ s disease; therapeutic targets; potential treatments; molecular targets; drug delivery; neurodegenerative disease

(This special issue belongs to the Section Molecular Neurobiology)

Natural and Synthetic Modified Nucleic Acids: Their Properties, Functions and Applications

edited by

Malgorzata Sierant

submission deadline 31 Oct 2025 | Viewed by 11 | Submission Open

Keywords: DNA; RNA; nucleic acid analogues; modified nucleosides; modified nucleosides identification techniques; nucleoside modifying enzymes; gene therapy; therapeutic nucleic acids; biomedical applications; drug delivery

(This special issue belongs to the Section Molecular Biology)

Bioactives from Natural Products

edited by

Antía González Pereira

submission deadline 31 Oct 2025 | Viewed by 11 | Submission Open

Keywords: natural products; bioactive compounds; therapeutic potential; secondary metabolites; omics technologies; biotechnology; phytochemistry; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Toxicity of Nanoparticles: Second Edition

edited by Lucyna Kapka-Skrzypczak

submission deadline 31 Oct 2025 | 1 articles | Viewed by 11 | Submission Open

Keywords: nanoparticles; nanotoxicity; exposure to nanoparticles; health effects; biological effects; oxidative stress; environmental health

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Photodiagnosis and Photodynamic Therapy

edited by

Tomasz Kubrak

submission deadline 31 Oct 2025 | Viewed by 11 | Submission Open

Keywords: photodiagnosis; photodynamic therapy; photosensitizers; natural photosensitizers; biomedical imaging; nanomedicine; targeted therapies; light as a therapeutic tool

(This special issue belongs to the Section Molecular Pharmacology)

Blood–Brain Barrier Dysfunction in Neurodegenerative Disorders

edited by

Amal Kaddoumi

submission deadline 31 Oct 2025 | Viewed by 10 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; Alzheimer’ s disease; amyotrophic lateral sclerosis; Parkinson's disease; BBB as a therapeutic target; neuroinflammation; molecular mechanisms; cerebral blood flow

(This special issue belongs to the Section Molecular Neurobiology)

The Involvement of the Ubiquitin Proteasome System in the Healthy and Diseased Heart

edited by

Ofer Binah

submission deadline 31 Oct 2025 | Viewed by 9 | Submission Open

Keywords: UPS; ubiquitin; proteasome; cardiac pathophysiology; coronary ischemia/reperfusion injury; heart failure; cardiomyopathies; E334K mutation; cMyBPC; electrophysiological dysfunction; hypertrophic cardiomyopathy; pharmacological targeting

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Metabolomics for Animal Health and Nutrition

edited by

María Dolores Llobat Bordes

and

Pablo Jesús Marín-García

submission deadline 31 Oct 2025 | Viewed by 9 | Submission Open

Keywords: metabolomics; animal health; animal nutrition; biomarkers; mass spectrometry; NMR spectroscopy; precision nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Bioactive Compounds and Their Antioxidant Role: 2nd Edition

edited by Tamara Jurina

submission deadline 31 Oct 2025 | Viewed by 8 | Submission Open

Keywords: bioactive compounds; antioxidants; polyphenolic compounds; nutraceuticals; phytochemicals; bioavailability; medicine

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Electrochemical Nanomaterials for Energy and Catalysis

edited by

Sankar Sekar

submission deadline 31 Oct 2025 | Viewed by 7 | Submission Open

Keywords: advanced micro- and nanomaterials for electrochemical applications; electrochemical energy storage; electrocatalysis; photoelectrochemical water splitting; electrochemical sensors; supercapacitor; batteries; nanocomposites and functionalized materials; energy storage and conversion application; natural resources-based materials

(This special issue belongs to the Section Molecular Nanoscience)

Recent Advances in Antitumor Agents from Natural Source

edited by Fábio Ferreira Perazzo

submission deadline 31 Oct 2025 | Viewed by 7 | Submission Open

Keywords: natural products; cancer; medicinal plants; phytochemistry; fermented compounds; isolated compounds; tumor; in vitro; in vivo; clinical trials

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Environmental Stress-Induced Human Diseases

edited by

Silvia Cantara

submission deadline 31 Oct 2025 | Viewed by 6 | Submission Open

Keywords: environmental stress; oxidative stress; inflammation; epigenetic modifications; DNA damage and repair; cellular signaling pathways; mitochondrial dysfunction; autophagy; air pollution; heavy metal toxicity; endocrine disruptors; climate change and health; neurodegeneration; cancer biology; immune system dysregulation; gene– environment interactions; biomarkers of exposure and disease; systems biology; translational research

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

3D Printing in Pharmaceutical Drug Delivery

edited by

Sagar Narala

and

Dinesh Nyavanandi

submission deadline 31 Oct 2025 | Viewed by 6 | Submission Open

Keywords: personalized medication; 3-dimensional printing; solubility and bioavailability enhancement; polymers for 3D printing; bio-inks; 3D-printed implants; additive manufacturing

(This special issue belongs to the Section Molecular Pharmacology)

Gene Therapy Approaches in Haploinsufficiency Disorders

edited by

Paolo Prontera

submission deadline 31 Oct 2025 | Viewed by 4 | Submission Open

Keywords: haploinsufficiency disorders; molecular medicine; gene dosage imbalance; RNA-based therapy; CRISPR activation; transcriptomic regulation; epigenetic modulation; gene therapy; neurodevelopment

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research in Leukemia

edited by Juan Manuel Mejia-Arangure

submission deadline 31 Oct 2025 | Viewed by 4 | Submission Open

Keywords: leukemia; molecular biology; genetic testing; epigenomics; targeted therapy; precision medicine; diagnostic techniques; molecular pathways

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Nano-Biomaterials for Biomedicine and Tissue Regeneration

edited by

Silvia Barbon

and

Elena Stocco

submission deadline 31 Oct 2025 | Viewed by 3 | Submission Open

Keywords: nanostructured biomaterials; cell-scaffold interactions; drug delivery systems; tissue engineering; regenerative medicine

(This special issue belongs to the Section Molecular Nanoscience)

New Trends in Green Synthesis of Nanomaterials

edited by Rocío Redón

submission deadline 31 Oct 2025 | Viewed by 2 | Submission Open

Keywords: nanoparticles; cytotoxicity; drug delivery; nanomaterials; green synthesis

(This special issue belongs to the Section Molecular Nanoscience)

Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment

edited by

Deborah J. Good

submission deadline 10 Nov 2025 | Viewed by 229 | Submission Open

Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Systems Genetics of Metabolic Disorders: From Omics Signatures to Molecular Mechanisms

edited by

Seong-Hee Maria Ko

submission deadline 10 Nov 2025 | Viewed by 13 | Submission Open

Keywords: metabolic syndrome; single-nucleotide polymorphism (SNP); genome-wide association study (GWAS); copy number variation; diet; metabolomics; nutritional genetics; lipid metabolism; omics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Innovative Approaches in Personalized Medicine: Cancer, Inherited Diseases, and Beyond

edited by Julia Hentschel

submission deadline 10 Nov 2025 | Viewed by 4 | Submission Open

Keywords: personalized medicine; hereditary diseases; pharmacogenomics; proteomics; polygenic factors; molecular pathology; therapeutic approaches; biomarkers

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Mechanism Discovery of the Bioactive Phytochemicals Against Different Diseases Based on Network Pharmacology and Molecular Docking, 2nd Edition

edited by

Baojun Xu

submission deadline 15 Nov 2025 | 1 articles | Viewed by 318 | Submission Open

Keywords: molecular mechanism; phytochemicals; network pharmacology; molecular docking; diseases; curing targets; signaling pathway; biological processes

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in the Molecular Biological Effects of Magnetic Fields

edited by

Viacheslav V. Krylov

submission deadline 20 Nov 2025 | 8 articles | Viewed by 20110 | Submission Open

Keywords: magnetoreception magnetoperception alternating magnetic field static magnetic field hypomagnetic field cryptochrome radical-pair mechanism zebrafish Aquatic Species

(This special issue belongs to the Section Molecular Biology)

Cellular and Molecular Progression of Cardiovascular Diseases

edited by

Andrea Borghini

Antonio Rizza

and

Alessandro Tonacci

submission deadline 20 Nov 2025 | 7 articles | Viewed by 13307 | Submission Open

Keywords: cardiovascular diseases; multi-omics data; biomarkers; molecular level; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Pain and Analgesia

edited by

Dong-Ho Youn

and Hee Young Kim

submission deadline 20 Nov 2025 | 3 articles | Viewed by 10788 | Submission Open

Keywords: pain; analgesia; sensory transmission and integration; molecular pathways; pain genes; drug targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Understanding the Mechanisms of Mitochondrial Stress and Its Association with Human Diseases

edited by

Jaeseok Han

submission deadline 20 Nov 2025 | 5 articles | Viewed by 10431 | Submission Open

Keywords: mitochondrial stress; mitochondrial quality control; mitophagy; mitochondrial unfolded protein response; mitochondrial fission and fusion; mitochondria-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Lipid Signaling Molecules

edited by Roberta Ottria

submission deadline 20 Nov 2025 | 4 articles | Viewed by 9828 | Submission Open

Keywords: endocannabinoid hydrolytic enzyme inhibitors; endocannabinoids; oxylipins; eicosanoids; lipid signaling (fatty acid derivatives); protectins; maresins; and resolvins

(This special issue belongs to the Section Molecular Biology)

Diet and Oxidative Stress

edited by

Matteo Becatti

submission deadline 20 Nov 2025 | 3 articles | Viewed by 9091 | Submission Open

Keywords: diet; antioxidants; personalized medicine; oxidative stress; health and disease

(This special issue belongs to the Section Biochemistry)

Drug Treatment for Bacterial Infections

edited by Janusz Madaj

submission deadline 20 Nov 2025 | 6 articles | Viewed by 7652 | Submission Open

Keywords: bacterial infection; antibiotic-resistant bacteria; new agents in the treatment of bacterial infections; optimization of the use of already registered drugs; single antibacterial agents; combined antibacterial agents; new drug forms

(This special issue belongs to the Section Molecular Pharmacology)

Plant Development and Hormonal Signaling

edited by

Naoufal Lakhssassi

submission deadline 20 Nov 2025 | 5 articles | Viewed by 7299 | Submission Open

Keywords: plant growth; reproductive growth; phytohormones; signal transduction; transcription factors; root development; shoot development; floral development; seed development; environmental interactions; regulatory networks; apical dominance

(This special issue belongs to the Section Molecular Plant Sciences)

Advanced Research on Chemokines and Chemokine Receptors

edited by

Bouchra Edderkaoui

submission deadline 20 Nov 2025 | 4 articles | Viewed by 7295 | Submission Open

Keywords: chemokines; chemokine receptors; chronic diseases; angiogenesis; fracture; regeneration; chemokine function; expression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Abnormal Organelles and Protein Expression in Acute and Chronic Neurodegeneration

edited by

Francesco Fornai

submission deadline 20 Nov 2025 | 3 articles | Viewed by 6342 | Submission Open

Keywords: brain ischemia; epileptic damage; basal ganglia pathology; catecholamine cell damage; excitotoxicity; autophagy; dopamine system norepinephrine system; protein unfolding; protein misfolding; cholinergic system

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanism of Circadian Rhythm

edited by Rosângela Vieira de Andrade

submission deadline 20 Nov 2025 | 1 articles | Viewed by 5984 | Submission Open

Keywords: circadian cycle; exercise; aging; clock genes; health

(This special issue belongs to the Section Molecular Biology)

Inflammatory Airway Diseases: Diagnosis, Pathology, Molecular Mechanisms and Treatment Options

edited by

Stefanie Krick

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5940 | Submission Open

Keywords: inflammatory airway diseases; asthma; COPD; anti-inflammatory

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Design and Development for Neurological Diseases

edited by

Alicja Nowaczyk

and

Grzegorz Grześk

submission deadline 20 Nov 2025 | 4 articles | Viewed by 5903 | Submission Open

Keywords: neurological disorders and their therapies; molecular modeling; synthesis and structural analysis; neurotransmitters ligands; mechanism of action; drug repurposing

(This special issue belongs to the Section Molecular Pharmacology)

From Biomolecules to Therapies: Bridging the Gap with Molecular Mechanisms, Computational Design, and Drug Delivery

edited by

Jesús Vicente de Julián-Ortiz

Francisco Torrens

and

Gloria Castellano

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5568 | Submission Open

Keywords: biomolecules; molecular mechanisms; computational studies; drug delivery; xenobiotics

(This special issue belongs to the Section Molecular Informatics)

Exploring the Molecular Mechanisms of Chronic Kidney Disease

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 Nov 2025 | 3 articles | Viewed by 5039 | Submission Open

Keywords: chronic kidney disease; hereditary renal disease; renal hypertension; diabetic nephropathy; secondary hyperparathyroidism; cardiovascular disease; renal osteodystrophy; peritoneal dialysis; hemodialysis; anemia; metabolic acidosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Antimicrobial Nanoparticles

edited by

Tarek Ali Ahmed Ibrahim Alshaal

submission deadline 20 Nov 2025 | 1 articles | Viewed by 4977 | Submission Open

Keywords: nanotechnology; antimicrobial agents; nanoparticle synthesis; biomedical applications; targeted delivery; mechanisms of action

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Insights into Reproductive Biology and Related Diseases

edited by

Alejandro Vicente-Carrillo

submission deadline 20 Nov 2025 | 4 articles | Viewed by 4948 | Submission Open

Keywords: spermatozoa; oocyte; molecular reproduction; infertility

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Exploring Abiotic Stress in Plants: Mechanisms, Adaptations, and Mitigation Strategies

edited by

Tarek Alshaal

submission deadline 20 Nov 2025 | 6 articles | Viewed by 4830 | Submission Open

Keywords: abiotic stress; plant physiology; stress tolerance; crop resilience; molecular mechanisms; biotechnological interventions

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Autophagy in Disease and Cancer

edited by

Antonio Ieni

and

Giovanni Tuccari

submission deadline 20 Nov 2025 | 3 articles | Viewed by 4819 | Submission Open

Keywords: autophagy; autophagy-related proteins; target therapy; cancer; neurodegenerative disease; infections; aging; metabolic disease; autoimmunity

(This special issue belongs to the Section Molecular Biology)

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