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Antibacterial and Antioxidant Effects of Plant-Sourced Compounds: 2nd Edition

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 October 2026 | Viewed by 1091

Special Issue Editor


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Guest Editor
Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences, Czech University of Life Sciences Prague, 16500 Praha, Czech Republic
Interests: antibiotic resistance; antimicrobial combination effect; antimicrobial activity; antioxidant activity; future smart food; green extraction methods; medicinal plants; micronutrients; neglected and underutilized species (NUS); tropical fruits and vegetables; Staphylococcus aureus
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Special Issue Information

Dear Colleagues,

This is a continuation to our series on the hot topic of “Antibacterial and Antioxidant Effects of Plant-Sourced Compounds”. We have already published a successful Special Issue, which has received interesting contributions and stimulating discussions (https://www.mdpi.com/journal/ijms/special_issues/SK46RGU4IT).

Plants produce a large number of diverse bioactive compounds that help them defend against pathogens and other environmental stressors. For centuries, humans have exploited plants as an invaluable source of secondary metabolites for various purposes, including treating infections, preventing chronic diseases, and preserving food. Many of these bioactive phytochemicals exhibit antibacterial and antioxidant properties, and they continue to play a significant role in modern research and medicine.

Over the last few years, antioxidants have received significant attention because of their ability to inhibit free radicals responsible for oxidative stress and the development of non-communicable diseases (NCDs). Plants are abundant sources of antioxidants, including vitamins, phenolics, and carotenoids, which play a crucial role in neutralizing harmful free radicals and reactive oxygen species, and thus they can have beneficial effects on human health.

Similarly, an extensive increase in antibiotic resistance due to the sustained persistence of resistant bacteria has led to an increased interest in plant-derived compounds and their possible antibacterial effects. Moreover, some previous studies found that combinations of antibiotics with plant extracts or phytochemicals can significantly enhance antibiotic activity and overcome bacterial antibiotic resistance.

Although plants have been traditionally used in various forms of indigenous medicinal systems and many of their compounds hold promise in terms of their antibacterial and antioxidant properties, further research is needed to fully discover their potential and to understand their mechanisms of action and possible applications in medicine and health. Moreover, their effectiveness can vary as a result of factors such as plant species, extraction methods, and concentrations used. Thus, the papers in this Special Issue will provide up-to-date literature analyses and outline newly generated research on the antibacterial and antioxidant effectiveness of plant extracts, plant-derived compounds, or their synthetic analogs, including innovative approaches for obtaining phytochemical-rich extracts/higher yields of phytocompounds and to evaluate their activities, including combinatory effects.

Dr. Johana Rondevaldova
Guest Editor

Manuscript Submission Information

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Keywords

  • antibacterial effect
  • antioxidants
  • medicinal plants
  • anti-infective agents
  • phytochemicals

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Published Papers (1 paper)

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Research

19 pages, 3131 KB  
Article
Bacteriostatic Effect of Some Plant Extracts Against Crown Gall Caused by Agrobacterium tumefaciens L.
by Beata Jacek and Michał Miłek
Int. J. Mol. Sci. 2026, 27(2), 711; https://doi.org/10.3390/ijms27020711 - 10 Jan 2026
Viewed by 669
Abstract
The agar diffusion method was used to test the antibacterial activity of 12 plant species against Agrobacterium tumefaciens, the bacterium that is responsible for crown gall disease. Leaf, root, or flower extracts were prepared, but not all parts were used for each [...] Read more.
The agar diffusion method was used to test the antibacterial activity of 12 plant species against Agrobacterium tumefaciens, the bacterium that is responsible for crown gall disease. Leaf, root, or flower extracts were prepared, but not all parts were used for each of the 12 plants listed. Plant extracts from leaves exhibited higher antibacterial activity than those from flowers and roots. Furthermore, the type of solvent had a significant influence on both the antibacterial activity and the flavonoid and polyphenol content. Acetone and alcohol extracts contained higher contents of these compounds than water extracts. The strongest bacteriostatic effect was of the leaf extracts of eucalyptus (Eucalyptus nicholii L.) and St. John’s wort (Hypericum perforatum L.). Based on HPTLC analysis, eucalyptus extracts contained, among others, chlorogenic acid, hyperoside, and quercetin, while St. John’s wort extracts contained rutin, hyperoside, and quercetin. The tansy leaf extracts (Tanacetum vulgare L.) were also rich in flavonoids and phenolic acids, such as kaempferol-3-glucoside, luteolin, chlorogenic acid, cynarine, and rutin. However, a moderate inhibitory effect against the tested bacterium was found in tansy extracts, as well as hop (Humulus lupulus L.), wormwood (Artemisia absinthium L.), peppermint (Mentha piperita L.), yarrow (Achillea millefolium L.), and nettle (Urtica dioica L.) extracts. The least effective were the root extracts of dandelion (Taraxacum officinale F.H. Wiggers coll.) and valerian (Valeriana officinalis L.), as well as the flower extracts of chamomile (Matricaria chamomilla L.) and marigold (Calendula officinalis L.). Given the lack of effective chemical products and the unavailability of commercially resistant cultivars, the use of plant-based extracts for protecting against crown gall appears to be of particular interest. The preliminary results are promising and suggest that eucalyptus and St. John’s wort extracts are the most promising for controlling A. tumefaciens. Full article
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