The Molecular Link Between Nutrition and Obesity
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 2988
Special Issue Editor
Interests: food and nutrition; functional food; antioxidants; phytochemical; food biochemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The molecular link between diet and obesity is a complex interaction involving genetic and epigenetic factors, hormonal regulation (insulin, leptin, and ghrelin), adipokines (e.g., adiponectin and resistin), and environmental factors that regulate energy balance and metabolism. Obesity is associated with chronic low-grade inflammation, and the adipose tissue of obese individuals secretes pro-inflammatory cytokines (e.g., TNF-α and IL-6) that may impair insulin signaling and contribute to metabolic dysfunction. In addition, the composition of the gut microbiota may influence dietary energy expenditure, inflammation, and fat accumulation. Together, these mechanisms contribute to the development of obesity. Nutritional interventions targeting these pathways, such as diets low in refined sugars and high in fiber, may help alleviate obesity by modulating these molecular processes.
Dr. Elena Azzini
Guest Editor
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Keywords
- hormonal regulation
- chronic low-grade inflammation
- nutrient sensing pathways
- gut microbiota
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