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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Molecular Research on Snake Venoms

edited by

Isadora Sousa De Oliveira

and

Eliane Candiani Arantes

submission deadline 31 Jul 2026 | Viewed by 210 | Submission Open

Keywords: snake venoms; venomics; toxin diversity; toxin evolution; structure– function relationships; bioactive peptides; antivenom development; recombinant toxins; molecular mechanisms of toxicity

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanism of Xenobiotics on Respiratory Disorders

edited by

Miguel Santibáñez-Andrade

submission deadline 31 Jul 2026 | Viewed by 209 | Submission Open

Keywords: xenobiotics; polycyclic aromatic hydrocarbons-PHAs; volatile organic compounds-VOCs; metals; respiratory disorders; asthma; chronic obstructive pulmonary disease (COPD); lung cancer; environmental pollutants; DNA methylation; non-coding RNA deregulation; oxidative damage

(This special issue belongs to the Section Molecular Biology)

Cancer Genomics and Immunotherapy: Mechanisms, Biomarkers, and Clinical Translation

edited by

Apostolos Zaravinos

submission deadline 31 Jul 2026 | Viewed by 207 | Submission Open

Keywords: cancer genomics; cancer immunotherapy; tumor immune microenvironment; immunogenomics biomarkers; precision oncology

(This special issue belongs to the Section Molecular Oncology)

Polycystic Ovary Syndrome: Targeted Therapeutics and Future Perspectives

edited by Noha Shawky and

Manar A. Eissa

submission deadline 31 Jul 2026 | Viewed by 206 | Submission Open

Keywords: PCOS; maternal-offspring; developmental origins of health and disease; aging

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Advances in Specialized Metabolites from Medicinal Plants

edited by Hong Wang

submission deadline 31 Jul 2026 | Viewed by 205 | Submission Open

Keywords: medicinal plants; specialized metabolites; medicinal– edible traditional Chinese medicines; natural products; multidimensional LC– MS; metabolomics; proteomics; biosynthesis; bioactive compound screening; molecular mechanisms; multi-omics integration

(This special issue belongs to the Section Molecular Plant Sciences)

Genetic-Driven Precision Oncology in Prostate Cancer

edited by

Pierre Tennstedt

submission deadline 31 Jul 2026 | Viewed by 205 | Submission Open

Keywords: prostate cancer; genetic; biomarker; liquid biopsy; urine; blood; tissue; treatment strategies; diagnosis; progression; metastasis; survival; hormone-sensitive; hormone-resistant; androgen deprivation therapy

(This special issue belongs to the Section Molecular Oncology)

Calcium Signaling in Human Health and Diseases, 4th Edition

edited by

Francesco Moccia

submission deadline 31 Jul 2026 | Viewed by 203 | Submission Open

Keywords: Ca2+ signalling; intracellular organelles; plasma membrane; inositol-1; 4; 5-receptors; ryanodine receptors; ionotropic receptors; metabotropic receptors; TRP channels; two-pore channels; STIM and Orai

(This special issue belongs to the Section Biochemistry)

Proteoglycans and Glycosaminoglycans in Cancer Biology and Therapy

edited by Masao Nakamura

submission deadline 31 Jul 2026 | Viewed by 202 | Submission Open

Keywords: proteoglycans; glycosaminoglycans; tumor microenvironment; chondroitin sulfate; heparan sulfate; sulfation patterns; extracellular matrix remodeling; metastasis and invasion; angiogenesis; immune evasion; antibody therapeutics and ADCs; drug resistance mechanisms

(This special issue belongs to the Section Molecular Oncology)

Molecular Diagnosis and Prevention of Infectious Diseases

edited by

Marília Andreza Da Silva Ferreira

submission deadline 31 Jul 2026 | Viewed by 201 | Submission Open

Keywords: host– pathogen interactions; molecular diagnostics; infectious diseases; emerging and reemerging pathogens; prevention; diagnosis; molecular epidemiology; omics; molecular surveillance

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Rheumatic Diseases: From Pathophysiology to Novel Therapeutic Approaches

edited by Namrata Singh

submission deadline 31 Jul 2026 | Viewed by 200 | Submission Open

Keywords: rheumatic diseases; disease mechanisms; treatment; long-term outcomes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Computational Models in Oncology: From Tumor Initiation to Progression to Treatment

edited by

Vladimir Simic

submission deadline 31 Jul 2026 | Viewed by 199 | Submission Open

Keywords: computational models; tumor growth; computational oncology; multiscale modeling; cancer progression; treatment response modeling; mathematical modeling

(This special issue belongs to the Section Molecular Informatics)

Coordination Architectures for Next-Generation Chemical Sensors: Metal Complexes, Coordination Polymers and MOFs

edited by

Tamara Basova

and

Darya Klyamer

submission deadline 31 Jul 2026 | Viewed by 197 | Submission Open

Keywords: metal complexes; coordination polymers; MOFs

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Molecular Advances in Plant–Microbial Interaction

edited by

Diby Paul

submission deadline 31 Jul 2026 | Viewed by 197 | Submission Open

Keywords: plant microbe intractions; molecular mechanisms; microbiome dynamics; multi-omics approach; stress responses; metagenomics; rhizosphere signalling

(This special issue belongs to the Section Molecular Microbiology)

Exploring Molecular Mechanisms of Lens Development and Growth

edited by

Michael L. Robinson

submission deadline 31 Jul 2026 | Viewed by 197 | Submission Open

Keywords: lens development; lens fiber cell differentiation; organelle degradation; transcriptional regulation; signal transduction; lens regeneration; chromatin remodeling; ocular development

(This special issue belongs to the Section Molecular Biology)

Microbes in Obstetrics: Current Importance of Ascending Bacterial Infection (ABI)

edited by Alfredo Ovalle and Enrique Oyarzun

submission deadline 31 Jul 2026 | Viewed by 195 | Submission Open

Keywords: ascending bacterial infection (ABI); vaginal dysbiosis; spontaneous preterm birth (sPTB); group B streptococcus (GBS); fetal inflammatory response syndrome (FIRS); microbiomics; maternal immunology; cervical insufficiency

(This special issue belongs to the Section Molecular Microbiology)

Viral-Host Interplay: Molecular Mechanisms of Immunity and Pathogenesis

edited by

Jarosław Widelski

submission deadline 31 Jul 2026 | Viewed by 192 | Submission Open

Keywords: virus– host interaction; innate immunity; viral immune evasion; pathogenesis; pattern recognition receptors (PRRs); adaptive immunity; antiviral defense

(This special issue belongs to the Section Molecular Immunology)

Epigenetic and Molecular Control of Plant Hormones in Development and Abiotic Adaptation

edited by

Leonardo Bruno

and

Emanuela Talarico

submission deadline 31 Jul 2026 | Viewed by 190 | Submission Open

Keywords: plant hormones; phytohormone signaling; epigenetic regulation; chromatin remodeling; abiotic stress; plant development; hormone crosstalk; stress adaptation; epigenetic memory

(This special issue belongs to the Section Molecular Plant Sciences)

Advances in Cardiovascular Disease: Pathophysiology, Diagnosis, and Therapy

edited by Masaru Tanaka

submission deadline 31 Jul 2026 | Viewed by 187 | Submission Open

Keywords: cardiovascular disease; endothelial dysfunction; vascular remodeling; inflammation; immunothrombosis; biomarkers; extracellular vesicles; mitochondrial dysfunction; cellular senescence; therapeutic targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Viral Infection: Molecular Mechanisms and Vaccine Approaches

edited by

Ismaïl Moukadiri

submission deadline 31 Jul 2026 | Viewed by 187 | Submission Open

Keywords: viral infection; molecular virology; molecular mechanisms; antigen engineering; next-generation vaccine design

(This special issue belongs to the Section Molecular Immunology)

Spinal Cord Injury: A Comprehensive Approach to Pathophysiology, Treatment, and Recovery

edited by Raúl Silva Garcia and Elisa García-Vences

submission deadline 31 Jul 2026 | Viewed by 185 | Submission Open

Keywords: spinal cord injury; neuroprotection; inflammation; therapy; pathophysiology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Beyond Solid-State Drugs: Liquid-State Pharmaceutical Re-Engineering—from Molecular Design to Delivery Performance

edited by

O. Andreea Cojocaru

submission deadline 31 Jul 2026 | Viewed by 185 | Submission Open

Keywords: liquid-state pharmaceuticals; pharmaceutical re-engineering; active pharmaceutical ingredient ionic liquids (API-ILs); deep eutectic and ionic systems; solid-to-liquid drug transformation; physicochemical property modulation; structure– property– performance relationships; non-oral drug delivery; molecular design of pharmaceutical materials; drug solubility enhancement; permeability and drug delivery; solid-to-liquid transformation; transdermal delivery; pharmaceutical material design; ionic and hydrogen-bonded pharmaceutical systems

(This special issue belongs to the Section Molecular Pharmacology)

Recent Progress in Fabrication, Properties, and Applications of Biomaterials for Tissue Engineering

edited by

Paulina Sobierajska

and

Rafał Jakub Wiglusz

submission deadline 31 Jul 2026 | Viewed by 184 | Submission Open

Keywords: biomedical applications; tissue engineering; biomaterials; nanomaterials; scaffolds; hydrogels; cell– material interaction; 3D printing; bioreactors

(This special issue belongs to the Section Materials Science)

Molecular Mechanisms and Cellular Functions of Tubulin in Neuronal Health and Disease

edited by

Antonella Sferra

submission deadline 31 Jul 2026 | Viewed by 182 | Submission Open

Keywords: tubulin; microtubules; neurodegeneration; neuron; brain; neurodevelopment; motor proteins

(This special issue belongs to the Section Molecular Biology)

Molecular Investigations in Neurodevelopmental Disorders: 2nd Edition

edited by Giorgio Medici

submission deadline 31 Jul 2026 | Viewed by 182 | Submission Open

Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms Regulating Oxidative and Stress Responses in Pseudomonas aeruginosa: Implications for Adaptation and Virulence

edited by Magdalena Pezzoni

submission deadline 31 Jul 2026 | Viewed by 179 | Submission Open

Keywords: Pseudomonas aeruginosa; oxidative stress; stress response regulation; redox homeostasis; transcriptional regulation; small RNAs; virulence and persistence; antibiotic resistance

(This special issue belongs to the Section Molecular Microbiology)

Mitochondrial Bioenergetics and Signaling in Diseases

edited by

Carlos Palmeira

and

Anabela P. Rolo

submission deadline 31 Jul 2026 | Viewed by 178 | Submission Open

Keywords: mitochondria; bioenergetics; oxidative phosphorylation; mitochondrial signaling; metabolism; reactive oxygen species (ROS); mitochondrial dynamics; mitophagy; calcium signaling; mitochondrial DNA; redox homeostasis; cell death; inflammation; neurodegeneration; cancer metabolism; cardiometabolic diseases; aging; therapeutic targeting

(This special issue belongs to the Section Biochemistry)

Extracellular Vesicles as Drivers of Cancer Therapy Resistance: Mechanistic Insights and Emerging Therapeutic Strategies

edited by Abraham Pedroza-Torres

submission deadline 31 Jul 2026 | Viewed by 177 | Submission Open

Keywords: extracellular vesicles; exosomes; cancer resistance; tumor microenvironment; biomolecule transfer

(This special issue belongs to the Section Molecular Oncology)

From Natural Products to Synthetic Small-Molecule Antioxidants: Mechanistic and Kinetic Foundations for Drug Discovery

edited by Cvijeta Jakobušić Brala

submission deadline 31 Jul 2026 | Viewed by 176 | Submission Open

Keywords: oxidative stress; antioxidant mechanisms; reaction kinetics; natural products; small-molecule antioxidants; drug discovery

(This special issue belongs to the Section Molecular Pharmacology)

Mapping Lipid Metabolism in Cancer: Cellular, Metabolic, and Molecular Approaches

edited by

Iorio Egidio

submission deadline 31 Jul 2026 | Viewed by 174 | Submission Open

Keywords: lipid metabolism; cancer; metabolomics

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Mechanisms and Biomarkers of Renal Injury: Bridging the Gap Between Micro-Environment Damage and Clinical Diagnosis

edited by Alexandre Braga Libório

submission deadline 31 Jul 2026 | Viewed by 174 | Submission Open

Keywords: renal injury; molecular biomarkers; AKI-CKD transition; regulated cell death; precision nephrology; renal microenvironment; epigenetics; tubulointerstitial fibrosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Mechanisms and Immune Regulation in Prostate Cancer

edited by Nigel Peter Murray

submission deadline 31 Jul 2026 | Viewed by 173 | Submission Open

Keywords: prostate cancer; immunosupressision; molecular changes; tumour microenvironment; anti-tumour immune changes; next-generation methods of molecular investigation

(This special issue belongs to the Section Molecular Oncology)

Deciphering the Molecular Mechanisms and Etiology of Thrombosis

edited by Omri Snir

submission deadline 31 Jul 2026 | Viewed by 173 | Submission Open

Keywords: thrombogenesis; molecular mechanisms; etiology; thrombo-inflammation; therapeutic targets; endothelial dysfunction; extracellular vesicles; coagulation; fibrinolysis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Cancer Genomics: Key Advances in the Precision Era

edited by

Maria Samara

submission deadline 31 Jul 2026 | Viewed by 171 | Submission Open

Keywords: cancer genomics; next-generation sequencing; artificial intelligence; computational biology; liquid biopsy; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular and Cellular Mechanisms in the Pathophysiology of Gliomas

edited by

Sylvester Omoruyi

submission deadline 31 Jul 2026 | Viewed by 171 | Submission Open

Keywords: genetic and epigenetic alterations; cellular signalling pathways; tumour microenvironment; glioma stem cells; molecular targets and biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Systems Medicine Approaches for Human Diseases: Data Integration, Modeling, and Therapeutic Insights

edited by Mohamed El-Agamy Farh

submission deadline 31 Jul 2026 | Viewed by 170 | Submission Open

Keywords: drug repurposing; single-cell analysis; multi-omics; pharmacogenomics; network-based modeling; metabolic-based modeling; biomarker discovery; deep learning; computational disease modeling; drug discovery

(This special issue belongs to the Section Molecular Informatics)

Effects of Diets and Environmental Pollutants on the Intestine and Liver: A Molecular Perspective

edited by

Aneta Sokal-Dembowska

submission deadline 31 Jul 2026 | Viewed by 170 | Submission Open

Keywords: gut– liver axis; diet; environmental pollutants; molecular mechanisms; gut microbiota; intestinal barrier; liver disease; inflammation; oxidative stress; epigenetics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Panomics Approaches for Deciphering Salinity Stress Tolerance in Plants

edited by

Hafiz Abdul Kareem

and

Mohd Faheem Khan

submission deadline 31 Jul 2026 | Viewed by 168 | Submission Open

Keywords: salinity stress; panomics integration; multi-omics; salt tolerance; spatial transcriptomics; AI-driven breeding; systems biology; climate-smart crops; molecular breeding

(This special issue belongs to the Section Molecular Plant Sciences)

Electrochemical Applications in Medicine and Biotechnology

edited by Ajay Kumar Yagati

submission deadline 31 Jul 2026 | Viewed by 168 | Submission Open

Keywords: electrochemical biosensors; molecular recognition; biomarkers and diagnostics; point-of-care testing; nanomaterials and biointerfaces; precision medicine; bioelectronics and bioinstrumentation; medical biotechnology; pathogen and disease detection; wearable and implantable sensing

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Epigenetic Mechanism in Gynecologic Oncology

edited by

Aneta Słabuszewska-Jóźwiak

submission deadline 31 Jul 2026 | Viewed by 166 | Submission Open

Keywords: epigenetics; cancer; molecular medicine; molecular mechanism; gene expression; cancer pathogenesis

(This special issue belongs to the Section Molecular Oncology)

Natural Products: Pharmacological Insights and Prospects

edited by

Youhua Xu

submission deadline 31 Jul 2026 | Viewed by 166 | Submission Open

Keywords: natural products; pharmacological mechanisms; bioactive compounds; drug discovery; ethnopharmacology; translational research; molecular targets; therapeutic applications

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Breaking the Shield: New Insights in Overcoming Bacterial Resistance

edited by Wilfried Moreira

submission deadline 31 Jul 2026 | Viewed by 165 | Submission Open

Keywords: bacterial resistance; antimicrobial resistance; multi-drug resistant pathogens; antibiotics; phage therapy; antimicrobial peptides; drug delivery systems

(This special issue belongs to the Section Molecular Pharmacology)

Molecular Aspects of Nanomaterial-Based Sensors: Design and Surface Modification Towards Advanced Non-Invasive Detection of Volatile Markers

edited by Patrycja Suchorska-Wozniak and Helena Teterycz

submission deadline 31 Jul 2026 | Viewed by 165 | Submission Open

Keywords: nanomaterials; halitosis; VOC; breath; nanostructures; gas sensing; markers

(This special issue belongs to the Section Molecular Nanoscience)

Screening and Identification of Crop Abiotic Stress Tolerance Functional Genes: 2nd Edition

edited by

Liezhao Liu

submission deadline 31 Jul 2026 | Viewed by 163 | Submission Open

Keywords: plant; abiotic stress; gene; identification; function

(This special issue belongs to the Section Molecular Plant Sciences)

The Role of Extracellular Matrix Proteins in Pathogenesis: 3rd Edition

edited by

Davide Raineri

submission deadline 31 Jul 2026 | Viewed by 162 | Submission Open

Keywords: extracellular matrix proteins; autoimmune disease; cancer; cardiovascular diseases; inflammation; chronic diseases; human diseases

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Research in Postharvest Biology

edited by Hua Zhang

submission deadline 31 Jul 2026 | Viewed by 162 | Submission Open

Keywords: postharvest biology; molecular regulation; plant hormone signaling; gas signaling molecules; ripening-related genes; transgenic technology; postharvest quality preservation

(This special issue belongs to the Section Molecular Plant Sciences)

Exploring Plant Stress Tolerance: Molecular Regulatory Networks and Biotechnological Innovations

edited by

Mustapha Faghire

submission deadline 31 Jul 2026 | Viewed by 161 | Submission Open

Keywords: plant abiotic stress; molecular signaling pathways; regulatory networks; transcriptional regulation; plant– microbe interactions; stress tolerance mechanisms; climate-resilient crops

(This special issue belongs to the Section Molecular Plant Sciences)

Anticancer Drugs: Molecular Research and Progress

edited by

Alejandro Castro-Alvarez

submission deadline 31 Jul 2026 | Viewed by 159 | Submission Open

Keywords: anticancer agents; molecular mechanisms; drug design; computational chemistry; experimental oncology

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms and Treatments of Prostate Cancer

edited by

Sara Merler

submission deadline 31 Jul 2026 | Viewed by 156 | Submission Open

Keywords: prostate cancer; molecular mechanisms; tumor progression; androgen receptor signaling; genetic and epigenetic alterations; biomarkers; tumor microenvironment; therapeutic resistance; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Design and Engineering of Polymeric Systems for Biomedical Applications

edited by

Donatella Duraccio

and

Giovanna Gomez D’Ayala

submission deadline 31 Jul 2026 | Viewed by 156 | Submission Open

Keywords: polymers; polymer systems; drug delivery; tissue engineering; medical devices; regenerative medicine

(This special issue belongs to the Section Macromolecules)

Molecular Disruption Strategies for Enhancing Tumor Radiosensitization

edited by

Salomé Pires

submission deadline 31 Jul 2026 | Viewed by 155 | Submission Open

Keywords: radiosensitization; radiobiology; tumor microenvironment; DNA damage response; molecular oncology; ionizing radiation; radioresistance; targeted therapy

(This special issue belongs to the Section Molecular Oncology)

Displaying special issue 951-1000 on page 20 of 65.

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