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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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RNA Vaccines and Therapeutics: Challenges and Opportunities

edited by

Seong-Wook Lee

submission deadline 20 Dec 2025 | 3 articles | Viewed by 7467 | Submission Open

Keywords: RNA-based therapy; RNA vaccine; mRNA; circRNA; saRNA; non-coding RNA/sRNA; microRNA/siRNA/antisense RNA; RNA aptamer; ribozyme; RNA editing/genome editing

(This special issue belongs to the Section Molecular Pharmacology)

Primary and Secondary Bladder Disorders in Neurourology and Inflammatory Diseases

edited by

Wei-Chia Lee

and

Yung-Shun Juan

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7164 | Submission Open

Keywords: bladder ischemia; bladder pain syndrome; interstitial cystitis; irradiation cystitis; ketamine cystitis; microbiota; overactive bladder; underactive bladder; botulinum toxin for bladder disorders

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Advances in Molecular Targets for Treatment and Drug Delivery in Tumors

edited by

Emily Capone

submission deadline 20 Dec 2025 | 6 articles | Viewed by 7136 | Submission Open

Keywords: targeted therapy; tumor; molecular target; drug delivery; drug design

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Therapeutic Approaches to Osteoarthritis

edited by

Masato Sato

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7127 | Submission Open

Keywords: mode of action; molecular mechanisms; pathogenesis; drug delivery; disease-modifying drug; translational research; cell therapy; regenerative medicine

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Molecular Modeling, Docking and Simulations of Protein Structure, 2nd Edition

edited by

Lorant Janosi

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7098 | Submission Open

Keywords: molecular modeling; protein structure; molecular mechanisms; protein interactomics; ligand design; peptides; molecular dynamics; molecular docking

(This special issue belongs to the Section Macromolecules)

Innovations in Polymeric Materials: Exploring Advancements and Applications

edited by

Silvia Vasiliu

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6980 | Submission Open

Keywords: eco-friendly polymers; nanocomposites; biodegradable polymers; smart materials; polymer recycling; drug delivery systems; biocompatible polymers; food industry; wastewater treatment

(This special issue belongs to the Section Materials Science)

Molecular Research in Infective Mycobacteria

edited by

Giovanni Stelitano

submission deadline 20 Dec 2025 | 4 articles | Viewed by 6892 | Submission Open

Keywords: infections; mycobacteria; molecular biology; antimicrobials; bacteria biochemistry

(This special issue belongs to the Section Molecular Microbiology)

Nutrition as a Tool for Modulating Cellular Metabolism

edited by

Francesca Oppedisano

Anna Spagnoletta

and

Salvatore Nesci

submission deadline 20 Dec 2025 | 2 articles | Viewed by 6786 | Submission Open

Keywords: cell metabolism; mitochondria; ROS; RNS; proliferation and cell death; metabolic pathways; transporters; natural compounds; bioactive molecules; novel foods; metabolic diseases; human pathology

(This special issue belongs to the Section Biochemistry)

High Resolution Mass Spectrometry in Molecular Sciences: 2nd Edition

edited by

Laszlo Prokai

submission deadline 20 Dec 2025 | 4 articles | Viewed by 6763 | Submission Open

Keywords: antibodies; astrobiology; biomarkers; drug discovery; drug development; drug metabolism; Fourier transform; glycomics; imaging; ion cyclotron resonance; ion mobility; lipids; lipidomics; mass spectrometry; metabolomics; nucleic acids; Orbitrap; organometallics; polymers; peptides; proteins; proteomics; structural biology; structure elucidation; tandem mass spectrometry; time-of-flight

(This special issue belongs to the Section Biochemistry)

Genetic Engineering of Plants for Stress Tolerance, Second Edition

edited by

Moxian Chen

submission deadline 20 Dec 2025 | 7 articles | Viewed by 6610 | Submission Open

Keywords: CRISPR-Cas system; RNA interference; abiotic and biotic stresses; transcriptional regulation; post-transcriptional regulation; post-translational modification; genetic evolution; biotechnology; molecular mechanisms; regulatory circuits

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic Research in Neurological Diseases

edited by

Eva Bagyinszky

submission deadline 20 Dec 2025 | 2 articles | Viewed by 6445 | Submission Open

Keywords: neurodegenerative diseases; genetic risk factor; next-genetation sequencing; genome-wide association studies; disease models

(This special issue belongs to the Section Molecular Neurobiology)

Topoisomerase Inhibitors: Future Perspectives and Challenges

edited by

Ben Bax

and Mark Mitton-Fry

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6344 | Submission Open

Keywords: antibiotic; topoisomerase; inhibitor; anticancer; resistance; safety

(This special issue belongs to the Section Molecular Pharmacology)

Novel Molecular Mechanisms Underlying Tumorigenesis and Innovative Therapeutic Approaches for Cancer-Fighting, 3rd Edition

edited by

Annapina Russo

and Giulia Russo

submission deadline 20 Dec 2025 | 5 articles | Viewed by 6330 | Submission Open

Keywords: cancer; nucleolus; nucleolar stress; tumorigenesis; cancer therapy

(This special issue belongs to the Section Molecular Oncology)

Diabetes: Advances in Molecular Research

edited by

Alexandra E. Butler

and

Stephen Atkin

submission deadline 20 Dec 2025 | 3 articles | Viewed by 6294 | Submission Open

Keywords: type 1 diabetes; type 2 diabetes; retinopathy; nephropathy; neuropathy; molecular pharmacology; cardiovascular disease; cerebrovascular disease; normal physiology; counter-regulatory hormones; hypoglycemia TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian // TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back // This page is in English Translate to Simplified Chinese Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Lymphatic Disorders: From Molecular Mechanisms to Therapies

edited by

Laura Patton

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5879 | Submission Open

Keywords: lymphoedema; lipedema; matrix; vascular disorder; ultrasound; lacteal; microbiota; intersitial fluid

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Natural and Synthetic Sulfur Compounds in Human Health and Diseases

edited by

Eugenia Piragine

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5533 | Submission Open

Keywords: sulfur compounds; sulfur metabolism; hydrogen sulfide; H2S-donors; human health; human disease; nutraceuticals

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research and New Therapy in Melanoma and Other Skin Cancers: 2nd Edition

edited by

Rüdiger Greinert

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5406 | Submission Open

Keywords: epigenetics; cancer stem cells; noncoding RNA (miRNA); personalized diagnostic (medicine); personalized medicine; DNA repair; skin cancer biomarker; skin cancer prevention; genomics; transcriptomics; immunomodulation; ctDNA; circulating tumor cells; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Targeting Glioblastoma Metabolism

edited by

José M. Matés

and

José Ángel Campos Sandoval

submission deadline 20 Dec 2025 | 2 articles | Viewed by 5280 | Submission Open

Keywords: glioblastoma; metabolic heterogeneity; metabolic reprogramming; cancer stem cells; therapeutic resistance; metabolic vulnerabilities; IDH1/2 mutations; tumor microenvironment; epigenetic regulation

(This special issue belongs to the Section Molecular Oncology)

Cellular and Molecular Mechanisms of Plant Responses to Light (Second Edition)

edited by

Qichang Yang

and

Byoung Ryong Jeong

submission deadline 20 Dec 2025 | 4 articles | Viewed by 5270 | Submission Open

Keywords: celluar mechanism; light; molecular mechanism; plant growth; plant development; gene expression; primary and secondary metabolites; photomorphogenesis; photoperiod response; stress resistance; nutrient uptake

(This special issue belongs to the Section Molecular Plant Sciences)

Insights into Redox Homeostasis and Oxidative Stress

edited by

Dimitrios Kouretas

, Zoi Vasiliki Skaperda and

Fotios Tekos

submission deadline 20 Dec 2025 | 3 articles | Viewed by 5251 | Submission Open

Keywords: oxidative stress; redox homeostasis; redox signaling; reactive oxygen species; oxidative damage; diseases

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Targeting Macrophages in Immunotherapy

edited by Vinod Nadella

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4884 | Submission Open

Keywords: tumor-associated macrophages; tumor microenvironment; tumor immunology; carcinogenesis; macrophage repolarization; checkpoint inhibitor; immunotherapy; nanomaterials; metabolic reprogramming; epigenetics

(This special issue belongs to the Section Molecular Immunology)

Advances in Synaptic Transmission and Plasticity

edited by

Manuela Dicarlo

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4826 | Submission Open

Keywords: synaptic transmission; synapse; neurotransmitters; synaptic plasticity; memory; learning; neurodegenerative diseases; neuropsychiatric diseases

(This special issue belongs to the Section Molecular Neurobiology)

The Role of Natural Products in Drug Discovery

edited by

Luciana Scotti

and

Marcus Tullius Scotti

submission deadline 20 Dec 2025 | 6 articles | Viewed by 4795 | Submission Open

Keywords: natural product; medicinal chemistry; drug design; drug discovery; pharmacy; chemistry

(This special issue belongs to the Section Molecular Pharmacology)

New Insight into Extracellular Vesicles in Proliferative Diseases

edited by Sergio Esquivel-Ruiz

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4753 | Submission Open

Keywords: proliferation; extracellular vesicles; intercellular communication; vesicle cargo; therapeutic applications; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Current Research on Plant Hormones Affecting Crop Yield and Fruit Quality

edited by

María Serrano

and

Daniel Valero

submission deadline 20 Dec 2025 | 1 articles | Viewed by 4652 | Submission Open

Keywords: auxins; gibberellins; citokynis; ethylene; yield; quality; antioxidant; storage

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Recognition and Biosensing

edited by

Longjiao Zhu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4504 | Submission Open

Keywords: molecular recognition; biosensor; nanomaterials; aptamer; nucleic acids; sensitivity

(This special issue belongs to the Section Biochemistry)

The Importance of Molecular Circadian Rhythms in Health and Disease

edited by

Telma Quintela

and

Diana Rita Barata Costa

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4210 | Submission Open

Keywords: molecular clock; circadian dysfunction; health; chronotherapy; circadian rhythms

(This special issue belongs to the Section Molecular Biology)

Molecular Insights into Multiple Sclerosis

edited by Yoshio Bando

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4056 | Submission Open

Keywords: multiple sclerosis; molecular mechanism; pathogenesis; biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Neurobiology)

Atherosclerosis: From Molecular Mechanisms, Pathophysiology to Novel Therapeutic Approaches (3rd Edition)

edited by

Antonio Barbato

submission deadline 20 Dec 2025 | 2 articles | Viewed by 4045 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Basis and Advances of Targeted Therapy for Breast Cancer: Second Edition

edited by

Nicoletta Cordani

and

Manfioletti Guidalberto

submission deadline 20 Dec 2025 | 4 articles | Viewed by 4029 | Submission Open

Keywords: breast cancer; targeted therapy; cancer therapy; resistance; epigenetic modulations

(This special issue belongs to the Section Molecular Oncology)

New Perspective on Inflammatory Diseases: Role of Natural Compounds

edited by

Floriana D'Angeli

Carlo Genovese

and

Cristina Russo

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3972 | Submission Open

Keywords: natural compounds; immunomodulatory activity; anti-inflammatory activity; synergistic effect; nanotechnologies; delivery systems; bioinformatic analysis

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Innovative Therapeutic Approaches in Neuropsychiatric Disorders

edited by Marta Pardo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3893 | Submission Open

Keywords: neuropsychiatric disorders; pharmacogenomics; pathophysiology; molecular treatment mechanisms; molecular targets for novel drug development; neurotransmitters; synaptic plasticity; epigenetics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cytochrome P450 Mechanism and Reactivity

edited by

Samuel De Visser

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3872 | Submission Open

Keywords: enzyme function; enzyme catalysis; bioengineering; inorganic reaction mechanisms; enzyme inhibition

(This special issue belongs to the Section Biochemistry)

Signal Transduction Mechanism in Plant Disease and Immunity: 2nd Edition

edited by

Hideo Nakashita

and

Takumi Nishiuchi

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3651 | Submission Open

Keywords: plant disease resistance; biotic stress; pathogen; plant-microbe interaction; priming; signal transduction; phytohormone; proteomics

(This special issue belongs to the Section Molecular Plant Sciences)

Advancing Neurological Disorders via Computational Neuroscience and Neural Networks

edited by

Elnaz Pashaei

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3580 | Submission Open

Keywords: neurological disorders; neuroimaging analysis; biomarker identification; computational neuroscience; machine learning; brain aging

(This special issue belongs to the Section Molecular Informatics)

The Molecular Link Between Nutrition and Obesity

edited by

Elena Azzini

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3444 | Submission Open

Keywords: hormonal regulation; chronic low-grade inflammation; nutrient sensing pathways; gut microbiota

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Therapeutic Targets in Pancreatic Cancer: 2nd Edition

edited by

Dorota Lubgan

Nathalie Britzen-Laurent

and

Benjamin Frey

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3376 | Submission Open

Keywords: pancreatic cancer; translational research; therapeutic targets and novel interventional strategies; mechanisms of anti-tumor reactions; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Wnt/β-Catenin Signaling in Cancer

edited by

Teresa Catalano

and

Gitana Maria Aceto

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3373 | Submission Open

Keywords: Wnt/β -catenin pathway; tumors; gene expression; molecular targets; tumor microenvironment; carcinogenesis and metastasis; biomarkers; therapeutic approaches

(This special issue belongs to the Section Molecular Oncology)

Neuroinflammation: Advancements in Pathophysiology and Therapies (2nd Edition)

edited by

David Martín-Hernández

submission deadline 20 Dec 2025 | 2 articles | Viewed by 3354 | Submission Open

Keywords: neuroinflammation; CNS diseases; pathophysiology; therapeutic strategies; pharmacological treatments; neurological disorders; neurodegenerative diseases; cardiovascular diseases; psychiatric disorders

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Research on Antifungal Resistance

edited by Anna Tomova

submission deadline 20 Dec 2025 | 3 articles | Viewed by 3222 | Submission Open

Keywords: antifungal resistance; antifungal therapy; drug discovery; molecular mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Psoriasis: Molecular Research and Novel Therapy

edited by Tsen-Fang Tsai

submission deadline 20 Dec 2025 | 1 articles | Viewed by 3110 | Submission Open

Keywords: psoriasis; pathogenesis; treatment; biologics; novel therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research on Reproductive Physiology and Endocrinology

edited by

Kamil Gill

submission deadline 20 Dec 2025 | 5 articles | Viewed by 3063 | Submission Open

Keywords: reproductive; endocrinology; reproductive hormones; embryology; molecular research; IVF; obesity

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanomedicine in Gene Therapy and Immunotherapy

edited by

Ruosen Xie

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2955 | Submission Open

Keywords: nanomedicine; drug delivery; gene delivery; genome editing; immunotherapy

(This special issue belongs to the Section Molecular Immunology)

Molecular Research of Dystonia and Parkinson’s Disease

edited by

Ryoma Morigaki

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2921 | Submission Open

Keywords: dystonia; Parkinson’ s disease; molecular mechanism; molecular pathology; cell biology; genetic predisposition to disease; physiopathology; neural plasticity; animal models; biomedical translational science

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology and Treatment of Alzheimer's Disease

edited by

Jeffrey Fessel

submission deadline 20 Dec 2025 | 1 articles | Viewed by 2918 | Submission Open

Keywords: Alzheimer's disease; Alzheimer’ s dementia; neurodegeneration; AD; pathogenesis; cure for AD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biochemistry and Molecular Biology of Coronaviruses

edited by

Shu-Qun Liu

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2914 | Submission Open

Keywords: SARS-CoV; MERS-CoV; COVID-19; RNA viruses; infection; antivirals; vaccines; therapeutics; host-virus interactions

(This special issue belongs to the Section Molecular Microbiology)

Voltage-Gated Ion Channels and Human Diseases

edited by María A. Gandini

submission deadline 20 Dec 2025 | 5 articles | Viewed by 2874 | Submission Open

Keywords: channelopathies; voltage gated-ion channels; human diseases; mutations; calcium; sodium; potassium

(This special issue belongs to the Section Molecular Biophysics)

The Role of Neurons in Human Health and Disease—3rd Edition

edited by

Yasemin M. Akay

submission deadline 20 Dec 2025 | 3 articles | Viewed by 2799 | Submission Open

Keywords: brain; nervous system; neurons; immune system; human health and disease

(This special issue belongs to the Section Molecular Neurobiology)

Cancer Drug Treatment and Cancer Cell Drug Resistance

edited by

Juan Sebastian Yakisich

submission deadline 20 Dec 2025 | 2 articles | Viewed by 2766 | Submission Open

Keywords: cellular plasticity; heterogeneity; combinational chemotherapy; metastasis; tumor relapse; novel targets; drug delivery

(This special issue belongs to the Section Molecular Pharmacology)

Biomarker Discovery and Validation for Precision Oncology

edited by

Luís Lima

submission deadline 20 Dec 2025 | 4 articles | Viewed by 2698 | Submission Open

Keywords: biomarker discovery; biomarker validation; precision oncology; cancer screening; cancer diagnostics; liquid biopsy; multi-omics integration; targeted therapies; immunotherapy biomarkers; translational cancer research

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 2701-2750 on page 55 of 70.

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