Purine Signaling as a Therapeutic Target in Human Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 20 October 2026 | Viewed by 1426
Special Issue Editor
Special Issue Information
Dear Colleagues,
It is well known that adenosine and ATP play a dual role within the purinergic system. They mediate both energy storage and release through ATP and its phosphate hydrolysis to ADP and AMP, thereby meeting cellular energy demands and facilitating nucleotide assembly. Additionally, they serve as signaling molecules. Purine molecules bind to extracellular purinergic receptors, stimulate signaling pathways, and exert specific functions. Purinergic signaling interacts with other signal molecules in a complex network, regulating a wide variety of cellular processes. The pathological dysregulation of purinergic signaling has been observed in aging, as well as in the development of different diseases, including inflammation, neurodegeneration, and tumors. A deeper understanding of the molecular mechanisms behind purinergic signaling could lead to new and exciting perspectives on the treatment of human diseases. In launching this Special Issue, we hope to highlight recent advances in this field, with a focus on less-known areas, if only to allow them to be explored in greater depth. We invite the submission of original papers on purinergic signaling in human diseases, as well as narrative reviews, meta-analyses, and systematic reviews, for this Special Issue.
Dr. Aránzazu Mediero
Guest Editor
Manuscript Submission Information
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Keywords
- disease
- adenosine
- ATP
- receptors
- transporters
- therapeutics
- molecular mechanisms
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