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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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The Role of Micronutrients in Cancer Prevention
edited by Jacek Baj
submission deadline 30 Sep 2025 | Viewed by 42 | Submission Open
Keywords: micronutrient; metallomics; metallomic analysis; nutrient; ICP-MS; ICP-OES; prevention; carcinogenesis
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Bioplastic-Related Toxicity in Humans: New Insights and Molecular Mechanisms submission deadline 30 Sep 2025 | Viewed by 42 | Submission Open
Keywords: bioplastics and biopolymers -related toxicity; microplastics and nanoplastics accumulation/degradation in mammals; cell cultures; human health; in vivo models; epigenetics effects; endocrine disruptor properties of bioplastics; bioplastics and inflammation; bioplastics in neurodegeneration and neuroinflammation; reproduction; cell metabolism; immunomodulation
(This special issue belongs to the Section Molecular Toxicology)
Advances in Molecular Approaches to Asthma Management submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open
Keywords: severe asthma; type 2 and non-type 2 inflammation; antibodies; comorbidities; treatable traits
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Microbiology in the Omics Era: Genomics, Metagenomics and Computational Insights
edited by
submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open
Keywords: microbial genomics; metagenomics; computational biology; antimicrobial resistance; host– microbe interactions; multi-omics integration; bioinformatics tools; machine learning in microbiology
(This special issue belongs to the Section Molecular Microbiology)
Molecular Advances in Detection and Analysis of Microbial Pathogens
edited by Ignacio Garcia
submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open
Keywords: molecular diagnostics; antimicrobial resistance; emerging pathogens; bioinformatics; metagenomics; clinical microbiology; environmental microbiology; surveillance; outbreak detection
(This special issue belongs to the Section Molecular Microbiology)
Research on Plant Genomics and Breeding: 3rd Edition submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open
Keywords: gene cloning and function; genetic engineering; molecular genetics; genome editing; regulatory mechanisms; germplasm enhancement; molecular breeding and marker-assisted selection
(This special issue belongs to the Section Molecular Plant Sciences)
Application of NMR Spectroscopy in Biomolecules: 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 41 | Submission Open
Keywords: advanced solution and solid state biomolecular NMR techniques; structure and dynamics of biomolecules: proteins; peptides; and nucleic acids; paramagnetic NMR; in/on cell-NMR; protein– ligand; protein– DNA; protein– RNA interaction; protein folding and misfolding; structure-based drug screening; fragment-based drug screening; computational NMR methods; sample preparation and isotope labeling strategies; NMR metabolomics and foodomics; membrane proteins and lipids; natural-abundance NMR spectroscopy; pharmaceutical NMR applications; disordered proteins and peptides; drugs development; metal-binding biomolecules; hyperpolized NMR techniques; 19F NMR spectroscopy; NMR techniques for the analysis of complex mixtures; integrated NMR-based methodologies
(This special issue belongs to the Section Molecular Biophysics)
Hormone Receptors and Signaling in Breast Cancer, 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 40 | Submission Open
Keywords: breast cancer; hormone receptor; growth factor receptor; estrogen receptor; endocrine therapies; PI3K; AKT; mTOR; signaling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Pesticide Exposure and Toxicity Research: Impacts on Endocrine and Nervous System Pathophysiology
edited by
submission deadline 30 Sep 2025 | Viewed by 40 | Submission Open
Keywords: pesticide exposure; neurotoxicity; endocrine disruption; risk assessment; toxicological mechanisms; human health effects; biomonitoring; animal models
(This special issue belongs to the Section Molecular Toxicology)
Advances in Plant Biotechnology: From Pathogen Diagnostics to Disease Management submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open
Keywords: plant pathogens; diagnostic; isothermal; biosensor; RNAi; CRISPRi; QTL mapping; GWAS; MAS or MABC
(This special issue belongs to the Section Molecular Plant Sciences)
Drug Repurposing: Emerging Approaches to Drug Discovery (2nd Edition)
edited by
submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open
Keywords: repurposed drugs; network medicine; systems medicine; drug design; therapeutic strategies; drug repurposing in the era of artificial intelligence; drug repositioning; machine learning
(This special issue belongs to the Section Molecular Pharmacology)
Advances in Novel Therapeutic Strategies for Cancers submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open
Keywords: precision medicine; molecular targeted therapies; kinase inhibitors; PROTAC; CAR-T cell therapy; tumor microenvironment; host microbiota; resistance mechanisms; biomarkers; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Surfactants: Design, Synthesis and Properties
edited by
submission deadline 30 Sep 2025 | Viewed by 39 | Submission Open
Keywords: design and synthesis of surfactants; adsorption and aggregation properties of surfactants; behavior of surfactants at different interfaces; application of biosurfactants and specialist surfactants (industry; agriculture; medicine; pharmacy)
(This special issue belongs to the Section Materials Science)
Eco-Conscious Therapeutics: Molecular Foundations and Future Directions in Green Medicine
edited by and
submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open
Keywords: green medicine; molecular therapeutics; sustainable healthcare; biomarker profiling; predictive toxicology; eco-friendly drug design; environmental impact; biodegradable materials
(This special issue belongs to the Section Molecular Toxicology)
Research on System Biology Methods and Tools for Integrating Omics Data
edited by Yuanyan Xiong
submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open
Keywords: systems biology; multi-omics integration; network analysis; computational biology; bioinformatics tools; machine learning; precision medicine
(This special issue belongs to the Section Molecular Informatics)
The Role of Extracellular Vesicles in Disease and Therapeutic Applications
edited by Sunyoung Park
submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open
Keywords: extracellular vesicles (EVs); disease biomarkers; EV-based therapeutics; cancer diagnosis; drug delivery; immune modulation; regenerative medicine
(This special issue belongs to the Section Molecular Biology)
Advances in Epigenetics of Mental Disorders
edited by
submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open
Keywords: mental disorders; epigenetic; epigenomic; gene– environment interactions
(This special issue belongs to the Section Molecular Neurobiology)
Plant Senescence Under Environmental Stresses submission deadline 30 Sep 2025 | Viewed by 38 | Submission Open
Keywords: plant senescence; environmental stresses; phytohormones
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Advances in Immunosuppressive Therapy
edited by
submission deadline 30 Sep 2025 | Viewed by 37 | Submission Open
Keywords: immunosuppressive drugs; calcineurin inhibitors; corticosteroids; inhibitors of purine synthesis; mammalian target of rapamycin inhibitors; biological treatment; cell-based therapies; biomarkers; genetic profiling
(This special issue belongs to the Section Molecular Immunology)
Lifestyle Interventions in MASLD: A Molecular Perspective
edited by Muhammad Y. Sheikh
submission deadline 30 Sep 2025 | Viewed by 36 | Submission Open
Keywords: NAFLD (nonalcoholic fatty liver disease); MASLD (metabolic syndrome-associated steatotic liver disease); metabolic syndrome; dyslipidemia; diabetes mellitus 2; hypertension; natural bioactive
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular and Cellular Mechanisms of Apoptosis and Aging Complexes
edited by
submission deadline 30 Sep 2025 | Viewed by 36 | Submission Open
Keywords: cell biology; antioxidants; transmembrane signalisation; actin cytoskeleton; anti-tumor therapy; cytotoxicity; apoptosis; aging; neurodegenerative diseases
(This special issue belongs to the Section Molecular Biology)
RNA in Human Diseases: Challenges and Opportunities: 2nd Edition
edited by
submission deadline 30 Sep 2025 | Viewed by 36 | Submission Open
Keywords: microRNA; piRNA; lncRNA; circRNA; RNA therapeutics; ceRNET; RNA disease; RNA processing; RNA modification
(This special issue belongs to the Section Molecular Biology)
Bone Microenvironment and Bone Metastasis submission deadline 30 Sep 2025 | Viewed by 36 | Submission Open
Keywords: bone metastasis; tumor– bone interaction; bone microenvironment; osteoclastogenesis; osteoblast signaling; bone remodeling; dormancy; immune evasion; extracellular matrix
(This special issue belongs to the Section Molecular Oncology)
Mitochondrial Functions and Dynamics
edited by
submission deadline 30 Sep 2025 | Viewed by 35 | Submission Open
Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system
(This special issue belongs to the Section Molecular Biology)
Plant Breeding Strategies: Employment of Plant Adaptation Mechanisms to Biotic and Abiotic Stresses
edited by
submission deadline 30 Sep 2025 | Viewed by 35 | Submission Open
Keywords: marker-assisted selection; molecular breeding; whole-transcriptome analysis; RNA sequencing; DNA sequencing; plant stress response
(This special issue belongs to the Section Molecular Plant Sciences)
Neuroendocrine Integration of Stress and Reproduction
edited by Maria Bernardete Cordeiro De Sousa
submission deadline 30 Sep 2025 | Viewed by 35 | Submission Open
Keywords: HPA axis; HPG axis; stress and reproduction; neuroendocrine regulation; cortisol and fertility; neuropeptides; epigenetics; reproductive dysfunction
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Marine Fungi: From Molecular Biology to Biotechnology Application
edited by
submission deadline 30 Sep 2025 | Viewed by 34 | Submission Open
Keywords: marine fungi; marine yeasts; marine filamentous fungi; biosynthesis; metabolic engineering; regulatory mechanism; functional biomolecules; exopolysaccharides; glycolipids; organic acids; biofuel; enzymes; cell factories; gene editing tools; fermentation optimization
(This special issue belongs to the Section Molecular Microbiology)
3D Cell and Tissue Culture Systems: Benefits to Research and Disease Diagnostics
edited by
submission deadline 30 Sep 2025 | Viewed by 34 | Submission Open
Keywords: 3D physiological relevance vs. 2D biology; 3D research; and diagnostic systems; evolving 3D “ omics” applications; research and clinical medicine; drug applications; toxicity evaluations
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies
edited by Noah R. Johnson and
submission deadline 30 Sep 2025 | Viewed by 33 | Submission Open
Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery
(This special issue belongs to the Section Molecular Neurobiology)
Advances in Surfactant Systems: Thermodynamics, Molecular Interactions, and Applications
edited by
submission deadline 30 Sep 2025 | Viewed by 33 | Submission Open
Keywords: micelles; mixed micelles; thermodynamic functions of micellization; micellar solubilization; enthalpy– entropy compensation; boundary surface; Langmuir isotherm; theoretical models
(This special issue belongs to the Section Biochemistry)
Molecular Forensics and the Genetic Foundations of Forensic Biology
edited by
submission deadline 30 Sep 2025 | Viewed by 33 | Submission Open
Keywords: molecular forensics; forensic genetics; epigenetics; biological fluid identification; forensic microbiology; sexual assault
(This special issue belongs to the Section Molecular Biology)
Natural Compounds in Cancer Therapy: Molecular Mechanisms and Translational Potential submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open
Keywords: natural compounds; cancer research; oxidative stress
(This special issue belongs to the Section Molecular Oncology)
Genetic, Functional and Therapeutic Aspects of Procoagulant and Anticoagulant Factors (Third Edition)
edited by and
submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open
Keywords: procoagulant factors; anticoagulant factors; hemostasis; inflammation; genetics; therapeutics; cell signaling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Insights into Probiotics and Prebiotics in Gut Health and Disease
edited by
submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open
Keywords: probiotics; prebiotics; gut microbiota; intestinal health; dysbiosis; host– microbe interactions; omics; gut– brain axis
(This special issue belongs to the Section Molecular Microbiology)
Recent Progress in Nanomedicine for Cancer Therapy
edited by Peisheng Xu
submission deadline 30 Sep 2025 | Viewed by 32 | Submission Open
Keywords: nanomedicine; cancer-targeted therapy; theragnostic; nanodevice
(This special issue belongs to the Section Molecular Nanoscience)
Molecular Mechanisms of Mitochondrial Neurodegenerative Diseases
edited by and Paola Pontieri
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: mitochondrial disease; nuclear genome; mitochondrial genome; human MRP genes; MRPL44; NAM9; GEP3; Alzheimer’ s disease; Parkinson’ s disease; yeast and C. elegans model organisms
(This special issue belongs to the Section Molecular Neurobiology)
Biochemical Advancements in Filler Technology and Their Impact on Tissue Engineering
edited by Samuel J. Lin
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: biochemical filler technology; tissue regeneration; bioactive materials; injectable scaffolds; molecular signaling in tissue engineering; biomaterials for soft tissue repair; filler– cell interactions; regenerative esthetics
(This special issue belongs to the Section Biochemistry)
Molecular Mechanism and Pharmacological Target of Neuroprotection
edited by
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: neurodegeneration; animal model; brain regeneration; pharmacological drug; molecular analysis
(This special issue belongs to the Section Molecular Neurobiology)
Design, Synthesis and Application of Cellulose Materials
edited by and
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: cellulose; polymer materials; biomass
(This special issue belongs to the Section Materials Science)
Surfactant Sciences: Design, Synthesis, and Applications
edited by Zakaria Hafidi
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: surfactants; synthesis; biodegradation; catalysis; biological activity; nanoparticles; design; green chemistry; self-assembly; surface chemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Advances in the Molecular Biology of Lipids and Mitochondria
edited by
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: lipids; lipid transport mechanisms; lipid peroxidation; mitochondrial integrity; bioenergetics; mitochondrial phospholipid
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Microbial Interactions with Insect Hosts: Mechanisms, Evolution and Ecological Implications
edited by Jin-Hua Xiao
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: insect-microbe symbiosis; host-microbe coevolution; microbial-mediated behavior; insect adaptive evolution; cross-domain evolution
(This special issue belongs to the Section Molecular Microbiology)
Antimicrobial Agents and the Quest for Resistance Breakthroughs
edited by
submission deadline 30 Sep 2025 | Viewed by 31 | Submission Open
Keywords: drug resistance; antimicrobial resistance (AMR); drug-resistant bacteria; drug-resistant viruses; drug-resistant fungi; drug-resistant parasite; drug resistance biomolecular studies; mechanism of resistance; novel antimicrobial agents; treatment of infectious diseases
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Research on Stroke
edited by
submission deadline 30 Sep 2025 | Viewed by 30 | Submission Open
Keywords: stroke; microglia; neuroinflammation; molecular mechanisms; ischemic injury
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Research in Natural Products
edited by
submission deadline 30 Sep 2025 | Viewed by 29 | Submission Open
Keywords: synaptic plasticity regulation; bioactive compounds; signal transduction pathways; gene expression regulation; molecular neurobiology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Research on Microbial Natural Products
edited by Wenli Li
submission deadline 30 Sep 2025 | Viewed by 29 | Submission Open
Keywords: microbial natural products; biosynthetic gene clusters; structural elucidation; metabolic engineering; synthetic biology; bioactivity profiling; sustainable biomanufacturing
(This special issue belongs to the Section Molecular Microbiology)
Unraveling the Molecular Crosstalk Between Ferroptosis and Tumorigenesis
edited by
submission deadline 30 Sep 2025 | Viewed by 29 | Submission Open
Keywords: tumorigenesis; ferroptosis; cancer biology; tumor development
(This special issue belongs to the Section Molecular Oncology)
Targeting MAPK in Human Diseases
edited by
submission deadline 30 Sep 2025 | Viewed by 29 | Submission Open
Keywords: ERK; DUSP; cancer; inflammation; neurodegenerative diseases; autoimmune diseases; targeted therapy; cell signaling
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Molecular Research on Candida Resistance
edited by
submission deadline 30 Sep 2025 | Viewed by 29 | Submission Open
Keywords: Candida resistance; antifungal resistance; biofilm; drug repurposing; novel therapies; molecular mechanisms; antifungal agents; Candida albicans; Candida auris; host– pathogen interactions
(This special issue belongs to the Section Molecular Microbiology)
Advances in Endoplasmic Reticulum Stress and Apoptosis—Second Edition submission deadline 30 Sep 2025 | Viewed by 28 | Submission Open
Keywords: ER stress; apoptosis initiated by ER stress; cellular survival; redox homeostasis of ER; autophagy initiated by ER stress; cell death pathways initiated by ER stress
(This special issue belongs to the Section Biochemistry)
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