Neurodegenerative Disease: From Molecular Basis to Therapy, 5th Edition
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: 20 October 2026 | Viewed by 570
Special Issue Editor
Interests: neurogenetics; motor neuron diseases; amyotrophic lateral sclerosis; genotype-phenotype correlations; gene variant consequences; microRNAs
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases are a heterogeneous, largely age-dependent group of disorders that affect the central nervous system and ultimately lead to neurodegeneration. The prevalence of these diseases is increasing, partly due to the aging population, which is causing a growing economic burden on healthcare systems. Current treatments are mostly symptomatic, do not address the underlying cause of the disease, and have little or no effect on disease progression.
Recent advancements in neurobiology and neurogenetics have provided valuable insights into the pathogenesis of neurodegenerative diseases. This has paved the way for the development of molecularly targeted therapies that can pause or slow down the fundamental pathological processes that cause neuronal damage and consequent cognitive and motor dysfunctions. In some cases, neurodegenerative diseases are caused by genetic variants and/or cellular pathway dysregulation. Common mechanisms have been identified for several neurodegenerative conditions, such as the presence of misfolded protein aggregates, the abnormal accumulation of proteins, RNA toxicity, and translational products from the expansion of repeats within genes. As advances are made in understanding critical aspects of the underlying molecular pathophysiology, therapeutic strategies continue to evolve. Among these, gene therapy is attracting significant interest due to its ability to deliver functional genetic material to cells and correct defective genes.
This Special Issue aims to provide an updated overview of the advancements in research on neurodegenerative diseases, from understanding the molecular bases to the development of new therapies. Contributions related to, but not limited to, Alzheimer's disease and other types of dementia, Parkinson's disease, and motor neuron diseases are welcome, including original research articles as well as full and short reviews.
Dr. Claudia Ricci
Guest Editor
Manuscript Submission Information
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Keywords
- neurodegenerative diseases
- molecular biology
- neurogenetics
- pathogenesis
- therapy
- personalized medicine
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