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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Recent Advances and Challenges in Colorectal Cancer: From Molecular Research to Treatment

edited by

Premila Leiphrakpam

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1399 | Submission Open

Keywords: tumor biology; tumor heterogeneity; molecular mechanism involved in cancer initiation; progression; and metastasis; compensatory pathways; cancer screening; cancer biomarkers discovery; tumor molecular profiling methods; early cancer diagnosis; novel therapeutic strategies; targeted therapies; drug resistance

(This special issue belongs to the Section Molecular Oncology)

New Anti-cancer Agents: Design, Synthesis and Applications

edited by

Robert Czarnomysy

submission deadline 20 Sep 2025 | 2 articles | Viewed by 1398 | Submission Open

Keywords: anti-cancer drugs; cancer drug development; cancer therapy; rational drug design; structure– activity relationship; cancer therapeutics; cytotoxicity; apoptosis; anti-tumor activity

(This special issue belongs to the Section Molecular Pharmacology)

High Fat Diet Metabolism and Diseases

edited by

Miguel Walter Fornés

and

Luís Fernando Barbisan

submission deadline 20 Sep 2025 | 3 articles | Viewed by 1340 | Submission Open

Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

The Impact of Mitochondria on Human Disease and Health

edited by

Martina Semenzato

submission deadline 20 Sep 2025 | 3 articles | Viewed by 1326 | Submission Open

Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer

(This special issue belongs to the Section Biochemistry)

Scleroderma: From Biomarkers to Therapeutic Targets

edited by Kathryn Seraphin Torok

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1314 | Submission Open

Keywords: scleroderma; biomarkers; epigenetics; RNA sequencing; genetics and genomics; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Advances in the Field of Thrombosis and Hemostasis

edited by

Claudia Maria Radu

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1284 | Submission Open

Keywords: bleeding; thrombosis; new diagnostic tests; rare diseases; platelet function; biomarkers; risk factors; thrombocytopenia; endothelial dysfunction; autoantibodies; extracellular vesicles; stem cells; gene therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Research in Spatial Proteomics

edited by

Andrew Smith

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1284 | Submission Open

Keywords: spatial proteomics; mass spectrometry imaging; mass cytometry; biomarker; machine learning; spatial biology; molecular pathology; cancer

(This special issue belongs to the Section Molecular Informatics)

The Molecular Role of Platelets in Human Diseases

edited by

Lukasz Szarpak

and

Michał Pruc

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1257 | Submission Open

Keywords: platelet; biomarkers; platelet membrane proteins; platelet-derived microparticles; platelet-related diseases; thrombosis; inflammatory diseases; cardiovascular disease; cancer; tumor growth and metastasis

(This special issue belongs to the Section Molecular Biology)

Molecular Dynamics Simulation of Biomolecules

edited by

Pavel Rehak

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1253 | Submission Open

Keywords: molecular dynamics simulations; biochemical processes; biomaterial properties

(This special issue belongs to the Section Molecular Biophysics)

Genetic Prediction of Risk of Common Diseases

edited by

Grant Morahan

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1247 | Submission Open

Keywords: complex genetic diseases; cancer; heart disease; diabetes; dementia; polygenic risk score; genetic risk signatures

(This special issue belongs to the Section Molecular Genetics and Genomics)

Peptide Self-Assembly

edited by

Yi Jia

submission deadline 20 Sep 2025 | 2 articles | Viewed by 1245 | Submission Open

Keywords: peptide assembly; aromatic short peptides; bioinspired supramolecular architectures; functional materials; peptide microfabrication; anticancer therapy; supercapacitor; biosensing

(This special issue belongs to the Section Macromolecules)

Phytochemical Dynamics: Plant Metabolite Responses to Environmental Factors

edited by

Ivana Sola

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1233 | Submission Open

Keywords: plant metabolites; phytochemicals; biotic and abiotic factors; environmental influences; biochemical pathways; interactions

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Advances in Forensic Toxicology: Innovations Approaches in Detection of New Psychoactive Substances

edited by Roberta Tittarelli and Giulio Mannocchi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1230 | Submission Open

Keywords: addiction; new psychoactive substances; mass spectrometry; biological matrices; diversion; forensic toxicology; drug testing

(This special issue belongs to the Section Molecular Toxicology)

Characterization and Biological Function of Plant Extracts

edited by

Simonetta Cristina Di Simone

submission deadline 20 Sep 2025 | 2 articles | Viewed by 1220 | Submission Open

Keywords: plant extracts; phytochemical characterization; bioactive compounds; biological activity; molecular mechanisms; gene expression; pharmacognosy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Investigation of Natural Products as Sources of Bioactive Molecules, 2nd Edition

edited by

Stefania Garzoli

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1203 | Submission Open

Keywords: metabolomic; secondary metabolites; phytochemical analysis; bioactivity; chemical investigation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Reproductive Genetics and Epigenetics: Insights into Infertility Failures and Treatment Pathways

edited by

Hossam H. Shawki

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1176 | Submission Open

Keywords: infertility; epigenetics; polymorphism; gametogenesis; fertilization; embryo development; reproductive organs; congenital malformations

(This special issue belongs to the Section Molecular Genetics and Genomics)

Glutamatergic Signaling in the Nervous System

edited by

Osama Abulseoud

and

Frank Schmitz

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1175 | Submission Open

Keywords: glutamate glutamine cycle; neurotoxicty; ferroptosis; hyperglutamatergic states; innovative pharmacological interventions

(This special issue belongs to the Section Molecular Neurobiology)

Chronic Liver Disease and Hepatocellular Carcinoma—2nd Edition

edited by

Daniela Gabbia

and Sara Carpi

submission deadline 20 Sep 2025 | 2 articles | Viewed by 1169 | Submission Open

Keywords: hepatocellular carcinoma; NAFLD/NASH; viral hepatitis; autoimmune liver disease; immunotherapy; biomarker

(This special issue belongs to the Section Molecular Oncology)

Advances and Current Challenges in Plasma Medicine

edited by

Andrei Vasile Nastuta

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1155 | Submission Open

Keywords: plasma medicine; plasma pharmacology; plasma oncology; plasma bioengineering; plasma agronomy; plasma and food; plasma and automotive; plasma and aerospace; plasma diagnostics; plasma material processing; plasma polymerization and coating; simulation of plasma phenomena during interaction with matter

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pathophysiology and New Therapies of Alopecia

edited by Jong-Hyuk Sung

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1140 | Submission Open

Keywords: alopecia; pathophysiology; novel pharmacological treatments; regenerative medicines; gene therapy; cell therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug-Induced Neurotoxicity and Neurodegeneration: Mechanisms, Models and Implications

edited by

Daniel José Barbosa

and

Renata Silva

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1107 | Submission Open

Keywords: drugs of abuse; pharmaceutical drugs; environmental toxins; drug exposure; neurotoxicity; neurodegeneration; brain health; substance use disorders; therapeutic interventions; in vivo models; in vitro models; in silico models; biomarkers of damage; translational studies

(This special issue belongs to the Section Molecular Neurobiology)

Reproductive Diseases and Modern Lifestyle: From Bench to Bedside

edited by

Georgios Valsamakis

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1097 | Submission Open

Keywords: infertility; endocrine disrupting chemicals; reproductive hormones; lifestyle; metabolic diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Recent Research on Cardiac Troponins

edited by

Chiara Caselli

and

Rosetta Ragusa

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1090 | Submission Open

Keywords: cardiac troponin; gene mutations; post-translational modifications; therapy; high-sensitivity (hs) immunoassays; mechanisms of release; biomarkers; cardiovascular disease

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Retinal Neurobiology

edited by

Tamas Kovacs-Oller

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1081 | Submission Open

Keywords: retina; vision; disease; ganglion cells; amacrine cells; bipolar cells; horizontal cells; photoreceptors; astrocytes; microglia; Mü ller cells

(This special issue belongs to the Section Molecular Neurobiology)

Hybrid Organic–Inorganic Materials: From Synthesis to Applications

edited by

Mirta Rubčić

and

Višnja Vrdoljak

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1079 | Submission Open

Keywords: hybrid; organic– inorganic; functional materials; structure– property; design; synthesis

(This special issue belongs to the Section Materials Science)

Molecular Mechanism and Therapeutic Approaches of Breast Cancer, Metastatic Breast Cancer, 3rd Edition

edited by

Mi Kyung Park

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1065 | Submission Open

Keywords: breast cancer; metastatic breast cancer; epithelial-to-mesenchymal transition (EMT); epigenetic and post-translational modifications (PTM); tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Characterization and Biological Functions of Plant Extracts

edited by

Muna Ali Abdalla

and

Lyndy McGaw

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1047 | Submission Open

Keywords: biological activity of plant-derived products; antimicrobial activity; in vitro antibiofilm activity; anticancer activity; anti-inflammatory activity; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Chemistry Triggered by Low-Energy Particles

edited by Hassan Abdoul-Carime

submission deadline 20 Sep 2025 | 2 articles | Viewed by 1030 | Submission Open

Keywords: low energy (< 50 eV); photons; electrons; ions; gas phase; single molecules; clusters; condensed phase liquids and films; experimental techniques; density functional theory; IA-based prediction models

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Cell Fate Decisions: Autophagy, Apoptosis, Pyroptosis, Necroptosis, Ferroptosis and PANoptosis in Health and Disease

edited by

Yaqiu Wang

submission deadline 20 Sep 2025 | 1 articles | Viewed by 1019 | Submission Open

Keywords: inflammation; autophagy; apoptosis; pyroptosis; necroptosis; PANoptosis; ferroptosis; cell death; cell survival

(This special issue belongs to the Section Molecular Biology)

Molecular Research of Natural Products in Cancer Diseases

edited by

Angeliki Tiptiri-Kourpeti

submission deadline 20 Sep 2025 | Viewed by 1002 | Submission Open

Keywords: cancer; natural products; drug resistance; side effects; bioactive compounds; prevention; treatment; signaling pathways; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Novel Nanoparticle Composites: Functionalization and Application

edited by

Jovan M. Nedeljković

and

Vesna Lazić

submission deadline 20 Sep 2025 | 1 articles | Viewed by 995 | Submission Open

Keywords: nanoparticles; nanocomposites; synthesis; functionalization; interface; photocatalysis; antimicrobial nanoparticles; nanomedicine; theoretical modelling; computer simulations

(This special issue belongs to the Section Molecular Nanoscience)

Human Hereditary Diseases: Advances in Molecular Genetics, Genomics and Therapeutic Strategies

edited by Yulin Jin and

Yujing Li

submission deadline 20 Sep 2025 | 1 articles | Viewed by 931 | Submission Open

Keywords: hereditary diseases; genetics and genomics; molecular mechanism; gene regulation; therapeutic approach

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unraveling the Genetic Background of Neurological Disorders: 2nd Edition

edited by

Vasileios Siokas

Efthimios Dardiotis

and

Ioannis Liampas

submission deadline 20 Sep 2025 | 1 articles | Viewed by 929 | Submission Open

Keywords: neurological disorders; neurogenetics; personalized treatments; gene-association studies; genetics; genome-wide association studies; genetic linkage studies

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Research on Tumor Metastasis and Inhibition

edited by

Yu-Chan Chang

submission deadline 20 Sep 2025 | 1 articles | Viewed by 926 | Submission Open

Keywords: metastasis; epithelial– mesenchymal transition; small-molecule compounds; animal imaging; signal transduction

(This special issue belongs to the Section Molecular Oncology)

The Blood–Brain Barrier and Neuroprotection

edited by Aruna Sharma and Hari Shanker Sharma

submission deadline 20 Sep 2025 | 1 articles | Viewed by 899 | Submission Open

Keywords: blood– brain barrier; neurodegenerative diseases; nanoformulations; drug development; delivery systems

(This special issue belongs to the Section Molecular Neurobiology)

Personalized Nanomedicine in Oncology

edited by Sajid Ali

submission deadline 20 Sep 2025 | Viewed by 894 | Submission Open

Keywords: drug/gene delivery; biomaterials; stimuli-responsive systems; lipid– polymer nanoparticles; lipodendriplexes; dual delivery; inorganic nanoparticles; targeted delivery system

(This special issue belongs to the Section Molecular Nanoscience)

Molecular Advances in Omics in Agriculture

edited by

Sebastian Wojciech Przemieniecki

submission deadline 20 Sep 2025 | 1 articles | Viewed by 887 | Submission Open

Keywords: agronomy; plant production; animal production; genome; microbiome; metagenomics; RNAseq; molecular mechnisms; molecular pest diagnostics; molecular interactions; gene editing

(This special issue belongs to the Section Molecular Informatics)

Molecular Advances in Electrochemical Materials

edited by

Raj Karthik

submission deadline 20 Sep 2025 | 1 articles | Viewed by 878 | Submission Open

Keywords: electrochemical materials; molecular design; energy storage; electrocatalysis; sensing applications; nanomaterials; sustainable materials; hybrid systems; interface engineering; green chemistry

(This special issue belongs to the Section Materials Science)

Mitochondria as a Therapeutic Target for Anti-Cancer Drugs

edited by

Dalia Marija Kopustinskiene

submission deadline 20 Sep 2025 | Viewed by 872 | Submission Open

Keywords: mitochondria; cancer; apoptosis; oxidative phosphorylation; Warburg effect; cardiolipin; inflammation

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Pathophysiology of Cystic Fibrosis

edited by

Stefanie Krick

and George M. Solomon

submission deadline 20 Sep 2025 | 1 articles | Viewed by 847 | Submission Open

Keywords: cystic fibrosis; aging; CF airway disease; CF complications; CF molecular pathogenesis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 20 Sep 2025 | 1 articles | Viewed by 802 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

Extracellular Vesicles: Functions and Therapeutic Applications

edited by Deepshikha Tewari

submission deadline 20 Sep 2025 | Viewed by 802 | Submission Open

Keywords: extracellular vesicles; exosome; cell-to-cell communication; diagnosis; treatment; molecular markers; diseases

(This special issue belongs to the Section Molecular Biology)

Advances in Molecular Therapeutics for HIV Co-Infections

edited by

Vishwanath Venketaraman

and

Selvakumar Subbian

submission deadline 20 Sep 2025 | 1 articles | Viewed by 793 | Submission Open

Keywords: HIV co-infections; molecular therapeutics; Mtb; ART; immune responses

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Diagnosis and Targeted Therapies in Ischemic Stroke

edited by Alicia Aliena-Valero and María Castelló-Ruiz

submission deadline 20 Sep 2025 | 1 articles | Viewed by 790 | Submission Open

Keywords: ischemic stroke; cerebral protection; repair treatments; therapeutic approaches

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioconjugates and Application

edited by

Gábor Mező

submission deadline 20 Sep 2025 | 1 articles | Viewed by 758 | Submission Open

Keywords: bioconjugates; targeted therapy; homing moieties; drug delivery; bioconjugates as diagnostic tools; targeted nanoparticles; antibody– drug conjugates; linkage systems

(This special issue belongs to the Section Macromolecules)

Amyotrophic Lateral Sclerosis Behind Motor Neurons

edited by

Patrizia Longone

and Ezia Guatteo

submission deadline 20 Sep 2025 | 1 articles | Viewed by 747 | Submission Open

Keywords: non-neuronal cells; neurotransmitters; systemic disease; motor system; neuronal circuitry; skeletal muscle metabolism; muscle oxidative metabolism

(This special issue belongs to the Section Molecular Neurobiology)

Type 1 Diabetes: Molecular Mechanisms and Therapeutic Approach

edited by Preeti Chhabra

submission deadline 20 Sep 2025 | 1 articles | Viewed by 739 | Submission Open

Keywords: type 1 diabetes; microbiome; proteomics; immunotherapy; β -cell replacement; single-cell sequencing; stem cells; gene editing technologies; tolerance

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Research on Apoptosis and Autophagy in Osteosarcoma

edited by

Hyung-Mun Yun

and

Kyung-Ran Park

submission deadline 20 Sep 2025 | 1 articles | Viewed by 705 | Submission Open

Keywords: apoptosis; autophagy; bioactive molecule; cancer; necroptosis; osteosarcoma; osteoclast; osteoblast

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Intestinal Microbiome and Its Function

edited by

Simone Baldi

submission deadline 20 Sep 2025 | 1 articles | Viewed by 699 | Submission Open

Keywords: human microbiome; gut microbiome; microbiota-derived metabolites; SCFAs; gut– organ axis

(This special issue belongs to the Section Molecular Microbiology)

Advances in Diabetic Ischemic Heart Failure

edited by Branko Beleslin

submission deadline 20 Sep 2025 | 1 articles | Viewed by 690 | Submission Open

Keywords: diabetes; ischemic cardiomyopathy; pathophysiology; diagnostics; therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2251-2300 on page 46 of 70.

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