Gasotransmitters in Oxidative Stress and Neurological Diseases
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2026 | Viewed by 29
Special Issue Editor
Special Issue Information
Dear Colleagues,
This Special Issue in the International Journal of Molecular Sciences will explore the diverse and growing role of gasotransmitters—namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H₂S)—in the pathophysiology of neurological diseases, with particular emphasis on their involvement in oxidative stress. These endogenous gaseous molecules have emerged as critical regulators of redox signalling, mitochondrial dynamics, neuroinflammation, and cell survival, all of which are fundamental to the onset and progression of a wide array of neurological disorders.
This Special Issue aims to provide a comprehensive platform for high-impact research that bridges basic science with translational perspectives, highlighting how the modulation of gasotransmitter pathways could lead to novel therapeutic strategies. It will welcome contributions addressing both acute (e.g., stroke, traumatic brain injury) and chronic (e.g., Alzheimer’s disease, Parkinson’s disease, and multiple sclerosis) neurological conditions.
Topics for this Special Issue may include, but are not limited to, the following:
- Molecular Mechanisms: The roles of NO, CO, and H₂S in redox homeostasis, oxidative/nitrosative stress, and neuronal signalling in health and disease.
- Neurodegeneration and Aging: How gasotransmitter dysregulation contributes to aging-related neurodegenerative diseases such as Alzheimer's, Parkinson’s, and ALS, particularly through oxidative stress pathways.
- Inflammation and Immunity: Interactions between gasotransmitters and neuroinflammatory processes, including the modulation of microglial and astrocytic activity.
- Mitochondrial Function and Apoptosis: The impact of gasotransmitters on mitochondrial biogenesis, mitophagy, calcium signalling, and neuronal apoptosis under oxidative stress conditions.
- Therapeutic Development: Advances in the design and delivery of gasotransmitter donors, inhibitors, and releasing molecules for intervention in oxidative-stress-mediated neurological disorders.
- Neurological Disorders Beyond Alzheimer’s: Exploration of gasotransmitter roles in epilepsy, ischemic injury, Huntington’s disease, multiple sclerosis, and psychiatric conditions with oxidative stress components.
- Preclinical and Clinical Research: Translational studies evaluating the safety, efficacy, and mechanistic underpinnings of gasotransmitter-based therapies in neurological settings.
- Biomarkers and Imaging: Development and validation of gasotransmitter-associated biomarkers for diagnosis, prognosis, and therapeutic monitoring in neurological diseases.
This broadened scope is intended to attract interdisciplinary submissions from neuroscience, pharmacology, medicinal chemistry, and clinical neurology, enhancing the visibility and impact of the Special Issue.
Dr. Malamati Kourti
Guest Editor
Manuscript Submission Information
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Keywords
- gasotransmitters
- neurological diseases
- oxidative stress
- therapeutic strategies
- biomarkers
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