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Innovative Therapeutic Approaches in Neuropsychiatric Disorders

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 June 2025 | Viewed by 2816

Special Issue Editor


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Guest Editor
1. Department of Psychobiology, Psychology Faculty, Campus of Blasco Ibáñez, University of Valencia, Valencia, Spain
2. Interuniversity Research Institute for Molecular Recognition and Technological Development (IDM), Valencia, Spain
Interests: cognitive neuroscience; dopamine; dopamine transporter; stress; addiction; nanoparticles; neurodegeneration
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Special Issue Information

Dear Colleagues,

Innovative therapeutic approaches in neuropsychiatric disorders are revolutionizing the treatment landscape for conditions such as depression, anxiety, schizophrenia, and PTSD. Advances in molecular biology, genetics, and neuroimaging have led to a deeper understanding of these disorders’ pathophysiology. Current treatments include neuromodulation techniques like transcranial magnetic stimulation (TMS) and deep brain stimulation (DBS), which directly alter brain activity to alleviate symptoms. Pharmacogenomics enables personalized medicine, tailoring treatments based on individual genetic profiles to improve efficacy and reduce side effects. Additionally, novel pharmacotherapies, including psychedelics like psilocybin and ketamine, are showing promise in clinical trials for their rapid and sustained effects on mood disorders. These innovative approaches, grounded in cutting-edge research, offer hope for more effective and personalized treatments, ultimately improving the quality of life for individuals with neuropsychiatric conditions. This Special Issue aims to showcase cutting-edge research that explores innovative therapeutic approaches at the molecular level for neuropsychiatric disorders.

Dr. Marta Pardo
Guest Editor

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Keywords

  • neuropsychiatric disorders
  • pharmacogenomics
  • pathophysiology
  • molecular treatment mechanisms
  • molecular targets for novel drug development
  • neurotransmitters
  • synaptic plasticity
  • epigenetics

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Published Papers (1 paper)

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Review

33 pages, 935 KiB  
Review
Pharmaco-Multiomics: A New Frontier in Precision Psychiatry
by Dhoha Dhieb and Kholoud Bastaki
Int. J. Mol. Sci. 2025, 26(3), 1082; https://doi.org/10.3390/ijms26031082 - 26 Jan 2025
Cited by 1 | Viewed by 2153
Abstract
The landscape of psychiatric care is poised for transformation through the integration of pharmaco-multiomics, encompassing genomics, proteomics, metabolomics, transcriptomics, epigenomics, and microbiomics. This review discusses how these approaches can revolutionize personalized treatment strategies in psychiatry by providing a nuanced understanding of the molecular [...] Read more.
The landscape of psychiatric care is poised for transformation through the integration of pharmaco-multiomics, encompassing genomics, proteomics, metabolomics, transcriptomics, epigenomics, and microbiomics. This review discusses how these approaches can revolutionize personalized treatment strategies in psychiatry by providing a nuanced understanding of the molecular bases of psychiatric disorders and individual pharmacotherapy responses. With nearly one billion affected individuals globally, the shortcomings of traditional treatments, characterized by inconsistent efficacy and frequent adverse effects, are increasingly evident. Advanced computational technologies such as artificial intelligence (AI) and machine learning (ML) play crucial roles in processing and integrating complex omics data, enhancing predictive accuracy, and creating tailored therapeutic strategies. To effectively harness the potential of pharmaco-multiomics approaches in psychiatry, it is crucial to address challenges such as high costs, technological demands, and disparate healthcare systems. Additionally, navigating stringent ethical considerations, including data security, potential discrimination, and ensuring equitable access, is essential for the full realization of this approach. This process requires ongoing validation and comprehensive integration efforts. By analyzing recent advances and elucidating how different omic dimensions contribute to therapeutic customization, this review aims to highlight the promising role of pharmaco-multiomics in enhancing patient outcomes and shifting psychiatric treatments from a one-size-fits-all approach towards a more precise and patient-centered model of care. Full article
(This article belongs to the Special Issue Innovative Therapeutic Approaches in Neuropsychiatric Disorders)
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