Epigenetic Elicitation of Dormant Microorganisms for Anti-Cancer Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 31
Special Issue Editor
Interests: cell culture; bioactivity; phytochemicals; extraction; chromatography; microbiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Dormant microbes, including actinomycetes and fungi, represent a hidden treasure in our pharmaceutical industry. The epigenetic elicitation of microorganisms' silenced genes can allow them to produce bioactive secondary metabolites that cannot be synthesized under normal circumstances. Epigenetic elicitors include DNA methyltransferase inhibitors (DNMTis) and histone deacetylase inhibitors (HDACis). Epigenetic modulation leads to the transient activation of silent gene clusters among microbes and can produce some bioactive compounds. These types of compounds may have pharmacological activities.
This Special Issue will focus on bioactive molecules produced via epigenetic elicitation that exhibit bioactivity, particularly anti-cancer activity. Moreover, articles on the biosynthetic pathways of such molecules will also be considered, because the epigenetic elicitation of silenced genes is often not replicable and their effect is reversible. We also welcome articles reporting on studies on irreversible genetic changes for the production of anti-cancer compounds.
Dr. Komal Anjum
Guest Editor
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Keywords
- dormant microbes
- epigenetic
- bioactive molecules
- anti-cancer therapy
- biosynthetic pathways
- bioactive secondary metabolites
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