Nutrition in Neurodegenerative Diseases: Molecular Perspectives
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 30 November 2025 | Viewed by 13
Special Issue Editor
Special Issue Information
Dear Colleagues,
There is evidence that nutrition greatly affects neuronal physiology and predisposes to neurodegenerative disease. The role of the quality of nutrition in diets such as the Mediterranean diet is essential, but so is the quantity of food ingested. The total amount of carbohydrate ingested regulates the insulin secretion. Insulin influences cerebral bioenergetics, enhances synaptic viability and dendritic spine formation, and increases turnover of neurotransmitters, such as dopamine; insulin dysregulation could contribute to neurodegeneration.
The following are examples:
- Phenols are a group of dietary bioactive molecules; these phytochemicals are present in high amounts in plant-based foods and beverages. They have potential benefits, presenting evidence for cognitive brain health and neuroprotection.
- The B vitamin group, at doses in significant excess of the current governmental recommendations, may be a rational approach for preserving brain health.
- Alpha-tocotrienol possesses unique biological activity that is independent of its potent antioxidant capacity, which demonstrates neuroprotective properties.
In this Special Issue, we are particularly interested in original research articles and comprehensive reviews that explore the potential targets through which dietary factors may influence neurodegenerative diseases. Specifically, we seek contributions that investigate these mechanisms based on the bioavailability and intestinal absorption of biomolecules. Additionally, we welcome studies that elucidate the indirect effects on neurodegeneration arising from the interplay among diet, the intestinal microbiota, intestinal permeability, the immune system, and the central nervous system.
Dr. Vittorio Emanuele Bianchi
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- nutrition
- neurodegenerative disease
- phenols
- B vitamins
- alpha-tocotrienol
- dietary factors
- intestinal microbiota
- central nervous system
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.
Further information on MDPI's Special Issue policies can be found here.
