Mitochondrial Disorders: From Molecular Mechanisms to New Therapies
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 139
Special Issue Editors
Interests: cAMP; AMPK; sirtuins; mitochondria; autophagy; heart failure; aging
Special Issues, Collections and Topics in MDPI journals
Interests: cAMP; AMPK; mitochondria; vascular permeability; Rho GTPases; purinergic receptors; endothelial function; ROS
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue is dedicated to investigating the crucial role of mitochondria-related molecular mechanisms in the progression and treatment of human diseases. Mitochondria, which are central to cellular energetics and homeostasis, play a key role in a wide range of pathophysiological processes, including ischemia–reperfusion injury, oxidative stress, genetic disorders, neurodegeneration, toxicological damage, and the adverse effects of pharmacological treatments. Due to their involvement in essential cellular functions, such as ATP synthesis, ion homeostasis, cell growth, redox regulation, cell signaling, thermogenesis, and cell death, mitochondrial dysfunction can lead to profound disruptions in cell viability and contribute to the onset of numerous diseases. A deeper understanding of the molecular mechanisms that regulate mitochondrial function is critical to advancing our knowledge of these conditions and developing targeted therapeutic approaches.
This Special Issue aims to bring together a collection of original research and review articles highlighting all aspects of mitochondrial biology regulation, including, among others, OXPHOS activity, ROS formation, apoptosis, mitochondrial life cycle, dynamics, and communication with the nucleus and other organelles. Special focuses of this issue include the presentation of new pharmacological targets and enhancing our understanding of diseases related to mitochondrial dysfunction.
Dr. Yury Ladilov
Dr. Muhammad Aslam
Guest Editors
Manuscript Submission Information
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Keywords
- mitochondrial disorders
- mitochondrial dysfunction
- molecular mechanisms
- targeted therapeutic approaches
- mitochondrial biology regulation
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