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Advances in Research on Antifungal Resistance
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Advances in Research on Antifungal Resistance

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Microbiology".

Deadline for manuscript submissions: 20 December 2025 | Viewed by 2932

Special Issue Editor

Dr. Anna Tomova

E-Mail Website
Guest Editor
Department of General and Industrial Microbiology, Faculty of Biology, Sofia University "St. Kliment Ohridski", Blvd. "Dragan Tsankov", 81164 Sofia, Bulgaria
Interests: yeast; molecular identification of yeast; biologically active compounds from yeast

Special Issue Information

Dear Colleagues,

Antifungal resistance poses a significant global threat, undermining the effectiveness of current therapies against fungal pathogens. The increasing prevalence of resistant strains, coupled with limited antifungal drug options, demands urgent attention from the scientific community. This Special Issue, entitled “Advances in Research on Antifungal Resistance”, aims to explore cutting-edge developments in molecular science to combat this growing challenge.

We welcome contributions that investigate the molecular mechanisms underlying resistance, novel targets for antifungal therapy, and innovative approaches in drug discovery and design. Studies employing genomics, transcriptomics, proteomics, and structural biology to understand resistance pathways are particularly encouraged. By fostering collaboration among experts in molecular biology, pharmacology, and clinical research, this Special Issue aspires to advance our knowledge and strategies to overcome antifungal resistance, ultimately improving patient outcomes.

Join us in addressing this critical issue and shaping the future of antifungal therapeutics.

Dr. Anna Tomova
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antifungal resistance
  • antifungal therapy
  • drug discovery
  • molecular mechanisms

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Published Papers (3 papers)

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Research

18 pages, 6389 KiB  
Article
Synthesis, Physicochemical Properties and Anti-Fungal Activities of New Meso-Arylporphyrins
by Hayfa Mkacher, Raja Chaâbane-Banaoues, Soukaina Hrichi, Philippe Arnoux, Hamouda Babba, Céline Frochot, Habib Nasri and Samir Acherar
Int. J. Mol. Sci. 2025, 26(5), 1991; https://doi.org/10.3390/ijms26051991 - 25 Feb 2025
Viewed by 566
Abstract
In this work, we describe the synthesis of three new meso-arylporphyrins, named meso-tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (H2TNPP), meso-tetrakis [4-(picolinoyloxy)phenyl] porphyrin (H2TPPP), and meso-tetrakis [4-(isonicotinoyloxy) phenyl] porphyrin (H2TIPP). These [...] Read more.
In this work, we describe the synthesis of three new meso-arylporphyrins, named meso-tetrakis [4-(nicotinoyloxy)phenyl] porphyrin (H2TNPP), meso-tetrakis [4-(picolinoyloxy)phenyl] porphyrin (H2TPPP), and meso-tetrakis [4-(isonicotinoyloxy) phenyl] porphyrin (H2TIPP). These new synthesized meso-arylporphyrins are characterized using spectroscopic analysis: Fourier Transform Infrared Spectroscopy (FTIR) and One-dimensional Nuclear Magnetic Resonance (1D NMR), and mass spectrometry (MS). The photophysical studies (UV–visible absorption, singlet oxygen (1O2) luminescence, and fluorescence emissions) demonstrate their potential uses as photosensitizers (PSs) in photodynamic therapy (PDT) applications. An in vitro investigation of the anti-fungal activity of H2TNPP, H2TPPP, and H2TIPP against Candida (C.) species (C. albicans, C. glabrata, and C. tropicalis) reveals that their minimum inhibitory concentration (MIC) values ranged from 1.25 to 5 mg/mL. In addition, their in vitro anti-fungal susceptibilities against three dermatophyte clinical isolates (Trichophyton rubrum, Microsporum canis, and Trichophyton mentagrophytes) are also evaluated and they demonstrate good anti-fungal activities. A molecular docking study of these meso-arylporphyrins as anti-fungal agents against C. tropicalis extracellular aspartic proteinases, Protein data Bank in Europe (PDBe code: 1J71) and Trichophyton rubrum Sialidases (PDBe code: 7P1D) underlines the possible interactions of H2TNPP, H2TPPP, and H2TIPP with the key amino acid residues of these fungal target proteins. Full article
(This article belongs to the Special Issue Advances in Research on Antifungal Resistance)
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25 pages, 1886 KiB  
Article
The Role of Oxidative Stress in the Antifungal Activity of Two Mollusk Fractions on Resistant Fungal Strains
by Lyudmila Velkova, Radoslav Abrashev, Jeny Miteva-Staleva, Vladislava Dishliyska, Aleksandar Dolashki, Boryana Spasova, Pavlina Dolashka, Maria Angelova and Ekaterina Krumova
Int. J. Mol. Sci. 2025, 26(3), 985; https://doi.org/10.3390/ijms26030985 - 24 Jan 2025
Cited by 1 | Viewed by 999
Abstract
Fungal infections are a significant global public health challenge because of their widespread occurrence, morbidity, and profound social and economic consequences. Antifungal resistance is also an increasing concern, posing a substantial risk to public health. There is a growing interest in searching for [...] Read more.
Fungal infections are a significant global public health challenge because of their widespread occurrence, morbidity, and profound social and economic consequences. Antifungal resistance is also an increasing concern, posing a substantial risk to public health. There is a growing interest in searching for new antifungal drugs isolated from natural sources. This study aimed to evaluate the antifungal activity of novel mollusk fractions against fungal strains resistant to nystatin and amphotericin B. In addition, the role of oxidative stress in the mechanism of damage was determined. The mucus from the garden snail Cornu aspersum (MCa/1-20) and the hemolymph fraction from the marine snail Rapana venosa (HLRv/3-100) were obtained and characterized via 12% sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) and mass spectrometric -analyses. The results demonstrate that the spores and biomass of both mollusk fractions have a significant fungicidal effect against Penicillium griseofulvum, and Aspergillus niger. Compared to the control group, the release of intracellular proteins and reducing sugars was significantly increased in the treated groups. The data showed increased levels of oxidative stress biomarkers (lipid peroxidation and oxidatively damaged proteins) and a downregulated antioxidant enzyme defense, corresponding to increased antifungal activity. To our knowledge, this is the first study evaluating oxidative stress as a factor in mollusk fractions’ antifungal activity. Full article
(This article belongs to the Special Issue Advances in Research on Antifungal Resistance)
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17 pages, 7886 KiB  
Article
A Potent Antibacterial Peptide (P6) from the De Novo Transcriptome of the Microalga Aureococcus anophagefferens
by Kexin Zhang, Xiaoting Yin, Yu Huang, Chao Liu, Qingchun Zhang, Qing Liu, Senyu Wang, Wenwu Fei, Qiong Shi and Limei Qiu
Int. J. Mol. Sci. 2024, 25(24), 13736; https://doi.org/10.3390/ijms252413736 - 23 Dec 2024
Viewed by 1023
Abstract
Marine microalgae are a rich source of natural products, and their amino acid-based antimicrobial agents are usually obtained by enzymatic hydrolysis, which is inefficient and limits the research on antimicrobial peptides (AMPs) from microalgae. In this study, Aureococcus anophagefferens is used as a [...] Read more.
Marine microalgae are a rich source of natural products, and their amino acid-based antimicrobial agents are usually obtained by enzymatic hydrolysis, which is inefficient and limits the research on antimicrobial peptides (AMPs) from microalgae. In this study, Aureococcus anophagefferens is used as a model to predict antimicrobial peptides through high-throughput methods, and 471 putative peptides are identified based on the de novo transcriptome technique. Among them, three short peptides, P1, P6, and P7 were found to have antimicrobial activity against Escherichia coli, Staphylococcus aureus, Micro1coccus luteus, and yeast Pichia pastoris, and they showed no hemolytic activity even at higher concentrations up to 10 mg/mL. Especially P6, a 12-amino acid peptide with three positive charges, which exhibited the most significant microbicidal effect with the lowest MIC of 31.25 μg/mL against E. coli, and electron microscope observations showed the surface of P6 treated E. coli with granular protrusions and ruptures, suggesting that it likely caused cell death by directly destroying the bacterial cell membrane. This study may enrich the database of microalgal AMPs and demonstrate an efficient process for searching and validating microalgal source AMPs by combining computer analysis with bioactivity experiments. Full article
(This article belongs to the Special Issue Advances in Research on Antifungal Resistance)
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