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Molecular Research in Renal Endocrinology

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 20 August 2026 | Viewed by 688

Special Issue Editor

Special Issue Information

Dear Colleagues,

The complex interplay between the kidneys and the endocrine system plays an important role in renal physiology and overall body physiology, as well as in the pathophysiology of various diseases. Understanding these mechanisms is crucial for developing successful therapeutic approaches for various renal conditions, including chronic and acute kidney failure, glomerulonephritis, disturbances in blood pressure and fluid balance regulation, various bone and mineral metabolism diseases, and obesity. New studies on the molecular mechanisms in renal endocrinology are necessary for the development of innovative therapeutic approaches aimed at restoring hormonal balance and preventing the progression of kidney disease. By utilizing advanced technologies such as gene editing, genomics, proteomics, and various in vivo or in vitro model systems, we can provide new innovative tools for studying these mechanisms. We invite researchers to contribute to this Special Issue by sharing their original articles and review papers related to different aspects of renal endocrinology.

Dr. Natalija Filipović
Guest Editor

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Keywords

  • renin–angiotensin system
  • natriuretic peptides
  • calcitriol
  • erythropoietin
  • prostaglandins
  • endothelins
  • adrenomedullin

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Published Papers (1 paper)

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27 pages, 15722 KB  
Article
Connexin 43 and Pannexin 1 in Renal Cell Populations in Diabetic Kidney Disease
by Marinela Jelinčić Korčulanin, Anita Racetin, Nikola Pavlović, Ivo Jeličić, Merica Glavina Durdov, Monika Andrzejewska, Leo Jerčić, Ivana Bočina, Nives Kević, Ivana Restović, Katarina Vukojević, Patricija Bajt, Karla Svaguša and Natalija Filipović
Int. J. Mol. Sci. 2026, 27(5), 2152; https://doi.org/10.3390/ijms27052152 - 25 Feb 2026
Viewed by 454
Abstract
We studied the expression of connexin 43 (Cx43) and pannexin 1 (PANX1) in different cellular populations of the kidneys of diabetic mice and diabetic and non-diabetic patients, to evaluate their role as potential therapeutic targets in diabetic kidney disease (DKD). A combination of [...] Read more.
We studied the expression of connexin 43 (Cx43) and pannexin 1 (PANX1) in different cellular populations of the kidneys of diabetic mice and diabetic and non-diabetic patients, to evaluate their role as potential therapeutic targets in diabetic kidney disease (DKD). A combination of a low dose of streptozotocin and a high-fat diet (HFD) was used to induce a type 2 diabetes model (DM2) in mice. Kidney tissues from diabetic (n = 9) and control patients (n = 11) who underwent nephrectomy were collected. Tissues from mice and humans were processed for double immunofluorescence, using antibodies against Cx43, phosphorylated Cx43 (pCx43) or PANX1 and markers for specific cell populations: endothelium (CD31/PECAM1); pericytes/mesangium (PDGFRB); podocytes (nephrin/synaptopodin); proximal tubules and collecting ducts (aquaporin 2). The results showed a significant decrease in the expression of pCx43 in PDGFRB-immunoreactive mesangium in diabetic patients compared to the control group (p < 0.0001). This contrasted with an increase in pCx43 in pericytes of diabetic mice (p = 0.1). However, we found a general decrease in Cx43 protein expression in diabetic mouse kidneys (p < 0.05). We also found a decrease in the expression of PANX1 in endothelial cells of diabetic patients (p < 0.05) and a significant increase in PANX1 expression in cells expressing PDGFRB (p < 0.05). Expression of PANX1 in endothelium (r = −0.50; p < 0.05) and pCx43 in the mesangium (r = −0.65; p < 0.01) correlated negatively with the percentage of sclerotic glomeruli. The expression and activation of Cx43 and the expression of PANX1 are altered in distinct populations of renal cells during long-term type 2 diabetes mellitus, especially cells of the vascular wall. This may indicate their role in the pathophysiological processes of DKD. Therefore, connexin and pannexin channels could be considered as possible therapeutic targets in the prevention and treatment of diabetic kidney disease. Full article
(This article belongs to the Special Issue Molecular Research in Renal Endocrinology)
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