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New Perspective on Inflammatory Diseases: Role of Natural Compounds

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 27 October 2024 | Viewed by 77

Special Issue Editors

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Guest Editor
Department of Human Sciences and Quality of Life Promotion, San Raffaele Roma Open University, 00166 Rome, Italy
Interests: natural compounds; biological activity; anticancer activity; anti-inflammatory activity; immunomodulatory activity; drug discovery
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Guest Editor
Department of Medicine and Surgery, “Kore” University of Enna, 94100 Enna, Italy
Interests: antimicrobial resistance; bacterial adhesion; biofilm; natural extracts; drug delivery systems; clinical infectious diseases
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Guest Editor
Department of Biomedical and Biotechnological Sciences, University of Catania, Via Santa Sofia 97, 95124 Catania, Italy
Interests: physio-pathology; immunology; micronutrients
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Special Issue Information

Dear Colleagues, 

Inflammation is a defence mechanism triggered by the immune system in response to injury and infection. However, chronic and uncontrolled inflammation can contribute to a variety of diseases including diabetes, cancer, neurodegenerative, cardiovascular diseases, and autoimmune disorders.

Anti-inflammatory drugs allow managing pain and inflammation. However, they show therapeutic limitations, including limited effectiveness for underlying conditions, dosage dependence, individual variations, and side effects. The inflammatory drugs can cause a wide spectrum of side effects, sometimes severe enough to make the risk–benefit ratio unfavourable. In this context, natural compounds, derived from the vegetable matrix or produced by prokaryotic or eukaryotic cells, possess a wide range of biological properties, including anti-inflammatory and immunomodulatory activities.

The present Special Issue, entitled "New Perspective on Inflammatory Diseases: Role of Natural Compounds", of the International Journal of Molecular Sciences focuses on natural compounds' anti-inflammatory and immunomodulatory effects, highlighting the strategies for improving their selectivity and efficacy. Therefore, original research articles and reviews proving the protective effect of natural compounds against inflammatory-based diseases are welcome. Specifically:

  • Nanotechnology-based delivery systems for natural compounds (polymer nanoparticles, crystal nanoparticles, solid lipid nanoparticles (SLNs), liposomes, dendrimers, and micelles) improving their bioavailability or efficacy;
  • Natural anti-inflammatory and immunomodulatory agents able to counteract the inflammatory state;
  • Anti-inflammatory combinatorial treatments: synergistic interaction between natural compounds and conventional drugs;
  • Bioinformatic analysis to identify natural compounds mediating the anti-inflammatory activity and reveal the molecular mechanism underlying the natural compounds' effects.

We look forward to receiving your contributions.

Dr. Floriana D'Angeli
Prof. Dr. Carlo Genovese
Dr. Cristina Russo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • natural compounds
  • immunomodulatory activity
  • anti-inflammatory activity
  • synergistic effect
  • nanotechnologies
  • delivery systems
  • bioinformatic analysis

Published Papers

This special issue is now open for submission.
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