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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Neuronal Differentiation: From Pathology to Therapeutic Strategies
edited by
submission deadline 20 Mar 2025 | Viewed by 61 | Submission Open
Keywords: neuronal differentiation; molecular mechanisms of neurodifferentiation; neurodegenerative diseases; ischemic stroke; spinal cord and brain injury; neural tissue recovery; regeneration therapy; stem cells
(This special issue belongs to the Section Molecular Neurobiology)
Plant Resistance to Biotic and Abiotic Stresses
edited by and
submission deadline 20 Mar 2025 | Viewed by 61 | Submission Open
Keywords: biotic stress; abiotic stress; resistance; molecular mechanisms; molecular biology; plant disease; plant pathogens; drought; salinity; extreme temperatures
(This special issue belongs to the Section Molecular Plant Sciences)
Antimicrobial Agents: Synthesis and Design
edited by
submission deadline 20 Mar 2025 | Viewed by 47 | Submission Open
Keywords: multi-drug resistant Gram-negative and Gram-positive pathogens; clinically relevant superbugs; severe and almost untreatable infections; immunocompromised individuals; synthetic antimicrobial cationic macromolecules; synthetic cationic dendrimers; polymers; and copolymers; polymerizing strategies; quaternary ammonium and phosphonium salts; amino-acid modified macromolecules; electrostatic interactions and membrane permeabilization; membrane disruptors; drug delivery systems; cationic bola-amphiphiles
(This special issue belongs to the Section Materials Science)
Design of Bioactive Agents and Interaction with Biological Systems
edited by
submission deadline 20 Mar 2025 | Viewed by 40 | Submission Open
Keywords: natural and synthetic compounds; bioactive agents and materials; design and discovery; targeting; intermolecular interactions; omics; structure and dynamics of biomolecules; theoretical analysis of biomolecular structures; analytical and biophysical methods; molecular biology/biochemistry; chemical biology/biological chemistry
(This special issue belongs to the Section Molecular Biology)
The Molecular Role of Platelets in Human Diseases submission deadline 20 Mar 2025 | Viewed by 35 | Submission Open
Keywords: platelet; biomarkers; platelet membrane proteins; platelet-derived microparticles; platelet-related diseases; thrombosis; inflammatory diseases; cardiovascular disease; cancer; tumor growth and metastasis
(This special issue belongs to the Section Molecular Biology)
Recent Progress in Advanced Computing Techniques for Molecules and Nanomaterials
edited by
submission deadline 20 Mar 2025 | Viewed by 27 | Submission Open
Keywords: nanomaterials; machine learning; artificial intelligence; computing techniques; modeling; energy storage; catalysis
(This special issue belongs to the Section Molecular Nanoscience)
Advances in Bioactive Peptides: Mechanisms of Action and Biosynthesis
edited by and
submission deadline 20 Mar 2025 | Viewed by 27 | Submission Open
Keywords: mechanisms of action; biosynthesis; bioactive peptides (BAPs); innate immunity; synthetic peptides; therapeutic applications; antimicrobial peptides (AMPs)
(This special issue belongs to the Section Biochemistry)
Potential Health Benefits of Resveratrol: Laboratory-Confirmed Mechanisms of Action
edited by
submission deadline 20 Mar 2025 | Viewed by 22 | Submission Open
Keywords: resveratrol; polyphenol; phytoalexin; phytoestrogen; natural compound; reactive oxygen species; antioxidant effects; anti-inflammatory effects; antiaging properties; antidiabetic properties; cardioprotective effects; neuroprotective effects; anticancer properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Advances in Endometrial Cancer
edited by Ursula Catena
submission deadline 20 Mar 2025 | Viewed by 20 | Submission Open
Keywords: endometrial cancer; risk factors; early detection; molecular profiling; targeted therapy; immunotherapy; surgical management; fertility-sparing treatment; quality of life
(This special issue belongs to the Section Molecular Oncology)
Molecular Research Progress of Skin and Skin Diseases: 2nd Edition
edited by
submission deadline 20 Mar 2025 | Viewed by 16 | Submission Open
Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Anti-Inflammatory Strategies and Cell Models for Alzheimer’s Disease
edited by Sophia Lavrentiadou
submission deadline 20 Mar 2025 | Viewed by 14 | Submission Open
Keywords: Alzheimer’ s disease; neuroinflammation; anti-inflammatory strategies; cell models
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition submission deadline 20 Mar 2025 | Viewed by 11 | Submission Open
Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations
(This special issue belongs to the Section Molecular Oncology)
Innovative Delivery Technologies for Nucleic Acid Therapeutics: From In Vitro to In Vivo Applications
edited by Karim Daliri
submission deadline 20 Mar 2025 | Viewed by 7 | Submission Open
Keywords: nucleic acid therapeutics; nucleic acid delivery; mRNA; siRNA; ASOs; plasmid DNA; CRISPR/Cas9
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Research on Plant Bioactive Compounds submission deadline 25 Mar 2025 | Viewed by 242 | Submission Open
Keywords: plant bioactive compounds; extraction and analysis of plant bioactive compounds; bioactivity and pharmacokinetics of plant compounds; natural products and modern diseases; plant bioactive compounds and by-products; discovery and development of natural plant drugs
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Blood Cells in Human Health and Disease
edited by Leonid Livshits
submission deadline 25 Mar 2025 | Viewed by 105 | Submission Open
Keywords: red blood cell; RBC membrane; RBC biophysical properties; RBC rheology; RBC mechanical properties; RBC membrane vesiculation; RBC clearance; RBC in diabetes; hemoglobinopathies; RBC storage TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Biochemistry)
Big Data in Multi-Omics submission deadline 25 Mar 2025 | Viewed by 98 | Submission Open
Keywords: data science; big data; omics; data management; data analytics TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in Shona   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate Shona to Simplified Chinese Never translate Shona Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Informatics)
Navigating Lung Cancer in the Era of Cancer Pharmacology and Precision Therapy
edited by
submission deadline 25 Mar 2025 | Viewed by 94 | Submission Open
Keywords: lung cancer; pharmacology; precision therapy; targeted therapy; immunotherapy; biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases
edited by , and
submission deadline 25 Mar 2025 | Viewed by 73 | Submission Open
Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biological Pathways and Nutraceutical Compounds in Genetic Disease Treatment
edited by
submission deadline 25 Mar 2025 | Viewed by 69 | Submission Open
Keywords: micronutrients; supplements; functional foods; inherited disease; microbiome; RNA expression; protein expression; signaling pathways; DNA methylation; animal models; cell lines; clinical trials
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular and Physiological Mechanisms of Exercise
edited by Zoran Nikolovski
submission deadline 25 Mar 2025 | Viewed by 65 | Submission Open
Keywords: molecular biology; biochemistry and exercise; athletic performance; multi-omic
(This special issue belongs to the Section Molecular Biology)
Innovative Biological Molecules for Cancer Therapy
edited by
submission deadline 25 Mar 2025 | Viewed by 37 | Submission Open
Keywords: cancer treatment; immunotherapy; biological therapy; natural products; active molecule; biological peptide; antibody; nucleic acid; pharmacology
(This special issue belongs to the Section Molecular Biology)
Roles and Mechanisms of Non-Coding RNAs in Breast Cancer
edited by
submission deadline 25 Mar 2025 | Viewed by 25 | Submission Open
Keywords: breast cancer; NcRNA; MmiRNA; LncRNA; CircRNA; PiRNA; exosome-packed ncRNA; role and mechanisms of ncRNA in breast cancer tissue or cell lines; modulation of ncRNA levels by knock-out or knock-down approaches; effects on breast cancer cell proliferation; invasion; or apoptosis; identification of BC-relevant ncRNA– mRNA networks; targeting ncRNAs with potential clinical implications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Biomarkers of Lung Disorders
edited by Alexandru Caraba and Diana Manolescu
submission deadline 25 Mar 2025 | Viewed by 6 | Submission Open
Keywords: biomarkers; thoracic ultrasonography; pulmonary high resolution computed tomography; COPD; asthma; pneumonia; pulmonary hypertension; interstitial lung diseases; lung cancer; collagen vascular diseases; cardiac failure
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Computer Analysis for Molecular Pathological Research
edited by
submission deadline 26 Mar 2025 | Viewed by 18 | Submission Open
Keywords: machine learning; artifical intelligence; large language models; pathology; digital pathology; multimodal learning
(This special issue belongs to the Section Molecular Informatics)
The Impact of Mitochondria on Human Disease and Health
edited by
submission deadline 27 Mar 2025 | Viewed by 18 | Submission Open
Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer
(This special issue belongs to the Section Biochemistry)
Anti-Inflammatory and Metabolic Effects of G Protein-Coupled Receptor Signaling
edited by
submission deadline 28 Mar 2025 | Viewed by 64 | Submission Open
Keywords: G protein-coupled receptors (GPCRs); seven transmembrane domain (7TM) receptors; metabotropic receptors; membrane receptors; GPCRs signaling; GPCRs signaling pathways; anti-inflammatory effects; inflammatory diseases; metabolic diseases; metabolic effects; anti-inflammatory treatment
(This special issue belongs to the Section Molecular Immunology)
Application of Genetic Engineering in Treatments for Human Diseases
edited by Claudio Mussolino
submission deadline 28 Mar 2025 | Viewed by 25 | Submission Open
Keywords: genome editing; epigenome editing; CRISPR-Cas systems; gene therapy; precision medicine; molecular mechanisms; innovative therapies; gene expression regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Research on Signal Transduction Mechanisms of Cancer Cells
edited by
submission deadline 28 Mar 2025 | Viewed by 10 | Submission Open
Keywords: signal transduction mechanisms; cancer cell invasion; cancer cell metastasis; tumorigenesis; cell proliferation
(This special issue belongs to the Section Molecular Oncology)
Trace Elements, Metal Ions, Channels and Transporters in Metabolism
edited by
submission deadline 28 Mar 2025 | Viewed by 4 | Submission Open
Keywords: cancer; cardiac dysfunction; enzyme function; metabolism; metal ions; neurologic disorders; pathophysiology; trace elements
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Research on Type 1 Diabetes and Its Complications: 2nd Edition submission deadline 29 Mar 2025 | Viewed by 13 | Submission Open
Keywords: type 1 diabetes mellitus; diabetic microangiopathy; diabetic macroangiopathy; continuous glucose monitoring; experimental diabetic models; biomarkers; endothelium dysfunction; diabetes-related diseases; comorbidities; pregnancy; pathophysiology; metabolic syndrome; treatment; precision medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Role of Natural Products in Non-alcoholic Fatty Liver Disease submission deadline 30 Mar 2025 | 2 articles | Viewed by 4022 | Submission Open
Keywords: fatty liver; steatosis; steatohepatitis; hepatocarcinoma; non-alcoholic fatty liver disease; inflammation; fibrosis; oxidative stress; liver injury; active biomolecules; natural products; food; precision nutrition
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Cytochrome P450: Metabolism, Structure-Function, Evolution and Applications submission deadline 30 Mar 2025 | 1 articles | Viewed by 1638 | Submission Open
Keywords: cytochrome P450 monooxygenase; metabolism; structure-function; evolution; applications
(This special issue belongs to the Section Biochemistry)
Clinical and Biological Perspectives on Apoptosis
edited by Syed Qadri, Rosi Bissinger and
submission deadline 30 Mar 2025 | 1 articles | Viewed by 1078 | Submission Open
Keywords: erythrocytes; apoptosis; eryptosis; anemia; systemic diseases
(This special issue belongs to the Section Molecular Biology)
Survival of the Fittest: Physiological Adaptations of Insects in Hostile Environments submission deadline 30 Mar 2025 | Viewed by 78 | Submission Open
Keywords: insect adaptation; temperature tolerance; insect physiology; detoxification; symbiosis and stress tolerance mechanisms
(This special issue belongs to the Section Molecular Biology)
T Cells in Immune Diseases: Regulation and Function
edited by Chia-Rui Shen
submission deadline 30 Mar 2025 | Viewed by 41 | Submission Open
Keywords: T cell function; T cells in immune diseases; regulation and function
(This special issue belongs to the Section Molecular Immunology)
Interactions of Plants with Bacteria and Fungi submission deadline 30 Mar 2025 | Viewed by 33 | Submission Open
Keywords: plant– pathogen interaction; plant protection; multidisciplinary approaches; environmental sustainability; pathogen evolution; food security; plant health
(This special issue belongs to the Section Molecular Plant Sciences)
Plant Molecular Breeding and Resistance: Phenomics, Genomics and Gene Editing—Second Edition
edited by
submission deadline 30 Mar 2025 | Viewed by 31 | Submission Open
Keywords: plant; molecular breeding; plant resistance; plant abiotic stress; plant biotic stress; throughput phenotyping; plant phenomics; plant phenomics; plant genetics; genetic variation; gene editing; CRISPR/Cas9; plant computational modeling
(This special issue belongs to the Section Molecular Plant Sciences)
Research in Novel Immune Adjuvants
edited by Bei Li
submission deadline 30 Mar 2025 | Viewed by 31 | Submission Open
Keywords: adjuvants; vaccine; immunology; toxicology; biology
(This special issue belongs to the Section Molecular Immunology)
Pathogenesis and Treatment of Prostate Cancer submission deadline 30 Mar 2025 | Viewed by 29 | Submission Open
Keywords: prostate cancer; pathogenesis; genetic mutations; target therapy; surgery; radiation therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Radiation-Induced DNA Damage and Toxicity submission deadline 30 Mar 2025 | Viewed by 28 | Submission Open
Keywords: radiation; DNA damage; toxicity; immune response
(This special issue belongs to the Section Molecular Biology)
Design, Synthesis and Biological Activity of Heterocyclic Compounds submission deadline 30 Mar 2025 | Viewed by 26 | Submission Open
Keywords: synthesis of new bioactive compounds; biological activity of heterocyclic compounds; structural analysis; pharmacokinetic analysis of potential drugs; molecular docking study of new heterocyclic compounds
(This special issue belongs to the Section Biochemistry)
Molecular Insights and Innovations in Brain Cancer Research
edited by Vinay K. Sharma
submission deadline 30 Mar 2025 | Viewed by 26 | Submission Open
Keywords: glioblastomas; astrocytomas; brain tumors; targeted therapies; immunotherapy; tumor microenvironment
(This special issue belongs to the Section Molecular Oncology)
Respiration and Photosynthetic Function in Plants
edited by
submission deadline 30 Mar 2025 | Viewed by 23 | Submission Open
Keywords: photosynthesis; day and dark respiration; photorespiration; water relations; metabolism; partitioning; carbon budget; nutrients; isotopes; allocation; phloem; gas exchange
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Neuroinflammation and Brain Aging
edited by
submission deadline 30 Mar 2025 | Viewed by 22 | Submission Open
Keywords: neurotoxicology; aging; Alzheimer's disease
(This special issue belongs to the Section Molecular Toxicology)
Molecular Structure, Function and Application of Graphene Materials submission deadline 30 Mar 2025 | Viewed by 22 | Submission Open
Keywords: graphene functionalization; 2D materials; vdW heterostructures; graphene properties; graphene structure
(This special issue belongs to the Section Molecular Nanoscience)
Heart Failure and Cardiac Remodeling: Molecular Mechanisms and Therapeutic Strategies
edited by
submission deadline 30 Mar 2025 | Viewed by 22 | Submission Open
Keywords: heart failure; cardiac remodeling; molecular mechanisms; therapeutic strategies; cardiomyopathy; biomarkers; gene therapy; regenerative medicine; pharmacology; inflammation; fibrosis; signal transduction
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Plant Genomics and Genetics: 2nd Edition
edited by
submission deadline 30 Mar 2025 | Viewed by 21 | Submission Open
Keywords: plant genomics; plant genetics; abiotic stresses; salt resistance; genome; next-generation sequencing
(This special issue belongs to the Section Molecular Genetics and Genomics)
Functional Microbiomes and the Organization of Marine Communities: Molecular Biological Insights
edited by
submission deadline 30 Mar 2025 | Viewed by 20 | Submission Open
Keywords: marine communities; functional microbiomes; exoenzymes; chemical communication; organization of complex ecosystems
(This special issue belongs to the Section Molecular Microbiology)
Genetic Prediction of Risk of Common Diseases
edited by
submission deadline 30 Mar 2025 | Viewed by 20 | Submission Open
Keywords: complex genetic diseases; cancer; heart disease; diabetes; dementia; polygenic risk score; genetic risk signatures
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Advances in Functional Products for Health Prevention and Promotion
edited by
submission deadline 30 Mar 2025 | Viewed by 17 | Submission Open
Keywords: functional foods; food fortification; biofortification; bioactive food ingredients; human nutrition; nutrition and immunity; health prevention; chronic non-communicable diseases; epigenetics
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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