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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances in Graphene-Based Nanocomposites and Perspectives on Their Design
edited by Aleksey E. Kuznetsov
submission deadline 10 Oct 2025 | Viewed by 56 | Submission Open
Keywords: graphene; graphene oxide; nanocomposite; synthesis; computational study; characterization; application; design
(This special issue belongs to the Section Molecular Nanoscience)
Chlamydia trachomatis Pathogenicity and Disease (Third Edition) submission deadline 10 Oct 2025 | Viewed by 34 | Submission Open
Keywords: Chlamydia trachomatis; virulence factors; host susceptibility or resistance; innate and adaptive immune responses; genetic studies; cervico-vaginal microbiota; clinical outcomes with molecular study
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
MDSCs in Health and Disease submission deadline 10 Oct 2025 | Viewed by 21 | Submission Open
Keywords: MDSCs; inflammation; immune regulation; cancer; autoimmune diseases; pregnancy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Genetics of Human Disease: Emphasis on X-Linked Diseases and Clinical Practice
edited by Antonella La Russa
submission deadline 15 Oct 2025 | Viewed by 282 | Submission Open
Keywords: rare diseases; X-linked disease; X chromosome inactivation (XCI); mosaicism; epigenome; undiagnosed rare diseases; phenotype– genotype correlations; biomarkers; personalized medicine; precision medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Drug Discovery: Natural Products and Compounds submission deadline 15 Oct 2025 | Viewed by 195 | Submission Open
Keywords: natural products; drug discovery; bioactive compounds; phytochemicals; marine natural compounds; microorganisms; structure– activity relationships (SARs); pharmacological activity; cheminformatics; metabolomics
(This special issue belongs to the Section Molecular Pharmacology)
The Natural Products for Cancer Therapy
edited by María Jesus Rodríguez-Yoldi
submission deadline 15 Oct 2025 | Viewed by 20 | Submission Open
Keywords: apoptosis; antioxidant; anti-inflammatory; cancer; cell viability; food-by-products; natural products; polyphenols
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Targeted Therapy for Immune Diseases
edited by
submission deadline 20 Oct 2025 | 13 articles | Viewed by 29643 | Submission Open
Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers
(This special issue belongs to the Section Molecular Immunology)
New Players in the Research of Oxidative Stress and Cancer submission deadline 20 Oct 2025 | 8 articles | Viewed by 27921 | Submission Open
Keywords: cancer; oxidative stress; biomarkes; redox signaling pathway; therapy resistance
(This special issue belongs to the Section Biochemistry)
Phytochemicals and Nutrients in Cancer Prevention and Treatment: Recent Trends and Advances, 2nd Edition submission deadline 20 Oct 2025 | 5 articles | Viewed by 14783 | Submission Open
Keywords: phytochemicals; polyphenols; cancer; antioxidant; pro-oxidant; DNA damage; dietary supplements; signaling pathways; epigenetic; metabolism; immune system; chemoprevention
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Neural Crest Development in Health and Disease (Volume 2)
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 14475 | Submission Open
Keywords: animal models; cellular models; cell fate determination; cell metabolism; cell migration; cell signaling; disease modeling; evolution; gene– environment interactions; gene regulatory networks; neural-crest-related congenital malformations; neural-crest-related cancers; molecular genetics; molecular therapies; pathogenic mechanisms; stem-cell-based therapies
(This special issue belongs to the Section Molecular Neurobiology)
Novel Therapeutic Strategies for Neurodegenerative Disease submission deadline 20 Oct 2025 | 2 articles | Viewed by 11777 | Submission Open
Keywords: neurodegenerative diseases; Alzheimer’ s disease; Parkinson’ s disease; therapy
(This special issue belongs to the Section Molecular Neurobiology)
Plant-Sourced Functional and Bioactive Compounds—Nature’s Blueprint for Improving Human Well-Being submission deadline 20 Oct 2025 | 4 articles | Viewed by 11067 | Submission Open
Keywords: plants; antioxidants; phytochemicals; phyto-nutrition; natural products; health enhancing
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Allergy and Asthma: 3rd Edition submission deadline 20 Oct 2025 | 5 articles | Viewed by 10446 | Submission Open
Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology
(This special issue belongs to the Section Molecular Biology)
Rare Genetic Diseases: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 9658 | Submission Open
Keywords: rare genetic disease; innate metabolic errors; neurodegenerative diseases; therapeutic; molecular diagnosis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Applicability of Graphene-Based Materials in the Pharmaceutical, Biological and Biomedical Sectors
edited by and Pogacean Florina
submission deadline 20 Oct 2025 | 5 articles | Viewed by 9583 | Submission Open
Keywords: graphene; graphene-based composites; graphene-based sensors; biomedical applications; tissue engineering; drug delivery
(This special issue belongs to the Section Molecular Nanoscience)
Potential Health Benefits of Resveratrol: Laboratory-Confirmed Mechanisms of Action
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 8879 | Submission Open
Keywords: resveratrol; polyphenol; phytoalexin; phytoestrogen; natural compound; reactive oxygen species; antioxidant effects; anti-inflammatory effects; antiaging properties; antidiabetic properties; cardioprotective effects; neuroprotective effects; anticancer properties
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Research and Application of Platelet-Rich Plasma (PRP)
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 8709 | Submission Open
Keywords: platelet-rich plasma; platelet-rich fibrin; platelets; exosome; mitochondria; growth factors; tissue regeneration
(This special issue belongs to the Section Molecular Biology)
Interactions Between Microbes and Hosts: Physiology, Pathology and Treatment
edited by
submission deadline 20 Oct 2025 | 14 articles | Viewed by 8671 | Submission Open
Keywords: microbial infection; microbes– host interaction; virulence factors; molecular and cell biology; antimicrobial therapy; antibiotics; antimicrobial peptides; resistance mechanisms
(This special issue belongs to the Section Molecular Microbiology)
Viral Infections and Cancer: Recent Advances and Future Perspectives
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 8566 | Submission Open
Keywords: virus; infection; cancer; immune response
(This special issue belongs to the Section Molecular Oncology)
Cellular and Molecular Mechanisms of Autoimmune Disorders
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 8501 | Submission Open
Keywords: autoimmune diseases; self-tolerance; immune cells; autoantibodies; autoantigens; pathomechanisms
(This special issue belongs to the Section Molecular Immunology)
Advances in Cell Metabolism in Endocrine Diseases
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 8450 | Submission Open
Keywords: cellular metabolism; homeostasis; endocrine disorders; hormonal signals; dynamic system
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanisms and Therapeutic Targets in Skin Diseases
edited by Hanna Mys̈liwiec
submission deadline 20 Oct 2025 | 5 articles | Viewed by 8295 | Submission Open
Keywords: inflammatory skin diseases; systemic inflammation; infectious skin diseases; comorbidity; pathogenesis; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mesenchymal Stem Cells and Cancer
edited by Krisztián Németh and Balazs Mayer
submission deadline 20 Oct 2025 | 3 articles | Viewed by 8264 | Submission Open
Keywords: cancer; microenvironment; tumor stroma; cancer-associated fibroblast; mesenchymal stem cell; cancer immunology; angiogenesis; metastasis; targeted cancer therapy; checkpoint inhibitor; CAR-T cells; immunotherapy; signal transduction; small molecules
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanism in DNA Replication and Repair
edited by Ryszard Maciejewski
submission deadline 20 Oct 2025 | 3 articles | Viewed by 8021 | Submission Open
Keywords: DNA replication; genome stability; DNA repair mechanisms; mismatch repair mechanism; nucleotide excision repair; cancer risk
(This special issue belongs to the Section Molecular Biophysics)
Spinocerebellar Ataxias: Uncovering Their Molecular Mechanisms, Biomarker Development, and Therapies
edited by Anna Sulek
submission deadline 20 Oct 2025 | 5 articles | Viewed by 7961 | Submission Open
Keywords: spinocerebellar ataxia; biomarker; neurodegeneration; preclinical models; transcriptomics; proteomics; microRNA; iPSC; dynamic mutations
(This special issue belongs to the Section Molecular Neurobiology)
Genetic Mutations in Health and Disease
edited by
submission deadline 20 Oct 2025 | 6 articles | Viewed by 7470 | Submission Open
Keywords: genetic diseases; mutations; genetic screening; structure prediction; haploinsufficeincy; germline mutations; somatic mutations; gene enviroment interaction; gene-gene interations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetics- and Genomics-Based Crop Improvement and Breeding: 3rd Edition
edited by Jian Ma
submission deadline 20 Oct 2025 | 6 articles | Viewed by 7338 | Submission Open
Keywords: crop; germplasm; genetics; genomics; breeding
(This special issue belongs to the Section Molecular Plant Sciences)
Editorial Board Members’ Collection Series: Human Traits and Genomics submission deadline 20 Oct 2025 | 5 articles | Viewed by 7180 | Submission Open
Keywords: genetic data analysis; genomic profiling; trait inheritance; DNA and RNA sequencing approaches; deep learning methods
(This special issue belongs to the Section Molecular Genetics and Genomics)
Targeting RNA Molecules submission deadline 20 Oct 2025 | 2 articles | Viewed by 7132 | Submission Open
Keywords: riboswitch; noncoding RNA; antibiotics; resistance; bacteria; antimicrobial resistance
(This special issue belongs to the Section Molecular Biology)
Gut Microbiota in Disease and Health 3.0 submission deadline 20 Oct 2025 | 3 articles | Viewed by 7111 | Submission Open
Keywords: microbiota; microbiome; gut metabolites; short-chain fatty acids; secondary bile acids; microRNA; microvesicles; cell signaling; prebiotics/probiotics; nutrition; fecal transplantation; bacteriophages; gene editing
(This special issue belongs to the Section Molecular Microbiology)
Innovative Antimicrobial Therapies: Overcoming Virulence of Microorganisms and Drug Resistance
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 7045 | Submission Open
Keywords: antibiotics; antimicrobial resistance; antivirals; commensal; pathogenesis; virulence
(This special issue belongs to the Section Molecular Microbiology)
Molecular Research and Treatment of Prostate Cancer submission deadline 20 Oct 2025 | 3 articles | Viewed by 6846 | Submission Open
Keywords: prostate cancer; PI3K/AKT pathway; resistance mechanism; androgen receptor; MAPK
(This special issue belongs to the Section Molecular Oncology)
MicroRNA and Non-Coding RNA: From Basic Research to Potential Clinical Application
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 6766 | Submission Open
Keywords: miRNA; ncRNA; biomarkers; therapeutics; microarray; NGS
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in RNA Drug Development
edited by Hidenori Tani
submission deadline 20 Oct 2025 | 3 articles | Viewed by 6695 | Submission Open
Keywords: RNA therapeutics; drug development; antisense oligonucleotides; siRNA; miRNA; aptamers; CRISPR-Cas9; delivery systems; clinical applications; emerging technologies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Molecular Insights into Antimicrobial Photo-Treatments
edited by Pietro Delcanale
submission deadline 20 Oct 2025 | 3 articles | Viewed by 6687 | Submission Open
Keywords: photodynamic inactivation; photo-thermal therapy; photosensitization; antimicrobials; reactive oxygen species; photo-treatments; antibiotic resistance; singlet oxygen; antivirals
(This special issue belongs to the Section Molecular Microbiology)
Mitochondrial and Energy Metabolic Function in Heart and Skeletal Muscle
edited by Yoshitake Cho
submission deadline 20 Oct 2025 | 1 articles | Viewed by 6337 | Submission Open
Keywords: heart; skeletal muscle; metabolism; glucose; mitochondria; metabolic disorder
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Extracellular Vesicles: From Molecular Mechanisms to Therapeutic Applications
edited by Jung-Hyun Lee
submission deadline 20 Oct 2025 | 6 articles | Viewed by 6207 | Submission Open
Keywords: extracellular vesicles; intercellular communications; biomarkers; drug delivery systems
(This special issue belongs to the Section Biochemistry)
Exosomes—3rd Edition
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 6129 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes; cancer; sleep cardiovascular diseases; lung disease and upper airways; obesity; sleep and end-organ morbidity
(This special issue belongs to the Section Molecular Biology)
New Advances in Epigenetics and Epigenomics
edited by Vicki Maltby
submission deadline 20 Oct 2025 | 4 articles | Viewed by 6107 | Submission Open
Keywords: epigenetics; epigenomics; multi-omics; epitranscriptomics; single cell
(This special issue belongs to the Section Molecular Genetics and Genomics)
Novel Extracellular Vesicle-Based Therapy for Central Nervous System Diseases
edited by Andrea Cabrera-Pastor
submission deadline 20 Oct 2025 | 2 articles | Viewed by 5815 | Submission Open
Keywords: extracellular vesicles (EVs); exosomes; therapy; CNS disorders; neuroinflammation; signal transduction; mechanism; interorgan crosstalk; biomarker; EVs from MSCs; drug delivery
(This special issue belongs to the Section Molecular Neurobiology)
Advanced Research in Plant–Fungus Interactions: Second Edition
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 5812 | Submission Open
Keywords: plant– fungus interactions; symbiotic association; endophytes; plant conservation; mycorrhizal symbioses
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Cancer Invasion and Metastasis
edited by
submission deadline 20 Oct 2025 | 5 articles | Viewed by 5727 | Submission Open
Keywords: cancer; cancer invasion; metastasis; tumor microenvironment; molecular basis of cancer; immunotherapy; cell motility; cancer genetics; cancer development
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolic Dysfunction-Associated Steatotic Liver Disease: From Basic Science to Therapy
edited by
submission deadline 20 Oct 2025 | 4 articles | Viewed by 5420 | Submission Open
Keywords: MASLD; liver steatosis; steatohepatitis; liver cirrhosis; hepatocellular carcinoma; in vivo; in vitro; therapy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Brain Plasticity in Health and Disease
edited by
submission deadline 20 Oct 2025 | 2 articles | Viewed by 5398 | Submission Open
Keywords: brain plasticity; brain structure and function; cerebral cortex; cerebellum; neurological disorders; neuropsychiatric disorders; neurophysiology; computational modeling; brain imaging; Neuroplasticity
(This special issue belongs to the Section Molecular Neurobiology)
Molecular and Cellular Research in Pregnancy-Related Complications, 2nd Edition submission deadline 20 Oct 2025 | 2 articles | Viewed by 5227 | Submission Open
Keywords: pregnancy loss/miscarriage; pregnancy complications; pre-eclampsia; maternal– placental– fetal interactions; trophoblast; immune cells; immune tolerance; red blood cells; oxidative stress; blood and fetal proteins; DNA; RNA; stem cells
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insights into Liver Biology and Disease Pathogenesis: Shedding Light on Novel Diagnostic and Therapeutic Approaches submission deadline 20 Oct 2025 | 3 articles | Viewed by 5151 | Submission Open
Keywords: liver molecular biology; novel biomarkers; liver regeneration; liver repair; liver carcinogenesis; brain– gut– liver axis; novel therapeutic targets; molecular diagnostic tools; host– pathogen interactions; novel in vitro and in vivo models of liver diseases  
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Research and Treatment in Multiple Sclerosis
edited by Nada Starčević Čizmarević and
submission deadline 20 Oct 2025 | 3 articles | Viewed by 5118 | Submission Open
Keywords: multiple sclerosis; neuroinflammation; neurodegeneration; genetics; molecular research; biomarkers; neuroimaging; therapy
(This special issue belongs to the Section Molecular Biology)
Molecular Research on Cancer and Molecular Imaging
edited by Mi-Ae Park
submission deadline 20 Oct 2025 | 3 articles | Viewed by 4786 | Submission Open
Keywords: molecular imaging; radiology; cancer detection; precision medicine; cancer mechanisms
(This special issue belongs to the Section Molecular Biology)
Design, Synthesis, and Bioapplications of Multifunctional Materials submission deadline 20 Oct 2025 | 3 articles | Viewed by 4722 | Submission Open
Keywords: bioactivity; biodegradability; polymers; composite materials; (nano)structured materials; packaging; biological and biomedical materials
(This special issue belongs to the Section Materials Science)
Cell Signaling and Molecular Pathology of Retinal Diseases: 2nd Edition
edited by
submission deadline 20 Oct 2025 | 3 articles | Viewed by 4720 | Submission Open
Keywords: retinal degeneration; regenerative medicine; gene therapy; electroretinogram; visually evoked potential; RNA-seq; apoptosis; animal model
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
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