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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Allergic Reactions and Immune Factors

edited by

Liborija Lugovic-Mihic

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1205 | Submission Open

Keywords: allergic reactions; immunity; immunological factors; hypersensitivity; antibody; cytokine; immune response; etiology; pathogenesis; clinical manifestations; diagnostic; therapy

(This special issue belongs to the Section Molecular Immunology)

Alzheimer’s Disease: Molecular Mechanisms and Novel Therapies

edited by Noah R. Johnson and

Chih Hung Lo

submission deadline 20 Nov 2026 | 2 articles | Viewed by 1107 | Submission Open

Keywords: intrinsically disordered proteins; apolipoproteins; neuroinflammation and neuroimmune; autolysosomal and mitochondrial functions; lipid metabolism; blood-brain barrier; biosensors; nanomedicine; high-throughput screening; therapeutic discovery

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Sepsis: Molecular and Biochemical Perspectives

edited by

Akrivi Chrysanthopoulou

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1023 | Submission Open

Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes

(This special issue belongs to the Section Biochemistry)

Current Research on Autophagy in Aging and Age Related Diseases

edited by

Tímea Sigmond

submission deadline 20 Nov 2026 | 1 articles | Viewed by 1022 | Submission Open

Keywords: autophagy; aging; molecular mechanisms; age related diseases; mitochondria

(This special issue belongs to the Section Biochemistry)

Radiobiology: New Challenges and Advances

edited by

Lorenzo Manti

and

Pavel Bláha

submission deadline 20 Nov 2026 | 1 articles | Viewed by 896 | Submission Open

Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT; proton– boron capture therapy; radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy; ferroptosis; fibroblast activation protein; non-cancer effects and non-targeted effects

(This special issue belongs to the Section Molecular Biology)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 20 Nov 2026 | Viewed by 865 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathogenesis and Treatment Approaches of Hematological Malignancies

edited by

Yosuke Minami

submission deadline 20 Nov 2026 | 1 articles | Viewed by 817 | Submission Open

Keywords: leukemia; lymphoma; minimal residual disease (MRD); cancer genomic profiling (CGP); molecular targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Biophysical Studies of Protein Structure-Function Relationships

edited by

Almerinda Di Venere

Giampiero Mei

and Velia Minicozzi

submission deadline 20 Nov 2026 | 1 articles | Viewed by 732 | Submission Open

Keywords: protein structure; molecular dynamics; computational modeling; drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Human Meningioma: Recent Developments

edited by Jason P. Sheehan, Yuki Shinya and Stylianos Pikis

submission deadline 20 Nov 2026 | Viewed by 580 | Submission Open

Keywords: meningioma; molecular pathogenesis; genomic alteration; radiogenomics; tumor microenvironment; biomarkers; neurosurgery; radiosurgery; translational neuroscience; artificial intelligence

(This special issue belongs to the Section Molecular Oncology)

Plant Responses to Abiotic and Biotic Stresses: 2nd Editon

edited by

Longxing Tao

and

Tingting Chen

submission deadline 20 Nov 2026 | 1 articles | Viewed by 488 | Submission Open

Keywords: climate change and crop production; abiotic stress; biotic stress; plant resistance to abiotic and biotic stresses; molecular mechanism; physiological responses; plant hormones; carbohydrate metabolism and transport; molecular signaling; reactive oxygen species (ROS); calcium ions; photosynthesis; respiration; energy metabolism

(This special issue belongs to the Section Molecular Plant Sciences)

Dietary Polyphenols and Human Health

edited by

Chunmei Li

submission deadline 20 Nov 2026 | Viewed by 458 | Submission Open

Keywords: natural polyphenols; health and disease; neurodegenerative diseases; gut microbiota; lowest effective dose; molecular mechanisms

(This special issue belongs to the Section Bioactives and Nutraceuticals)

ErbB Family of Receptor Tyrosine Kinases in Cancer and Drug Therapy

edited by Ilaria Marrocco and

Donatella Romaniello

submission deadline 20 Nov 2026 | Viewed by 411 | Submission Open

Keywords: ErbB; RTKs; EGFR; HER2; HER3; cancer; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Metal-Organic Frameworks: Pioneering New Solutions for Biomedical Challenges

edited by

David Rodríguez-Lucena

and

Belén Begines

submission deadline 20 Nov 2026 | Viewed by 380 | Submission Open

Keywords: MOFs; biomedical advances; drug delivery; personalized medicine; biomedical imaging; bio-sensor; smart MOFs; nanomedicine; cancer therapy

(This special issue belongs to the Section Materials Science)

Bioactive Compounds in Foods: From Structural Profiling to Bioavailability and Health Benefits

edited by Cong Wang

submission deadline 20 Nov 2026 | Viewed by 375 | Submission Open

Keywords: food bioactives; profiling; bioactive compounds; characterization; bioavailability; bioaccessibility; functionality; health-promoting benefits; structure/constituents– bioactivity relationship

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Regulation of Gene Expression in Cell Differentiation

edited by

Iole Robuffo

submission deadline 20 Nov 2026 | Viewed by 371 | Submission Open

Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research in Hepatic Amino Acid Catabolism

edited by Carolina Conter

submission deadline 20 Nov 2026 | Viewed by 313 | Submission Open

Keywords: amino acid catabolism; essential amino acids; non-essential amino acids; liver metabolism; urea cycle; gluconeogenesis; lipid metabolism; nutritional regulation; mTOR signaling; metabolic diseases

(This special issue belongs to the Section Biochemistry)

Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research

edited by

Paola Muggeo

submission deadline 20 Nov 2026 | Viewed by 297 | Submission Open

Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies

(This special issue belongs to the Section Molecular Oncology)

Tau Pathology Mechanisms and Therapeutic Interventions

edited by

Claudia Marino

submission deadline 20 Nov 2026 | Viewed by 279 | Submission Open

Keywords: tau; misfolding; neurodegeneration; Alzheimer’ s disease; oligomer; tauopathies; therapies; hyperphorphorylation; frontotemporal lobe dementia; synapses; spreading

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Stress Resilience: Unveiling Mechanisms and Mitigation Strategies

edited by

Giuseppe Mannino

submission deadline 20 Nov 2026 | Viewed by 260 | Submission Open

Keywords: plant stress resilience; abiotic stress; biotic stress; stress signaling pathways; biostimulants; genetic and molecular mechanisms; crop improvement; GMO

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Insights into Cardiomyopathy

edited by

Selina Hein

submission deadline 20 Nov 2026 | Viewed by 235 | Submission Open

Keywords: cardiomyopathy; inflammation; molecular mechanisms; targeted therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Understanding Involved in Age-Related Diseases

edited by

David Della-Morte

and

Francesca Pacifici

submission deadline 20 Nov 2026 | Viewed by 85 | Submission Open

Keywords: sirtuins; frailty; aging; age-related diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecules and Mechanisms of Oxidative Stress Relevant in the Pathophysiology of Diseases: 2nd Edition

edited by

Cinzia Signorini

submission deadline 20 Nov 2026 | Viewed by 79 | Submission Open

Keywords: redox-active iron; reactive oxygen species; antioxidants; oxidative damage; biomarkers; degenerative disease

(This special issue belongs to the Section Molecular Biology)

The Impact of the Exposome on Gut Health: Deciphering Molecular Mechanisms and Pathophysiological Pathways

edited by

Sylwia Smolińska

submission deadline 20 Nov 2026 | Viewed by 78 | Submission Open

Keywords: exposome (internal & external); molecular gastroenterology; intestinal barrier function; gut-microbiota-host crosstalk; environmental toxicology; signal transduction pathways; nutritional epigenomics; metabolic dysregulation

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Molecular Discoveries of Arthropod-Borne Viruse

edited by Henry Puerta-Guardo

submission deadline 20 Nov 2026 | Viewed by 57 | Submission Open

Keywords: arbovirus; whole genome sequencing; pathogenesis; transcriptomics; CRISPR-Cas9; in silico; antivirals; vaccines; diagnostics

(This special issue belongs to the Section Molecular Microbiology)

Drug Delivery for Human Diseases: From Basic Research to Clinical Applications

edited by

Kushagra Khanna

submission deadline 20 Nov 2026 | Viewed by 35 | Submission Open

Keywords: drug delivery systems; nanomedicine; targeted therapy; traditional medicine; translational pharmaceutical research

(This special issue belongs to the Section Molecular Pharmacology)

Role of MicroRNAs in Human Diseases: 2nd Edition

edited by

Lorenzo F. Sempere

submission deadline 25 Nov 2026 | 10 articles | Viewed by 17365 | Submission Open

Keywords: microRNAs; miRNAs; miRs; preclinical models; target interaction; regulatory networks; oncology; cancer biology; cardiovascular disease; neurodegenerative conditions; diagnostic applications; therapeutic development and clinical trials

(This special issue belongs to the Section Molecular Genetics and Genomics)

Nutrition and Cardiovascular Development, from Fetal Origins to Adulthood

edited by

Deanne H. Hryciw

submission deadline 25 Nov 2026 | Viewed by 216 | Submission Open

Keywords: fetal programming; developmental origins of health and disease; maternal nutrition; placental function; offspring; cardiovascular function; cardiometabolic risk; cardio renal development; essential fatty acids; linoleic acid

(This special issue belongs to the Section Molecular Biology)

Advanced 3D-Bioprinting for Next-Generation In Vitro Models: Molecular and Technological Perspectives

edited by

Alberto Portone

and

Laura Sercia

submission deadline 25 Nov 2026 | Viewed by 114 | Submission Open

Keywords: 3D bioprinting; in vitro models; biofabrication; bioinks; hydrogels; disease modeling; toxicology; drug screening; biomaterials; organ-on-a-chip

(This special issue belongs to the Section Macromolecules)

Nanomaterial: Synthesis and Application

edited by

Hesam Kamyab

submission deadline 25 Nov 2026 | Viewed by 28 | Submission Open

Keywords: nanomaterials; green synthesis; surface functionalization; nanoparticle engineering; drug delivery systems; energy storage; catalysis; environmental remediation; biocompatibility; molecular nanotechnology

(This special issue belongs to the Section Molecular Nanoscience)

Novel Antiviral Agents: Challenges and Opportunities from Molecular Targeting to Validation

edited by

Luis Adrián De Jesús-González

and

Moises Leon-Juarez

submission deadline 25 Nov 2026 | Viewed by 1 | Submission Open

Keywords: antiviral agents; molecular targeting; virus– host interactions; drug repurposing; host-directed antivirals; combination therapy; antiviral resistance; translational virology

(This special issue belongs to the Section Molecular Pharmacology)

Mitochondrial Functions and Dynamics

edited by

Raffaella Isola

submission deadline 27 Nov 2026 | 3 articles | Viewed by 14369 | Submission Open

Keywords: bioenergetics; mitochondrial biogenesis; mitochondrial morphology; apoptosis; mitophagy; reactive oxygen species; calcium homeostasis; cardiovascular diseases; neurodegenerative diseases; in vitro; cellular; and animal models; myopathies; mitochondria and immune system

(This special issue belongs to the Section Molecular Biology)

Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Human Health

edited by

Margarida Ferreira Lorigo

submission deadline 27 Nov 2026 | 2 articles | Viewed by 3931 | Submission Open

Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health

(This special issue belongs to the Section Molecular Toxicology)

Molecular Insight into Catalysis of Nanomaterials

edited by Dandan Liu

submission deadline 27 Nov 2026 | 3 articles | Viewed by 3725 | Submission Open

Keywords: nanomaterial catalyst; thermal catalysis; photocatalysis; electrocatalysis; DFT calculation

(This special issue belongs to the Section Molecular Nanoscience)

Recent Approaches for Wound Treatment: 3rd Edition

edited by

Cinzia Pagano

Luana Perioli

and

César Viseras

submission deadline 27 Nov 2026 | 1 articles | Viewed by 2368 | Submission Open

Keywords: wound healing; inflammation; angiogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Insights into Buckwheat Reproductive Biology

edited by

Agnieszka Płażek

submission deadline 27 Nov 2026 | 1 articles | Viewed by 1781 | Submission Open

Keywords: antioxidant properties; biotechnological methods; embryology; seed chemical composition; yield

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Various Diseases and Drugs Involved in Vascular Tone Regulation in Cardiovascular Disease

edited by

Ju-Tae Sohn

submission deadline 27 Nov 2026 | 1 articles | Viewed by 1678 | Submission Open

Keywords: vasoconstriction; vasodilation; calcium; protein kinase C; Rho-kinase; hypertension; nitric oxide

(This special issue belongs to the Section Molecular Biology)

Solid Tumours in Focus: Tissue Biomarkers and Spatial Technologies in Cancer Pathology

edited by Kathryn Pennel

submission deadline 27 Nov 2026 | 1 articles | Viewed by 968 | Submission Open

Keywords: biomarkers; cancer pathology; spatial biology; molecular mechanisms; tumour microenvironment; cell signalling and communication

(This special issue belongs to the Section Molecular Oncology)

Tissue Engineering and Advanced Biomaterials for Regenerative Medicine

edited by

Hak Soo Choi

Motoichi Kurisawa

and

Joo Eun Chung

submission deadline 27 Nov 2026 | 1 articles | Viewed by 906 | Submission Open

Keywords: tissue engineering; regenerative medicine; drug delivery; bioengineering; angiogenesis

(This special issue belongs to the Section Molecular Biology)

Harnessing Natural Compounds to Combat Cancer and Metastasis

edited by

Mohd Farhan

submission deadline 27 Nov 2026 | Viewed by 850 | Submission Open

Keywords: natural compounds; bioactive molecules; natural extracts; chemotherapy; immunomodulatory compounds; anti-metastatic compounds; anti-angiogenic compounds

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Cellular Plasticity in Cancer: Mechanisms, Measurement and Therapeutic Opportunities

edited by Costa Frangou and

Jianmin Zhang

submission deadline 27 Nov 2026 | 1 articles | Viewed by 610 | Submission Open

Keywords: cellular plasticity; cancer progression; EMT/MET; lineage infidelity; therapy-induced reprogramming; stem-like states; single-cell analysis; spatial transcriptomics; lineage tracing; computational modeling; biomarkers; therapeutic re-sistance; metastasis; solid tumors

(This special issue belongs to the Section Molecular Oncology)

New Advances in DNA Nanotechnology

edited by Zhaoqi Yang

submission deadline 27 Nov 2026 | Viewed by 571 | Submission Open

Keywords: DNA nanotechnology; DNA-based drug delivery; DNA cages and DNA polyhedra; DNA origami; DNA-based electronic circuits; DNA-based sensors; DNA-based catalysis; DNA-based data storage

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Targeting and Pharmacology of Neuroinflammation

edited by

Lisa Lione

submission deadline 27 Nov 2026 | Viewed by 406 | Submission Open

Keywords: glia-targeted therapeutics; neuroinflammation; CNS drug development; astrocyte; microglia; neurodegeneration; translational neuroscience; biomarkers; human genetics; cytokine signaling

(This special issue belongs to the Section Molecular Neurobiology)

Targeting Receptor Tyrosine Kinases and Related Signalling Pathways in Cancer: Mechanisms, Resistance, and Therapeutic Advances

edited by

Athina-Myrto Chioni

and

Richard Grose

submission deadline 27 Nov 2026 | Viewed by 369 | Submission Open

Keywords: tyrosine kinase receptors (TKRs); tyrosine kinase inhibitors (TKIs); cancer; therapeutic resistance/cancer drug resistance/chemotherapy resistance; signaling pathways; metastasis; combination therapy; targeted therapy; next-generation inhibitors; allosteric inhibitors; personalized medicine; tumor microenvironment; immune evasion; immunotherapy; crosstalk in cancer signaling; miRNAs; lncRNAs; cancer therapeutics; biomarkers

(This special issue belongs to the Section Molecular Oncology)

Molecular Research on Endocrine and Metabolic Diseases

edited by

Ferenc Sztanek

submission deadline 27 Nov 2026 | Viewed by 260 | Submission Open

Keywords: systems biology; metabolomics; fluxomics; organoid models; epigenetic regulation; precision medicine; endocrine–metabolic crosstalk

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanocomplexes and Drug Delivery Systems for Cancer Therapy

edited by

Ângela Sousa

submission deadline 27 Nov 2026 | Viewed by 252 | Submission Open

Keywords: nanocomplexes; drug delivery systems; cancer therapy; nanocarriers; stimuli-responsive systems; theranostics; biomolecules delivery; tumor microenvironment; personalized medicine; multidrug resistance

(This special issue belongs to the Section Molecular Nanoscience)

Current Research for Heart Disease Biology and Therapeutics: Fourth Edition

edited by Claudia Kusmic

submission deadline 29 Nov 2026 | 2 articles | Viewed by 1240 | Submission Open

Keywords: myocardial hypertrophy; cardiac remodeling; heart failure; drug therapy; molecular therapeutic targets; myocardial gene therapy; heart disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Ethylene Signaling in Plants: Molecular Mechanisms from Growth Regulation to Postharvest Biology

edited by

María Serrano

and

Nasratullah Habibi

submission deadline 29 Nov 2026 | Viewed by 223 | Submission Open

Keywords: ethylene signaling networks; ethylene in plant development and senescence; ethylene-responsive gene expression; ethylene control of senescence and ripening; ethylene in postharvest biology

(This special issue belongs to the Section Molecular Plant Sciences)

Viruses as Therapeutic Tools: Medical and Biotechnological Applications

edited by

Víctor Romanowski

submission deadline 30 Nov 2026 | 4 articles | Viewed by 23350 | Submission Open

Keywords: molecular virology; virus– host interactions; immunology; gene therapy vectors; vaccines; antivirals

(This special issue belongs to the Section Molecular Microbiology)

Antimicrobial and Antiviral Peptides: 2nd Edition

edited by

Tecla Ciociola

submission deadline 30 Nov 2026 | 4 articles | Viewed by 17673 | Submission Open

Keywords: antimicrobial peptides; antiviral peptides; peptide mining; molecular mechanism of biological activity; structure– activity relationship; molecular targets; in silico design; in vivo models; peptide delivery strategies; biomedical applications

(This special issue belongs to the Section Biochemistry)

Molecular Advances on Cannabinoid and Endocannabinoid Research, 3rd Edition

edited by

Rosaria Meccariello

submission deadline 30 Nov 2026 | 5 articles | Viewed by 15830 | Submission Open

Keywords: cannabinoid; endocannabinoid; cannabinoid receptor; endogenous cannabinoid; pharmacological research

(This special issue belongs to the Section Molecular Pharmacology)

Displaying special issue 2551-2600 on page 52 of 64.

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