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Pharmacological Approaches in Inflammation, Aging, and Cardiovascular Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pharmacology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 1037

Special Issue Editors


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Guest Editor
Department of Cardiac Surgery, University Hospital Zurich, 8091 Zurich, Switzerland
Interests: minimally invasive cardiac surgery; reconstructive surgery; heart failure; cardiopulmonary bypass; aortic diseases; heart valve diseases; mitral valve surgery; coronary artery bypass surgery; off-pump coronary artery bypass; TAVI; thoracic aortic aneurysm; thoracic aorta; hemodynamics perfusion; aortic valve; coronary artery bypass
Special Issues, Collections and Topics in MDPI journals
Faculty of Medicine, University of Zürich, 8032 Zurich, Switzerland
Interests: pharmacological strategy; hypertension; myocardial infarction; cardiovascular disorders

Special Issue Information

Dear Colleagues,

Inflammation and aging are key drivers of cardiovascular disease (CVD) progression. Advances in molecular biology, bioinformatics, and translational research have paved the way to extensive research on the underlying mechanisms, opening potential avenues for targeted therapeutic strategies. At the same time, cardiac surgery remains an essential component in the management of advanced CVD, yet it is associated with inflammatory responses that can significantly affect patient outcomes.

We are pleased to invite you to contribute to this Special Issue, which focuses on innovative pharmacological approaches to understanding and addressing inflammation, aging, and CVD, integrating insights from bench to bedside.

This Special Issue aims to provide a comprehensive and state-of-the-art overview of this critical area, highlighting the multifaceted roles of inflammation and aging in cardiovascular diseases.

In this Issue, original research articles, reviews, commentaries, and meta-analyses are welcome. Research areas may include (but are not limited to) the following:

  • Mechanisms linking inflammation, aging, and cardiovascular disease;
  • Biomarkers and diagnostic tools;
  • Translational and bioinformatics approaches;
  • Inflammation and outcomes in cardiac surgery;
  • Cardiometabolic health and vascular aging;
  • Therapeutic/pharmacological strategies and interventions.

We look forward to receiving your contributions.

Prof. Dr. Omer Dzemali
Dr. Era Gorica
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammation
  • aging
  • cardiovascular diseases
  • approaches
  • translational research
  • therapeutic targets

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Published Papers (1 paper)

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Review

17 pages, 281 KB  
Review
Topical Probiotics in Diabetic Wound Healing: Emerging Therapeutic Strategies
by Eni Çelo, Aida Dama, Sokol Hasho and Leonard Deda
Int. J. Mol. Sci. 2026, 27(6), 2826; https://doi.org/10.3390/ijms27062826 - 20 Mar 2026
Viewed by 766
Abstract
Diabetic foot ulcers (DFUs) are among the most serious and costly complications of diabetes, characterised by delayed healing, frequent infections, and a high risk of recurrence. Despite advances in wound care, many current therapies fail to address the multifactorial pathophysiology of diabetic wounds, [...] Read more.
Diabetic foot ulcers (DFUs) are among the most serious and costly complications of diabetes, characterised by delayed healing, frequent infections, and a high risk of recurrence. Despite advances in wound care, many current therapies fail to address the multifactorial pathophysiology of diabetic wounds, including vascular dysfunction, immune dysregulation, chronic inflammation, and microbial imbalance. In this context, topical probiotics have emerged as a promising microbiome-based strategy aimed at restoring microbial balance while promoting tissue repair. This review summarises current evidence on the use of topical probiotics in diabetic wound healing, with a particular focus on DFUs, outlining key pathophysiological barriers to healing and examining how probiotic therapies may counteract these processes through antimicrobial, antibiofilm, immunomodulatory, and pro-angiogenic mechanisms. Preclinical studies suggest that topical probiotics may promote accelerated wound closure, reduce bacterial burden, modulate inflammatory responses, and enhance collagen deposition and angiogenesis following topical probiotic application. Early clinical studies investigations remain limited to small pilot studies and case series but have reported preliminary signals of enhanced healing and acceptable short-term tolerability in small exploratory cohorts. In addition, recent advances in probiotic delivery, such as bioengineered dressings, postbiotic formulations, and nano-enabled systems designed to improve stability and therapeutic performance, are also discussed. While existing data indicate biological plausibility and early clinical feasibility, larger, well-designed randomized controlled trials and deeper mechanistic investigations are still required to confirm efficacy, clarify safety in high-risk populations, and enable responsible clinical translation. Full article
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