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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hydrogels and Nanogels: Revolutionizing Drug Delivery and Disease Detection

edited by Enrico Gallo

submission deadline 30 Sep 2025 | Viewed by 28 | Submission Open

Keywords: hydrogel and nanogel networks; supramolecular systems; hydrogel synthesis and analysis; nanogel preparation and characterization; nanostructured fibers; multiphase gels; biomedicine applications; supramolecular probes for imaging; hydrogels and nanogels as drug release systems; coatings and surface treatments; polymeric systems; peptide-based supramolecular systems

(This special issue belongs to the Section Materials Science)

Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition

edited by

Orsolya Kapuy

and

Beáta Lizák

submission deadline 30 Sep 2025 | Viewed by 28 | Submission Open

Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress

(This special issue belongs to the Section Biochemistry)

Advances in Plant–Pathogen Interactions (4th Edition)

edited by

Fucheng Lin

submission deadline 30 Sep 2025 | Viewed by 27 | Submission Open

Keywords: host; effection; pathogenicity; pathogen; plant immunity; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathogenesis and Therapeutic Innovations in Oral Diseases

edited by Tatsuji Nishihara

submission deadline 30 Sep 2025 | Viewed by 27 | Submission Open

Keywords: molecular-based analysis; diagnosis of oral disease; oral disease treatment; regeneration therapy; drug therapy; periodontitis; implantitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Serum Amyloid A: Established Roles and Emerging Questions in Health and Disease

edited by Preetha Shridas

submission deadline 30 Sep 2025 | Viewed by 27 | Submission Open

Keywords: Serum Amyloid A; high-density lipoprotein; acute inflammation; chronic inflammatory

(This special issue belongs to the Section Biochemistry)

Roles of Exosomes in Health and Disease

edited by

Paulo Pereira

submission deadline 30 Sep 2025 | Viewed by 27 | Submission Open

Keywords: exosomes; extracellular vesicles; intercellular communication; diagnostics; therapeutics; disease; biomarkers; cellular biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cyclodextrins: Properties and Applications, 3rd Edition

edited by

Miguel A. Esteso

and

Carmen M. Romero

submission deadline 30 Sep 2025 | Viewed by 27 | Submission Open

Keywords: cyclodextrins; controlled release systems; structure modification; thermodynamic properties; transport properties

(This special issue belongs to the Section Macromolecules)

Autosomal Dominant Polycystic Kidney Disease (ADPKD): Molecular Mechanism, Management and Therapy

edited by

Maria Teresa Sciarrone Alibrandi

submission deadline 30 Sep 2025 | Viewed by 27 | Submission Open

Keywords: autosomal dominant polycystic kidney disease; ADPKD progression; cystic kidney disease; cardiovascular complications in ADPKD; biomarkers of ADPKD; genetics of polycystic kidney disease; renal imaging; targeted therapies in ADPKD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Modeling of Protein Targets & Therapeutic Molecules

edited by

Whelton Miller

submission deadline 30 Sep 2025 | Viewed by 26 | Submission Open

Keywords: biophysics; chemistry; drug discovery; computer-aided drug design; protein target

(This special issue belongs to the Section Molecular Informatics)

New Developments in Chronic Myeloid Leukemia

edited by

Parviz Kokhaei

submission deadline 30 Sep 2025 | Viewed by 26 | Submission Open

Keywords: CML; small molecule inhibitors; biologicall treatment; prognostic markers

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights on Myogenic Progenitors: Regulation of Differentiation

edited by

James M. Holaska

submission deadline 30 Sep 2025 | Viewed by 26 | Submission Open

Keywords: myogenic progenitors; skeletal muscle; muscle regeneration; myogenesis

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Urological Cancer

edited by Andrea Zivi and Sara Merler

submission deadline 30 Sep 2025 | Viewed by 25 | Submission Open

Keywords: genitourinary oncology; urologic surgery; urologic radiotherapy innovations; translational research; emerging therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Studies in Gynecological Oncology: Advancing Diagnosis and Treatment

edited by

Ivonne Nel

submission deadline 30 Sep 2025 | Viewed by 25 | Submission Open

Keywords: biomarker; cancer screening; clinical trial; DNA repair; invasion; metastasis; methylation; molecular diagnostics; molecular tumor pathology; next-generation sequencing; omics; personalized medicine; prognosis; single-cell analysis; targeted therapy; translational cancer research; treatment response; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Oral Microbiota in Health and Disease: Novel Insights and Therapeutic Approaches

edited by

Biagio Rapone

submission deadline 30 Sep 2025 | Viewed by 25 | Submission Open

Keywords: oral microbiome; periodontal health and disease; host-microbiome interactions; oral pathogens; antimicrobial strategies; probiotics; prebiotics; postbiotics; ioactive metabolites; immunocompromised

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Calcium Homeostasis of Cells in Health and Disease: Third Edition

edited by

Péter Szentesi

and

László Csernoch

submission deadline 30 Sep 2025 | Viewed by 24 | Submission Open

Keywords: Ca2+; calcium homeostasis; calcium-binding proteins; aging; disease

(This special issue belongs to the Section Biochemistry)

New Insights into Adipose Tissue Metabolic Function and Dysfunction, 4th Edition

edited by

Federica Mannino

submission deadline 30 Sep 2025 | Viewed by 23 | Submission Open

Keywords: inflammation; browning; thermogenesis; adipogenesis; diabetes; adipokines; energy storage; insulin resistance; obesity; lipolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Biomathematics, Computational Biology, and Bioengineering

edited by

Grzegorz Matyszczak

submission deadline 30 Sep 2025 | Viewed by 23 | Submission Open

Keywords: biomathematics; machine learning; artificial intelligence; data science; systems biology; reaction– diffusion systems; nonlinear dynamics; bioreactors; biochemical reaction engineering

(This special issue belongs to the Section Molecular Informatics)

Molecular Insight into Polymer Dynamics

edited by

Sirui Ge

submission deadline 30 Sep 2025 | Viewed by 23 | Submission Open

Keywords: polymer dynamics; glass transition; segmental relaxation; bulk relaxation; structure– property relationship; functional polymers; spectroscopy; instrumental characterization; simulations and modeling; polymer diffusion

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms of Antimicrobial Resistance and Host–Pathogen Interactions: From Genes to Therapeutics

edited by

Carlo Acierno

submission deadline 30 Sep 2025 | Viewed by 23 | Submission Open

Keywords: antimicrobial resistance; host– pathogen interaction; MDR pathogens; biofilm; immune evasion; pharmacodynamics; sepsis; critical care infections; quorum sensing; immunoparalysis

(This special issue belongs to the Section Molecular Immunology)

Novel Biomaterials and Technologies for Environmental Science

edited by Cátia Venâncio

submission deadline 30 Sep 2025 | Viewed by 23 | Submission Open

Keywords: biomass conversion; bio-based materials; circular bioeconomy; sustainable manufacturing; eco-friendly materials; environmental sustainability

(This special issue belongs to the Section Materials Science)

Cytokines and Other Biomarkers of Health Status

edited by Anna Cywińska and

Ewelina Maculewicz

submission deadline 30 Sep 2025 | Viewed by 23 | Submission Open

Keywords: cytokine concentration; cytokine gene expression; cytokine receptors; biomarkers; pathogenesis; adaptation; homeostasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

MicroRNAs in Physiology and Pathophysiology

edited by Małgorzata Guz

submission deadline 30 Sep 2025 | Viewed by 23 | Submission Open

Keywords: miRNA; cell physiology; metabolism; cancer; biomarkers; disease; molecular mechanisms; diagnosis; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Progress in Male Reproduction

edited by

Ahmet Ayaz

submission deadline 30 Sep 2025 | Viewed by 22 | Submission Open

Keywords: male infertility; spermatogenesis; epigenetics; sperm function; testicular molecular biology; bioinformatics; reproductive genomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Metal Toxicity and Particle Toxicity

edited by Alicja Piotrowska-Niczyporuk

submission deadline 30 Sep 2025 | Viewed by 22 | Submission Open

Keywords: metals; particles; toxicity; microplastic; environment pollution; animals; plants; algae

(This special issue belongs to the Section Molecular Toxicology)

Advancements in Metal-Organic Frameworks: Synthesis, Properties, and Applications

edited by

Maria Milanova

submission deadline 30 Sep 2025 | Viewed by 22 | Submission Open

Keywords: metal– organic frameworks; hybrid materials; powder X-ray diffraction; single-crystal diffraction; synthesis approach; gas separation; adsorbents; sensors; catalysts; separation; magnetism; LEDs

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

CD8⁺ T Cells in the Cancer Immunity Cycle: Mechanisms, Barriers, and Therapeutic Opportunities

edited by Wael Traboulsi

submission deadline 30 Sep 2025 | Viewed by 21 | Submission Open

Keywords: CD8+ T cell; cancer immunotherapy; checkpoint inhibitor; CAR-T cell therapy; CD8 differentiation; epigenetic regulation; metabolism; exhaustion; dysfonctional CD8+ T cell

(This special issue belongs to the Section Molecular Immunology)

The Role of Endocrine Disruptors in Immune Diseases

edited by

Eui-Bae Jeung

submission deadline 30 Sep 2025 | Viewed by 21 | Submission Open

Keywords: endocrine disruptors; immune disease; cytokine signaling; autoimmunity; immunotoxicity; epigenetic modulation; hormone receptors; inflammation; environmental toxicology; EDC exposure

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Bioactive Phenolics and Polyphenols 2025

edited by

Davide Barreca

submission deadline 30 Sep 2025 | Viewed by 20 | Submission Open

Keywords: phenolic metabolism; biological activities; stability to food processing; elicitation; methods of analysis; dietary supplements; nutraceutical ingredients; non-thermal processing; extraction and purification

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Latest Research on Probiotics: Molecular Mechanisms and Health Applications

edited by

Ying Zhang

submission deadline 30 Sep 2025 | Viewed by 20 | Submission Open

Keywords: probiotics; molecular signaling; microbial– host crosstalk; metabolomic profiling; microbiome modulation; metabolite– receptor interaction

(This special issue belongs to the Section Molecular Microbiology)

Molecular Insight into Catalysis of Nanomaterials

edited by Dandan Liu

submission deadline 30 Sep 2025 | Viewed by 20 | Submission Open

Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation

(This special issue belongs to the Section Molecular Nanoscience)

Exploring Molecular Advances in Contaminant Removal

edited by Dexin Liu

submission deadline 30 Sep 2025 | Viewed by 20 | Submission Open

Keywords: removing pollutants; novel adsorbents; catalyst molecules; environmental science and technology

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Pathology and Next-Generation Biomarkers in Nephrology

edited by

Marijn Speeckaert

submission deadline 30 Sep 2025 | Viewed by 20 | Submission Open

Keywords: nephrology; genetic mutations; epigenetics; next-generation biomarkers; proteomics; metabolomics; single-cell sequencing; spatial transcriptomics; liquid biopsy; cfDNA; exosomes; microRNAs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Glioblastoma Pathogenesis and Therapeutics

edited by

Claudia Desiderio

Giovanni Sabatino

and

Edoardo Mazzucchi

submission deadline 30 Sep 2025 | Viewed by 19 | Submission Open

Keywords: glioblastoma; proteomics; immunopeptidomics; genomics; extracellular vesicles; biomarkers; molecular mechanisms; i-knife mass spectrometry; intra-operative imaging; cancer stem cells; cancer progression; neurosurgery; radiomics; personalized medicine

(This special issue belongs to the Section Molecular Oncology)

New Advances of Magnetic Nanomaterials in Biomedical Applications

edited by

Izabell Craciunescu

submission deadline 30 Sep 2025 | Viewed by 19 | Submission Open

Keywords: magnetic nanomaterials; biomedical applications; drug delivery systems; magnetic hyperthermia; magnetic resonance imaging (MRI)

(This special issue belongs to the Section Materials Science)

The Role of Cytokines in Inflammation and Diseases

edited by

Keiichi Yamanaka

submission deadline 30 Sep 2025 | Viewed by 19 | Submission Open

Keywords: inflammation; cytokine; complication; systemic inflammation; internal organ

(This special issue belongs to the Section Molecular Immunology)

Molecular Pathology and Drug Therapy in Orthopedic Injuries

edited by Dror Robinson

submission deadline 30 Sep 2025 | Viewed by 19 | Submission Open

Keywords: molecular therapy; regenerative medicine; stem cell therapy; exosomes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mitochondrial Dysfunction and Oxidative Stress in Human Diseases: Molecular Targets and Therapeutic Strategies

edited by

Carlo Acierno

submission deadline 30 Sep 2025 | Viewed by 19 | Submission Open

Keywords: mitochondria; oxidative stress; redox signaling; mitophagy; immunometabolism; metabolic reprogramming; ROS; bioenergetics; molecular therapeutics; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Machine Learning Approaches in Drug Molecule Design

edited by

Bing Niu

submission deadline 30 Sep 2025 | Viewed by 18 | Submission Open

Keywords: machine learning; drug design; deep learning; virtual screening; QSAR; molecular property prediction; de novo drug design; pharmacokinetics; computational chemistry; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Colorectal Cancers: New Approach to Their Pathology, Diagnosis and Therapy

edited by

Mariusz Chabowski

submission deadline 30 Sep 2025 | Viewed by 17 | Submission Open

Keywords: occult blood test; colorectal cancer; colonoscopy; rectal bleeding; abdominal pain; hemicolectomy; novel oncological drugs

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Hypertension

edited by Pedro A. José

submission deadline 30 Sep 2025 | Viewed by 17 | Submission Open

Keywords: salt sensitivity; inverse salt sensitivity; epigenetics; genetics; organ-to-organ communication

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Bioactive Compounds for Human Health, 3rd Edition

edited by

Hongjie Zhang

submission deadline 30 Sep 2025 | Viewed by 16 | Submission Open

Keywords: natural bioactive plant products; biological and pharmacological activity; natural plant drug discovery and development; nutraceuticals; botanical dietary supplement

(This special issue belongs to the Section Molecular Pharmacology)

Biomarkers in Diabetes Mellitus: From Discovery to Clinical Application

edited by Jelena Vekic and

Aleksandra Zeljkovic

submission deadline 30 Sep 2025 | Viewed by 15 | Submission Open

Keywords: diabetes mellitus; biomarkers; diabetes complications; omics technologies; risk stratification; therapeutic response; personalized medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Lung Inflammation, Injury, and Repair (Second Edition)

edited by

Andreas Schwingshackl

submission deadline 30 Sep 2025 | Viewed by 15 | Submission Open

Keywords: lung; inflammation; injury; repair; fibrosis; diagnostics; therapeutics; acute respiratory distress syndrome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Horizons in the Diagnosis of Gynecological Malignancies

edited by Nina Montik

submission deadline 30 Sep 2025 | Viewed by 15 | Submission Open

Keywords: gynecological cancers; early diagnosis; biomarkers; molecular profiling; liquid biopsy; imaging techniques; artificial intelligence; translational research; personalized medicine; prognostic evaluation

(This special issue belongs to the Section Molecular Oncology)

New Perspectives in Protein Structure

edited by

Csaba Magyar

submission deadline 30 Sep 2025 | Viewed by 13 | Submission Open

Keywords: stability of protein complexes structural; background of protein function; allosteric regulation of proteins; fuzzy complexes; intrinsically disordered proteins; liquid-liquid phase separation; mutual synergistic folding; protein folding; protein structure; protein-protein interactions; transmembrane proteins

(This special issue belongs to the Section Molecular Biophysics)

Influenza Pathogenesis and Vaccine Development

edited by

Awad Shehata

submission deadline 30 Sep 2025 | Viewed by 13 | Submission Open

Keywords: avian influenza; influenza virus; influenza surveillance; interspecies transmission; immune response; pandemic preparedness; pathogenesis; One Health; universal vaccines; vaccine development; viral adaptation; viral evolution; zoonotic infections

(This special issue belongs to the Section Molecular Microbiology)

Drug Development and Discovery for Alzheimer's Disease

edited by Martha Cecilia Rosales-Hernández

submission deadline 30 Sep 2025 | Viewed by 9 | Submission Open

Keywords: Alzheimer's disease; drug design; repurposed molecules; therapeutic targets; amyloid-β ; β -secretase; acetylcholin-esterase; in silico studies; oxidative stress; chemical synthesis

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Pathways Involved in Age-Related Musculoskeletal Disorders

edited by

Abhishek Chandra

and Neha Dole

submission deadline 1 Oct 2025 | Viewed by 78 | Submission Open

Keywords: musculoskeletal disorders; cellular senescence; aging; genetic mutations; oxidative stress; mitochondrial dysfunction; bone homeostasis

(This special issue belongs to the Section Molecular Biology)

Surfactants: Design, Synthesis and Application

edited by

Urszula Bazylinska

submission deadline 9 Oct 2025 | Viewed by 97 | Submission Open

Keywords: surfactants; adsorption phenomena; critical micellar concentration (CMC); hydrophilic– lipophilic balance (HLB); critical packing parameter (CPP); emulsion formulations; vesicular and non-vesicular origin nanocarriers; drug delivery; theranostics

(This special issue belongs to the Section Materials Science)

A Metabolomics Approach to Tackling Toxicological and Pharmacological Issues: 2nd Edition

edited by