Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 49
Special Issue Editor
Interests: cell biology; tumor biology; cancer immunotherapy; TME; tumor infiltrating myeloid and T cells; tumor immune escape; immunotherapy; drug resistance
Special Issue Information
Dear Colleagues,
Cancer immune infiltration plays a crucial role in cancer progression and response to immunotherapies. The tumor immune microenvironment (TIME), composed of immune cells, stromal elements, and signaling molecules, can either support anti-tumor immunity or promote immune evasion. Recent studies highlight the need to understand how tumors manipulate immune responses to enhance progression, drug resistance, and survival. In immunosuppressive tumors, increased infiltration of activated regulatory T cells, myeloid-derived suppressive cells (MDSCs), and the immunosuppressive reprogramming of neutrophils and macrophages contribute to angiogenesis, tumor growth, metastasis, alter inflammation and immune checkpoint expression. These changes impair cytotoxic immune cell trafficking and activation. However, the immune reprogramming of the TME has not been fully uncovered. A deeper understanding of the biological mechanisms shaping the TIME during tumor progression is essential for developing more effective immunotherapies, improving patient outcomes, and overcoming drug resistance.
This Special Issue Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment, invites original research and review articles. Topics include but are not limited to:
- Mechanisms of immune cell reprogramming in the TME
- Cancer immune evasion strategies
- Mechanisms of cancer resistance to immunotherapies
- Development of novel cancer immunotherapies.
Dr. Alessandro Canella
Guest Editor
Manuscript Submission Information
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Keywords
- TIME
- TME
- immunosuppression
- inflammation
- immune cells
- immunotherapy
- cancer immune evasion
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