The Role of Dietary Fibre, Nutrition in Gastrointestinal Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".
Deadline for manuscript submissions: 20 October 2026 | Viewed by 568
Special Issue Editor
Interests: gastrointestinal disease; gut microbiome; inflammatory bowel disease; nutrients; nutrition
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
An adequate diet plays a key role not only in maintaining digestive health, but also in preventing intestinal diseases and supporting their treatment. Dietary fibre has a beneficial effect on the intestinal microbiome by providing food for fermenting bacteria that produce short-chain fatty acids, such as butyrate. These metabolites promote mucosal integrity and modulate immune system function through various molecular pathways. In inflammatory bowel diseases, such as Crohn's disease and ulcerative colitis, intestinal dysbiosis, and impaired intestinal homeostasis are often observed. In this case, the role of fibre becomes even more important, especially since its fermentation products can affect gene expression and inflammatory signalling at the cellular level.
A balanced diet that provides adequate nutrients, particularly a variety of fibre fractions, can alleviate symptoms and promote the restoration of intestinal barrier integrity. Interactions involve complex mechanisms such as modulation of oxidative stress, cytokine regulation, and even epigenetic changes. Understanding the interactions between dietary fibre, the gut microbiome, and gastrointestinal disease is crucial to developing effective nutritional strategies to support the therapeutic process, especially in the context of molecular medicine.
Dr. Sara Jarmakiewicz-Czaja
Guest Editor
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Keywords
- dietary fibre
- gut microbiome
- gastrointestinal disease
- inflammatory bowel disease
- nutrients
- nutrition
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