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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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New Strategy on Diagnosis and Treatment of Meningioma and Glioma

edited by

Giuseppe Lombardi

submission deadline 30 Nov 2025 | Viewed by 16 | Submission Open

Keywords: meningiomas; gliomas; molecular characterization; biomarker discovery; targeted therapy; neuroimaging; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Antibiotics Science: Molecular Insights, Detection Strategies, Resistance Challenges and Interdisciplinary Applications

edited by

Lidia Magerusan

submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open

Keywords: antibiotics; antibiotic molecular design and synthesis; antibiotic action mechanism; antibiotics resistance; environmental contamination; therapeutic monitoring; antibiotic sensing and detection; food and environmental safety

(This special issue belongs to the Section Molecular Microbiology)

Chronic Kidney Disease: Underlying Molecular Mechanisms—2nd Edition

edited by

Luís Belo

and

Márcia Carvalho

submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open

Keywords: chronic kidney disease; molecular mechanisms; toxicity mechanisms; inflammation; environmental factors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Aspects of Viral Pathogenesis: From Infection to Host Response

edited by

Quang Duy Trinh

submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open

Keywords: viruses; viral pathogenesis; virus– host interaction; molecular virology; immunity; viral entry; viral replication; emerging viruses; infectious diseases; inflammation

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research on Andrology

edited by Elikanah Olusayo Adegoke

submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open

Keywords: fertilty; assisted reproduction technology; endocrine disrupting chemicals; hormones; male reproductive aging; semen analysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Molecular and Cellular Pathophysiologic Mechanisms Underlying Ocular Diseases and Emerging Therapies (2nd Edition)

edited by

Snježana Kaštelan

submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open

Keywords: eye disease; immunobiological features; molecular pathogenesis; biomarkers; clinical implications; emerging therapies; lacrimal gland; ocular tumors; glaucoma; diabetic retinopathy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Unraveling Bioactive Peptides: Structure, Function, and Applications

edited by

Sara Elsa Aita

submission deadline 30 Nov 2025 | Viewed by 15 | Submission Open

Keywords: bioactive peptides; peptide structure– activity relationship; peptidomics; bioactivity assays; human health

(This special issue belongs to the Section Macromolecules)

Signal Transduction Pathways: From Molecular Mechanisms to Therapeutic Targets

edited by

Boratkó Anita

submission deadline 30 Nov 2025 | Viewed by 14 | Submission Open

Keywords: signal transduction; molecular mechanism; cell signaling; disease pathways; therapeutic targets

(This special issue belongs to the Section Molecular Biology)

Signaling in Cells Proliferating in Two- and Three-Dimensional Cultures

edited by Hedwig Sutterluety-Fall

submission deadline 30 Nov 2025 | Viewed by 13 | Submission Open

Keywords: proliferation; signaling; two-dimensional; three-dimensional; cell culturing; in vitro; growth factors

(This special issue belongs to the Section Molecular Biology)

Molecular Progression of Genome-Related Diseases: 2nd Edition

edited by

Salvatore Saccone

submission deadline 30 Nov 2025 | Viewed by 13 | Submission Open

Keywords: next-generation sequencing; genetic diseases; multifactorial diseases; diagnostic tolls; human health

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Treatment Models in Hepatocellular Carcinomas

edited by

Michał P. Wasilewicz

submission deadline 30 Nov 2025 | Viewed by 13 | Submission Open

Keywords: hepatocellular carcinoma (HCC); liver tumors; liver cancer; molecular mechanisms; systemic therapies; immunochemotherapy; immunotherapy; adjuvant therapy; neoadjuvant therapy; hepatocellular carcinoma microenvironment; liver resection/liver transplantation in HCC; microwave ablation (MWA); transarterial chemoembolisation (TACE)

(This special issue belongs to the Section Molecular Oncology)

Host DNA Damage Responses in Virus Propagation and Human Disease

edited by Nimrat Chatterjee

submission deadline 30 Nov 2025 | Viewed by 11 | Submission Open

Keywords: DNA repair; DNA viruses; RNA viruses; translesion synthesis; cancer

(This special issue belongs to the Section Molecular Microbiology)

Enhancing Stem Cell Grafting in Tissue Regeneration and Repair

edited by

Yuanyuan Zhang

submission deadline 30 Nov 2025 | Viewed by 11 | Submission Open

Keywords: stem cell therapy; tissue regeneration; graft enhancement; molecular mechanisms; engraftment; biomaterials; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Innovative Nano- and Microcarrier Systems for Targeted Delivery

edited by

Matteo Perra

submission deadline 30 Nov 2025 | Viewed by 11 | Submission Open

Keywords: drug delivery systems; nanocarriers; microcarriers; targeted delivery; controlled release; bioactive compounds; nanomedicine

(This special issue belongs to the Section Molecular Nanoscience)

Natural Product as Therapeutic Agent: From Molecular Targets to Cellular and Functional Modulation

edited by Su-Yun Lyu

submission deadline 30 Nov 2025 | Viewed by 11 | Submission Open

Keywords: natural products; molecular targets; cellular modulation; functional modulation; therapeutic agents

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Emerging Roles of the Gut-Brain Axis (GBA) in Health and Disease

edited by Vinata Vedam-Mai

submission deadline 30 Nov 2025 | Viewed by 10 | Submission Open

Keywords: gut– brain axis; gut microbiota; brain function; diagnostic tools

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Ocular Inflammation and Infection

edited by

Christine Fardeau

submission deadline 30 Nov 2025 | Viewed by 9 | Submission Open

Keywords: ocular infections; uveitis; choroiditis; masquerade syndrome; pseudo-uveitis; intraocular lymphoma; retinal dystrophy; ocular inflammation; neuroinflammation; immunotherapy-induced uveitis; autoimmune eye diseases; sarcoidosis; OCT; indocyanine green angiography

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanism and Therapeutics in Human Cancer

edited by

Rachel Bar-Shavit

submission deadline 30 Nov 2025 | Viewed by 6 | Submission Open

Keywords: oncogenes; Wnt/b-catenin; G-protein-coupled receptors (GPCR); translational means; cancer stem cells; ubiquitination and deubiquitinating in cancer

(This special issue belongs to the Section Molecular Oncology)

Novel Molecular Pathways in Oncology, 3rd Edition

edited by

Giovanna Casili

submission deadline 1 Dec 2025 | 3 articles | Viewed by 3106 | Submission Open

Keywords: molecular pathway involved in tumorigenesis; cancer therapy; targeted therapy; anticancer drugs; brain cancer; oral cancer; gastrointestinal cancer

(This special issue belongs to the Section Molecular Oncology)

The Current Landscape of Microglia-Glioma Research: From Basic Science to Therapeutic Potential

edited by

Manuel Benedikt Graeber

submission deadline 1 Dec 2025 | Viewed by 321 | Submission Open

Keywords: microglia; glioma; tumor associated macrophages; immunosuppression; epigenetics

(This special issue belongs to the Section Molecular Neurobiology)

Gene Editing for Cereal Crops

edited by

Ke Wang

submission deadline 1 Dec 2025 | Viewed by 112 | Submission Open

Keywords: gene-editing techniques; novel germplasm; quality; nutrition; agronomic traits

(This special issue belongs to the Section Molecular Plant Sciences)

Long-COVID and Its Complications

edited by

Alexey Sarapultsev

submission deadline 4 Dec 2025 | 6 articles | Viewed by 23148 | Submission Open

Keywords: acquired immune deficiency; auto-immunity; blood– brain barrier dysfunction; complication; COVID-19; gut microbiome; hypothalamic– pituitary– adrenal axis; immune dysfunction; long COVID; multisystem dysfunction; neurological complications; SARS-CoV-2; systemic inflammation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biology of Oral Cancer

edited by Rafał Pęksa

submission deadline 10 Dec 2025 | 1 articles | Viewed by 254 | Submission Open

Keywords: oral cancer; molecular mechanisms; biomarkers; tumor microenvironment; therapy resistance; precision medicine; carcinogenesis; oral squamous cell carcinoma; epigenetics; microbiome; immunotherapy; liquid biopsy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Characterization and Molecular Engineering of Multidomain Proteins (4th Edition)

edited by

Koichi Kato

and

Takayuki Uchihashi

submission deadline 10 Dec 2025 | Viewed by 33 | Submission Open

Keywords: multidomain proteins; protein dynamics; domain interactions; allosteric regulation; protein engineering; SAXS; Cryo-EM; protein NMR; computational modeling; protein design

(This special issue belongs to the Section Molecular Biophysics)

Pathogenesis and Molecular Therapy of Brain Tumor

edited by

Theo Kraus

submission deadline 15 Dec 2025 | Viewed by 10 | Submission Open

Keywords: brain tumor; glioma; glioblastoma; astrocytoma; oligodendroglioma; epigenetics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

High-Density Lipoproteins in Health and Disease

edited by

Ilaria Zanotti

submission deadline 20 Dec 2025 | 6 articles | Viewed by 20138 | Submission Open

Keywords: omics; protein; lipid; cardiovascular; neurodegenerative disease; inflammation; preclinical studies; therapy

(This special issue belongs to the Section Molecular Biology)

Advances in Retinal Diseases: 2nd Edition

edited by Minzhong Yu

submission deadline 20 Dec 2025 | 7 articles | Viewed by 18964 | Submission Open

Keywords: retina; optic nerve; ocular disorder; retinal disease; genetic mutation; aging; drug side effects; novel mutations/biomarkers; signaling pathways; spectral domain optical coherence tomography; stem cell; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomimetic Materials Applied in the Analytical and Biomedical Fields

edited by

Iacob Bogdan-Cezar

and

Ede Bodoki

submission deadline 20 Dec 2025 | 6 articles | Viewed by 15926 | Submission Open

Keywords: biomimetics; molecular recognition; imprinted polymers; smart materials; molecular complexes; polymeric biomaterials; biomedical materials; analytical methods; molecular interactions; artificial receptors

(This special issue belongs to the Section Materials Science)

Bacteriophages Biology and Bacteriophage-Derived Technologies

edited by Wilfried Moreira

submission deadline 20 Dec 2025 | 5 articles | Viewed by 15840 | Submission Open

Keywords: bacteriophage; antibiotic resistance; biofilm; molecular biology; genetic engineering; synthetic biology

(This special issue belongs to the Section Biochemistry)

Plant Responses to Biotic and Abiotic Stresses

edited by

Shu Yuan

submission deadline 20 Dec 2025 | 16 articles | Viewed by 13847 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Biodiversity and Molecular Marker Technology: Discovery and Application of DNA Polymorphisms

edited by

Luigi De Masi

submission deadline 20 Dec 2025 | 13 articles | Viewed by 13090 | Submission Open

Keywords: plant biodiversity; plant genetic resources; genetic variability; molecular characterization; biomolecular resources; DNA-based molecular markers; DNA sequencing; next generation sequencing; biosequences; DNA polymorphisms; bioinformatics

(This special issue belongs to the Section Molecular Plant Sciences)

Plant Genome Editing

edited by Lei Gao

submission deadline 20 Dec 2025 | 5 articles | Viewed by 11898 | Submission Open

Keywords: plant genome editing; Cas9/Cas12a; CRISPR/CRISPRa/CRISPRi; anti-CRISPR; gene editing; off target impact; prime editing; bioinformatics/database

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights of Fungal and Plant Lipids: Structural Diversity, Metabolism and Applications

edited by

Ekaterina Kotlova

submission deadline 20 Dec 2025 | 5 articles | Viewed by 11453 | Submission Open

Keywords: lipidomics; fatty acids; glycerolipids; sphingolipids; sterols; oxylipins; fungal and plant lipid metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Computational Approaches in Drug Design: Novel Methodologies and Applications

edited by

Serena Vittorio

submission deadline 20 Dec 2025 | 6 articles | Viewed by 11079 | Submission Open

Keywords: drug design; computational approaches; molecular docking; molecular dynamics; pharmacophore modeling; homology modeling; computer aided drug design; ADME/Tox predictions; artificial intelligence

(This special issue belongs to the Section Molecular Informatics)

(Meta)Genomic, Functional, Structural and Evolutionary Analysis of Transport Systems

edited by

Arturo Medrano-Soto

, Milton Saier and Gabriel Moreno-Hagelsieb

submission deadline 20 Dec 2025 | 3 articles | Viewed by 11076 | Submission Open

Keywords: molecular transport; transport mechanisms; evolution; families and superfamilies; genomics; metagenomics; 3D structural insights; bioinformatics

(This special issue belongs to the Section Molecular Biology)

Natural Bioactives and Inflammation, 2nd Edition

edited by

Juan Gambini

submission deadline 20 Dec 2025 | 5 articles | Viewed by 10803 | Submission Open

Keywords: inflammation; bioactive compounds; polyphenols; nutraceutical; diet; nutrition; pharmacology; health; lifespan; healthspan; aging; inflammaging

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Exosomes and Extracellular Vesicles in Health and Diseases: 3rd Edition

edited by

Manuela Zavatti

and

Francesca Beretti

submission deadline 20 Dec 2025 | 7 articles | Viewed by 10211 | Submission Open

Keywords: exosome; extracellular vesicles; network signals; biomarkers; pathological conditions

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mass Spectrometry Approaches as Clinical Diagnostic/Prognostic Tools

edited by

Federica Iavarone

submission deadline 20 Dec 2025 | 2 articles | Viewed by 10094 | Submission Open

Keywords: mass spectrometry; quantitative analysis; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advanced Research on HIV Virus and Infection

edited by

Patricia Price

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9924 | Submission Open

Keywords: HIV; viral proteins; immunogenetics; pathogenesis

(This special issue belongs to the Section Molecular Immunology)

In Honor of Elie Metchnikoff, a Nobel Prize Winner, Who Discovered Macrophages as Phagocyte Cells Involved in the Process of Innate Immunity

edited by

Pierre Tennstedt

submission deadline 20 Dec 2025 | 4 articles | Viewed by 9815 | Submission Open

Keywords: macrophages; monocytes; phagocytes; fibroblast; cytokines; chronic disease; autoimmune disease; inflammatory disease; immune response; disease treatment

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biomarkers and Early Detection Strategies of Ovarian Tumors

edited by Lukasz Szafron

submission deadline 20 Dec 2025 | 6 articles | Viewed by 9243 | Submission Open

Keywords: biomarker; ovarian cancer; borderline ovarian tumor; genetic variant; epigenetics; transciptomics; proteomics; metabolomics; ovarian tumor prevention; ovarian tumor treatment

(This special issue belongs to the Section Molecular Oncology)

Updates on Synthetic and Natural Antioxidants

edited by

Izabela Sadowska-Bartosz

and

Grzegorz Bartosz

submission deadline 20 Dec 2025 | 5 articles | Viewed by 8901 | Submission Open

Keywords: antioxidants; synthetic; natural compounds

(This special issue belongs to the Section Biochemistry)

Impact of Diet on the Endocrine System: Insights into Cellular and Molecular Mechanisms

edited by

Gaia Favero

and

Luca Vanella

submission deadline 20 Dec 2025 | 3 articles | Viewed by 8894 | Submission Open

Keywords: antioxidants; diet; endocrine system; ROS; lifestyle; nutraceuticals

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recombinant Proteins, Protein Folding and Drug Discovery

edited by

Mohamed Raafat El-Gewely

submission deadline 20 Dec 2025 | 7 articles | Viewed by 8843 | Submission Open

Keywords: heterologous hosts for gene expression; recombinant therapeutic proteins; antigens; and antibodies; large scale production of recombinant proteins; recombinant protein bioreactor; downstream processing of recombinant proteins; codon optimization for protein expression; refolding of misfolded recombinant proteins; solubilization of aggregated and inclusion bodies of recombinant proteins; protein target validation for drug discovery and development; protein target expression for drug discovery and development; metabolic engineering of recombinant protein production; regulatory noncoding RNAs to boost the expression of protein; the use of foldases & conformases in recombinant protein expression; delivery of therapeutic proteins; therapeutic protein Vs mRNA therapeutics

(This special issue belongs to the Section Biochemistry)

Breast Cancer: From Pathophysiology to Novel Therapies

edited by Jennifer Sims-Mourtada

submission deadline 20 Dec 2025 | 6 articles | Viewed by 8481 | Submission Open

Keywords: breast cancer; genetics; tumor microenvironment; model systems; organoids; immune cells; tumor stroma; therapeutic resistance; novel therapies

(This special issue belongs to the Section Molecular Oncology)

Current Research on Bioactives from Natural Products

edited by

Carmen Lizette Del-Toro-Sánchez

submission deadline 20 Dec 2025 | 4 articles | Viewed by 8395 | Submission Open

Keywords: antioxidants; molecular models; natural products; bioactive compounds; food; materials; antimicrobials; mechanisms of action; extraction techniques; health benefits

(This special issue belongs to the Section Molecular Biology)

Molecular Basis of Neuropsychiatric Disorders: Recent and Future Developments

edited by

Konstantinos Tsamakis

submission deadline 20 Dec 2025 | 5 articles | Viewed by 8011 | Submission Open

Keywords: molecular; schizophrenia; depression; genetic; autism; mechanisms; genetic

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Therapies in Skeletal Muscle Diseases

edited by Valeria Guglielmi

submission deadline 20 Dec 2025 | 3 articles | Viewed by 7747 | Submission Open

Keywords: skeletal muscle; skeletal muscle diseases; pathogenesis; molecular mechanism; muscle degeneration; muscle regeneration; myokines; cell therapy; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Enzymes in Metabolic Processes

edited by

Koichi Fujisawa

submission deadline 20 Dec 2025 | 4 articles | Viewed by 7699 | Submission Open

Keywords: enzyme; metabolism; glycolysis; mitochondria; kinase; cell growth; carcinogenesis

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

New Insights into Immunity and Inflammation in Cardiovascular Diseases

edited by

David J. Vigerust

submission deadline 20 Dec 2025 | 5 articles | Viewed by 7538 | Submission Open

Keywords: pathogens; oxidative stress; cytokines; chemokines; immunity; chronic inflammation

(This special issue belongs to the Section Molecular Immunology)

Displaying special issue 2651-2700 on page 54 of 70.

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