Nonalcoholic Liver Disease: Mechanisms, Prevention, and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 June 2025 | Viewed by 1844
Special Issue Editors
Interests: liver disease; NAFLD; NASH; chronic hepatitis C; chronic hepatitis B; hepatocellular carcinoma; liver fibrosis; gene profiling; SNPs; transcriptomic analysis; GWAS
Special Issues, Collections and Topics in MDPI journals
Interests: study of molecular mechanisms involved in MAFLD development and progression in terms of MASH and HCC; evaluation of the effects of compounds and phytonutrient administration, potentially capable of improving the lipid and glucose metabolic profiles, as well as steatosis and hepatic fibrosis, on in vitro models of continuous human hepatoma cell lines (HepG2) and hepatic stellate cells (LX2)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The globally estimated prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD) is 25.2% and includes a wide spectrum of clinical features from simple steatosis to metabolic dysfunction-associated steatohepatitis (MASH), characterized by necroinflammation and liver fibrosis, which is associated with high-risk complications, such as liver decompensation and hepatocellular carcinoma. MAFLD is characterized by clinical phenotipic heterogeneity due to its multifactorial etiology, which includes the presence of comorbidities (i.e. obesity, insulin resistance, type 2 diabetes mellitus), diet and behavior, but a key role in FLD inter-individual variation is played by the subject's genetic and epigenetic background. Lifestyle changes based on caloric restriction, the Mediterranean diet and physical activities are recommended for MAFLD prevention. However, currently, there are no approved therapeutics available for MAFLD, although several classes of drugs for MAFLD/MASH treatment are under development (i.e., FXR agonists, PPAR agonists). Genomic studies are revolutionizing the comprehension of MAFLD, improving patient stratifcation for clinical trials and for prognostication in the era of personalized medicine.
Dr. Stefania Grimaudo
Dr. Rosaria Maria Pipitone
Guest Editors
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Keywords
- MAFLD
- MASH
- metabolic syndrome
- steatosis
- lipid droplets
- SNPs
- GWAS
- therapeutc target
- fatty liver
- steatohepatitis
- HCC
- EpigEnetics
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