Atherosclerosis and Comorbidities: From Molecular Pathogenesis to Diagnosis and Therapeutic Targets
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 31
Special Issue Editors
Interests: atherosclerosis; lipidology; inflammation; arterial stiffness; peripheral arterial disease; COVID-19
Interests: atherosclerosis; acute and chronic heart failure; toxicology; metabolic syndrome
Special Issue Information
Dear Colleagues,
Atherosclerosis is the leading cause of cardiovascular disease, accounting for the majority of morbidity and mortality worldwide. Its development is driven by several risk factors, including smoking, dyslipidemia, inflammation, diabetes mellitus, obesity, metabolic dysfunction-associated fatty liver disease, arterial hypertension, chronic kidney disease, cancer therapies, and genetic factors. These determinants warrant attention not only as contributors to disease progression but also as potential therapeutic targets. Despite lipid-lowering therapies having reached a milestone in lowering low-density lipoprotein (LDL) cholesterol, new therapeutic agents have demonstrated efficacy in lowering lipoprotein (a) and triglyceride levels. There is growing interest in drugs targeting inflammatory pathways, with colchicine exhibiting beneficial effects in patients with chronic coronary syndromes. However, the effect of novel anti-inflammatory drugs on attenuating atherosclerotic burden and events is still being investigated. With obesity reaching pandemic levels, glucagon-like peptide-1 receptor agonists have been proven to reduce body weight and cardiovascular events. Similarly, sodium-glucose co-transporter 2 inhibitors decrease cardiovascular events in patients with chronic kidney disease. Due to the ongoing advances in the treatment of both atherosclerosis and atherosclerosis-related comorbidities, we are launching a Special Issue on this topic. We welcome original studies and reviews addressing the molecular pathogenesis, diagnosis, or therapeutic targets of atherosclerosis in the context of various comorbidities.
Dr. Alexandr Ceasovschih
Prof. Dr. Victoriţa Şorodoc
Dr. Yusuf Ziya Şener
Guest Editors
Manuscript Submission Information
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Keywords
- atherosclerosis
- comorbidities
- lipidology
- inflammation
- obesity
- arterial stiffness
- vascular remodeling
- cardiovascular risk
- cardiovascular diseases
- targeted therapies
- lifestyle
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