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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cardiovascular Research: From Molecular Mechanisms to Novel Therapies

edited by Piotr Musiałek, Monika M. Gladká and Lukasz Tekieli

submission deadline 31 Aug 2025 | Viewed by 128 | Submission Open

Keywords: cardiovascular diseases; cardiovascular repair and regeneration; molecular cardiology; gene and stem cell therapy; drug and gene delivery; advanced imaging; biomarkers; tissue engineering; thrombosis and clotting abnormalities; animal models of human disease

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Anxiety and Depression: Pathomechanisms and Therapeutic Strategies

edited by

Magdalena Sowa-Kućma

submission deadline 31 Aug 2025 | Viewed by 126 | Submission Open

Keywords: anxiety; depression; anxiolytics; antidepressants; animal models

(This special issue belongs to the Section Molecular Neurobiology)

Epigenetics and RNA Processing Involved in Disease

edited by

Naoyuki Kataoka

submission deadline 31 Aug 2025 | Viewed by 125 | Submission Open

Keywords: RNA processing; RNA splicing; epigenetics; DNA modification; histone modification; RNA modification; RNA diseases; genetic diseases

(This special issue belongs to the Section Molecular Genetics and Genomics)

P53 and Tumours: Strategies to Overcome Chemoresistance in a p53-Dependent Way

edited by

Mariano Francesco Caratozzolo

submission deadline 31 Aug 2025 | Viewed by 124 | Submission Open

Keywords: P53; chemoresistant tumours; drug design; regulatory RNAs; drugs targeting; NGS; transcriptional regulation; molecular networks

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Biotransformation and Engineering of Fungals and Microalgae

edited by Alejandro Chamizo-Ampudia

submission deadline 31 Aug 2025 | Viewed by 123 | Submission Open

Keywords: biotransformation pathways; metabolic engineering; bioactive compound synthesis; enzyme catalysis; microalgae– fungi synergy

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Targeted Therapy of Lymphedema and Lipedema

edited by

Raghu P. Kataru

and Geoffrey E. Hespe

submission deadline 31 Aug 2025 | Viewed by 123 | Submission Open

Keywords: secondary lymphedema; breast cancer related lymphedema; chronic CD4+ T cell inflammtion Th2 driven fribrosis; lymphatic pathophysiology; tissue fibrosis; lymphovenous bypass; lymph node transplanatation; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Environment, Human Stress, and Gut Microbiome: A Triad in Disease Development

edited by

Natalia Kurhaluk

and Halina Tkaczenko

submission deadline 31 Aug 2025 | Viewed by 117 | Submission Open

Keywords: gut microbiome stress interactions; environmental microbiome disease linkages; stress-driven microbiome dysbiosis; microbiome environment disease pathways; human microbiome stress responses; environmental stress disease mechanisms; gut microbiome oxidative stress interactions; environmental oxidative stress impacts; stress-driven microbiome oxidative imbalance; oxidative stress microbiome diseases; human oxidative stress pathways; oxidative stress disease mechanisms

(This special issue belongs to the Section Molecular Microbiology)

Molecular Research in Wearable Self Diagnostics: Against Microbiology Infection

edited by Suw Young Ly

submission deadline 31 Aug 2025 | Viewed by 115 | Submission Open

Keywords: in vivo; in vitro; assay; molecule; skin; AI medical doctor; semiconductor; digital signal; unmanned diagnosis treatment

(This special issue belongs to the Section Molecular Microbiology)

Neuroinflammation, and Alcohol Use Disorders: Molecular Mechanisms and Treatment

edited by

Marco Fiore

submission deadline 31 Aug 2025 | Viewed by 114 | Submission Open

Keywords: alcohol; addiction; abuse; inflammation; neurodegeneration; cognition; neuroimmunology; oxidative stress

(This special issue belongs to the Section Molecular Biology)

Purine Signaling as a Therapeutic Target in Human Diseases

edited by

Aránzazu Mediero

submission deadline 31 Aug 2025 | Viewed by 113 | Submission Open

Keywords: disease; adenosine; ATP; receptors; transporters; therapeutics; molecular mechanisms

(This special issue belongs to the Section Molecular Biology)

Autophagy and Apoptosis in Mammal Cells

edited by Kaja Urbańska and Anna Litwiniuk

submission deadline 31 Aug 2025 | Viewed by 111 | Submission Open

Keywords: autophagy; apoptosis; cellular homeostasis; intra- and intercellular crosstalk; autophagic cell death; programmed cell death

(This special issue belongs to the Section Molecular Biology)

Advancements in Hematology: Molecular Biology and Targeted Therapies

edited by Fabio Stagno and

Stefania Stella

submission deadline 31 Aug 2025 | Viewed by 110 | Submission Open

Keywords: hematological disorders; leukemia; lymphoma; anemia; blood malignancies; targeted therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Applications of Topical Probiotics in Dermatology: Addressing Multiple Skin Disorders

edited by

Mireia Mallandrich Miret

submission deadline 31 Aug 2025 | Viewed by 107 | Submission Open

Keywords: topical probiotics in dermatology; skin microbiome; skin disorders; therapeutic applications; molecular mechanisms

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Novel Immunotherapies for Reshaping the Tumor Immune Microenvironment

edited by

Alessandro Canella

submission deadline 31 Aug 2025 | Viewed by 106 | Submission Open

Keywords: TIME; TME; immunosuppression; inflammation; immune cells; immunotherapy; cancer immune evasion

(This special issue belongs to the Section Molecular Oncology)

Advancements in Antioxidant Molecules: From Discovery to Therapeutic Applications

edited by

Davide Moi

submission deadline 31 Aug 2025 | Viewed by 106 | Submission Open

Keywords: antioxidants; natural products; small molecules; polyphenols; reactive oxygen species; drug discovery; oxidative stress; apoptosis; target validation

(This special issue belongs to the Section Molecular Pharmacology)

Microbial Metabolism: From Pathway Analysis to Metabolic Engineering and Synthetic Biology

edited by

Elias R. Olivera

submission deadline 31 Aug 2025 | Viewed by 105 | Submission Open

Keywords: bacteria; fungi; archeobacteria; metabolic pathways; biodegradation; biosynthesis; biotransformation; omic sciences; metabolic engineering; synthetic regulatory circuits

(This special issue belongs to the Section Molecular Microbiology)

New Advances in Cervical Cancer and Its Therapy

edited by Ilaria Cuccu and

Violante Di Donato

submission deadline 31 Aug 2025 | Viewed by 105 | Submission Open

Keywords: cervical cancer; cervical cancer surgery; fertility-sparing techniques; targeted therapy; immunotherapy; immune checkpoint inhibitors; DNA damage repair inhibitors; antibody– drug conjugates; precision medicine; oncological outcomes

(This special issue belongs to the Section Molecular Oncology)

Development Biology of Immune Cells

edited by Jacek Z. Kubiak

submission deadline 31 Aug 2025 | Viewed by 104 | Submission Open

Keywords: immune cell development; macrophages; monocytes; B-cells; T-cells; dendritic cells; NK cells

(This special issue belongs to the Section Molecular Immunology)

Molecular Genetics and Genomics of Ruminants—Second Edition

edited by

Brad A. Freking

submission deadline 31 Aug 2025 | Viewed by 104 | Submission Open

Keywords: ruminant genomics; structural genomics; functional genomics; epigenomics; gene expression; genome sequencing; genome evolution; genome-wide association study; genomic selection; marker-assisted selection

(This special issue belongs to the Section Molecular Genetics and Genomics)

From Diet to Health: Which Molecules or Chemicals Are at Work?

edited by Sara Baldelli

submission deadline 31 Aug 2025 | Viewed by 101 | Submission Open

Keywords: balanced diet; functional nutrition; nutraceuticals; disease prevention; bioactive biomolecules

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Novel Mechanisms of Receptor Activation

edited by

Zong-Jie Cui

submission deadline 31 Aug 2025 | Viewed by 100 | Submission Open

Keywords: G protein-coupled receptors; nuclear (steroid) hormone receptors; catalytic receptors; receptor structural motifs important for activation; receptor pharmacophores; structure– function correlates; cellular functions; integrated physiology; compartmentalized GPCRs; receptor pharmacology; aryl hydrocarbon receptor (AHR); “ orphan” GPCRs

(This special issue belongs to the Section Biochemistry)

The Positive Impact of DNA-Derived Substances on Inflammation, Aging and Associated Symptoms

edited by

Mi Young Lee

submission deadline 31 Aug 2025 | Viewed by 98 | Submission Open

Keywords: PDRN; PN; DNA-derived substances; nucleic acid-based therapeutics; inflammation; aging

(This special issue belongs to the Section Molecular Biology)

Molecular Research of Cardiovascular Disease

edited by

John A. St. Cyr

submission deadline 31 Aug 2025 | Viewed by 97 | Submission Open

Keywords: myocardium; metabolism; ischemia; function; integrity; cardiovascular; disease; infarction; failure

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cell Biology and Biochemistry of Gynaecological Cancer: Pathways to Discovering Novel Treatments

edited by

Kenny Chitcholtan

submission deadline 31 Aug 2025 | Viewed by 95 | Submission Open

Keywords: gynaecological cancer; ovarian cancer; endometrial cancer; cervical cancer; cell biology; treatment; cell metastasis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Pharmacogenomics: The State of the Art and Future Perspectives

edited by

Satohiro Masuda

submission deadline 31 Aug 2025 | Viewed by 93 | Submission Open

Keywords: G-protein-coupled receptors; membrane transporters; drug-metabolizing enzyme; endocytosis receptors; companion diagnostic (CDx); data science in pharmacogenomics; precision medicine with pharmacogenomics; siRNA; microRNA; drug-induced organ injury; drug-induced adverse reactions

(This special issue belongs to the Section Molecular Pharmacology)

From Pathogenic Mechanisms to Therapy in Retinal Diseases

edited by

Nan-Kai Wang

and

Eugene Yu Chuan Kang

submission deadline 31 Aug 2025 | Viewed by 92 | Submission Open

Keywords: retinal degeneration; oxidative stress; angiogenesis; mitochondria; cellular metabolism; genetic disorders and gene therapy; genes; age-related macular degeneration; inherited retinal dystrophy; diabetic retinopathy; retinal ganglion cells; photoreceptors

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Melanoma: Molecular Diagnosis and Treatment

edited by

Teresa Lettini

submission deadline 31 Aug 2025 | Viewed by 91 | Submission Open

Keywords: molecular pathology; melanoma; skin cancer; molecular pathway; dermatopathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Techniques to Study Food Safety Challenges

edited by

María J. Andrade

and

Micaela Álvarez

submission deadline 31 Aug 2025 | Viewed by 87 | Submission Open

Keywords: food safety; hazards; foodborne pathogens; advanced microbial detection technologies; omics techniques; preventive measures

(This special issue belongs to the Section Molecular Microbiology)

HIV Expression in Diverse Cell Types: Mechanisms, Regulation, and Pathogenesis

edited by

Rosemary Kiernan

submission deadline 31 Aug 2025 | Viewed by 86 | Submission Open

Keywords: hiv transcription; latency; reactivation; host transcription factors; chromatin modifications; viral-host protein interactions

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Immunotherapy in Cancer

edited by Magdalena Król

submission deadline 31 Aug 2025 | Viewed by 85 | Submission Open

Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; monoclonal antibodies; cytokine signaling; tumor immune evasion; metabolic regulation in cancer; cell-based therapies

(This special issue belongs to the Section Molecular Immunology)

Natural Products: Potential Anti-Inflammatory or Anti-Oxidative Mechanisms

edited by

Dong-Sung Lee

and Chi-Su Yoon

submission deadline 31 Aug 2025 | Viewed by 85 | Submission Open

Keywords: inflammation; neuroinflammation; neurodegenerative disease; skin inflammation; skin disease; antioxidants; natural products; secondary metabolites

(This special issue belongs to the Section Bioactives and Nutraceuticals)

New Advances in Plant Genetic Research

edited by

Ming Chen

submission deadline 31 Aug 2025 | Viewed by 84 | Submission Open

Keywords: plant generative genomics; plant– microbe interaction gene-editing; single-cell omics in plants; plant non-coding RNAs; AI in plant science

(This special issue belongs to the Section Molecular Plant Sciences)

Cancer Progression and Therapeutic Resistance Mechanisms

edited by

Fabrizio Fontana

submission deadline 31 Aug 2025 | Viewed by 82 | Submission Open

Keywords: cancer drug resistance; growth factors; DNA repair; miRNAs; ABC transporters; cancer stem cells; extracellular vesicles; circulating cancer cells; circulating cancer DNA; liquid biopsies; natural anticancer compounds

(This special issue belongs to the Section Molecular Oncology)

Responses of Plants to Abiotic and Biotic Stresses: Concepts and Mechanisms

edited by

Ning Liu

submission deadline 31 Aug 2025 | Viewed by 81 | Submission Open

Keywords: plant stress tolerance; abiotic stresses; biotic stresses; molecular mechanisms; signal pathways; multi-omics technologies; epigenetic modifications; crop resilience

(This special issue belongs to the Section Molecular Plant Sciences)

Regulation of Gene Expression in Cell Differentiation

edited by

Iole Robuffo

submission deadline 31 Aug 2025 | Viewed by 80 | Submission Open

Keywords: cell differentiation; gene expression regulation; signal transduction; autophagy; nutrigenomics; mechanobiology; longevity; aging mechanism; tumor progression; regenerative medicine; gene therapy; tissue remodeling

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Imprinting Technologies for Biological and Biomedical Applications

edited by

Urtė Prentice

and

Simonas Ramanavičius

submission deadline 31 Aug 2025 | Viewed by 78 | Submission Open

Keywords: molecularly imprinted polymers; biosensors and diagnostics; biomolecular recognition; molecular imprinting; nanomaterials; molecular biology applications

(This special issue belongs to the Section Molecular Informatics)

Genetics and Genomics of Silkworm

edited by

Min-Jin Han

submission deadline 31 Aug 2025 | Viewed by 77 | Submission Open

Keywords: silkworm genome; gene identification; comparative genomics; silkworm domestication; population genetics; functional genomics; insect immunity; genetic manipulation; silkworm breeding

(This special issue belongs to the Section Molecular Genetics and Genomics)

Ovarian Pathologies: Insights into Mechanisms and Therapeutic Strategy

edited by Anna Ptak

submission deadline 31 Aug 2025 | Viewed by 75 | Submission Open

Keywords: subfertility and infertility; hormonal dysfunction; diminished ovarian reserve (DOR); ovarian cysts; polycystic ovary syndrome (PCOS); primary ovarian insufficiency (POI); ovarian cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Impact of the Immune System on the Tumor Microenvironment: Relevance to Glioma Development

edited by Gabriela Verónica Salamone

submission deadline 31 Aug 2025 | Viewed by 74 | Submission Open

Keywords: gliomas tumor microenvironment immune

(This special issue belongs to the Section Molecular Oncology)

Plant–Rhizobium Interaction

edited by Rujin Chen

submission deadline 31 Aug 2025 | Viewed by 71 | Submission Open

Keywords: legume; rhizobia; symbiotic nitrogen fixation

(This special issue belongs to the Section Molecular Plant Sciences)

New Advances in Food Allergenicity: From Molecular Mechanisms to Innovative Mitigation Strategies

edited by

Edyta Juszczuk-Kubiak

submission deadline 31 Aug 2025 | Viewed by 68 | Submission Open

Keywords: food allergenicity; food allergen detection; biosensors; mass spectrometry; immunoassays; allergen reduction; hypoallergenic food alternatives; personalized nutrition approaches

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Recent Molecular Research in Neuroimmunology

edited by Mireya Fernández-Fournier

submission deadline 31 Aug 2025 | Viewed by 67 | Submission Open

Keywords: neuroimmunology; antibodies; virus; multiple sclerosis; progression

(This special issue belongs to the Section Molecular Neurobiology)

Molecular and Cellular Neurobiology of Headache and Migraine

edited by

Mamoru Shibata

submission deadline 31 Aug 2025 | Viewed by 61 | Submission Open

Keywords: headache; migraine; calcitonin gene-related peptide (CGRP); spreading depolarization/depression; TRP channels; pituitary adenylate cyclase-activating polypeptide; PACAP; cluster headache

(This special issue belongs to the Section Molecular Neurobiology)

Multifunctional Antioxidants and Enzyme Inhibitors: Design, Synthesis and Mechanisms of Actions

edited by Choon Young Lee

submission deadline 31 Aug 2025 | Viewed by 57 | Submission Open

Keywords: antioxidant synthesis; multifunctional antioxidants; oxidant-generating enzyme inhibitors; activators of antioxidant-generating enzymes; phenolic antioxidant; thiol-based antioxidant; nitrogen-based antioxidants; anti-inflammatory; oxidative stress; free radical scavenging; reactive oxygen species; reactive nitrogen species; mechanisms of action; metal chelator

(This special issue belongs to the Section Macromolecules)

Advances in Amyloid Aggregation and Its Inhibition: Implementing Insights from Physiological Conditions

edited by

Andrius Sakalauskas

submission deadline 31 Aug 2025 | Viewed by 56 | Submission Open

Keywords: protein aggregation; amyloid; physiological conditions; aggregation inhibition; neurodegenerative diseases; amyloidosis

(This special issue belongs to the Section Molecular Neurobiology)

Recent Research in Nanoelectrochemistry

edited by

Ioan Baldea

submission deadline 31 Aug 2025 | Viewed by 48 | Submission Open

Keywords: nanoelectrochemistry; single-entity electrochemistry; nanoscale imaging; molecular electronics devices; nanostructured electrodes; electrochemical sensors; energy storage; catalysis; biomedical applications

(This special issue belongs to the Section Materials Science)

Molecular Insights into Pediatric Cancer: Advances in Hematopoietic Stem Cell Research

edited by Paola Muggeo

submission deadline 31 Aug 2025 | Viewed by 43 | Submission Open

Keywords: bone marrow; microenvironment; precursor; hematopoietic stem cells; pediatric hematological malignancies

(This special issue belongs to the Section Molecular Oncology)

Computational, Structural and Spectroscopic Studies of Macromolecules

edited by Sanja Dolanski Babić

submission deadline 10 Sep 2025 | 2 articles | Viewed by 3566 | Submission Open

Keywords: macromolecules; structure DNA; effects on DNA; protein; carbohydrate; lipids; spectroscopic methods; FTIR; NMR; UV; CD; numerical methods

(This special issue belongs to the Section Macromolecules)

Preimplantation Genetic Testing in Assisted Reproductive Technologies

edited by

Sung Tae Kim

submission deadline 10 Sep 2025 | Viewed by 124 | Submission Open

Keywords: preimplantation genetic testing; embryo selection; in vitro fertilization; infertility; implantation failure; miscarriage; mosaicism; segmental aneuploidy; non-invasive technology

(This special issue belongs to the Section Molecular Genetics and Genomics)

Current Advances in the Pathophysiology and Treatment of Multiple Sclerosis and Related Disorders

edited by Natalia Szejko and

Sara Samadzadeh

submission deadline 10 Sep 2025 | Viewed by 100 | Submission Open

Keywords: multiple sclerosis; MS; central nervous system; pathophysiology; immunological system

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 951-1000 on page 20 of 70.

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