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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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RNA Editing/Modification in Health and Disease

edited by Valeriana Cesarini and

Piergiorgio La Rosa

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1083 | Submission Open

Keywords: RNA editing; RNA transport and localization; miRNAs; siRNAs; lncRNAs

(This special issue belongs to the Section Molecular Genetics and Genomics)

Metabolomics in Coronary Artery Disease: From Pathogenesis to Personalized Medicine

edited by

Tomasz Urbanowicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1079 | Submission Open

Keywords: coronary artery disease (CAD); atherosclerosis; epicardial disease; CAD pathogenesis; personalized approach; drug response; metabolomic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Physiological and Pathophysiological Aspects of Intracellular and Extracellular Modulator Proteases

edited by

Takuro Miyazaki

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1043 | Submission Open

Keywords: a disintegrin and metalloproteinase domain-containing protein; calpain; ectoproteinase; inflammasome; secretase

(This special issue belongs to the Section Molecular Biology)

Epilepsy: From Molecular Basis to Therapy, 2nd Edition

edited by

Henry Hing Cheong Lee

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1043 | Submission Open

Keywords: genetic epilepsy; post-traumatic epilepsy; neurodevelopmental disorder; glutamate; GABA; ionic homeostasis; disease-modifying therapy; in vitro; in vivo; animal model; gene replacement therapy; gene editing; protein misfolding; small molecule; pharmacokinetics; pharmacodynamics; translational research; biomarker; clinical trial

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Drug Delivery Systems in Veterinary Medicine: Innovations and Applications

edited by

Hualin Fu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1036 | Submission Open

Keywords: design of novel veterinary drug delivery systems; methods of preparing a veterinary drug delivery system; mechanisms of action of veterinary drug delivery systems; impact of veterinary drug delivery systems on in vivo processes of veterinary drugs; clinical evaluation of veterinary drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Insights into Functional Nanomaterials: Application-Related Structural Analysis

edited by Zoltán Dudás

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1031 | Submission Open

Keywords: functional porous nanomaterials; structure– activity relationship; molecular structure; characterization; nanoporous materials

(This special issue belongs to the Section Molecular Nanoscience)

Cardioprotection and Mitochondrial Signaling: Insights from Molecular Mechanisms to Therapeutic Strategies

edited by Cecilia Zazueta

submission deadline 20 Dec 2025 | 1 articles | Viewed by 1017 | Submission Open

Keywords: cardioprotection; mitochondrial signaling; mitochondrial dysfunction; heart failure; ischemia/reperfusion; mitochondria; reactive oxygen species

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Approaches in Organic Synthesis and Functional Materials: From Design to Biological Impact

edited by

Antonio Rescifina

and

Chiara Zagni

submission deadline 20 Dec 2025 | 2 articles | Viewed by 1007 | Submission Open

Keywords: organic synthesis; bioactive molecules; functional materials; molecular informatics; biological activity; molecular docking; computational chemistry; drug design; medicinal chemistry; quantitative structure– activity relationships (QSARs); environmental applications; sustainable chemistry; natural products

(This special issue belongs to the Section Molecular Informatics)

Treatment of Neurodegenerative Diseases with Natural Products

edited by

Eugene Huh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 977 | Submission Open

Keywords: neurodegenerative diseases; natural product; misfolding protein aggregation; oxidative stress; neuroinflammation; autophagy; apoptosis; microbiota– gut– brain axis; therapeutic; prevention

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Research in Probiotic Yeasts: Molecular Aspects

edited by

Maurizio Ciani

and Francesca Comitini

submission deadline 20 Dec 2025 | 1 articles | Viewed by 972 | Submission Open

Keywords: probiotic yeasts; molecular mechanisms; mycocins active; compounds; functional compounds

(This special issue belongs to the Section Molecular Microbiology)

Molecular Advances in Plant Reproductive Development

edited by Zsolt Pónya and

Iman Mirmazloum

submission deadline 20 Dec 2025 | 1 articles | Viewed by 942 | Submission Open

Keywords: plant reproduction; sexual reproduction; gamete recognition; zygote formation; embryogenesis; endosperm development; seed maturation; plant developmental biology; epigenetic regulation; gene expression; cellular signalling pathways; protein interactions; hormonal controls

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into the Molecular Mechanisms of the UPR and Cell Stress

edited by

Quang Duy Trinh

submission deadline 20 Dec 2025 | 1 articles | Viewed by 918 | Submission Open

Keywords: unfolded protein response; ER stress; oxidative stress; mitochondrial dysfunction; cell stress; stress response; UPR signaling pathway; immunity; inflammation; infection

(This special issue belongs to the Section Molecular Biology)

Biocomposite Hydrogels for Biomedical Applications

edited by

Leonard Ionut Atanase

submission deadline 20 Dec 2025 | 1 articles | Viewed by 913 | Submission Open

Keywords: hydrogels; biocomposite; micro/nanoparticles; electrospun fibers; inorganic particles; tissue engineering; drug delivery; 3D printing

(This special issue belongs to the Section Materials Science)

Advances in the Pathogenesis of Allergic Diseases: From Mechanisms to Therapeutics

edited by Clinton B. Mathias and Michiko K. Oyoshi

submission deadline 20 Dec 2025 | 1 articles | Viewed by 900 | Submission Open

Keywords: food allergy; allergic mechanisms; asthma; allergic disease; mast cells; ILC2s; Th2 cells; eosinophils; IL-4; IL-33; IL-13

(This special issue belongs to the Section Molecular Immunology)

Pharmacokinetics of Psychoactive Substances: Molecular and Forensic Aspects

edited by

Angelo Montana

and

Fabrizio Lo Faro

submission deadline 20 Dec 2025 | Viewed by 897 | Submission Open

Keywords: psychoactive substances; pharmacokinetics; forensic Toxicology; forensic pathology; toxicological biomarkers; cerebral damage; in vitro; in vivo; and in silico models; new Psychoactive Substances (NPS); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography; tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Pharmacology)

Naturally Occurring Bioactive Compounds, Neuroinflammation and Cognitive Dysfunction: Molecular and Biochemical Mechanisms

edited by

Tosin Olasehinde

submission deadline 20 Dec 2025 | 1 articles | Viewed by 894 | Submission Open

Keywords: neuroinflammation; cognitive dysfunction; medicinal plants; bioactive compounds; neurodegenerative diseases; molecular mechanisms; anti-inflammatory

(This special issue belongs to the Section Molecular Toxicology)

Molecular Mechanisms of Esophageal Inflammation, Injury, and Repair

edited by Anisa Shaker

submission deadline 20 Dec 2025 | 1 articles | Viewed by 891 | Submission Open

Keywords: GERD; eosinophilic esophagitis; achalasia; esophageal cancer; barrett’ s esophagus; microbiome

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Diseases of the Respiratory System—Molecular Mechanisms and Pathogenesis: 3rd Edition

edited by

Andreas Beineke

submission deadline 20 Dec 2025 | 1 articles | Viewed by 874 | Submission Open

Keywords: respiratory diseases; pneumonia; pneumotropic viruses; pathogenesis; host– pathogen interaction; pulmonary pathology; immunopathology; immunity; disease prevention; treatment; zoonotic diseases; antiviral therapy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Structural Characterization and Pharmacological Activity of Natural Compounds

edited by

Ana Amić

submission deadline 20 Dec 2025 | 1 articles | Viewed by 874 | Submission Open

Keywords: natural compounds; bioactive molecules; molecular structure; characterisation; pharmacological activity; biochemical properties; pharmacokinetics; toxicity

(This special issue belongs to the Section Molecular Pharmacology)

Pathophysiology of Hair Loss

edited by

Kwang-Hyun Park

submission deadline 20 Dec 2025 | 1 articles | Viewed by 843 | Submission Open

Keywords: Hair Loss; Pathophysiology; Molecular Mechanisms; Genetic Mutations; Signaling Pathways; Nutrient Interactions; Personalized Therapies; Targeted Drug Delivery

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Development and Validation of New Analytical Methods for the Determination of Drugs and Their Metabolites

edited by

Anna Petruczynik

submission deadline 20 Dec 2025 | 1 articles | Viewed by 821 | Submission Open

Keywords: drugs; drug formulations; pharmacokinetics; metabolism studies; analytical techniques

(This special issue belongs to the Section Molecular Pharmacology)

Recent Advances in Protein Folding and Misfolding

edited by

Ho-Jin Lee

submission deadline 20 Dec 2025 | Viewed by 754 | Submission Open

Keywords: protein folding; protein misfolding; 3D protein structure; CRISPR/Cas 9

(This special issue belongs to the Section Molecular Biophysics)

Immune-Liver Axis—from Disease Pathogenesis to Therapeutic Target

edited by

Beata Kasztelan-Szczerbińska

submission deadline 20 Dec 2025 | 1 articles | Viewed by 753 | Submission Open

Keywords: immune response; inflammation; liver disease; liver injury; liver cirrhosis; immune-related liver disease; alcohol-related liver disease; metabolic dysfunction-associated steatotic liver disease (MASLD); Wilson’ s disease; hemochromatosis; liver cancer

(This special issue belongs to the Section Molecular Immunology)

Molecular Insights into Virus-Host Immune Interactions

edited by

Claudia Vanetti

submission deadline 20 Dec 2025 | 1 articles | Viewed by 750 | Submission Open

Keywords: viral diseases; virus– host interactions; vaccination; interferon signalling; antibody responses; viral proteins; SARS-CoV-2

(This special issue belongs to the Section Molecular Immunology)

New Insights of Autophagy and Apoptosis in Cells

edited by

Mirko Pesce

and

Antonia Patruno

submission deadline 20 Dec 2025 | 1 articles | Viewed by 742 | Submission Open

Keywords: autophagy; apoptosis; signal transduction; cell survival

(This special issue belongs to the Section Molecular Biology)

Nitric Oxide and Photosynthetic Machinery: Unveiling Molecular Mechanisms and Redox Balancing

edited by

Mun Bong-Gyu

submission deadline 20 Dec 2025 | 1 articles | Viewed by 736 | Submission Open

Keywords: nitric oxide; photosynthetic machinery; NO signaling pathways; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

Role of Ion Channels in Human Health and Diseases

edited by

Sheng-Nan Wu

submission deadline 20 Dec 2025 | Viewed by 725 | Submission Open

Keywords: sodium current; potassium current; ion channel kinetics; excitable cells; treatments; pathophysiology

(This special issue belongs to the Section Molecular Biology)

Electron Transport Mechanism in Optoelectronic Materials

edited by Paolo Umari

submission deadline 20 Dec 2025 | Viewed by 704 | Submission Open

Keywords: photovoltaics; density functional theory; quantum chemistry; optoelectronic devices; semiconductors; polymers; charge transport

(This special issue belongs to the Section Materials Science)

Latest Molecular Research on Polymer Coatings

edited by

Joanna Karasiewicz

submission deadline 20 Dec 2025 | 1 articles | Viewed by 687 | Submission Open

Keywords: synthesis of specialty compounds; specialty compounds in industrial treatment; amphiphilic compounds; wettability (including solids and biomaterials); antimicrobial activity; surface activity; superwetting; high hydrophobic/hydrophilic/olrophobic/olephilic properties; special applications: self-cleaning; anti-icing; self-healing; biocidal; etc.

(This special issue belongs to the Section Materials Science)

Sleep and Breathing: From Molecular Perspectives

edited by Alberto Alonso-Fernández

submission deadline 20 Dec 2025 | 1 articles | Viewed by 648 | Submission Open

Keywords: obstructive sleep apnea; cardiovascular risk; cardiovascular diseases/physiopathology; continuous positive airway pressure; hypertension; biomarkers; diabetes; pregnancy; gene expression profiling; genetic markers; inflammation mediators; oxidative stress; proteomics

(This special issue belongs to the Section Molecular Biology)

Novel Trends in the Research of Molecules Involved in Skin Inflammation and Dermatologic Conditions

edited by

Liborija Lugovic-Mihic

submission deadline 20 Dec 2025 | 1 articles | Viewed by 631 | Submission Open

Keywords: atopic dermatitis; contact dermatitis; psoriasis; urticaria; eczema; acne; rosacea; seborrheic dermatitis; drug-induced reaction; prurigo nodularis; lichen; hidradenitis suppurativa; alopecia; chronic urticaria; skin tumor; angioedema; venous ulcer; HPV skin manifestations; skin infection; vitiligo

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms of Age-Related Cognitive Decline

edited by

Cristovam Wanderley Picanço Diniz

submission deadline 20 Dec 2025 | Viewed by 601 | Submission Open

Keywords: cognitive decline; molecular mechanisms; aging individuals; therapeutic targets; neuroinflammation; oxidative stress; protein aggregation; vascular changes

(This special issue belongs to the Section Molecular Neurobiology)

Future Perspectives and Challenges in Molecular Research of Glioma

edited by Shanchun Guo

submission deadline 20 Dec 2025 | 1 articles | Viewed by 586 | Submission Open

Keywords: gliomas; genetic and epigenetic changes; molecular mechanisms; immunotherapy; innovative therapeutic strategies

(This special issue belongs to the Section Molecular Neurobiology)

Plant Responses to Heavy Metals: From Deficiency to Excess, 2nd Edition

edited by

Anna D. Kozhevnikova

and

Ilya Vladimirovich Seregin

submission deadline 20 Dec 2025 | 1 articles | Viewed by 581 | Submission Open

Keywords: heavy metals; deficiency; metal toxicity; metal (hyper-)accumulation; mechanisms of metal tolerance; metal transport; metal uptake; metal sequestration; metal homeostasis

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Research on Cancer Stem Cells

edited by

Sabrina Battista

submission deadline 20 Dec 2025 | Viewed by 580 | Submission Open

Keywords: self-renewal; microenvironment; plasticity; epigenetics; epithelial-mesenchymal transition; heterogeneity; targeting; dormancy

(This special issue belongs to the Section Biochemistry)

Neuroimaging Studies in Exploring the Molecular Mechanisms of Neurological Diseases

edited by

Ming-Chang Chiang

submission deadline 20 Dec 2025 | 1 articles | Viewed by 580 | Submission Open

Keywords: neuroimaging; neurological diseases; brain imaging; biomarkers; functional connectivity; AI in neuroimaging

(This special issue belongs to the Section Molecular Neurobiology)

Rethinking Fat: A Deeper Dive into the Diversity and Dynamic Roles of Adipose Tissue

edited by

Ahmed Bettaieb

submission deadline 20 Dec 2025 | Viewed by 553 | Submission Open

Keywords: adipose tissue biology; stem cell commitment and differentiation; thermogenic adipocytes; genetic regulation; metabolic homeostasis; selective targeting

(This special issue belongs to the Section Molecular Biology)

MicroRNAs and mRNA in Human Health and Disease

edited by

Paulina Gil-Kulik

submission deadline 20 Dec 2025 | 1 articles | Viewed by 525 | Submission Open

Keywords: stem cells; mesenchymal stem cells; gene expression; microRNA; mRNA

(This special issue belongs to the Section Molecular Biology)

Recent Advances in Biomolecular Recognition: 3rd Edition

edited by

Ray Luo

submission deadline 20 Dec 2025 | Viewed by 520 | Submission Open

Keywords: proteins; nucleic acids; membrane; ligand; binding

(This special issue belongs to the Section Molecular Biophysics)

Signaling in GPCR Research

edited by

Zvi Naor

submission deadline 20 Dec 2025 | Viewed by 516 | Submission Open

Keywords: GPCR; G protein; signaling; drug design; cell surface receptors

(This special issue belongs to the Section Biochemistry)

Exploring Natural Products for Antimicrobial Innovation: New Paths and Promising Leads

edited by

Shagufta Perveen

submission deadline 20 Dec 2025 | Viewed by 491 | Submission Open

Keywords: antimicrobial agents; drug resistance; plant-derived compounds; bioactive molecules; phytochemicals; marine natural products; fungal metabolites; novel drug discovery; microbial pathogens; natural product isolation; drug development; biotechnology in antimicrobial research

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Antifungal Drug Discovery: Progresses, Challenges, Opportunities, 2nd Edition

edited by

Bernhard Biersack

submission deadline 20 Dec 2025 | 1 articles | Viewed by 466 | Submission Open

Keywords: antifungal drugs; fungal infections; drug design; drug discovery; targeted therapy; drug resistance; fungal drug targets; neglected tropical diseases

(This special issue belongs to the Section Molecular Pharmacology)

The Role of Fibrinolytic Factors in Disease

edited by

Yosuke Kanno

submission deadline 20 Dec 2025 | Viewed by 455 | Submission Open

Keywords: fibrinolysis; plasminogen; plasmin; α 2-antiplasmin; uPA; uPAR; tPA; PAI-1

(This special issue belongs to the Section Molecular Biology)

Red Blood Cells in Health and Disease

edited by Annamaria Russo and Ester Tellone

submission deadline 20 Dec 2025 | Viewed by 402 | Submission Open

Keywords: oxidative stress; metabolism; hemoglobin; erythrocytes

(This special issue belongs to the Section Biochemistry)

The Role of Non-Coding RNAs in Female Reproduction

edited by

Angela Caponnetto

submission deadline 20 Dec 2025 | Viewed by 397 | Submission Open

Keywords: microRNAs; long non-coding RNAs; circular RNAs; female reproduction; reproductive aging; molecular biomarkers; ceRNA network

(This special issue belongs to the Section Molecular Genetics and Genomics)

Collagen-Based Biomaterials in Tissue Engineering and Regenerative Medicine

edited by Martin Braun,

Selestina Gorgieva

and

Eva Filova

submission deadline 20 Dec 2025 | Viewed by 374 | Submission Open

Keywords: collagen; tissue engineering; advanced biomaterials; biodegradable composites; scaffolds; protein structure; biochemical analysis; material characterization; medical application; gelatine

(This special issue belongs to the Section Macromolecules)

Histological and Molecular Perspectives on Immune Mechanisms of the Nasal and Bronchial Mucosa Diseases

edited by

Emanuela Chiarella

submission deadline 20 Dec 2025 | Viewed by 356 | Submission Open

Keywords: nasal and bronchial mucosa; nasal polyposis; bronchial inflammation; immunotherapy; mucosal immunity; inflammatory biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Adipose Tissue and Adipose Tissue-Derived Stem Cells in Multidisciplinary Research

edited by Oliver Felthaus

submission deadline 20 Dec 2025 | Viewed by 355 | Submission Open

Keywords: adipose tissue; adipose-derived stem cells; regenerative medicine; tissue engineering

(This special issue belongs to the Section Molecular Biology)

Molecular and Immunological Biomarkers in Cervical Cancer

edited by Janaina Cristiana de Oliveira Crispim and

Ricardo Ney Oliveira Cobucci

submission deadline 20 Dec 2025 | Viewed by 355 | Submission Open

Keywords: cervical cancer; molecular biomarkers; immunological biomarkers; human papillomavirus (HPV); tumor microenvironment; immune responses; immunotherapy; diagnostic biomarkers; prognostic biomarkers; therapeutic targets

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Nanoparticles in Molecular Pharmaceutics

edited by

Qingxin Mu

submission deadline 20 Dec 2025 | Viewed by 348 | Submission Open

Keywords: nanoparticles; molecular pharmaceutics; drug delivery; nanomedicine; nanoformulation

(This special issue belongs to the Section Molecular Nanoscience)

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