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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cell Motility and Its Underlying Cellular and Molecular Mechanisms

edited by

Maria Giulia Lionetto

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4639 | Submission Open

Keywords: cell motility; cell migration; cytoskeleton; adhesion; signaling; imaging; microscopy; molecular biology

(This special issue belongs to the Section Biochemistry)

Biomarkers in Cancer Immunology

edited by

Wioletta Olejarz

submission deadline 20 Oct 2025 | 1 articles | Viewed by 4627 | Submission Open

Keywords: immunotherapy; adoptive cell transfer; CAR-T cells; immune checkpoint inhibitors; tumor microenvironment; extracellular vesicles; biomarkers; miRNA; DNA

(This special issue belongs to the Section Molecular Immunology)

Ion Channels as a Potential Target in Pharmaceutical Designs 2.0

edited by

Sheng-Nan Wu

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4595 | Submission Open

Keywords: ion currents; current kinetics; gating properties; voltage-dependent hysteresis; frequency-dependent regulation; small-molecule modulator

(This special issue belongs to the Section Molecular Biology)

The Role of Heat Shock Proteins: From Molecular Mechanisms to Therapeutics: 2nd Edition

edited by

Gregory Blatch

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4556 | Submission Open

Keywords: heat shock proteins; molecular chaperones; co-chaperones; protein folding; chronic diseases; infectious diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Macrophage Polarization: Learning to Manage It (4th Edition)

edited by

Nadia Lampiasi

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4466 | Submission Open

Keywords: macrophages; macrophage plasticity; macrophage polarization; innate immunity; IFN-γ ; TNF-α ; immunomodulators; diseases; homeostasis; inflammation; cancer

(This special issue belongs to the Section Molecular Immunology)

Heart Failure: From Molecular Basis to Therapeutic Strategies

edited by

Michele Ciccarelli

submission deadline 20 Oct 2025 | 3 articles | Viewed by 4393 | Submission Open

Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research on Novel Lipid-Based Nano Drug Delivery Systems

edited by

Eder Lilia Romero

submission deadline 20 Oct 2025 | 1 articles | Viewed by 4289 | Submission Open

Keywords: lipids; nanoparticle; nanovesicle; algae; archaea; plant; bacteria; natural product

(This special issue belongs to the Section Molecular Pharmacology)

Chronic Kidney Disease: The State of the Art and Future Perspectives

edited by Alberto Rosati

submission deadline 20 Oct 2025 | 3 articles | Viewed by 4239 | Submission Open

Keywords: glomerulonephritis; chronic kidney disease; prevention; screening; cardiovascular mortality; patient outcomes; CKD progression

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Skin Diseases: 3rd Edition

edited by

Naoko Kanda

submission deadline 20 Oct 2025 | 2 articles | Viewed by 4110 | Submission Open

Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Cancer Biology and Therapeutics: Third Edition

edited by

Rafael Coveñas Rodríguez

submission deadline 20 Oct 2025 | 4 articles | Viewed by 4098 | Submission Open

Keywords: antiangiogenic; anticancer therapy; antimetastatic; apoptosis; antiproliferative; cancer; peptides; signaling molecules; transcription factors; tumor

(This special issue belongs to the Section Molecular Oncology)

Editorial Board Members’ Collection Series: “Selenium and Sulfur Chemistry”

edited by

Claudio Santi

and

Narimantas K. Cenas

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3894 | Submission Open

Keywords: selenium; sulfur; redox; catalysis; selenoproteins; green chemistry; materials; stereoselective synthesis

(This special issue belongs to the Section Biochemistry)

DNA Damage in Neurological Disorders: Etiological and Therapeutical Aspects

edited by Tam Quach, Ilaria Palmisano and Anne-Marie Duchemin

submission deadline 20 Oct 2025 | 1 articles | Viewed by 3865 | Submission Open

Keywords: neurological disorders; peripheral neuropathies; DNA damage; epigenetic dynamism; 3D chromatin organization/remodeling; therapeutic targets for DNA repair

(This special issue belongs to the Section Molecular Neurobiology)

Protein Biosensors

edited by

Antonio Varriale

and

Maria Staiano

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3806 | Submission Open

(This special issue belongs to the Section Biochemistry)

Zebrafish as a Model for Biomedical Studies—2nd Edition

edited by

Pierre-Olivier Angrand

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3681 | Submission Open

Keywords: zebrafish; cancer; metabolic diseases; neurological disorders; infectious diseases; xenografts; drug discovery

(This special issue belongs to the Section Molecular Biology)

Hormone/Receptor System in Human Diseases

edited by

Elena Zocchi

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3640 | Submission Open

Keywords: characteristics of hormones; mechanisms of hormone action; structure; subunits and complexes of receptors; receptor function; expression and regulation; hormone/receptor signaling; interactions between receptors and hormones

(This special issue belongs to the Section Molecular Pharmacology)

Pathophysiology and Pharmacology in Psychiatry

edited by

Galila Agam

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3620 | Submission Open

Keywords: psychiatric disorders; mental health; pathophysiology; neuropsychopharmacology; brain

(This special issue belongs to the Section Molecular Neurobiology)

Small Cell Lung Cancer Entering the Sphere of Personalized Treatment

edited by

Anna Grenda

, Michał Szczyrek and Izabela Chmielewska

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3578 | Submission Open

Keywords: small cell lung cancer; SCLC; pathological subtypes; molecular subtypes; DNA; RNA; NGS; next-generation sequencing transcriptome; mutations; molecular analysis

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Photocatalysis: An Innovation in Catalysis

edited by

Andreea L. Chibac-Scutaru

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3511 | Submission Open

Keywords: semiconducting nanostructures; photocatalyst immobilized on substrates; hybrid composites; metal-free photocatalyst; photocatalysis mechanism; pollutant removal; hydrogen production; organic synthesis

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Genetics in Ovarian Cancer

edited by

Bruna Scaggiante

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3511 | Submission Open

Keywords: chemotherapy resistance; differential gene expression; genomic structural variation; ovarian cancer mutations; ovarian cancer metastasis; ovarian cancer treatment; novel molecular targets

(This special issue belongs to the Section Molecular Genetics and Genomics)

Oxidation in Human Health and Disease

edited by

Isabel Fort

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3468 | Submission Open

Keywords: oxidative stress; oxidative balance; biochemical markers; reactive oxygen species TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Immunology)

Extracellular Vesicles: The Biology and Therapeutic Applications, 2nd Edition

edited by

Tamás Visnovitz

submission deadline 20 Oct 2025 | 1 articles | Viewed by 3453 | Submission Open

Keywords: extracellular vesicles (EVs); exosomes; release; uptake; bio-distribution; methods; biomarkers; therapeutic applications

(This special issue belongs to the Section Molecular Biology)

Plant Resilience: Insights into Abiotic and Biotic Stress Adaptations

edited by

Xujun Zhu

submission deadline 20 Oct 2025 | 4 articles | Viewed by 3403 | Submission Open

Keywords: plants; basis of life; environmental stress; complex responses; molecular mechanisms; abiotic and biotic stress adaptations

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Aspects of Cartilage Biology

edited by

Michela Geminiani

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3392 | Submission Open

Keywords: cartilage biology; tissue regeneration; molecular mechanisms; chondrocytes; cartilage disorders; therapeutic interventions; biomaterials

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism in Cardiovascular Pathology

edited by Andrea Marzullo

submission deadline 20 Oct 2025 | 3 articles | Viewed by 3301 | Submission Open

Keywords: cardiovascular diseases; molecular biology; sudden death; cardiomyopathies; heart failure; coronary artery diseases; pericarditis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Extracellular Matrix Proteins in Pathogenesis: 2nd Edition

edited by

Davide Raineri

submission deadline 20 Oct 2025 | 6 articles | Viewed by 3272 | Submission Open

Keywords: extracellular matrix proteins; autoimmune disease; cancer; cardiovascular diseases; inflammation; chronic diseases; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Paradox of Salmonella Survival and Host Defense Strategies

edited by

John Hwa Lee

and Amal Senevirathne

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3245 | Submission Open

Keywords: Salmonella; Salmonella serovars; virulence factors; host immune response; human health; animal health and poductivity; infection models

(This special issue belongs to the Section Molecular Microbiology)

Bioprinting: Progress and Challenges

edited by

Rui Vitorino

submission deadline 20 Oct 2025 | 1 articles | Viewed by 3229 | Submission Open

Keywords: advances in 3D bioprinting technologies; biomaterials for bioprinting; bioprinting applications in tissue engineering and regenerative medicine; cellular and molecular interactions in bioprinted constructs; bio-printed organ and tissue models for disease research

(This special issue belongs to the Section Materials Science)

Neuroprotective Effects of Food Ingredients

edited by

Elena Ibáñez

and

Alejandro Cifuentes

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3193 | Submission Open

Keywords: neuroprotection; Parkinson; Alzheimer; bioactive compounds; agri-food by-products; chemical characterization; foodomics; metabolomics; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Molecular Research in Rheumatoid Arthritis

edited by Ângelo Calado

submission deadline 20 Oct 2025 | 2 articles | Viewed by 3100 | Submission Open

Keywords: rheumatoid arthritis; synovium; autoimmunity; rheumatology; omics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Screening and Identification of Crop Abiotic Stress Tolerance Functional Genes

edited by

Liezhao Liu

submission deadline 20 Oct 2025 | 4 articles | Viewed by 2994 | Submission Open

Keywords: plant; abiotic stress; gene; identification; function

(This special issue belongs to the Section Molecular Plant Sciences)

An Update for Photodynamic Therapy as a Versatile Tool for Biological Breakthroughs

edited by

Leandro M. O. Lourenço

João P. C. Tomé

and

Augusto C. Tomé

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2961 | Submission Open

Keywords: photodynamic theraphy (aPDT); photochemistry; dyes; photosensitizers; porphyrins; phthalocyanines; and other derivatives; reactive oxygen species (ROS); singlet oxygen; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Heart Diseases: Molecular Pathogenesis, Biomarkers and Therapies

edited by

Nadia Aspromonte

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2959 | Submission Open

Keywords: heart diseases; biomarkers; molecular pathways; personalized medicine; interventional therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Diseases and Genetic Variants

edited by Rajkumar Dorajoo

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2952 | Submission Open

Keywords: genetic variants; DNA sequencing; metabolic disease; whole exome sequencing; quantitative trait loci; fine-mapping; epidemiology; omics; T2D; obesity

(This special issue belongs to the Section Molecular Genetics and Genomics)

Inflammation and Cellular Senescence in Age-Related Diseases

edited by

Calogero Caruso

and

Giuseppina Candore

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2936 | Submission Open

Keywords: age-related diseases; exposome; prevention; pathophysiology; pathogenesis; inflammation; senescence

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Drug Discovery, Treatment, and Repurposing in Neuropsychiatric Disorders

edited by

Maria Bogdan

and

Liliana Mititelu-Tartau

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2931 | Submission Open

Keywords: animal models; neurodegeneration; neuropsychiatric disorders; neuroprotection; nanoparticles

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insight into Autoinflammatory Diseases

edited by

Ferenc Sipos

and

Györgyi Műzes

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2892 | Submission Open

Keywords: autoinflammation; autoimmunity; genetics; epigenetics; molecular pathogenesis; therapy; diagnosis; rare cases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Applications of Bacteriophages

edited by

Grzegorz Wegrzyn

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2863 | Submission Open

Keywords: bacteriophages; gene cloning; phage display technology; phage

(This special issue belongs to the Section Molecular Biology)

Predictive and Diagnostic Biomarkers in Inflammatory and Neurodegenerative Diseases

edited by

Maria Morello

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2800 | Submission Open

Keywords: Parkinson’ s disease; Alzheimer’ s disease; multiple sclerosis; amyotrophic lateral sclerosis; neurodegenerative diseases; inflammation amyloid plaques; tau; alpha-synuclein; cytokines; neurofilaments; vitamins

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Treatment of Migraine

edited by Noboru Imai

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2786 | Submission Open

Keywords: migraine; nitric oxide synthase (NOS); neuropeptides; calcitonin gene-related peptide (CGRP); pituitary adenylate cyclase activating polypeptide (PACAP); molecular pathways; therapeutic targets; neurovascular condition

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanistic Insights into Cancer Immunotherapy and Immune-Related Adverse Events

edited by Noha Abdel-Wahab,

Bilal A. Siddiqui

and Kristen E. Pauken

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2771 | Submission Open

Keywords: cancer immunotherapy; immune-related adverse events; biomarker; immune checkpoint inhibitor; cancer progression

(This special issue belongs to the Section Molecular Oncology)

New Insights into Plant and Insect Interactions (Second Edition)

edited by

Yonggen Lou

and Xiaoling Sun

submission deadline 20 Oct 2025 | 3 articles | Viewed by 2727 | Submission Open

Keywords: plant defense responses; elicitors; effectors; defense-related signaling; insect– plant interactions; tritrophic interactions; detoxification; defensive compounds; defensive genes

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathways and Therapeutic Strategies for Fibrotic Conditions

edited by

Morena Scotece

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2716 | Submission Open

Keywords: fibrosis; fibrotic disorders; autoimmune diseases; cancer; adipose tissue fibrosis; repurposed drugs; gene therapies; cytokine-mediated pathways; anti-fibrotic therapies; systemic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Brain Tumors: From Biomarkers to Novel Therapies

edited by

Okay Saydam

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2681 | Submission Open

Keywords: glioblastoma; medulloblastoma; meningioma; brain tumors; exosomes; circulating tumor markers; drug development and delivery technologies; molecular biology

(This special issue belongs to the Section Molecular Oncology)

The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration

edited by

Sara Cruciani

submission deadline 20 Oct 2025 | 4 articles | Viewed by 2641 | Submission Open

Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Antimicrobial Resistance, Molecular Mechanisms and Fight Strategies: 4th Edition

edited by

Francesca Micoli

and

Aleksandra Królicka

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2625 | Submission Open

Keywords: antimicrobial resistance; mechanisms of antimicrobial resistance; rapid antimicrobial-sensitive assays; drug discovery; antibiotics; vaccine; monoclonal antibodies; infectious diseases

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Diabetes—2nd Edition

edited by

Alessandra Puddu

and

Davide Maggi

submission deadline 20 Oct 2025 | 3 articles | Viewed by 2621 | Submission Open

Keywords: diabetes; insulin; glucose metabolism; oxidative stress

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Opportunities and Challenges in the Use of Live Biotherapeutics to Fight Infections in the Era of Multi-Drug-Resistance

edited by

Giovanna Batoni

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2594 | Submission Open

Keywords: probiotics; postbiotics; bioengineered probiotics; engineered bacterium; next-generation probiotics; phage; phage therapy; multi-drug-resistant organisms; microbiota replacement; live biotherapeutic product

(This special issue belongs to the Section Molecular Immunology)

Depression: From Molecular Basis to Therapy—2nd Edition

edited by

Terezia Kiskova

submission deadline 20 Oct 2025 | 3 articles | Viewed by 2576 | Submission Open

Keywords: depression; neurobiology; molecular basis; neurotransmitters; genetic factors; psychopharmacology; psychotherapy; genetic markers

(This special issue belongs to the Section Molecular Neurobiology)

Cell Pathways Underlying Neuronal Differentiation

edited by

Michela Ferrucci

submission deadline 20 Oct 2025 | 2 articles | Viewed by 2449 | Submission Open

Keywords: neural progenitor cells; neuronal cell lines; induced pluripotent stem cells; neuronal phenotype; brain tumor cells

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Phytohormones in Plant Biotic/Abiotic Stress Tolerance

edited by

Gastón Pizzio

submission deadline 20 Oct 2025 | 1 articles | Viewed by 2418 | Submission Open

Keywords: biotic/abiotic stress; phytohormone; resistance to stress

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 2701-2750 on page 55 of 70.

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