Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 72
Special Issue Editor
Interests: neurotrophins; addiction; toxicology; polyphenols; oxidative stress; neurobiology; behavior
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Alcohol use disorders (AUD) are a significant global health concern, affecting millions of individuals and contributing to severe medical, psychological, and socioeconomic outcomes. Emerging research highlights the pivotal role of neuroinflammation in the pathophysiology of AUD, associating chronic alcohol abuse with dysregulated immune responses in the central nervous system. Alcohol-induced neuroinflammation affects neuronal function, promotes neurodegeneration, and exacerbates cognitive and behavioral impairments, ultimately potentiating the progression of addiction.
This Special Issue of the International Journal of Molecular Sciences explores the intricate molecular mechanisms underlying neuroinflammation in AUD, shedding light on crucial pathways involving glial cell activation, cytokine dysregulation, oxidative stress, and blood–brain barrier dysfunction. Additionally, it emphasizes recent developments in therapeutic approaches targeting neuroimmune interactions, including pharmacological interventions, biomarker discovery, and novel approaches such as gene therapy and neuroimmune modulation.
By assembling different cutting-edge research, this issue aims to strengthen our comprehension of the interplay between neuroinflammation and alcohol-related abuse, promoting the development of innovative treatments to counteract the long-term consequences of AUD. We invite researchers and clinicians to participate with their ideas and findings, contributing to the ongoing effort to translate molecular insights into efficient therapeutic solutions.
Prof. Dr. Marco Fiore
Guest Editor
Manuscript Submission Information
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Keywords
- alcohol
- addiction
- abuse
- inflammation
- neurodegeneration
- cognition
- neuroimmunology
- oxidative stress
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