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Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 1002

Special Issue Editor


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Guest Editor
Division of Oncology, University Hospital of Patras & Molecular Oncology Laboratory, Medical School, University of Patras, Patras, Greece
Interests: cancer translational research; exosomes; NF-κΒ; biomarkers; NSCLC; SCLC; CRC; breast cancer; pancreatic cancer; monoclonal antibodies; cancer treatment; mAbs; immune checkpoint inhibitors
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Special Issue Information

Dear Colleagues,

Over recent decades, exosomes and extracellular vesicles and their role in cancer development, progression, and treatment have attracted interest from the scientific community. The increasing amount of research on these vesicles in the context of cancer reflects the important role that these vesicles, which are naturally produced by any type of cell, play in cancer multistep process and especially in metastasis. Due to their cargo, which includes DNA, RNA, proteins, and lipids, they can influence recipient cells. In addition, in the face of the unmet need for clinically useful biomarkers in cancer patients, exosomes and extracellular vesicles appear to represent promising biomarkers with diagnostic, prognostic, and predictive potential. Furthermore, a growing number of publications have investigated their value in cancer treatment and resistance, and, more recently, they have been studied for their use as delivery carriers for treatment.

This Special Issue, entitled “Exosomes in the Processes of Tumorigenesis, Cancer Progression, Metastasis, and Treatment”, will showcase original research and review articles covering all aspects of this field, broadening our knowledge on the role of extracellular vesicles and exosomes in cancer.

Dr. Foteinos-Ioannis Dimitrakopoulos
Guest Editor

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Keywords

  • exosomes
  • extracellular vesicles
  • metastasis
  • cancer
  • prognosis
  • prediction
  • biomarker
  • cancer treatment

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Published Papers (1 paper)

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Review

21 pages, 931 KB  
Review
Exosomes and Triple-Negative Breast Cancer: Current Knowledge and Clinical Significance
by Maria Loukopoulou, Anastasia Kottorou, Angelos Koutras and Foteinos-Ioannis Dimitrakopoulos
Int. J. Mol. Sci. 2026, 27(4), 1918; https://doi.org/10.3390/ijms27041918 - 17 Feb 2026
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Abstract
Exosomes, acting as vital mediators of cellular communication and carriers of diverse biomolecular cargo, are increasingly documented as important participants in cancer pathogenesis and progression. When it comes to triple-negative breast cancer (TNBC), a disease that comes with significant therapeutic hurdles, finding new, [...] Read more.
Exosomes, acting as vital mediators of cellular communication and carriers of diverse biomolecular cargo, are increasingly documented as important participants in cancer pathogenesis and progression. When it comes to triple-negative breast cancer (TNBC), a disease that comes with significant therapeutic hurdles, finding new, non-invasive biomarkers is absolutely crucial. This systematic review considers recent research, focusing on the role of exosomal biomarkers in diagnosing, predicting prognosis and foreseeing treatment response in TNBC patients. After an extensive search across PubMed and Google Scholar, we found many exosomal molecules showing great promise for early detection, tracking disease progression and tailoring treatments. This truly highlights liquid biopsy as a valuable, minimally invasive tool. However, there are still some big challenges to treat. These include variations in methodology, the sheer diversity of samples studied and the prevalence of research in specific populations, all of which make it harder to generalize findings. It has been suggested that future research must prioritize protocol standardization, achieving a deeper understanding of underlying biological mechanisms and, crucially, developing combinatorial biomarker panels. Ultimately, the successful translation of exosomal biomarkers into clinical practice will significantly advance personalized medicine in TNBC, leading to improved patient outcomes and an enhanced quality of life. Full article
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