Molecular Mechanisms of Nephrotoxicity: From Environmental Toxins to Therapeutic Agents
A Special Issue of International Journal of Molecular Sciences (ISSN 1422-0067) belonging to the section "Molecular Toxicology".
Deadline for manuscript submissions: 20 October 2026 | Viewed by 2273
Editor
Interests: toxicology; food safety; nephrology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Kidney injury remains a major health concern worldwide, with environmental toxins and therapeutic agents both recognized as critical contributors to nephrotoxicity. Increasing evidence demonstrates that exposure to pesticides, emerging pollutants, and environmental toxicants can disrupt renal cellular homeostasis, leading to oxidative stress, DNA damage, inflammation, and cell death. These mechanisms are closely associated with the initiation and progression of acute kidney injury and chronic kidney disease.
At the same time, therapeutic agents, although indispensable in modern medicine, may also induce nephrotoxic effects through complex molecular pathways, highlighting the urgent need to balance efficacy and safety in clinical practice. Recent advances in nephrology and toxicology have begun to clarify the interplay between toxicant exposure, renal pathophysiology, and protective therapeutic strategies.
This Special Issue will explore the molecular mechanisms of nephrotoxicity, ranging from environmental toxins to therapeutic interventions. We welcome studies that investigate the underlying pathways, biomarkers, and translational approaches, as well as research aiming to identify novel therapeutic strategies for prevention or treatment. By integrating insights from toxicology, nephrology, and public health, this Special Issue will broaden our understanding and foster innovative solutions to mitigate nephrotoxic risks.
Prof. Dr. Chih-Kang Chiang
Guest Editor
Manuscript Submission Information
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Keywords
- pesticides
- emerging pollutants
- environmental toxicants
- therapeutic strategies
- nephrology
- toxicology
- public health
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