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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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In Silico Approaches to Unravelling Toxicity Mechanisms in Molecular Drugs

edited by

Yoshihiro Uesawa

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: cheminformatics; in silico analysis; QSAR; toxicity prediction; machine learning; toxicity mechanisms; omics data integration; toxicity biomarkers; artificial intelligence; adverse event database

(This special issue belongs to the Section Molecular Pharmacology)

Plant Extracts: Molecular Insights and Functional Potential

edited by Abdelaziz Yasri

submission deadline 30 Nov 2025 | Viewed by 36 | Submission Open

Keywords: plant extract; phytochemistry; plant secondary metabolites; plant extraction techniques; product valorization

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Tau Protein Research

edited by

Taxiarchis Katsinelos

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: tau biology; disease model systems; protein aggregation; tauopathies; neurodegeneration; Alzheimer’ s disase; seeded aggregation; amyloid filaments; tau propagation; antibodies; targeted protein degradation; tau therapeutics

(This special issue belongs to the Section Molecular Biology)

Sarcomas: From Molecular Signatures to Morphologic Patterns

edited by

Isidro Machado

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: sarcomas; histopathology; molecular pathology; FISH; gene fusion in sarcomas

(This special issue belongs to the Section Molecular Oncology)

Molecular Pathophysiology of Chronic Lung Diseases: Mechanisms and Therapeutics

edited by Gary C. Mouradian

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: chronic lung disease; vagal sensory neurons; inflammation; airway remodeling; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Venom and Antivenom

edited by

Vance G. Nielsen

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: venom; antivenom; mass spectroscopy; spectrophotometry; thromboelastography; coagulation; neuromuscular junction

(This special issue belongs to the Section Molecular Toxicology)

Advances in Fluorescent Sensors

edited by

Levente Cseri

and

Ervin Kovács

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: fluorescence probe; fluorescent nanomaterials; analyte recognition; fluorescence imaging; real-time monitoring; photoinduced electron transfer; Fö rster resonance energy transfer; genetically encoded indicators; sensor devices; fluorescence microscopy

(This special issue belongs to the Section Materials Science)

Neurobiology and Psychopharmacology of Mood Disorders

edited by

Luca Steardo

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: mood disorders; psychopharmacology; neurobiology; molecular mechanisms; biomarkers; translational psychiatry; neuroinflammation; signal transduction; animal models; epigenetics

(This special issue belongs to the Section Molecular Neurobiology)

Pathogenesis and Treatments of Head and Neck Cancer: 2nd Edition

edited by

Marko Tarle

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: HNSCC; premalignant changes; tumor microenvironment; molecular biomarkers; targeted therapy; oral tumorigenesis; molecular pathogenesis; tumor biology; tumor immunology

(This special issue belongs to the Section Molecular Oncology)

Viral Infections: Molecular, Cellular, and Systems Perspectives

edited by Arnaldo Caruso and

Francesca Caccuri

submission deadline 30 Nov 2025 | Viewed by 35 | Submission Open

Keywords: virus– host interaction; epidemiology; evolution; innate immunity; computational modeling

(This special issue belongs to the Section Molecular Microbiology)

Natural Product Therapies in Cancer

edited by

Domenica Mangieri

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: natural compounds; phytochemicals; flavonoids; alkaloids; metastasis; epithelial– mesenchymal transition; cancer cell invasion; cell cycle; programmed cell death; signaling pathways

(This special issue belongs to the Section Molecular Pharmacology)

Latest Research in Neuroinflammation

edited by Reza Khorooshi

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: neuroinflammation; central nervous system disorders; neuroimmune interactions; inflammation and neurodegeneration; therapeutic strategies in neurology

(This special issue belongs to the Section Molecular Neurobiology)

Integrative Approaches to Musculoskeletal Disorders Using Natural Products

edited by

Jae-Hyun Kim

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: natural products; bone metabolism; sarcopenia; osteoporosis; herbal medicine; osteo-sarcopenic obesity; bone– muscle crosstalk; low-molecular-weight compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Understanding and Combating Antimicrobial Resistance: Molecular Insights and Innovative Approaches

edited by

Giovanni Di Bonaventura

submission deadline 30 Nov 2025 | Viewed by 34 | Submission Open

Keywords: genetic mutations; horizontal gene transfer; efflux pump mechanisms; biofilm formation; novel antibiotic development; antimicrobial peptides; phage therapy; CRISPR-based tools; antimicrobial stewardship programs

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Nanotechnology for Natural Products

edited by

Carmen Lizette Del Toro Sánchez

submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open

Keywords: molecular nanotechnology; natural products; bioactive compounds; nanocarriers; targeted delivery; encapsulation; bioavailability; pharmacological applications; food applications; biomedical nanotechnology

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nutrition in Neurodegenerative Diseases: Molecular Perspectives

edited by

Vittorio Emanuele Bianchi

submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open

Keywords: nutrition; neurodegenerative disease; phenols; B vitamins; alpha-tocotrienol; dietary factors; intestinal microbiota; central nervous system

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases

edited by

Eiko Nakamaru-Ogiso

submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open

Keywords: mitochondrial dysfunction; oxidative stress; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms in Cardiovascular Disease Progression

edited by Ying-Hsi Lin

submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open

Keywords: cardiovascular disease progression; molecular mechanisms; inflammation; signal transduction; transcriptional and epigenetic regulation; mitochondrial dysfunction; sarcomeric remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Targeting Epigenetic Complexes and Alternative Protein Degradation Pathways in Medicinal Chemistry

edited by Jean Leandro Dos Santos

submission deadline 30 Nov 2025 | Viewed by 33 | Submission Open

Keywords: protein degradation; LYTAC; AUTAC; ATTEC; epigenetics; NuRD; HDAC; BRD; SWI/SNF; PRC2; chromatin; conjugates; lysosome; autophagy; drug discovery

(This special issue belongs to the Section Biochemistry)

Molecular Informatics and AI in Cancer Research

edited by

Nabil Adam

and

Robert Wieder

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: molecular informatics; artificial intelligence (AI); cancer research; personalized medicine; high-throughput data; biomarkers; clinical applications; longitudinal data

(This special issue belongs to the Section Molecular Informatics)

Current Treatment Models in Hepatocellular Carcinomas

edited by

Michał P. Wasilewicz

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: hepatocellular carcinoma (HCC); liver tumors; liver cancer; molecular mechanisms; systemic therapies; immunochemotherapy; immunotherapy; adjuvant therapy; neoadjuvant therapy; hepatocellular carcinoma microenvironment; liver resection/liver transplantation in HCC; microwave ablation (MWA); transarterial chemoembolisation (TACE)

(This special issue belongs to the Section Molecular Oncology)

Diversity in Structure, Function, and Regulation of Calcium-Permeable Channels

edited by

Lucie Parent

submission deadline 30 Nov 2025 | Viewed by 32 | Submission Open

Keywords: calcium-permeable channels in health and disease; calcium-permeable channels in calcium cycling; TRP channels; voltage-gated calcium channels; STIM / Orai complexes; intracellular IP3 calcium channels; intracellular RyR calcium channels; posttranslational calcium channel modifications; calcium-permeable channel inhibitors; calcium-permeable channel biophysics; calcium-permeable channel evolution

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Pathology and Treatment of Oral Diseases

edited by

Paolo Boffano

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: odontogenic tumor; odontogenic cyst; oral pathology; oral cancer; molecular

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Evolution and Genetic Diversity in Viruses

edited by

Jennifer H. Lun

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: viral mutation; recombination reassortment; viral genomics; quasispecies dynamics; antiviral resistance; viral phylogenetics; zoonotic transmission; genomic surveillance

(This special issue belongs to the Section Molecular Microbiology)

Molecular Pathology of the Placenta in Pregnancy Complications

edited by

Zoltan Kozinszky

and

Andrea Suranyi

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: pregnancy complications; placental histology; biomarker; trophoblast invasion; molecular diagnostics and therapeutics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Kidney Disease: Molecular Insights and Emerging Therapies

edited by

Yaochun Zhang

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: kidney disease; molecular mechanism; precision medicine; translational nephrology; targeted molecular therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Immunity and Autoimmunity in Cardiovascular and Respiratory Diseases

edited by

Mizanur Rahman

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: cardiovascular diseases; respiratory diseases; autoimmune diseases; T cell; B cell; lipid mediators; autoantibodies; genetic variants; mucin

(This special issue belongs to the Section Molecular Immunology)

Toxicology Research: Understanding and Predicting Compound-Induced Toxicity

edited by

Miriam Beatríz Virgolini

submission deadline 30 Nov 2025 | Viewed by 31 | Submission Open

Keywords: toxicity; adverse-outcome pathway; metals; pesticides; drugs of abuse; pharmaceuticals

(This special issue belongs to the Section Molecular Toxicology)

T Cell Malignancies: Translating Basic Research into Better Therapy

edited by

Grzegorz Przybylski

submission deadline 30 Nov 2025 | Viewed by 30 | Submission Open

Keywords: T-Cell malignancies; specific target antigens; gene-targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Functional Genomics and Computational Biology of Horticultural Plants

edited by

Claudio Pugliesi

submission deadline 30 Nov 2025 | Viewed by 30 | Submission Open

Keywords: transcriptomics; computational model; genome editing; GWAS; multi-omics; NGS technologies; MAS; genomic selection; mutagenesis; RNA-silencing

(This special issue belongs to the Section Molecular Plant Sciences)

Enhancing Stem Cell Grafting in Tissue Regeneration and Repair

edited by

Yuanyuan Zhang

submission deadline 30 Nov 2025 | Viewed by 29 | Submission Open

Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Advancements in Cardiovascular Health Research: Investigating Novel Biomaterials, Cellular Responses, and Therapeutic

edited by Magdalena Wawrzyńska

submission deadline 30 Nov 2025 | Viewed by 29 | Submission Open

Keywords: cardiovascular biomaterials; nanomaterials; surface coatings; drug delivery systems; polymers; biocompatibility; hemocompatibility; molecular response

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Serotonin

edited by Joachim Neumann

submission deadline 30 Nov 2025 | Viewed by 29 | Submission Open

Keywords: serotonin; serotonin receptors; migraine; depression; hypertension; heart failure; arrhythmias

(This special issue belongs to the Section Molecular Biology)

Computational Approaches in Biomedicine: Innovations and Insights

edited by

Carlos Leon

submission deadline 30 Nov 2025 | Viewed by 29 | Submission Open

Keywords: computational biomedicine; artificial intelligence; machine learning; omic technologies; system biology; medical imaging; structural biology; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Structure and Function of Subcellular Organelle and Protein-Membrane Systems

edited by

Chikara Sato

submission deadline 30 Nov 2025 | Viewed by 29 | Submission Open

Keywords: immuno-electron microscopy; cell signaling; comparative anatomy; diagnosis; molecular recognition; molecular complexes; electro-chemistry; liquid-phase synthesis; metal sedimentation; membrane endoskeleton

(This special issue belongs to the Section Molecular Biophysics)

Advances in Traits in Animals and Aquatic Species, and Their Improvement Technologies

edited by

Lishi Yang

submission deadline 30 Nov 2025 | Viewed by 29 | Submission Open

Keywords: biotechnology; genetic breeding; stress responses; epigenetics; non-coding RNAs; gene regulation; molecular ecology; animals; aquaculture; development

(This special issue belongs to the Section Molecular Biology)

Recent Advances in the Structure, Biological Activity and Structure–Activity Relationship of Polysaccharides

edited by

Natalia Nowacka-Jechalke

and

Marta Kinga Lemieszek

submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open

Keywords: natural polysaccharides; phytochemicals; nutraceuticals; structure– activity relationship; anticancer potential; immunomodulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Oncogenes and Tumor Suppressors: From Basic Science to Therapeutic Applications

edited by

Ariel Fernando Castro

submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open

Keywords: oncogenes; tumor suppressors; cancer biology; molecular mechanisms; tumor microenvironment; biomarkers; targeted cancer therapy; cancer initiation and progression

(This special issue belongs to the Section Molecular Oncology)

Role of DNA Methylation Signatures in Genetic Disorders

edited by

Jair Tenorio-Castano

submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open

Keywords: DNA methylation; genetic disorders; episignature; genomic medicine; differentially methylated regions

(This special issue belongs to the Section Molecular Genetics and Genomics)

Natural Product as Therapeutic Agent: From Molecular Targets to Cellular and Functional Modulation

edited by Su-Yun Lyu

submission deadline 30 Nov 2025 | Viewed by 28 | Submission Open

Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lectins: Structural Diversity, Molecular Recognition and Emerging Applications

edited by

Patrícia Maria Guedes Paiva

submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open

Keywords: lectins; structural diversity; molecular recognition; bioactivities; biomedical applications

(This special issue belongs to the Section Biochemistry)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 30 Nov 2025 | Viewed by 27 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Advancements in Regenerative Medicine Research

edited by

Rosa V. Ventrella

submission deadline 30 Nov 2025 | Viewed by 26 | Submission Open

Keywords: regenerative medicine; tissue repair; wound healing; stem cells; cell differentiation; cell signalling; gene regulation; mechanotransduction; precision medicine

(This special issue belongs to the Section Molecular Biology)

Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures

edited by Hedwig Sutterluety-Fall

submission deadline 30 Nov 2025 | Viewed by 26 | Submission Open

Keywords: proliferation; signaling; two-dimensional; three-dimensional; cell culturing; in vitro; growth factors

(This special issue belongs to the Section Molecular Biology)

Ion Regulation in Human Pathophysiology

edited by

Lars Kaestner

submission deadline 30 Nov 2025 | Viewed by 26 | Submission Open

Keywords: ion channels; ion gradients; membrane potential; action potential; ion pumps; uniporter; co-transporter; patch-clamp; ion flux; concentration gradient; ion stores; physiological processes; pathophysiological processes

(This special issue belongs to the Section Molecular Biology)

Exploring Recent Research on Natural Compounds: From Biosynthesis to Application

edited by

Nitin Mantri

submission deadline 30 Nov 2025 | Viewed by 26 | Submission Open

Keywords: proteins like antibodies and enzymes; small molecules; plant extracts; biosynthesis; nanodelivery; drug discovery

(This special issue belongs to the Section Biochemistry)

Oral Stem Cells: Molecular Characteristics and the Applications in Regenerative Medicine

edited by

Emi Shimizu

and

Motoki Okamoto

submission deadline 30 Nov 2025 | Viewed by 25 | Submission Open

Keywords: oral stem cells; regenerative medicine; molecular mechanisms; stem cell therapy; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Monovalent Ion-Exchange Membranes for Various Applications

edited by Noor ul Afsar

submission deadline 30 Nov 2025 | Viewed by 25 | Submission Open

Keywords: molecular design; ion-exchange membranes; membrane-based separations; energy and resource recovery

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Aspects of Viral Pathogenesis: From Infection to Host Response

edited by

Quang Duy Trinh

submission deadline 30 Nov 2025 | Viewed by 24 | Submission Open

Keywords: viruses; viral pathogenesis; virus– host interaction; molecular virology; immunity; viral entry; viral replication; emerging viruses; infectious diseases; inflammation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insights in Renal and Epithelial Physiology

edited by Pedro A. Jose

submission deadline 30 Nov 2025 | Viewed by 24 | Submission Open

Keywords: renal and epithelial physiology; ion transport; glomerulo-tubular balance

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2601-2650 on page 53 of 70.

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