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Advances in Secondary Metabolites in Plants

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Plant Sciences".

Deadline for manuscript submissions: 30 May 2025 | Viewed by 785

Special Issue Editor


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Guest Editor
1. Department of Analytical Chemistry, Medical University of Lublin, Chodźki 4a, 20-093 Lublin, Poland
2. Department of Plant Physiology and Biophysics, Institute of Biological Sciences, Faculty of Biology and Biotechnology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland
Interests: phytochemistry; pharmacognosy; plant–environment interactions; elicitation of secondary metabolites; chemoinformatics in phytochemistry
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Special Issue Information

Dear Colleagues,

This Special Issue, entitled “Advances in Secondary Metabolites in Plants”, focuses on the diverse and significant roles of plant secondary metabolites. With over 200,000 known compounds, these metabolites are integral to the survival, adaptation, and evolution of plants and have immense ecological, medicinal, and pharmaceutical value. This Special Issue will explore the biosynthesis, biochemical mechanisms, and biological activities of these compounds, shedding light on their roles in plant communication, stress resistance, and mutualistic relationships. We invite submissions on the pharmacological potential of secondary metabolites, their therapeutic applications, and biotechnology approaches to their production and modification. This Special Issue aims to provide a comprehensive overview of current advances, highlighting the significance of secondary metabolites for both plant science and human health.

Prof. Dr. Sławomir Dresler
Guest Editor

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Keywords

  • specialized metabolites
  • biosynthesis pathways
  • pharmacological applications
  • medicinal plants
  • plant stress resistance
  • abiotic and biotic elicitors
  • chemometric analysis
  • plant biotechnology
  • therapeutic potential
  • plant signaling and communication

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Published Papers (1 paper)

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Research

16 pages, 4329 KiB  
Article
The Enhancement of Biomass Accumulation, Caffeoylquinic Acid Derivative Production, and Antioxidant Activity of Rhaponticum carthamoides Transformed Roots Cultured in a Nutrient Sprinkle Bioreactor
by Ewa Skała, Monika A. Olszewska and Agnieszka Kicel
Int. J. Mol. Sci. 2025, 26(4), 1422; https://doi.org/10.3390/ijms26041422 - 8 Feb 2025
Viewed by 569
Abstract
Rhaponticum carthamoides (Willd.) Iljin. is an endemic plant species found in Siberia, Mongolia, and Kazakhstan. Its roots and rhizomes are used to treat physical fatigue and weakness following illness. The present study examines the scaling up of caffeoylquinic acid (CQA) derivative and flavonoid [...] Read more.
Rhaponticum carthamoides (Willd.) Iljin. is an endemic plant species found in Siberia, Mongolia, and Kazakhstan. Its roots and rhizomes are used to treat physical fatigue and weakness following illness. The present study examines the scaling up of caffeoylquinic acid (CQA) derivative and flavonoid production in R. carthamoides transformed roots. The transformed roots were grown in shaken Erlenmeyer flasks of varying volumes (0.5–2 L), a temporary immersion system (TIS) (Rita® and PlantForm bioreactors), and a nutrient sprinkle bioreactor (NSB) in Woody Plant medium for 35 days. The highest dry biomass production was achieved in the 0.5 L and 1 L flasks and in the NSB bioreactor, yielding 22.2 to 20.4 g/L—approximately 14 to 23 times the weight of the inoculum. The accumulation of individual specialized metabolites varied depending on the culture system used. The peak amount of CQAs (544.5 mg/L), in terms of the increase in dry weight and metabolite levels, was obtained in the NSB bioreactor. The primary CQAs were chlorogenic acid (5-CQA) and a tri-CQA 1. The highest concentration of 5-CQA (7.38 mg/g DW) was found in the roots cultivated in the NSB bioreactor. In contrast, the tri-CQA 1 dominated in the roots from 2 L shaken Erlenmeyer flasks (8.44 mg/g DW). Our findings demonstrate that transformed roots growing in an NSB bioreactor are an effective system for increasing CQA production, potentially serving as an alternative source. This biotechnological approach could help reduce the overexploitation of field-grown R. carthamoides, a currently threatened species. Full article
(This article belongs to the Special Issue Advances in Secondary Metabolites in Plants)
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