Understanding and Treating Amyotrophic Lateral Sclerosis and Related Motor Neuron Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 December 2025 | Viewed by 1641
Special Issue Editor
2. Service de Biochimie et Biologie Moléculaire, CHU de Tours, 37044 Tours, France
Interests: ALS; genetics; neurobiology; post-translational modifications; aggregation; neurogenesis
Special Issue Information
Dear Colleagues,
Our understanding of the pathophysiology of amyotrophic lateral sclerosis (ALS) and its related motor neuron diseases has progressed dramatically in recent years, leading to some very interesting reflections on their definition and heterogeneity, as well as to numerous preclinical and clinical studies on potential therapeutic approaches. Some ALS/MND clinicians have indicated that this is a time for optimism. However, there are still enormous challenges to overcome. We need to better understand the complexity of these diseases, i.e., describe the molecular mechanisms involved at different stages; identify overlaps between these pathologies or with other pathologies; search for new, robust biomarkers and link them to clinical heterogeneity, disease progression, and response to therapeutic approaches; intensify research on the causes of ALS/MND, which are still unknown in the majority of patients; determine new mutations, genetic factors (causal, risk, progression), and epigenetics factors, etc.; better study the roles played by the various cell types in the motor neuron environment; and better characterize existing and new in vitro and in vivo study models. This Special Issue invites manuscript submissions that address these and any other questions that will help to better understand ALS/MND at the molecular level.
Prof. Dr. Patrick Vourc'h
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegenerative
- ALS
- motor neuron
- genetics
- molecular pathways
- biomarkers
- models
- treatments
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