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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Heart Failure Risk Factors and Therapies-Molecular Basis
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2144 | Submission Open
Keywords: heart failure; risk factors; inflammatory; neutrophils; cytokines; pharmacological; therapies; molecular-based processes
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Musculoskeletal Diseases: Inflammation, Degeneration or Mechanical Stress
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2127 | Submission Open
Keywords: musculoskeletal diseases; inflammation; degeneration; mechanical stress; aging
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Application of Genetic Engineering in Treatments for Human Diseases
edited by Claudio Mussolino
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2123 | Submission Open
Keywords: genome editing; epigenome editing; CRISPR-Cas systems; gene therapy; precision medicine; molecular mechanisms; innovative therapies; gene expression regulation
(This special issue belongs to the Section Molecular Genetics and Genomics)
Antiphospholipid Syndrome: From Pathophysiology to Therapy
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2120 | Submission Open
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Editorial Board Members’ Collection Series: Cancer Metabolism submission deadline 20 Sep 2025 | 1 articles | Viewed by 2112 | Submission Open
Keywords: cancer metabolism; metabolic pathway; glucose consumption and energy production; amino acid requirement
(This special issue belongs to the Section Molecular Oncology)
Nutraceuticals for the Maintenance of Brain Health submission deadline 20 Sep 2025 | 1 articles | Viewed by 2083 | Submission Open
Keywords: vitamin; nutraceutics; brain; neuroinflammation; neurodegeneration; cognitive function
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Application of Artificial Intelligence in Molecular Sciences
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2081 | Submission Open
Keywords: artificial intelligence; deep learning; algorithms; molecular modeling and simulation; materials discovery; analysis of biological sequence data; computational chemistry; bioinformatics; genomics; protein structure prediction; molecular dynamics simulation
(This special issue belongs to the Section Molecular Informatics)
Integrated Approaches, Molecular Mechanism and Therapies in Ocular Surface Diseases submission deadline 20 Sep 2025 | 2 articles | Viewed by 2075 | Submission Open
Keywords: ocular surface diseases; dry eye; corneal ulcers; persistent epithelial defects; blood-derived products; blood-based therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Gut-Brain Axis: Genomic and Metagenomic Involvement
edited by and Elias Odusseas Tzavellas
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2038 | Submission Open
Keywords: gut– brain axis; central nervous system; gastrointestinal tract; genomic; metagenomic
(This special issue belongs to the Section Molecular Neurobiology)
Current Trends in MOF (Metal–Organic Framework) and Metal X-ides Development, 2nd Edition
edited by Siwei Li
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2035 | Submission Open
Keywords: MOF; metal carbide; metal sulfide; metal phosphide; catalysis; biomedicine; electromagnetic absorption; energy conversion and storage
(This special issue belongs to the Section Materials Science)
Nanofibrous Biomaterials for Biomedicine and Medical Applications
edited by Jong-Young Kwak
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2024 | Submission Open
Keywords: nanofibers; biomaterials; 3D scaffold; 3D cell culture; tissue engineering; drug release
(This special issue belongs to the Section Materials Science)
Molecular Genetics, Breeding, and Multi-Omics Approaches in Rice Research
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 2014 | Submission Open
Keywords: rice genetics and breeding; molecular breeding of rice; rice genomics and proteomics; genes related to abiotic stress tolerance in rice; molecular biology and multi-omics in rice research
(This special issue belongs to the Section Molecular Plant Sciences)
Research of Hydroxyapatite-Based Materials and Their Applications
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 2002 | Submission Open
Keywords: hydroxyapatite; nanobiocomposite; biomedical applications; coatings; environment remediation; biological properties; drug delivery; pollutant adsorption efficiency; morphology and structural features
(This special issue belongs to the Section Materials Science)
Molecular Dimensional Design, Synthesis Modification and Application of Sustainable Polymer Materials
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1992 | Submission Open
Keywords: sustainable polymeric materials; 3D printing; sustainability; environmental impact; molecular modifications
(This special issue belongs to the Section Materials Science)
False-Positive and False-Negative Laboratory Biomarkers
edited by Michela Salvatici and Lorenzo Drago
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1959 | Submission Open
Keywords: biomarkers; false positives/negatives; protein biomarkers; nucleic acid markers; multi-omics; single-cell sequencing; liquid biopsy
(This special issue belongs to the Section Biochemistry)
Stem Cells and Regenerative Medicine: In Vitro and In Vivo Studies—2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1951 | Submission Open
Keywords: stem cells; stem cell homing; stem cell tracking; regeneration; tissue injury; immunomodulation; biomaterials; tissue-on-a-chip; organoids; differentiation
(This special issue belongs to the Section Molecular Biology)
Probiotics, Prebiotics and Postbiotics: The Secrets of Promoting Microbial Balance in the Gut
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1927 | Submission Open
Keywords: probiotics; prebiotics; postbiotics; gut microbiota; gut epithelial integrity
(This special issue belongs to the Section Molecular Microbiology)
Tumor Microenvironment and Cancer Progression: Molecular Insights for Targeted Therapy
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1906 | Submission Open
Keywords: tumor microenvironment; immune response modulation; signaling pathways; extracellular matrix components; tumor evolution
(This special issue belongs to the Section Molecular Oncology)
Novel Technologies in the Study of the Pathogenesis of Cardiac Diseases submission deadline 20 Sep 2025 | 1 articles | Viewed by 1893 | Submission Open
Keywords: artificial Intelligence; multi-omics; organoids; engineered heart tissue; advanced imaging; personalized medicine
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Olive and Its Derivatives
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1885 | Submission Open
Keywords: olive; structural and functional genomics; genomic variation; breeding; biotechnologies; next-generation sequencing
(This special issue belongs to the Section Molecular Plant Sciences)
Fungal Pathogen-Host Interactions
edited by Patricia Albuquerque
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1875 | Submission Open
Keywords: medical mycology; host– microbe interactions; macrophages; dendritic cells; neutrophils
(This special issue belongs to the Section Molecular Microbiology)
Recent Developments in Metabolism of Algal Toxins in Animals submission deadline 20 Sep 2025 | 1 articles | Viewed by 1874 | Submission Open
Keywords: marine toxins; bioacumulation; chemical conversion; detoxification mechanisms; toxin gene clusters
(This special issue belongs to the Section Molecular Toxicology)
Cellular Oxygen Homeostasis—3rd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1858 | Submission Open
Keywords: cellular oxygen homeostasis; redox signaling; cellular oxygen sensing; hypoxia; hyperoxia
(This special issue belongs to the Section Molecular Biology)
Anti-Inflammatory and Metabolic Effects of G Protein-Coupled Receptor Signaling
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1834 | Submission Open
Keywords: G protein-coupled receptors (GPCRs); seven transmembrane domain (7TM) receptors; metabotropic receptors; membrane receptors; GPCRs signaling; GPCRs signaling pathways; anti-inflammatory effects; inflammatory diseases; metabolic diseases; metabolic effects; anti-inflammatory treatment
(This special issue belongs to the Section Molecular Immunology)
Molecular Insights into Role of Anthranilic Acid in Neuropsychiatric Diseases submission deadline 20 Sep 2025 | 1 articles | Viewed by 1785 | Submission Open
Keywords: anthranilic acid; Alzheimer’ s disease; autism; schizophrenia; bipolar disorder; major depressive disorder; post-partum depression; COVID-19; interferons; attention deficit disorder; cognitive impairment; G-protein-coupled receptor 109A; microbiome; gut– brain axis
(This special issue belongs to the Section Molecular Neurobiology)
The Role of SARS-CoV-2 in Immunomodulation—Post-Pandemic Reflection on the Role of Viruses in Human Immunology submission deadline 20 Sep 2025 | 2 articles | Viewed by 1768 | Submission Open
Keywords: SARS-CoV-2; COVID-19; immunomodulation; T cells; B cells; dendritic cells; monocytes; cytokines
(This special issue belongs to the Section Molecular Immunology)
C. elegans as a Disease Model: Molecular Perspectives: 2nd Edition submission deadline 20 Sep 2025 | 2 articles | Viewed by 1767 | Submission Open
Keywords: Caenorhabditis elegans; model organism; disease model; neurodegenerative diseases; cancer model; ageing
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms and Treatment of Chronic Kidney Disease
edited by Xinming Chen
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1735 | Submission Open
Keywords: diabetes; cardiovascular diseases; nephrology; diabetic nephropathy
(This special issue belongs to the Section Molecular Biology)
New Cardiovascular Risk Factors: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1732 | Submission Open
Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation
(This special issue belongs to the Section Molecular Biology)
New Insights into Osteoclasts
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1723 | Submission Open
Keywords: osteoclast; bone remodeling; osteoporosis; inflammatory arthritis; bone tumor
(This special issue belongs to the Section Molecular Biology)
Molecular Insights into Flower Gene Regulation
edited by Wen‑Chieh Tsai
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1704 | Submission Open
Keywords: floral gene regulation; flowers; homeotic genes; MADSBox; pollination
(This special issue belongs to the Section Molecular Plant Sciences)
Protein Stability Research: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1695 | Submission Open
Keywords: protein stability; protein degradation; conformational stability and flexibility; thermodynamic stability of proteins; mutation-induced changes in protein stability; stability of oligomeric proteins; stability of protein complexes; thermal adaptation of protein structures; protein aggregation; molten globules; heat shock proteins; chaperones
(This special issue belongs to the Section Molecular Biophysics)
Advanced Molecular Research on the Diagnosis and Treatment of Chronic Liver Diseases
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1687 | Submission Open
Keywords: biomarker; genomic research; epigenomic research; molecular mechanisms; viral hepatitis; alcoholic-related liver disease; non-alcoholic fatty liver disease; autoimmune liver diseases; liver cirrhosis; hepatocellular carcinoma
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Blood Cells in Human Health and Disease
edited by Leonid Livshits
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1680 | Submission Open
Keywords: red blood cell; RBC membrane; RBC biophysical properties; RBC rheology; RBC mechanical properties; RBC membrane vesiculation; RBC clearance; RBC in diabetes; hemoglobinopathies; RBC storage TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Biochemistry)
Molecular Research on Oxidative Stress in Health and Disease submission deadline 20 Sep 2025 | 1 articles | Viewed by 1661 | Submission Open
Keywords: oxidative stress; antioxidants; cancer; redox signalling; reactive oxygen and nitrogen species
(This special issue belongs to the Section Molecular Biology)
Molecular Research Progress of Skin and Skin Diseases: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1637 | Submission Open
Keywords: atopic dermatitis; psoriasis; alopecia; vitiligo; acne; skin cancer; JAK-STAT; inflammatory skin disease
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Physiological Functions and Pathological Effects of Microglia
edited by Hiroshi Nakanishi
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1635 | Submission Open
Keywords: circadian clock; homeostasis; immune response; microglia; neurodegenerative diseases; neuroinflammation; neuropsychiatric disorders; neuromodulation; phagocytosis; synaptic pruning
(This special issue belongs to the Section Molecular Neurobiology)
Bilirubin: Health Challenges and Opportunities
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1598 | Submission Open
Keywords: bilirubin; biomedical science; neurobiology; Parkinson’ s disease; brain neuroprotection
(This special issue belongs to the Section Molecular Biology)
DNA Damage Response from Molecular Mechanisms to Cancer Therapy
edited by Luigi Alfano and
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1596 | Submission Open
Keywords: DNA damage response; synthetic lethality; homologous recombination; cancer therapy
(This special issue belongs to the Section Molecular Oncology)
Neuroinflammation in the Pathogenesis of Alzheimer’s Disease and Related Dementias: 2nd Edition
edited by
submission deadline 20 Sep 2025 | 2 articles | Viewed by 1576 | Submission Open
Keywords: Alzheimer’ s disease; neuroinflammation; drug development; microglia; astrocytes; cytokines; TREM2; risk factors; biomarkers
(This special issue belongs to the Section Molecular Immunology)
The Molecular Basis of Vascular Pathology submission deadline 20 Sep 2025 | 2 articles | Viewed by 1567 | Submission Open
Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Molecular Research on Retinopathy and Protection
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1548 | Submission Open
Keywords: retinopathy; neuroprotection; antioxidants; innovative therapy; emerging technology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Electrochemistry: Molecular Advances and Challenges
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1545 | Submission Open
Keywords: fundamental electrochemistry; electroanalytical techniques; sensors and biosensors; nano-electrochemistry; electrochemical energy production and storage; environmental electrochemistry
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Explore Marine Biodiversity: Discover Insights from Genomics and Transcriptomics
edited by and Ambrosino Luca
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1527 | Submission Open
Keywords: comparative genomics; functional genomics; transcriptomics; gene expression; adaptation; population genomics; marine biodiversity; evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
Smooth Muscle Cells in Vascular Disease submission deadline 20 Sep 2025 | 2 articles | Viewed by 1522 | Submission Open
Keywords: smooth muscle cells (SMCs); atherosclerosis; hypertension; aortic aneurysm; vascular ageing; extracellular matrix; endothelial cells (ECs); SMC senescence; interleukin; platelet-derived growth factor; phenotype switching; SMC plasticity; SMC-derived cells; molecular subtypes; intimal thickening; plaque stability; transcription factors; microRNAs; clonality
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellular Metabolism and Retinal Diseases: Unraveling Molecular Pathways and Therapeutic Targets submission deadline 20 Sep 2025 | 2 articles | Viewed by 1517 | Submission Open
Keywords: retina; metabolic dysfunction in retinal diseases; metabolism and retinal cell function; metabolism and oxidative stress; therapeutic targets; intracellular signaling; epigenetic modification
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advancements in Host-Directed Antiviral Therapies submission deadline 20 Sep 2025 | 1 articles | Viewed by 1508 | Submission Open
Keywords: antiviral drugs; drug discovery; host cell targets; HIV; HCV; influenza; SARS-CoV-2
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Blueprints of Enzymatic Function and Structure in Biocatalysis submission deadline 20 Sep 2025 | 1 articles | Viewed by 1501 | Submission Open
Keywords: enzyme; biocatalysis; enzyme structure; enzyme kinetics and thermodynamics; enzyme engineering; synthetic biology applications; sustainable biocatalyst design
(This special issue belongs to the Section Biochemistry)
Antimicrobial Resistology: A New Approach in the Fight Against Antimicrobial Resistance
edited by
submission deadline 20 Sep 2025 | 1 articles | Viewed by 1476 | Submission Open
Keywords: antimicrobial resistance; resistology; ESBL; AmpC; carbapenem resistance; one health
(This special issue belongs to the Section Molecular Pharmacology)
Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease:2nd Edition submission deadline 20 Sep 2025 | 1 articles | Viewed by 1410 | Submission Open
Keywords: antioxidants; biomarkers; cellular functions; disease etiology; disease progression; metabolic disorders; metabolic signaling; oxidative stress; pathophysiological states; reactive oxygen species; redox homeostasis; redox signaling
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
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