Nutrition in Neurodegenerative Diseases: Molecular Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (30 November 2025) | Viewed by 169
Special Issue Editor
Special Issue Information
Dear Colleagues,
There is evidence that nutrition greatly affects neuronal physiology and predisposes to neurodegenerative disease. The role of the quality of nutrition in diets such as the Mediterranean diet is essential, but so is the quantity of food ingested. The total amount of carbohydrate ingested regulates the insulin secretion. Insulin influences cerebral bioenergetics, enhances synaptic viability and dendritic spine formation, and increases turnover of neurotransmitters, such as dopamine; insulin dysregulation could contribute to neurodegeneration.
The following are examples:
- Phenols are a group of dietary bioactive molecules; these phytochemicals are present in high amounts in plant-based foods and beverages. They have potential benefits, presenting evidence for cognitive brain health and neuroprotection.
- The B vitamin group, at doses in significant excess of the current governmental recommendations, may be a rational approach for preserving brain health.
- Alpha-tocotrienol possesses unique biological activity that is independent of its potent antioxidant capacity, which demonstrates neuroprotective properties.
In this Special Issue, we are particularly interested in original research articles and comprehensive reviews that explore the potential targets through which dietary factors may influence neurodegenerative diseases. Specifically, we seek contributions that investigate these mechanisms based on the bioavailability and intestinal absorption of biomolecules. Additionally, we welcome studies that elucidate the indirect effects on neurodegeneration arising from the interplay among diet, the intestinal microbiota, intestinal permeability, the immune system, and the central nervous system.
Dr. Vittorio Emanuele Bianchi
Guest Editor
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Keywords
- nutrition
- neurodegenerative disease
- phenols
- B vitamins
- alpha-tocotrienol
- dietary factors
- intestinal microbiota
- central nervous system
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