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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Circadian Clock in Aging and Age-Related Diseases

edited by

Gianluigi Mazzoccoli

Tommaso Colangelo

and

Giovanni Damiani

submission deadline 30 Nov 2026 | 1 articles | Viewed by 957 | Submission Open

Keywords: circadian timing system; molecular clockwork; rhythmicity; biological clock; aging inflammation; metabolism; endoplasmic reticulum stress

(This special issue belongs to the Section Molecular Immunology)

Intron Retention (IR): RNA Processing, Post-Transcriptional Regulation in Stress Response, Genomic Function

edited by

Norihiro Okada

submission deadline 30 Nov 2026 | 1 articles | Viewed by 936 | Submission Open

Keywords: intron retention; alternative splicing; RNA processing; stress response; post-transcriptional regulation; nuclear export; nonsense-mediated decay; RNA surveillance; RNA-binding proteins; long-read sequencing; single-cell transcriptomics; biomarker; systems biology; disease mechanisms; proteostasis

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Pathogenic Mechanisms to Therapy in Gynecological Diseases

edited by

David B. Alexander

submission deadline 30 Nov 2026 | 1 articles | Viewed by 862 | Submission Open

Keywords: malignant gynecological diseases; screening for gynecological cancers; benign gynecological conditions; screening for benign gynecological diseases; endometriosis; polycystic ovaries syndrome; ovarian cysts; uterine fibroids; leiomyomas; adenomyosis; pelvic inflammatory disease; vaginitis; vaginal dysbiosis; treatment targets for gynecological diseases

(This special issue belongs to the Section Molecular Oncology)

Musculoskeletal Development and Skeletal Pathophysiologies, 3rd Edition

edited by

Elizabeth W. Bradley

submission deadline 30 Nov 2026 | 1 articles | Viewed by 846 | Submission Open

Keywords: musculoskeletal development; growth plate; endochondral ossification; intramembranous ossification; osteoporosis; osteoarthritis; bone; cartilage; osteoblast; osteoclast; chondrocyte

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Integrative Mechanisms and Translational Outcomes of Excitatory–Inhibitory Neurotransmission Switching in Neuropathic Pain

edited by

Poppy Schoenberg

submission deadline 30 Nov 2026 | 1 articles | Viewed by 843 | Submission Open

Keywords: neuropathic pain; excitatory– inhibitory balance (E/I balance); neurotransmission switching; microglia; spinal dorsal horn; circuit remodeling; translational biomarkers; computational modeling; glutamatergic signaling; neuromodulation

(This special issue belongs to the Section Molecular Neurobiology)

Oral Stem Cells: Molecular Characteristics and the Applications in Regenerative Medicine

edited by

Emi Shimizu

and

Motoki Okamoto

submission deadline 30 Nov 2026 | Viewed by 837 | Submission Open

Keywords: oral stem cells; regenerative medicine; molecular mechanisms; stem cell therapy; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular and Cellular Mechanism in Amyotrophic Lateral Sclerosis

edited by Nilo Riva

submission deadline 30 Nov 2026 | 1 articles | Viewed by 816 | Submission Open

Keywords: amyotrophic lateral sclerosis; motor neuron vulnerability; TDP-43; axonal degeneration; proteinopathy; stress granules; C9orf72; SOD1; RNA metabolism; FTD

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Biological Markers and Molecular Targets in Bladder Cancer

edited by Stanislav Žiaran

submission deadline 30 Nov 2026 | 1 articles | Viewed by 803 | Submission Open

Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology

(This special issue belongs to the Section Molecular Oncology)

Recent Advances in Breast Cancer Immunology and Immunotherapy

edited by Tamara Gulić

submission deadline 30 Nov 2026 | 1 articles | Viewed by 753 | Submission Open

Keywords: breast cancer; immunology; tumor microenvironment; immunotherapy tumor infiltrating lymphocytes; innate immunology; immune-checkpoint inhibitors; immunotherapy; biomarkers; targeted therapies

(This special issue belongs to the Section Molecular Immunology)

Epigenetic Mechanisms in Human Diseases: From Molecular Pathogenesis to Therapeutic Interventions

edited by Silvia Consalvi

submission deadline 30 Nov 2026 | 1 articles | Viewed by 743 | Submission Open

Keywords: epigenetics; DNA methylation; histone modifications; chromatin remodeling; non-coding RNAs; epigenomic profiling; epigenetic biomarkers; epigenetic therapy; epigenetic drugs; epigenome editing; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Pathways of Epithelial-Mesenchymal Transition

edited by

Noemi Monti

submission deadline 30 Nov 2026 | 1 articles | Viewed by 727 | Submission Open

Keywords: metastasis; fibrosis; tumor microenvironment; molecular pathways; EMT reversion

(This special issue belongs to the Section Molecular Biology)

Molecular Research on Aquatic Organisms

edited by

Nguyen Vu Linh

submission deadline 30 Nov 2026 | Viewed by 711 | Submission Open

Keywords: aquatic biotechnology; fish immunomodulation; antimicrobial resistance; omics technologies; natural feed additives

(This special issue belongs to the Section Molecular Biology)

Bioactive Compounds Targeting Metabolic Disorders: Molecular Mechanisms and Translational Applications

edited by

Dongmin Liu

submission deadline 30 Nov 2026 | 1 articles | Viewed by 703 | Submission Open

Keywords: bioactive compounds; obesity; type 2 diabetes; insulin resistance; adipose tissue; gut microbiota; inflammation; oxidative stress; nutraceuticals; molecular nutrition

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Photodiagnosis and Photodynamic Therapy

edited by

Tomasz Kubrak

and

David Aebisher

submission deadline 30 Nov 2026 | Viewed by 683 | Submission Open

Keywords: photodiagnosis; photodynamic therapy; photosensitizers; natural photosensitizers; biomedical imaging; nanomedicine; targeted therapies; light as a therapeutic tool

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Regulation of Plant Tolerance to Saline, Alkali, and Combined Stresses

edited by

Lixin Li

and Yiming Zhang

submission deadline 30 Nov 2026 | 1 articles | Viewed by 681 | Submission Open

Keywords: saline– alkali stress; plant's environmental adaptation mechanisms; metabolism and secondary metabolism; signal transduction; plant– microorganism interaction; omics

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Zoonoses and Vector-Borne Diseases

edited by Ravi Durvasula

submission deadline 30 Nov 2026 | 1 articles | Viewed by 608 | Submission Open

Keywords: malaria; leishmaniasis; soil-transmitted helminths; one health; cryptosporidiosis; trypanosomiasis; mosquito-borne infections; arboviral diseases; paratransgenesis; drug discovery; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Mitochondria in Renal and Cardiac Diseases

edited by

Ana Karina Aranda-Rivera

and

José Pedraza Chaverri

submission deadline 30 Nov 2026 | 1 articles | Viewed by 591 | Submission Open

Keywords: kidney and cardiac diseases; mitochondria; mitochondrial impairment; cardiorenal syndrome; mitochondrial proteins; dynamics; bioenergetics

(This special issue belongs to the Section Molecular Biology)

Molecular Research of Gastrointestinal Disease, 3rd Edition

edited by

Ainsley Robinson

and

Kulmira Nurgali

submission deadline 30 Nov 2026 | 1 articles | Viewed by 576 | Submission Open

Keywords: gastrointestinal health; gastrointestinal disorders; gastrointestinal disease; gastrointestinal homeostasis; molecular targets; mechanisms; pathways; molecular markers; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on New Targets and New Drugs for Dementia

edited by

Jianrong Xu

submission deadline 30 Nov 2026 | 1 articles | Viewed by 549 | Submission Open

Keywords: Alzheimer’ s disease; disease-modifying therapy; neuroinflammation; monoclonal antibodies; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Sphingolipids: Health and Disease

edited by

Paola Giussani

submission deadline 30 Nov 2026 | 1 articles | Viewed by 522 | Submission Open

Keywords: sphingolipids; ceramide; sphingosine-1-phosphate; complex sphingolipids; gangliosides

(This special issue belongs to the Section Biochemistry)

Gut–Brain Axis: Pathophysiological Mechanisms in Neurological Disorders and Metabolic Diseases

edited by

Giovanna Traina

submission deadline 30 Nov 2026 | Viewed by 521 | Submission Open

Keywords: gut– brain axis; intestinal microbiota; mood diseases; immune system; microbial molecules; behavior; metabolic diseases; signaling pathways; inflammation; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Mechanosensitive Ion Channels in the Nervous System

edited by

Rashid Giniatullin

submission deadline 30 Nov 2026 | Viewed by 500 | Submission Open

Keywords: mechanosensitive ion channels; Piezo1; Piezo2; mechanosensitive K2P channels; mechanical pain; pulsating blood flow; tissue stiffness; mechanobiology of glymphatic system; chemical agonists of mechanosensitive channels; mechanosensitive TRP channels; neuron; glial cells

(This special issue belongs to the Section Molecular Neurobiology)

Beyond the Scale: Metabolic Pathways and the Pathophysiology of Obesity

edited by

Marika Crescenzi

submission deadline 30 Nov 2026 | 1 articles | Viewed by 497 | Submission Open

Keywords: meta-inflammation; adipokynes; purinergic system; MASH; WAT; NAMs; gut microbiome

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Emerging Technologies in Musculoskeletal Research: From Molecular Mechanisms to Translational Innovation

edited by

Javad Tavakoli

submission deadline 30 Nov 2026 | 1 articles | Viewed by 495 | Submission Open

Keywords: musculoskeletal tissue; cell mechanobiology; biofabrication; tissue regeneration; organ-on-a-chip; disease mechanism and screening; molecular and cellular diagnostics; AI and machine learning; omics technology; wearable technologies; implant technologies; biomarkers; predictive modelling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metabolic Diseases: From Molecular Mechanisms to Innovative Therapeutics

edited by

Aleksandra Szopa

and Anna D. Serefko

submission deadline 30 Nov 2026 | Viewed by 490 | Submission Open

Keywords: metabolic dysregulation; neuropsychiatric disorders; molecular crosstalk; neuroinflammation; mitochondrial dysfunction; neuroendocrine signaling; gut– brain axis; innovative therapeutic strategies; natural compounds; drug repurposing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Current Research on Skin Pigmentation and Photoaging

edited by Chang-Cheng Chang and

Tzong-Yuan Juang

submission deadline 30 Nov 2026 | Viewed by 471 | Submission Open

Keywords: skin pigmentation; melasma; photoaging; energy-based devices; skin rejuvenation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Transition-Metal-Based Nanoparticles: Synthesis, Properties and Applications

edited by Ramin Yousefi and

Sasan Rezaee

submission deadline 30 Nov 2026 | Viewed by 455 | Submission Open

Keywords: transition metal nanoparticles; synthesis; structure– property relationship; catalysis; photocatalysis; energy storage and conversion; biomedical applications; drug delivery; environmental remediation; plasmonics

(This special issue belongs to the Section Molecular Nanoscience)

Drug-Induced Toxicity and Its Role in Disease Progression and Therapeutic Outcomes

edited by

Eugenia Gallardo

and

Tiago Rosado

submission deadline 30 Nov 2026 | Viewed by 454 | Submission Open

Keywords: drug-induced toxicity; drug-drug interactions; drug delivery systems; toxicity; disease

(This special issue belongs to the Section Molecular Toxicology)

Effects of Natural Bioactive Compounds on Cellular Responses

edited by

Amélia M. Silva

submission deadline 30 Nov 2026 | Viewed by 452 | Submission Open

Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Neuroinflammation: Emerging Insights and Advances in Drug Development

edited by

Guya Diletta Marconi

Francesca Diomede

Jacopo Pizzicannella

and Paolo Gugliemi

submission deadline 30 Nov 2026 | Viewed by 438 | Submission Open

Keywords: neuroinflammation; drugs; neurodegenerative; Parkinson’ s disease; Alzheimer’ s disease; multiple scleroris; stroke

(This special issue belongs to the Section Molecular Neurobiology)

New Advances in Xenobiotic Toxicology

edited by Marcelo Arbo

submission deadline 30 Nov 2026 | 1 articles | Viewed by 435 | Submission Open

Keywords: xenobiotics; toxicity tests; biotransformation; drug effects; signal transduction; environmental pollutants; chemically induced- injury; toxicogenomics; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Toxicology)

New Insights into Allergic Asthma

edited by

Jose Antonio Cañas Mañas

submission deadline 30 Nov 2026 | 1 articles | Viewed by 425 | Submission Open

Keywords: allergic asthma; type 2 inflammation; airway remodeling; molecular endotypes; biomarkers; biologic therapies; immune regulation; microRNAs; extracellular vesicles; precision medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Chronic Kidney Disease: Underlying Molecular Mechanisms—2nd Edition

edited by

Luís Belo

and

Márcia Carvalho

submission deadline 30 Nov 2026 | Viewed by 423 | Submission Open

Keywords: chronic kidney disease; molecular mechanisms; toxicity mechanisms; inflammation; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bridging the Omics of Protein Landscape of Aging and Disease: New Insights and Opportunities

edited by

Fátima Milhano Santos

submission deadline 30 Nov 2026 | Viewed by 423 | Submission Open

Keywords: age-related disease; aging; biomarkers; chronic diseases; neurodegenerative diseases; ocular diseases; proteomics; kidney diseases

(This special issue belongs to the Section Molecular Biology)

Quantum Chemical Intelligence: New Horizons of Molecular Structure and Reactivity

edited by

Mihai V. Putz

submission deadline 30 Nov 2026 | Viewed by 417 | Submission Open

Keywords: chemical bond and bonding; quantum states and measurements; chemical reactivity; valence models; complex coordination; reaction coordinates and paths; bio-nano-materials

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Advances in Plant-Derived Nanomaterials: From Molecular Mechanisms to Biofortification

edited by

Ágnes Szepesi

submission deadline 30 Nov 2026 | Viewed by 402 | Submission Open

Keywords: nanotechnology; green synthesis; sustainable nanomaterials; nano– bio interactions; crop production; plant-based solutions; bio-corona

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular, Cellular and Systems Research on Neuroanatomy, Brain Function and Its Impact on Human Behavior

edited by

Frank Schmitz

submission deadline 30 Nov 2026 | Viewed by 398 | Submission Open

Keywords: central nervous system; neuroanatomy; human behavior; nuclei; neuronal circuits; connectivity channels

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Probiotics and Prebiotics in Gut Health and Disease

edited by

Hikmate Abriouel

submission deadline 30 Nov 2026 | Viewed by 395 | Submission Open

Keywords: probiotics; prebiotics; gut microbiota; intestinal health; dysbiosis; host– microbe interactions; omics; gut– brain axis

(This special issue belongs to the Section Molecular Microbiology)

Molecular and Cellular Pathways Involved in Age-Related Musculoskeletal Disorders

edited by

Abhishek Chandra

and Neha Dole

submission deadline 30 Nov 2026 | Viewed by 393 | Submission Open

Keywords: musculoskeletal disorders; cellular senescence; aging; genetic mutations; oxidative stress; mitochondrial dysfunction; bone homeostasis

(This special issue belongs to the Section Molecular Biology)

Functional Genomics and Computational Biology of Horticultural Plants

edited by

Claudio Pugliesi

submission deadline 30 Nov 2026 | Viewed by 391 | Submission Open

Keywords: transcriptomics; computational model; genome editing; GWAS; multi-omics; NGS technologies; MAS; genomic selection; mutagenesis; RNA-silencing

(This special issue belongs to the Section Molecular Plant Sciences)

Effects of the Environmental Conditions on Bacterial Growth and Functions

edited by

Fernanda Abreu

submission deadline 30 Nov 2026 | Viewed by 384 | Submission Open

Keywords: bacterial growth; growth conditions; gene expression; bioproducts; biofilm; resistance; population dynamics

(This special issue belongs to the Section Molecular Microbiology)

The Influence of Genetics on Lymphatic System Diseases

edited by

Tomomi Watanabe-Asaka

submission deadline 30 Nov 2026 | Viewed by 382 | Submission Open

Keywords: lymphatic system; gene expression; disease model; medical application; lymphatic development; lymphatic function

(This special issue belongs to the Section Molecular Genetics and Genomics)

T Cell Malignancies: Translating Basic Research into Better Therapy

edited by

Grzegorz Przybylski

submission deadline 30 Nov 2026 | Viewed by 376 | Submission Open

Keywords: T-Cell malignancies; specific target antigens; gene-targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Bone Microenvironment and Bone Metastasis

edited by

Cristina Sanchez de Diego

submission deadline 30 Nov 2026 | Viewed by 375 | Submission Open

Keywords: bone metastasis; tumor– bone interaction; bone microenvironment; osteoclastogenesis; osteoblast signaling; bone remodeling; dormancy; immune evasion; extracellular matrix

(This special issue belongs to the Section Molecular Oncology)

Skeletal Muscle Aging: Mechanisms, Biomarkers, and Interventions

edited by

Ida Cariati

submission deadline 30 Nov 2026 | Viewed by 371 | Submission Open

Keywords: skeletal muscle aging; sarcopenia; muscle metabolism; mitochondrial dysfunction; inflammation; exercise adaptation; muscle adaptation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on Esophageal Cancer

edited by

Antônio Palumbo Júnior

and Nathalia de Oliveira Meireles Da Costa

submission deadline 30 Nov 2026 | 1 articles | Viewed by 371 | Submission Open

Keywords: esophageal carcinogenesis; esophageal cancer prevention and diagnosis; molecular profiling of esophageal cancer; microenvironment and metastasis of esophageal cancer; molecular therapy approaches in esophageal cancer

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Central Nervous System Inflammatory Demyelinating Diseases

edited by Yong Guo

submission deadline 30 Nov 2026 | Viewed by 369 | Submission Open

Keywords: central nervous system; autoimmune; demyelination; inflammation; multiple sclerosis; pathology

(This special issue belongs to the Section Molecular Neurobiology)

Hormetic Responses of Plants to Environmental Stress

edited by

Michael Moustakas

submission deadline 30 Nov 2026 | Viewed by 369 | Submission Open

Keywords: hormesis; environmental stress; dose– response; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms

edited by

Dong-Sung Lee

and

Chi-Su Yoon

submission deadline 30 Nov 2026 | Viewed by 366 | Submission Open

Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nutrition of Crustaceans: A Molecular Perspective

edited by

Cheng Chi

submission deadline 30 Nov 2026 | Viewed by 363 | Submission Open

Keywords: crustacean nutrition; molecular mechanisms; aquaculture; nutrient metabolism; reproduction

(This special issue belongs to the Section Molecular Biology)

Displaying special issue 2701-2750 on page 55 of 65.

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