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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Research Advances in Photodynamic Therapy

edited by

Samir Acherar

and

Céline Frochot

submission deadline 30 Oct 2026 | Viewed by 430 | Submission Open

Keywords: photodynamic therapy (PDT); photosensitizers and nanocarriers; targeting and molecular selectivity; photophysics and dosimetry; anticancer and antimicrobial applications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Role of Cytokines in Health and Diseases: Second Edition

edited by Hung-Jen Liu

submission deadline 30 Oct 2026 | 1 articles | Viewed by 398 | Submission Open

Keywords: cytokines; immune regulation; disease management; signaling pathways; translational research; clinical applications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular and Cellular Research on Cardiac Repair and Regeneration

edited by

Francesca Pagano

and

Vittorio Picchio

submission deadline 30 Oct 2026 | Viewed by 359 | Submission Open

Keywords: cardiac repair; cardiomyocyte differentiation; cardiac fibroblast activation; cardiac fibrosis; cardiac tissue microenvironment; cardiac remodeling

(This special issue belongs to the Section Molecular Biology)

The GPR81 Receptor: Lactate as Signaling Molecule in Health and Disease

edited by

Tania Fiaschi

submission deadline 30 Oct 2026 | Viewed by 359 | Submission Open

Keywords: lactate; GPR81 receptor; signaling cascade

(This special issue belongs to the Section Molecular Biology)

Precision Targets for Brain Health: The Molecular Era of Neuropharmacology

edited by

Terezia Kiskova-Simkova

submission deadline 30 Oct 2026 | Viewed by 343 | Submission Open

Keywords: neurology; neuropharmacology; molecular targets; biomarker; personalized medicine

(This special issue belongs to the Section Molecular Neurobiology)

Bioactive Molecules and Their Health Impacts: From Antioxidants to Therapeutic Potentials

edited by

Alessandro Attanzio

and

Marilena Briglia

submission deadline 30 Oct 2026 | Viewed by 335 | Submission Open

Keywords: bioactive molecules; cell signaling; redox homeostasis; mitochondrial bioenergetics; epigenetic modulation; host– microbiome crosstalk; therapeutic strategies

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Molecular and Genetic Mechanisms of Hypercholesterolemia

edited by

Seyed Saeed Tamehri Zadeh

submission deadline 30 Oct 2026 | Viewed by 299 | Submission Open

Keywords: ASCVD; MI; CVD; CAD; PVD; ischemic stroke; Lp(a); LPA gene; Lp(a)-lowering treatments; homozygous familial hypercholesterolemia; heterozygous familial hypercholesterolemia; low-density lipoprotein; epidemiology; genetic determinants; lipid metabolism; PCSK9 inhibitors; emerging therapies

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Insights into the Smallest Fullerene Nanocomposites from the Lab to Space

edited by

Quentin A. Parker

and

SeyedAbdolreza Sadjadi

submission deadline 30 Oct 2026 | Viewed by 296 | Submission Open

Keywords: fullerenes; C20; nanocomposites; molecular structure; outer space

(This special issue belongs to the Section Molecular Nanoscience)

Nanomedicine: Application of Nanostructured Biomaterials in the Biomedical Field

edited by

Yaser Dahman

submission deadline 30 Oct 2026 | Viewed by 295 | Submission Open

Keywords: nanomedicine; nanostructured biomaterials; targeted drug delivery; tissue regeneration; biosensing

(This special issue belongs to the Section Molecular Nanoscience)

Advances in Molecular Research on Candida Resistance

edited by

Angela Maione

submission deadline 30 Oct 2026 | Viewed by 292 | Submission Open

Keywords: Candida resistance; antifungal resistance; biofilm; drug repurposing; novel therapies; molecular mechanisms; antifungal agents; Candida albicans; Candida auris; host– pathogen interactions

(This special issue belongs to the Section Molecular Microbiology)

Nanostructured Materials and Functional Molecules for Sustainable Applications

edited by

Giulia Rando

Maria Rosaria Plutino

and

Silvia Sfameni

submission deadline 30 Oct 2026 | Viewed by 280 | Submission Open

Keywords: nanostructured materials; functional molecules; molecular design; sustainable materials; carbon nanotubes (CNTs); biochar; nanocomposites; nanohybrids; surface functionalization; molecular interactions; green synthesis; advanced functional materials

(This special issue belongs to the Section Materials Science)

Venoms and Beyond: Molecular Targets, Cellular and In Vivo Effects

edited by

Yuri N. Utkin

and

R. Manjunatha Kini

submission deadline 30 Oct 2026 | Viewed by 278 | Submission Open

Keywords: animal venoms; toxins; structure; biological activity; molecular mechanisms; molecular targets

(This special issue belongs to the Section Molecular Toxicology)

RNA Biology and Regulation, 2nd Edition

edited by

Naoyuki Kataoka

submission deadline 30 Oct 2026 | Viewed by 275 | Submission Open

Keywords: RNA processing; RNA transport; RNA localization; RNA editing; RNA synthesis; RNA stability; RNA modification; translation; transcription; RNA metabolism; human diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Mechanisms Underlying Plant Abiotic Stress Tolerance

edited by

Muhammad Tanveer Altaf

and

Muhammad Junaid Rao

submission deadline 30 Oct 2026 | Viewed by 224 | Submission Open

Keywords: abiotic stress (extreme temperatures; drought; salinity; submergence; heavy metals; and others); combine stresses; stress physiology; molecular biology; gene regulation; signal transduction; multi-omics approaches; plant– environment interaction; climate adaptation; crop improvement; molecular mechanisms

(This special issue belongs to the Section Molecular Plant Sciences)

The Mechanisms of Cucurbit Breeding, Cultivation and Quality Regulation

edited by Xiaotao Ding and Yongxue Zhang

submission deadline 30 Oct 2026 | Viewed by 205 | Submission Open

Keywords: omics; cultivation; breeding; quality; abiotic stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Pathology, Diagnosis and Therapeutic Strategies of Thrombotic Diseases

edited by Emanuele Valeriani

submission deadline 30 Oct 2026 | Viewed by 203 | Submission Open

Keywords: anticoagulants; cardiovascular diseases; diagnosis; platelet aggregation inhibitors; venous thromboembolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant Stress Responses and Their Gene Regulatory Networks

edited by

Anamika Pandey

and

Mohd. Kamran Khan

submission deadline 30 Oct 2026 | Viewed by 197 | Submission Open

Keywords: plant stress responses; gene regulatory networks (GRNs); functional genomics; multi-omics integration; transcriptional regulation; epigenetic regulation; CRISPR/cas gene editing; abiotic and biotic stress tolerance

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Molecular Therapeutics for Retinal Disease

edited by

Thomas Stax Jakobsen

submission deadline 30 Oct 2026 | Viewed by 197 | Submission Open

Keywords: retinal disease; retinal degeneration; retinal gene therapy; regenerative medicine; neuroprotection; delivery vehicles; viral vectors; nanoparticles; cell therapy; anti-angiogenic therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Latest Advances in Genetic Variants Involved in Breast and Ovarian Cancer

edited by

Maria Aparecida Nagai

submission deadline 30 Oct 2026 | Viewed by 173 | Submission Open

Keywords: breast cancer; ovarian cancer; genetic variants; HBOC; genetic testing; hereditary

(This special issue belongs to the Section Molecular Genetics and Genomics)

Immune Response in Animals

edited by Yuxiang Song

submission deadline 30 Oct 2026 | Viewed by 172 | Submission Open

Keywords: animal immunology; immune homeostasis; infectious diseases; metabolic disorders; immunomodulatory agents; nanomaterial-based immunotherapy; livestock immune response

(This special issue belongs to the Section Molecular Immunology)

Novel Biomarkers for Disease Prediction and Prognosis: Inflammatory, Metabolic and Composite Profiles

edited by

Recep Dokuyucu

and Mehmet Yilmaz

submission deadline 30 Oct 2026 | Viewed by 151 | Submission Open

Keywords: cancer biomarkers; inflammatory markers; metabolic biomarkers; composite indices; prognostic models; translational medicine; oxidative stress; precision medicine; risk stratification; clinical biochemistry

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pleiotropic Effects of Statins: Molecular Interactions and Therapeutic Potential in Human Diseases

edited by

Giulio Preta

submission deadline 30 Oct 2026 | Viewed by 145 | Submission Open

Keywords: statins; pleiotropic effects; lipid metabolism; adjuvant therapy

(This special issue belongs to the Section Molecular Pharmacology)

In Silico Drug Design and Virtual Screening: The Latest Advances

edited by

Alina Bora

and

Luminita Crisan

submission deadline 30 Oct 2026 | Viewed by 130 | Submission Open

Keywords: in silico drug design; drug discovery; virtual screening; CADD; artificial intelligence; machine learning; ADMET prediction; cheminformatics; drug repurposing; natural products

(This special issue belongs to the Section Molecular Informatics)

New Insight into the Discovery of Antiviral and Antibacterial Agents

edited by

Brankica Filipic

submission deadline 30 Oct 2026 | Viewed by 127 | Submission Open

Keywords: antiviral agents; antibacterial compounds; antimicrobial resistance; anti-virulence strategies; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Plant-Derived Bioactive Compounds for Pharmacological Applications, 2nd Edition

edited by

Ilian Badjakov

and

Ivayla Dincheva

submission deadline 30 Oct 2026 | Viewed by 101 | Submission Open

Keywords: plant-derived bioactive compounds; pharmacological applications; antioxidant activity; anti-inflammatory agents; antimicrobial properties; neuroprotective effects; drug discovery; high-throughput screening; extraction and isolation techniques; structural characterization; CRISPR technology; genome editing; bioprocess engineering; bioreactor production; therapeutic potential; metabolite profiling

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Zebrafish Models of Human Disease: Uncovering Immunometabolic Mechanisms and Therapeutic Targets

edited by Juliana Moreira Mendonça Gomes

submission deadline 30 Oct 2026 | Viewed by 89 | Submission Open

Keywords: zebrafish; immunometabolism; metabolism; inflammation; cancer; obesity; diabetes; cardiovascular disease; MASH; disease modeling

(This special issue belongs to the Section Molecular Biology)

Molecular Signatures of Environmental Toxicants in One Health: Implications for Biodiversity, Animal and Human Health

edited by Leonardo Bittencourt and

Rafael R. Lima

submission deadline 30 Oct 2026 | Viewed by 89 | Submission Open

Keywords: one health; omics; environmental toxicology; ecotoxicology; anthropocene; biodiversity; molecular biomarkers; bioindicators and sentinel species; environmental biomonitoring

(This special issue belongs to the Section Molecular Toxicology)

Stem Cells in Development and Regenerative Medicine: Molecular Insights

edited by

Jesus Chimal-Monroy

submission deadline 30 Oct 2026 | Viewed by 85 | Submission Open

Keywords: stem cells; cell differentiation; tissue regeneration; regenerative medicine; signaling pathways; gene expression

(This special issue belongs to the Section Molecular Biology)

Molecular Perspectives on Rare Diseases

edited by Maria del Carmen Garrido Navas

submission deadline 30 Oct 2026 | Viewed by 80 | Submission Open

Keywords: rare diseases; molecular mechanisms; genomics; multi-omics; long-read sequencing; structural variation; repeat expansions; artificial intelligence; machine learning; precision medicine; newborn screening; genotype– phenotype correlations; biomarkers; neuromuscular disorders; whole-genome sequencing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Co-Infections in Parasitic Diseases: Molecular Mechanisms, Diagnostic Challenges, and Therapeutic Strategies

edited by

Cecilia Parodi

and Paula Gabriela Ragone

submission deadline 30 Oct 2026 | Viewed by 73 | Submission Open

Keywords: parasites; protozoan; co-infections; disease outcome; immune modulation; metagenomic analysis; diagnostic methods; treatment strategies; drug resistance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights Into Cardiovascular Disease

edited by

Emrah İpek

and

Ömer Bedir

submission deadline 30 Oct 2026 | Viewed by 66 | Submission Open

Keywords: atherosclerosis; cardiopharmacogenetics; epigenetics; inflammation; omics; oxidative stress; remodelling; vascular biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

State-of-the-Art Molecular Endocrinology and Metabolism in Turkey

edited by

Gulali Aktas

submission deadline 30 Oct 2026 | Viewed by 63 | Submission Open

Keywords: molecular endocrinology; metabolic disorders; hormone signaling; multi-omics; precision medicine; diabetes and obesity; MASLD; endocrine disruptors; biomarkers; artificial intelligence in endocrinology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Antimicrobial Peptides: Biosynthesis, Molecular Mechanisms and Biomedical Applications

edited by Carlos Minahk and

Lucía Lanza

submission deadline 30 Oct 2026 | Viewed by 62 | Submission Open

Keywords: antimicrobial peptides (AMPs); bacteriocins; antimicrobial resistance; ribosomally synthesized peptides; non-ribosomal peptides; mechanism of action; structure– function relationship; artificial intelligence in peptide design; peptide engineering; pharmacokinetics and pharmacodynamics

(This special issue belongs to the Section Molecular Microbiology)

Molecular Biomarkers, Nutritional Status, and Immune Regulation in Gut and Lung Diseases

edited by

Andreina Bruno

submission deadline 30 Oct 2026 | Viewed by 62 | Submission Open

Keywords: immunity; immunometabolism; metabolism; adipocytokines; nutrition; microbiome; biomarkers; gut; lung; circular health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Anti-Parasitic Drugs: Mechanisms, Novel Molecules and Big Data Applications

edited by

Chun-Xue Zhou

submission deadline 30 Oct 2026 | Viewed by 60 | Submission Open

Keywords: anti-parasitic drugs; novel drug discovery; mechanism of action; drug resistance; big data analysis; machine learning; parasitic infections; drug delivery; preclinical evaluation; natural products

(This special issue belongs to the Section Molecular Pharmacology)

Global Impact of Malignant Pleural Mesothelioma: Current Knowledge, Emerging Therapies and Future Perspectives

edited by Saé Muñiz-Hernández

submission deadline 30 Oct 2026 | Viewed by 59 | Submission Open

Keywords: pattern identification through AI; gene-driven mesothelioma; biomarkers; organoid models; genetic and epigenetic analysis

(This special issue belongs to the Section Molecular Oncology)

Improving Antimicrobial Activity of Biopolymer-Based Films: Mechanisms, Functionalization Strategies, and Applications

edited by

Gabriela Dudek

submission deadline 30 Oct 2026 | Viewed by 59 | Submission Open

Keywords: biopolymer-based films; antimicrobial activity; functionalization strategies; bioactive compounds; nanoparticles; deep eutectic solvents; plasticizers; structure– property relationships; biodegradable materials; coatings and membranes

(This special issue belongs to the Section Materials Science)

Recent Advances in Plant Virus Life Cycle, Molecular Diagnosis, Virus–Host Interactions and Molecular Farming

edited by Srividhya Venkataraman

submission deadline 30 Oct 2026 | Viewed by 53 | Submission Open

Keywords: plant viruses; molecular biology; replication; assembly; transmission; trafficking; virus– host interactions; plant defense responses; molecular diagnostics; RNA silencing structure

(This special issue belongs to the Section Molecular Plant Sciences)

In Silico Methods of Assessing the Therapeutic Potential of Natural Substances

edited by

Radosław Zajdel

and

Anna Merecz-Sadowska

submission deadline 31 Oct 2026 | 5 articles | Viewed by 15336 | Submission Open

Keywords: in silico screening; natural products; molecular docking; computational drug discovery; QSAR modeling; molecular dynamics simulations; natural compounds; drug-target interactions; virtual screening; structure-activity relationships; computational chemistry; cheminformatics; ADMET prediction; bioinformatics; phytochemicals; machine learning in drug discovery; computer-aided drug design; pharmacophore modeling; natural therapeutics; computational pharmacology

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Metabolic Dysfunction-Associated Steatotic Liver Disease

edited by Rifaat Safadi and Johnny Amer

submission deadline 31 Oct 2026 | 7 articles | Viewed by 12034 | Submission Open

Keywords: MASLD (metabolic dysfunction-associated steatotic liver disease); lipotoxicity; inflammation; mitochondrial dysfunction; gut– liver axis; liver– spleen axis; fibrosis biomarkers; translational hepatology; precision liver medicine; insulin resistance; molecular therapeutics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Endocrinology of Pregnancy

edited by

Georgios Valsamakis

submission deadline 31 Oct 2026 | 3 articles | Viewed by 11303 | Submission Open

Keywords: pregnancy; endocrine system; fetal development; maternal health; metabolism

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Natural Medicines and Functional Foods for Human Health

edited by Qiong Wang

submission deadline 31 Oct 2026 | 3 articles | Viewed by 10079 | Submission Open

Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’ s disease; Parkinson’ s disease; space medicine; sleeplessness; anti-inflammation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Anti-Inflammatory and Anti-Oxidant Effects of Extracts from Plants

edited by

Sheila Leone

and

Lucia Recinella

submission deadline 31 Oct 2026 | 5 articles | Viewed by 9003 | Submission Open

Keywords: oxidative stress; inflammation; herbal extracts

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Advances in Protein Structure-Function and Drug Discovery

edited by Francesc Xavier Avilés and F. Xavier Gomis-Rüth

submission deadline 31 Oct 2026 | 6 articles | Viewed by 8862 | Submission Open

Keywords: protein structure; protein function; protein drug target; inhibition; protein structure-function; protein drug discovery; protein inhibition; protein activation; protein regulation; protein structure-function and evolution; protein structure-function engineering and design; protein structure-function and drug discovery

(This special issue belongs to the Section Macromolecules)

The Role of Autoimmunity in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

edited by Yang Mao-Draayer

submission deadline 31 Oct 2026 | 1 articles | Viewed by 8686 | Submission Open

Keywords: multiple sclerosis (MS); neuromyelitis optica spectrum disorder (NMOSD); myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD); immunomodulatory; neuroprotection; neuroregeneration; biomarker; imaging

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 31 Oct 2026 | 2 articles | Viewed by 8390 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Research Advances in Antibiotic Resistance

edited by

José Pascual Abad

and

Irma Marín

submission deadline 31 Oct 2026 | 4 articles | Viewed by 7300 | Submission Open

Keywords: antibiotic resistance; resistant pathogenic microorganisms; One Health; prevalence of antibiotic-resistant microorganisms; multidrug resistance; antibiotic resistance levels; alternative anti-infectious strategies and compounds; antibiotic-resistant genes; mechanisms of antimicrobial resistance

(This special issue belongs to the Section Molecular Microbiology)

Genomics of Human Disease

edited by

Sungkyoung Choi

submission deadline 31 Oct 2026 | 5 articles | Viewed by 7285 | Submission Open

Keywords: genome-wide association study (GWAS); next-generation sequencing (NGS); multi-omics analysis; epidemiology data analysis; precision medicine approaches; disease prediction analysis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Endothelial Cell Injury and Repair

edited by

Eleni Gavriilaki

and

Panagiota Anyfanti

submission deadline 31 Oct 2026 | 3 articles | Viewed by 6974 | Submission Open

Keywords: endothelial injury; endothelial repair; endotheliopathies; endothelial dysfunction

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 31 Oct 2026 | 3 articles | Viewed by 6174 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Displaying special issue 2251-2300 on page 46 of 64.

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